azelastine intranasal / Generic mfg. - LARVOL DELTA

Treatment of allergic rhinitis and allergic conjunctivitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Allergic Rhinitis • Allergy • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Comparison table: Some nasal sprays for seasonal allergic rhinitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Allergic Rhinitis • Allergy • Immunology • Inflammation

Comparative Pharmacokinetic and Tolerability Review of Over-the-Counter and Prescription Azelastine Hydrochloride for Allergic Rhinitis Management (AAAAI-WAO 2025) - "Conclusions The OTC switch to Astepro® 0.15% offers enhanced flexibility in dosing, 50% higher azelastine HCl concentration, and a novel bitterness taste masking technology. This formulation ensures greater systemic exposure with a similar safety profile compared to the prescription formulations, offering a promising solution for AR sufferers."

PK/PD data • Review • Allergic Rhinitis • Immunology • Inflammation

A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection (clinicaltrials.gov) - P4 | N=280 | Recruiting | Sponsor: University of Chicago | Trial completion date: Jul 2025 ➔ Dec 2025 | Trial primary completion date: Dec 2024 ➔ Dec 2025

Trial completion date • Trial primary completion date • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Factors Involved in Dymista's Superior Clinical Efficacy in the Treatment of Seasonal Allergic Rhinitis (clinicaltrials.gov) - P4 | N=22 | Completed | Sponsor: University of Chicago | Unknown status ➔ Completed

Trial completion • Allergic Rhinitis • Immunology • Inflammation

Onset-of-Efficacy of Azelastine HCl 0.15% Nasal Spray for allergic rhinitis in an environmental exposure chamber. (PubMed, Ann Allergy Asthma Immunol) - "Azelastine HCl 0.15% nasal spray relieves nasal symptoms associated with allergic rhinitis and has a fast onset of action within 30 minutes. The overall safety profile of azelastine has also been proven to be safe. These results, along with prior findings on efficacy and improved quality of life for people suffering from allergic rhinitis, establish the important clinical role of azelastine HCl 0.15%."

Journal • Allergic Rhinitis • Allergy • Immunology • Inflammation • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Chronic rhinosinusitis with nasal polyposis: an old problem with a new solution (EAACI 2024) - "Case report: 40-year-old male with CRSwNP, asthma and acetylsalicylic acid hypersensitivity, followed up by Otorhinolaryngology and Immunoallergology. Since adolescence, he described persistent nasal obstruction, rhinorrhea and anosmia, with significant impact on quality of life, treated with desloratadine 5mg id, montelukast 10mg id, mometasone nasal spray 50mcg bid, and formoterol+budesonide 160+4,5mcg bid...Despite medical treatment adjustment with ebastine 10mg id, budesonide nasal spray 100mcg bid and association of azelastine nasal spray 1mg/ml id, there was no significant improvement and multiple cycles of systemic corticosteroids were prescribed due to acute exacerbations... In this patient, treatment with dupilumab has translated into a substantial improvement of all the evaluated parameters. The advent of biological therapeutics offers new approaches for medical practitioners and hope for CRSwNP patients."

Immunology • IL4

Efficacy and Safety of On-demand and Continuous Administration of Nasal Spray in the Treatment of Allergic Rhinitis (clinicaltrials.gov) - P4 | N=150 | Recruiting | Sponsor: Zheng Liu ENT | Trial completion date: Jul 2024 ➔ Jan 2025 | Trial primary completion date: May 2024 ➔ Dec 2024

Trial completion date • Trial primary completion date • Allergic Rhinitis • Chronic Rhinosinusitis With Nasal Polyps • Immunology • Inflammation

The impact of nasal use of azelastine and mometasone furoate on drug-induced sleep endoscopy. (PubMed, Eur Rev Med Pharmacol Sci) - "This study first investigated nasal mometasone furoate and azelastine on DISE. This study showed that prior use of nasal mometasone furoate or azelastine before DISE did not affect the amount of secretion, tolerance level, severity, and configuration of obstruction."

Journal

A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection (clinicaltrials.gov) - P4 | N=280 | Recruiting | Sponsor: University of Chicago | Trial completion date: Jul 2024 ➔ Jul 2025 | Trial primary completion date: Dec 2023 ➔ Dec 2024

Trial completion date • Trial primary completion date • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Cytological Study of Topical Effect of Azelastine Hydrochloride on the Nasal Mucous Membrane Cells in Various Nasal Rhinitis Types. (PubMed, Cells) - "Such changes indicate new mechanisms of action of azelastine, which play a significant role in restoring homeostasis in the nasal mucosa. The presented research also results in a detailed description of cytological changes in both studied rhinitis types, which complements the knowledge regarding prognostic indicators."

Journal • Allergic Rhinitis • Immunology • Inflammation

SCITing To A Halt: A Case Of Mast Cell Activation Syndrome And Recurrent Anaphylaxis (ACAAI 2023) - "Current medications included cetirizine, nasal triamcinolone and nasal azelastine. Bone marrow biopsy was remarkable for atypical CD25+ mast cells involving 1-2% of marrow, with absence of KIT mutation and no further mast cell abnormalities, leading to a diagnosis of MCAS. Discussion In patients with recurrent severe anaphylaxis to SCIT, providers should maintain a high clinical suspicion and consider evaluation for underlying mast cell disorders, to include MCAS."

Clinical • IO biomarker • Allergic Rhinitis • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • IL2RA • ISG20 • KIT • TPSAB1

A double-blind, placebo-controlled trial of the efficacy and safety of two doses of azelastine hydrochloride in perennial allergic rhinitis. (PubMed, Front Allergy) - P3 | "It effectively relieves nasal and non-nasal symptoms. ClinicalTrials.gov, identifier: NCT00712920."

