ampicillin/sulbactam / Generic mfg. - LARVOL DELTA

Population pharmacokinetics of intravenous ampicillin in awake and anesthetised dogs. (PubMed, Vet J) - "The aim of this study is to describe a population pharmacokinetic model for intravenous ampicillin-sulbactam in awake and anaesthetized dogs in these two treatment scenarios and to compute PK/PD cut-offs (PK/PDCO)...In awake dogs, the standard regimen of 20mg/kg every 8h by intravenous route is probably insufficient to treat soft tissues infections caused by gram-negative bacteria. Using prolonged infusion could help to increase ampicillin efficacy against specific pathogens."

Journal • PK/PD data • Anesthesia • Infectious Disease

Thyroid Abscess Following Influenza Infection (ATA 2025) - "She was treated with intravenous ampicillin/sulbactam which was transitioned to oral amoxicillin/clavulanate, to complete a 10 day course of antibiotics. A potential risk factor for her thyroid abscess was impaired immune function given the recent infection. Our case highlights the importance of early diagnosis and management of acute thyroiditis and the consideration of abscess formation in healthy individuals during transient, immunocompromised states."

Diabetes • Endocrine Disorders • Human Immunodeficiency Virus • Infectious Disease • Influenza • Metabolic Disorders • Otorhinolaryngology • Respiratory Diseases

Overcoming phage resistance: efficacy of sequential phage-colistin therapy against carbapenem-resistant Acinetobacter baumannii. (PubMed, Microbiol Spectr) - "PAS was assessed in vitro using meropenem, colistin, tigecycline, rifampin, and ampicillin/sulbactam. Our findings provide valuable translational insights, supporting the potential application of phage therapy in human medicine. By addressing the critical issue of phage resistance, this study advances the development of sustainable bacteriophage-antibiotic treatment regimens against CRAB and other drug-resistant pathogens."

Journal • Infectious Disease

Shifts in Epidemiology and Antibiotic Resistance of Haemophilus Influenzae in Children From Chongqing (2019-2024): Pre-, During, and Post-COVID-19. (PubMed, Infect Drug Resist) - "High resistance was found for ampicillin (79.05%), cefuroxime (58.95%), ampicillin-sulbactam (59.82%), sulfamethoxazole-trimethoprim (68.51%), azithromycin (49.67%), and cefixime (37.78%), while meropenem (0.48%), levofloxacin (0.11%), chloramphenicol (4.85%), ceftriaxone (0.62%), rifampicin (0.15%), tetracycline (5.55%), and cefepime (6.11%) showed low resistance. The COVID-19 pandemic affected resistance patterns: resistance to ampicillin, aztreonam, cefuroxime, amoxycillin-clavulanic, and ampicillin-sulbactam were higher before and after the COVID-19 pandemic than during it (p< 0.001)...The COVID-19 pandemic influenced infection patterns of specific age groups and resistance trends. Caution is required for commonly resistant antibiotics, and continuous resistance monitoring is necessary."

Journal • Infectious Disease • Influenza • Novel Coronavirus Disease • Respiratory Diseases

False equivalence: differences in the in vitro activity of ampicillin-sulbactam and amoxicillin-clavulanate in several Enterobacterales species. (PubMed, JAC Antimicrob Resist) - "Isolates of E. coli, K. pneumoniae group and P. mirabilis with susceptibility profiles consistent with ESBL production (ceftriaxone resistant and cefoxitin susceptible) were more likely to be susceptible to AMC but not susceptible to SAM than isolates without this susceptibility phenotype (E. coli, 38% versus 27%, P < 0.0001; K. pneumoniae group: 40% versus 10%, P < 0.0001; P. mirabilis: 24% versus 6%, P < 0.0001). The high prevalence of SAM-not susceptible, AMC-susceptible isolates supports reporting AST results for both SAM and AMC to maximize options for antimicrobial therapy and to support antimicrobial stewardship."

Journal • Preclinical • Infectious Disease • Pneumonia

The Management and Considerations of a Patient With Sickle Cell Disease in the Head and Neck With Two Case Reports of an Unusual Presentations (AAOMS 2025) - "In patients that have sickle cell disease and signs and symptoms of an odontogenic infection, vaso-occlusive crisis should be considered. Effective treatment involves a thorough differential diagnosis and careful decision-making between surgical and non-surgical options. In both cases, antibiotics (IV Ceftriaxone, PO Metronidazole, or ampicillin-sulbactam), fluid management, dexamethasone, and physical therapy facilitated recovery without surgery.Reference:Chekroun M, Chérifi H, Fournier B, Gaultier F, Sitbon IY, Ferré FC, Gogly B. Oral manifestations of sickle cell disease."

Case report • Clinical • Anemia • Dermatology • Genetic Disorders • Hematological Disorders • Immunology • Infectious Disease • Otorhinolaryngology • Psychiatry • Sickle Cell Disease

A case of idiosyncratic drug-induced agranulocytosis because of sulbactam/ampicillin. (PubMed, J Gen Fam Med) - "We present a case of an 85-year-old man who developed agranulocytosis following SBT/ABPC treatment for pressure ulcer infection and aspiration pneumonia, accompanied by a narrative literature review. Awareness of this condition, prompt discontinuation of the suspected agent, and close monitoring of total white blood cell counts are essential for early detection and management of this life-threatening complication."

