ampicillin/sulbactam / Generic mfg. - LARVOL DELTA

NECROTIZING INFECTION BY LACTOBACILLUS ACIDOPHILUS: FRIEND OR FOE (WRMC 2026) - "She initially received oral clindamycin prescribed by her primary care physician without improvement...Based on these results, her antimicrobial regimen was narrowed to intravenous ampicillin/sulbactam, followed by oral amoxicillin/clavulanate upon discharge, with ongoing wound care follow-up. Although probiotics are generally considered safe, this case demonstrates that L. acidophilus can act as a pathogen in high-risk patients. Necrotizing infection due to L. acidophilus is exceptionally uncommon but should be recognized as possible, particularly in immunocompromised hosts."

Cardiovascular • Dermatology • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Septic Shock

Analysis of the Type VI secretion system and microbiological characteristics of hypervirulent Klebsiella pneumoniae causing urinary tract infections. (PubMed, J Infect Dev Ctries) - "T6SS-positive hvKP exhibits lower antimicrobial resistance but stronger virulence, playing a major role in bacterial competition."

Journal • Observational data • Retrospective data • Cardiovascular • Hematological Disorders • Infectious Disease • Nephrology • Pneumonia • Thrombosis

Distribution and antibiotic resistance of Gram-negative bacteria from blood cultures before and during the COVID-19 pandemic. (PubMed, J Infect Dev Ctries) - "K. pneumoniae remained the most frequently isolated bacterium in both periods, while A. baumannii showed a significant increase during the pandemic. The 2.6-fold increase in A. baumannii may have been caused by the increased use of broad-spectrum antibiotics during the pandemic. These findings reflect data from a single hospital and should be validated by further multicenter studies."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

An enzymatic microfluidic sensor for β-lactam antibiotics based on cross-linked ancestral β-lactamase crystals. (PubMed, Nanoscale Adv) - "Full catalytic activity of the ancestral enzyme was retained after immobilization, and inhibition by antibiotics such as ampicillin and sulbactam was detected at concentrations as low as parts per billion. These results support the use of ancient enzymes as stable and responsive biorecognition elements in cost-effective, high-throughput analytical systems targeting environmental pollutants and pharmaceutical compounds."

Journal

Abdominal and Back Pain Initially Suspected to Be Transient Intestinal Ischemia in a Case of Streptococcus dysgalactiae subsp. equisimilis Bacteremia. (PubMed, Cureus) - "After initiation of antimicrobial therapy with ampicillin/sulbactam and intravenous fluids, his fever and inflammatory response improved. Based on the clinical course, it was suggested that bacteremia-related circulatory disturbances and transient intestinal ischemia might have contributed to the nonspecific abdominal and back pain. This case highlights the importance of recognizing SDSE bacteremia as a potential etiology of atypical initial symptoms - such as abdominal or back pain - even before the development of overt skin lesions."

Journal • Back Pain • Cardiovascular • Dermatology • Infectious Disease • Inflammation • Musculoskeletal Pain • Pain

Comment on 'Pharmacokinetics of Ampicillin, Sulbactam, and Combined Ampicillin/Sulbactam in Subcutis, Muscle, and Plasma: A Microdialysis Trial in Healthy Volunteers'. (PubMed, Int J Antimicrob Agents) - No abstract available

Journal • PK/PD data

Randomized controlled trial on the effects of different antibiotic regimens in preterm premature rupture of membranes after 34 weeks. (PubMed, Medicine (Baltimore)) - "The 2 different antibiotic regimens administered to pregnant women diagnosed with PPROM after the 34th week of gestation demonstrated similar clinical effects in terms of maternal and neonatal outcomes. Although the differences in NICU stay duration and the number of chorioamnionitis cases were not statistically significant, we believe that these findings could reach significance in studies with larger sample sizes."

Clinical • Journal • Critical care • Infectious Disease • Obstetrics • CRP

Acinetobacter baumannii bacteraemia: evaluation of strategies for the treatment of in-hospital acquired infection (A-BEAST study), cefiderocol vs ampicillin/sulbactam vs their combination (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease

Ampicillin/sulbactam and ceftazidime/avibactam for the treatment of carbapenem-resistant Acinetobacter baumannii complex: correlation of genotype, phenotype, and clinical outcomes (ESCMID Global 2026) - No abstract available

Clinical • Clinical data

Pharmacodynamic activity of sulbactam/durlobactam and ampicillin/sulbactam combinations against Acinetobacter baumannii (ESCMID Global 2026) - No abstract available

PK/PD data

Frequency of CIT, EBC and DHA flocks (families) of AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae collected from hospitalized patients in North of Iran. (PubMed, Mol Biol Rep) - "The high ampicillin-sulbactam resistance represents a serious concern for the management of hospital-acquired infections. Furthermore, while the presence of the investigated blaCIT, blaEBC, and blaDHA genes did not show a statistically significant correlation with resistance to most tested antibiotics, their detection remains of potential clinical importance due to the risk of horizontal gene transfer to other bacterial species."