Journal • Allergic Rhinitis • Immunology • Inflammation

Analysis of the efficacy of azelastine nasal spray combined with mussel mucin in the treatment of allergic rhinitis and the influence of peripheral blood CCL26 and CCR3 levels. (PubMed, Eur Rev Med Pharmacol Sci) - "Azelastine nasal spray combined with mussel mucin is effective in the treatment of allergic rhinitis, which can effectively improve patients' clinical symptoms, alleviate nasal ventilation disorders, reduce inflammatory reactions, and improve sleep quality. This strategy of combined treatment is safe and, therefore, worth advocating."

Journal • Retrospective data • Allergic Rhinitis • Immunology • Inflammation • CCR3 • IL12A • IL4

Study to Compare the Pharmacokinetics of Fixed-Dose Combination of Mometasone + Azelastine Nasal Spray to Mometasone and Azelastine Nasal Sprays in Adolescents and Young Adults With Seasonal Allergic Rhinitis (clinicaltrialsregister.eu) - P1 | N=60 | Sponsor: Lek Pharmaceuticals d.d.

New P1 trial • Allergic Rhinitis • Immunology • Inflammation

Study to Compare the Pharmacokinetics of Fixed-Dose Combination of Mometasone + Azelastine Nasal Spray to Mometasone and Azelastine Nasal Sprays in Adolescents and Young Adults With Seasonal Allergic Rhinitis (clinicaltrials.gov) - P1 | N=38 | Terminated | Sponsor: Sandoz | N=60 ➔ 38 | Recruiting ➔ Terminated; Business decision (no safety concerns).

Enrollment change • Trial termination • Allergic Rhinitis • Immunology • Inflammation

Fluticasone Propionate with Azelastine Versus Standalone Fluticasone Propionate as Nasal Spray in Allergic Rhinitis: A Prospective Comparative Study in a Rural Population of Northern India. (PubMed, Indian J Otolaryngol Head Neck Surg) - "According to results obtained from the current study, while both fluticasone propionate with azelastine nasal spray and standalone fluticasone propionate nasal spray are widely used for control of symptoms in PER, the former offers better results with significant reduction of symptoms when compared to the latter."

Journal • Allergic Rhinitis • Immunology • Inflammation

Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis (clinicaltrials.gov) - P4 | N=81 | Recruiting | Sponsor: NorthShore University HealthSystem | Not yet recruiting ➔ Recruiting

Enrollment open • Inflammation

Prospective, Randomized, Multinational, Multicenter, Double-blind, Placebo and Active Controlled Trial in 4 Parallel-groups of Patients Suffering From Seasonal Allergic Rhinitis (clinicaltrials.gov) - P3 | N=669 | Completed | Sponsor: Sandoz | Recruiting ➔ Completed

Trial completion • Allergic Rhinitis • Immunology • Inflammation

Developing Nanosuspension Loaded with Azelastine for Potential Nasal Drug Delivery: Determination of Proinflammatory Interleukin IL-4 mRNA Expression and Industrial Scale-Up Strategy. (PubMed, ACS Omega) - "In order to increase bioavailability and intranasal absorbance, the current work set out to create azelastine nasal spray based on nanosuspension...Therefore, the azelastine nanosuspension could be suggested as a practical and simple nanosystem for intranasal delivery with improved permeability and bioavailability. The outcome obtained in this study indicated that azelastine nanosuspension has great potential to treat allergic rhinitis as intranasal treatment."

Journal • Allergic Rhinitis • Hematological Disorders • Immunology • Inflammation • IL4

Study to Compare the Pharmacokinetics of Fixed-Dose Combination of Mometasone + Azelastine Nasal Spray to Mometasone and Azelastine Nasal Sprays in Adolescents and Young Adults With Seasonal Allergic Rhinitis (clinicaltrials.gov) - P1 | N=60 | Recruiting | Sponsor: Sandoz | Not yet recruiting ➔ Recruiting

Enrollment open • Allergic Rhinitis • Immunology • Inflammation

Study to Compare the Pharmacokinetics of Fixed-Dose Combination of Mometasone + Azelastine Nasal Spray to Mometasone and Azelastine Nasal Sprays in Adolescents and Young Adults With Seasonal Allergic Rhinitis (clinicaltrials.gov) - P1 | N=60 | Not yet recruiting | Sponsor: Sandoz

New P1 trial • Allergic Rhinitis • Immunology • Inflammation

".@BayerUS -- congrats on Astepro Allergy Nasal Spray being featured in the @DrugStoreNews Future 50 powered by @HRG_Inc https://t.co/BB6jPLjUAL #future50 #pharmacy #brand #retail #HRGinsights" (@HRG_Inc)

Allergy • Immunology

Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients. (PubMed, Sci Rep) - "The shown effects of azelastine nasal spray may thus be suggestive of azelastine's potential as an antiviral treatment.Trial registration: The study was registered in the German Clinical Trial Register (DRKS-ID: DRKS00024520; Date of Registration in DRKS: 12/02/2021). EudraCT number: 2020-005544-34."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

The Rising Cost of Rhinologic Medications. (PubMed, Ann Allergy Asthma Immunol) - "The rising cost of highly utilized medications contribute to increased patient acquisition costs and may pose barriers of drug adherence to particularly vulnerable populations."

Journal • Allergy • Immunology • Otorhinolaryngology