Journal • Agranulocytosis • Granulocytopenia • Infectious Disease • Pneumonia • Respiratory Diseases

Population Pharmacokinetic Models of Ampicillin-Sulbactam Among Adult Patients with Infectious Diseases: A Systematic Review. (PubMed, Ther Drug Monit) - "Ampicillin-sulbactam clearance is primarily influenced by renal function (CLcr and SCr) and disease status. None of the studies performed external validation of the developed PK model. This review highlights the PK variability of ampicillin-sulbactam and the need for further research to refine dosing strategies and improve model reliability for clinical application."

Journal • PK/PD data • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Pneumonia • Respiratory Diseases

Campylobacter coli empyema resistant to macrolides and fluoroquinolones: A case report and literature review. (PubMed, Intern Med) - "Despite the initial treatment with intravenous ampicillin-sulbactam and chest tube drainage, the patient's condition did not improve...Meropenem, the only effective antibiotic, was initiated and surgical pleural debridement was performed, thus leading to a clinical recovery. Although 11 cases of empyema caused by Campylobacter spp. have been reported, this is the first case of empyema caused by C. coli that is resistant to both macrolides and fluoroquinolones."

Journal • Pulmonary Disease

Comparative In Vitro Activity of Sulbactam-Durlobactam and Ampicillin-Sulbactam Against A. baumannii with and without PBP3 Mutation (IDWeek 2025) - No abstract available

Preclinical • Infectious Disease

Comparison of Ceftriaxone vs. Ampicillin Sulbactam for the Treatment of Community Acquired Pneumonia (IDWeek 2025) - No abstract available

Infectious Disease

High-dose versus Standard-dose Ampicillin-Sulbactam for Acinetobacter baumannii Infections (IDWeek 2025) - No abstract available

Infectious Disease

The effectiveness and safety between colistin-based and high-dose ampicillin/sulbactam-based combination antibiotic therapy for hospital-acquired pneumonia caused by Carbapenem-resistant Acinetobacter baumannii pneumonia (ERS 2025) - No abstract available

Clinical • Infectious Disease • Pneumonia • Respiratory Diseases

Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes (clinicaltrials.gov) - P=N/A | N=40 | Completed | Sponsor: Yuzuncu Yıl University

New trial

Liver Abscess and ARDS in a Healthy Young Male Following Routine Dental Cleaning: An Uncommon Sequelae of Group G Streptococcal bacteremia (ACG 2025) - "He was started on IV piperacillin-tazobactam and underwent IR-guided abscess drainage...Post-extubation, antibiotics were narrowed to ampicillin-sulbactam...He improved with ertapenem and was discharged with outpatient follow-up. PLA in healthy individuals is rare...Early recognition and multidisciplinary care are critical to favorable outcomes as complications of PLA, such as ARDS, can occur due to systemic inflammatory response. This case adds to the limited literature on GGS-induced liver abscess in healthy individuals, highlighting the systemic implications of what may appear to be a routine outpatient procedure.Figure: CT abdomen with contrast shows a 6.1 cm * 6.2 cm * 6.4 cm right hepatic lobe fluid collection"

Clinical • Acute Respiratory Distress Syndrome • Hepatology • Immunology • Infectious Disease • Inflammation • Mood Disorders • Respiratory Diseases • Systemic Inflammatory Response Syndrome

A Rare Complication of Hepatic Cysts in Advanced Autosomal Dominant Polycystic Kidney and Liver Disease (ACG 2025) - "Patient was empirically started on intravenous meropenem and later de-escalated to ampicillin-sulbactam...The patient improved clinically and was discharged on oral amoxicillin-clavulanate, with plans for outpatient dialysis, and outpatient kidney and liver transplant evaluation. This case highlights a rare, but serious complication of ADPKD/PLD: hepatic cyst infection leading to sepsis and AKI on CKD...Figure: Figure 1: Non-contrast CT Imaging of the Abdomen Showing Extensive Polycystic Changes in Both Kidneys and Liver, Consistent with Advanced Autosomal Dominant Polycystic Kidney and Liver Disease. Liver cyst with measurement (13.8 cm x 11 cm) indicates the hepatic cyst that was drained percutaneously, with 1000 mL serous drainage output."