Journal • Gene Therapies • Infectious Disease • Pediatrics • Pneumonia

Clinical characteristics of pediatric Moraxella bacteremia in a children's hospital. (PubMed, Pediatr Int) - "The patients with bacteremia due to M. osloensis or M. catarrhalis had favorable clinical outcomes."

Journal • Observational data • Retrospective data • Critical care • Glomerulonephritis • Infectious Disease • Nephrology • Pediatrics • Pneumonia • Renal Disease • Respiratory Diseases

Anaerobic pericarditis due to Clostridium ramosum: First known case report. (PubMed, IDCases) - "He was treated with intravenous ampicillin-sulbactam followed by oral metronidazole, with resolution of the effusion and no recurrence on follow-up. Importantly, routine anaerobic cultures of pericardial fluid should be considered to avoid missed diagnoses. Recognition of rare anaerobic pathogens in pericardial infections expands the understanding of their pathogenic potential and informs future diagnostic and therapeutic approaches."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Depression • Dyslipidemia • Hematological Disorders • Hypertension • Infectious Disease • Psychiatry • Septic Shock

First Reported Case of Capnocytophaga cynodegmi Infective Endocarditis: A Diagnostic Odyssey. (PubMed, Int J Infect Dis) - "The patient underwent valve replacement and completed a 6-week course of ampicillin-sulbactam with clinical recovery...Clinicians should consider zoonotic Capnocytophaga spp. in culture-negative IE, particularly in high-risk patients with animal exposure or valvular abnormalities."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Septic Shock

Antibacterial Tactics Based on Presepsin Level in Thoracic Aorta Surgery Patients (clinicaltrials.gov) - P=N/A | N=50 | Recruiting | Sponsor: Petrovsky National Research Centre of Surgery | Trial completion date: Dec 2025 ➔ Feb 2027 | Trial primary completion date: Nov 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date • Cardiovascular

bla TEM-1 and blaTEM-176 overexpression underlies atypical ampicillin/sulbactam resistance in non-ESBL Salmonella from raw chicken. (PubMed, J Appl Microbiol) - "Host-dependent blaTEM overexpression and resulting β-lactamase hyperproduction can lead to atypical SAM resistance in Salmonella. This study furthers our understanding of the understudied SAM resistance in Salmonella spp."

Journal

Genetic Analysis of Virulence and β-Lactamase Determinants Related to β-Lactamase Inhibitors in Pseudomonas aeruginosa Strains from Nosocomial Infections. (PubMed, Antibiotics (Basel)) - "The MIC determination of ticarcillin/clavulanic acid and piperacillin/tazobactam was performed using the MIC test strip for antimicrobial susceptibility testing...In total, 100% (124/124) and 99.1% (123/124) of the strains isolated from patients with healthcare-associated and community-acquired infections were resistant to the β-lactamase inhibitor antibiotics, amoxicillin/clavulanic acid and ampicillin/sulbactam, respectively, while 54% (67/124) of the strains were resistant to piperacillin/tazobactam... We demonstrated different association profiles of virulence genotype related to the β-lactamase genotype, the β-lactamase inhibitor resistome, phylogroups, and clinical origin of the strains. Therefore, medical treatment regimens against infections caused by P. aeruginosa should be improved."

Journal • Infectious Disease

Prior culture-guided prediction of antibiotic susceptibility in recurrent respiratory tract infections: a retrospective cohort analysis. (PubMed, Front Cell Infect Microbiol) - "Prior cultures had good predictive value (>70%) for detecting future resistance to 22 antibiotics, with ciprofloxacin, levofloxacin, cefuroxime, cefotaxime, ampicillin, ampicillin/sulbactam, and ceftriaxone showing excellent predictive values (≥85%). Additionally, prior cultures had excellent predictive value (≥85%) for detecting future susceptibility to imipenem, amikacin, tobramycin, meropenem, minocycline, and tigecycline. Considerable antibiotic resistance was detected among isolates in patients with RRTIs. Using a prior culture as a guide can enhance the probability of selecting an effective empirical agent."