Metastases • Autosomal Dominant Polycystic Kidney Disease • Chronic Kidney Disease • Genetic Disorders • Hepatology • Infectious Disease • Nephrology • Polycystic Kidney Disease • Renal Disease • Septic Shock

A Rare Case of Septic Shock Secondary to Bacteroides fragilis Empyema in the Setting of Ruptured Liver Abscess (ACG 2025) - "Initially, the patient received broad-spectrum IV antibiotics, including piperacillin-tazobactam, which was later narrowed to ampicillin-sulbactam based on culture sensitivities. underscores the critical nature of this infection. Timely diagnosis through imaging and microbiological analysis, coupled with antibiotics and surgical drainage, is crucial for successful management"

Clinical • Addiction (Opioid and Alcohol) • Cardiovascular • Diabetes • Hepatology • Hypertension • Infectious Disease • Metabolic Disorders • Respiratory Diseases • Septic Shock • Type 2 Diabetes Mellitus

A Case Report of Clostridium perfringens Bacteremia Following Colorectal Cancer Resection (ACG 2025) - "Infectious Disease was consulted and recommended treatment with ampicillin-sulbactam with the transition to oral amoxicillin-clavulanate upon discharge. CT abdomen and pelvis showing colitis in the sigmoid colon (red arrows).Figure: Figure 2. CT abdomen and pelvis showing colitis in the descending colon (red arrows) and colonic hyperemia (blue arrow)."

Case report • Clinical • Biliary Cancer • Colon Cancer • Colorectal Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Genito-urinary Cancer • Immunology • Infectious Disease • Nephrology • Neutropenia • Oncology • Prostate Cancer • Renal Disease • Solid Tumor

A Rare Long Term Complication (ACG 2025) - "The patient was started on intravenous ampicillin-sulbactam 3 grams every 6 hours...A high index of suspicion and early treatment improve outcomes. Management should be individualized based on timing, location, and cause, with supportive measures (e.g., wound care, adequate feeding) as important as surgical repair.Figure: Figure 1Figure: Figure 2"

Cough • Gastrointestinal Disorder • Otorhinolaryngology • Respiratory Diseases

A Rare Case of Pylephlebitis Arising From Sigmoid Diverticulitis (ACG 2025) - "Patient was treated with ampicillin-sulbactam and discharged on amoxicillin-clavulanate. Thrombophlebitis was thought to be provoked, heparin drip was initiated, and transitioned to Eliquis with plans for 3 months of therapy...It was seen that these individuals did not have an underlying hypercoagulable state or mesenteric vein involvement. Overall, the decision to use anticoagulation should be individualized to patient risk factors and comorbidities."

Clinical • Cardiovascular • Fibrosis • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Hypertension • Immunology • Infectious Disease • Pancreatitis • Portal Hypertension • Thrombosis

MANAGEMENT OF SEPTIC SHOCK IN PNEUMONIA ASPIRATION OF STROKE PATIENT: A CASE REPORT (MTS 2025) - "Pneumonia treatment began with Ampicillin-Sulbactam and Levofloxacin...He was diagnosed with septic shock and managed with fluid resuscitation, antibiotics escalation, IV vasopressors, and hydrocortisone... Stroke significantly raises pneumonia risk, which can escalate into septic shock. Early diagnosis and aggressive treatment are essential to reduce mortality in such cases."

Case report • Clinical • Cardiovascular • CNS Disorders • Gastrointestinal Disorder • Hypotension • Infectious Disease • Metabolic Disorders • Pneumonia • Respiratory Diseases • Septic Shock

The effect of intraoperative excessive bleeding on the pharmacokinetics of ampicillin and sulbactam in recipients of living donor liver transplantation in Japan. (PubMed, JAC Antimicrob Resist) - "Guidelines recommend redosing with intravenous prophylactic antibiotics when excessive bleeding exceeds 1500 mL during surgery based on the pharmacokinetics data of cefazolin. Even with excessive bleeding, administering 3 g of ampicillin/sulbactam every 3 h maintained sufficient plasma concentration. Redosing may be unnecessary unless total bleeding exceeds 20 000 mL."

Journal • PK/PD data • Anesthesia • Transplantation

CASCADE: Cefiderocol and Ampicillin-sulbactam vs. Colistin +/- Meropenem for Carbapenem Resistant A. Baumannii (clinicaltrials.gov) - P4 | N=734 | Recruiting | Sponsor: Rambam Health Care Campus | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Pneumonia • Respiratory Diseases

Multidrug-resistant E. Coli in wastewater sources: a comparative study and identification of resistance hotspots. (PubMed, BMC Microbiol) - "Even though resistance was less in community wastewater than hospital wastewater, community outlets might be a source of spreading resistance. Furthermore, wastewater treatment might not be enough to eliminate resistant bacteria from the effluent; as a result, the effluent quality should be continuously monitored and evaluated."

Clinical • Journal

Cervical Necrotizing Fasciitis With Intractable Hiccups. (PubMed, Cureus) - "We report a case of a 61-year-old immunosuppressed man with rheumatoid arthritis on etanercept and past intravenous drug use who presented with intractable hiccups, an unreported feature of cervical necrotizing fasciitis (CNF)...The early surgical debridement, empirical broad-spectrum antibiotics (linezolid, ampicillin-sulbactam), and multidisciplinary teamwork were responsible for a good outcome after delayed diagnosis...This case illustrates the need for a high index of clinical suspicion and the utility of early imaging in immunocompromised patients with atypical presentations. These findings indicate a need for new diagnostic strategies to enhance the outcome of this deadly disease."

Journal • Cardiovascular • Gastrointestinal Disorder • Heart Failure • Immunology • Infectious Disease • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • Septic Shock