Journal • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Severe Necrotizing Community-Acquired Pneumonia and Bilateral Empyema in an Immunocompetent Patient due to Fusobacterium necrophorum. (PubMed, Case Rep Pulmonol) - "Treatment with piperacillin-tazobactam was complicated by drug-induced liver injury requiring antimicrobial change to ampicillin-sulbactam. The patient was discharged on oral amoxicillin-clavulanic acid and completed a total of 5 weeks of antimicrobial therapy with complete recovery. This case highlights the importance of considering F. necrophorum as a potential pathogen in necrotizing community-acquired pneumonia, even in immunocompetent adults, and in the absence of classic Lemierre's syndrome features. Furthermore, its novelty and contribution to the medical literature stem from the patient's presentation with bilateral empyema requiring bilateral drains, the combined blood culture and pleural fluid 16S confirmation of F. necrophorum infection, and the preceding steroid exposure that contributed to clinical deterioration."

Journal • Cardiovascular • Hematological Disorders • Hepatology • Infectious Disease • Liver Failure • Otorhinolaryngology • Pneumonia • Respiratory Diseases • Thrombosis

Comparative effectiveness of two antimicrobial regimens for the treatment of pan-drug-resistant Acinetobacter baumannii infections: results from the DESPAIR study. (PubMed, Antimicrob Agents Chemother) - "Salvage therapy and treatment discontinuation due to toxicity were more frequent in patients treated with regimen B. In multivariable analysis, regimen B was independently associated with 28-day mortality before (hazard ratio [HR]: 2.53; 95% CI: 1.08-5.94) but not after propensity matching (HR: 2.64; 95% CI: [0.99-7.02]). Treatment with colistin, ampicillin-sulbactam, and meropenem against severe PDR-AB infections was associated with favorable outcomes compared to colistin, ampicillin-sulbactam, and tigecycline."

HEOR • Journal • Infectious Disease • Pneumonia • Respiratory Diseases

When Should the Differential Diagnosis of Croup Be Reconsidered? (PubMed, Cureus) - "He was diagnosed with croup and treated with nebulized epinephrine and oral dexamethasone but showed minimal clinical improvement...Intubation was performed under sevoflurane anesthesia...The patient remained intubated for five days and received intravenous ampicillin/sulbactam for three weeks...In children with suspected croup who present with atypical features, such as severe sore throat, prolonged illness, or poor response to treatment, deep neck infections, including laryngeal abscess, should be considered. Early recognition and timely intervention are crucial for achieving favorable outcomes."

Journal • Anesthesia • Cough • Infectious Disease • Otorhinolaryngology • Pediatrics • Respiratory Diseases

Optimizing facility-specific urinary weighted-incidence syndromic antibiograms for nursing homes. (PubMed, Infect Control Hosp Epidemiol) - "These results suggest that WISCAs using 2-years of urinary culture data including all gram-negative isolates and excluding duplicate isolates within twelve months maximizes the number of NHs able to create a valid antibiogram."

Journal • Infectious Disease

RIV-TARGET: Efficacy and Safety of BV100 Plus Low Dose Polymyxin B Versus Colistin Plus High-dose Ampicillin/Sulbactam in Patients With Hospital-acquired or Ventilator-associated Bacterial Pneumonia Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex (clinicaltrials.gov) - P3 | N=248 | Not yet recruiting | Sponsor: BioVersys SAS

New P3 trial • Infectious Disease • Pneumonia • Respiratory Diseases

Pharmacokinetics of ampicillin, sulbactam, and combined ampicillin/sulbactam in subcutis, muscle, and plasma: a microdialysis trial in healthy volunteers. (PubMed, Int J Antimicrob Agents) - "Although tissue concentrations almost reached plasma levels, the target attainment of ampicillin may be suboptimal when administered three times daily. Sulbactam tissue and plasma levels were slightly higher after combined administration with ampicillin than after administration of sulbactam alone."

Journal • PK/PD data

Clinical, microbiological and genomic characterization of carbapenem-resistant Gram-negative bacteria in bloodstream infection: A multi-center study in Ecuador. (PubMed, J Appl Microbiol) - "Our findings demonstrate a high burden of CR-GNB, primarily due to K. pneumoniae and E. cloacae complex. Furthermore, the widespread distribution of blaKPC-2, blaNDM-1, and blaOXA-181 in high-risk clones, coupled with the frequent plasmid- and transposon-mediated mobilization of these genes, highlights the crucial role of horizontal gene transfer in the dissemination of resistance."

Journal • Gene Therapies • Infectious Disease • Pneumonia