Alfenta (alfentanil) / Abbott - LARVOL DELTA

Optimizing sedation in elderly patients: advantages and challenges of alfentanil-ciprofol for painless gastroscopy. (PubMed, Am J Transl Res) - "The use of the traditional narcotic sedation guidelines like fentanyl and propofol is linked to respiratory and circulatory suppression in this at-risk group. Furthermore, we address the challenges inherent to its use in this age group, such as dose individualization and respiratory management, and propose potential solutions. Lastly, we outline future research directions, emphasizing that individualized dosing strategies based on the principles of precision anesthesia will be central to optimizing outcomes for elderly patients."

Journal • Review • Anesthesia • Pain

A clinical study on the safety and efficacy of anesthesia with target-controlled infusion of remimazolam or propofol in endobronchial ultrasound diagnosis and treatment (ChiCTR) - P1 | N=110 | Not yet recruiting | Sponsor: Affiliated Hospital of Jiangsu University; Affiliated Hospital of Jiangsu University

New P1 trial • Anesthesia

Comparison of the efficacy and safety of equivalent doses of ciprofol versus propofol in elderly patients undergoing gastroscopy. (ChiCTR) - P1 | N=180 | Recruiting | Sponsor: Liaoning Cancer Hospital & Institute; Liaoning Cancer Hospital

New P1 trial • Anesthesia • Geriatric Disorders

Exploration of the ED50 value and appropriate administration time of alfentanil for preventing rocuronium-induced limb withdrawal movements in children: an age-stratified study (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: Taizhou Hospital of Zhejiang Province; Taizhou Hospital of Zhejiang Province

New trial • Pain

Comparison of Alfentanil and Sufentanil for General Anesthesia in Complex Impacted Tooth Extraction (ChiCTR) - P=N/A | N=180 | Completed | Sponsor: School and Hospital of Stomatology, Hebei Medical University; School and Hospital of Stomatology, Hebei Medical University

New trial • Anesthesia

ED50 of Ciprofol Combined with Alfentanil for Suppression of Laryngeal Mask Airway Insertion Responses in Patients Undergoing Gynecological Laparoscopic Surgery (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: Tai'an Central Hospital (Qingdao University Affiliated Tai'an Central Hospital, Taishan Medical Care Center); Tai'an Central Hospital (Qingdao Univers

New trial • Gynecology • Women's Health

Analgesic Efficacy and Adverse Effects of Epidural Ropivacaine Combined with Equipotent Alfentanil or Sufentanil for Labor Analgesia: A Multicenter Randomized Controlled Single-Blind Trial. (PubMed, Pain Ther) - P4 | "Both alfentanil and sufentanil, when combined with 0.075% ropivacaine, provide effective and safe epidural labor analgesia. However, alfentanil offers the advantage of a faster onset of analgesia, making it a valuable alternative to sufentanil in clinical practice."

Adverse events • Journal • Dermatology • Obstetrics • Pain • Pruritus

Dose-response relationship of remimazolam and afentanil for tympanostomy in children: based on the Dixon up-and-down sequential method (ChiCTR) - P=N/A | N=70 | Not yet recruiting | Sponsor: Affiliated Shunde Hospital of Jinan University; Affiliated Shunde Hospital of Jinan University

New trial • Otorhinolaryngology

Study on the Efficacy and Safety of Remimazolam Besylate Combined with Alfentanil in Elderly Patients Undergoing Flexible Bronchoscopy (ChiCTR) - P=N/A | N=146 | Not yet recruiting | Sponsor: Inner Mongolia Autonomous Region People's Hospital; Inner Mongolia Autonomous Region People's Hospital

New trial

The Effect and Safety of Alfentanil on Postoperative Vomiting in Children Aged 1-3 Years Undergoing Laparoscopic Herniorrhaphy：a randomized clinical trial (ChiCTR) - P4 | N=440 | Not yet recruiting | Sponsor: Children's Hospital of Chongqing Medical University; Children's Hospital of Chongqing Medical University

New P4 trial • Gastroenterology

Different doses of Afentanil combined EP mixture for painless gastrointestinal endoscopy application. (ChiCTR) - P=N/A | N=135 | Recruiting | Sponsor: Yanan University Affiliated Hospital; Yanan University Affiliated Hospital

New trial • Pain

Evaluation of the Hemodynamic Effects of Ciprofol Combined with Alfentanil in Patients Undergoing Painless Gastroenteroscopy via Echocardiography (ChiCTR) - P=N/A | N=84 | Not yet recruiting | Sponsor: Chongqing Red Cross Hospital; Chongqing Red Cross Hospital

New trial • Pain

A Comparative Study of Oliceridine versus Alfentanil and Sufentanil in Clinical Application for Painless Gastrointestinal Endoscopy (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: Qingdao Binhai University Affiliated Hospital; Qingdao Binhai University Affiliated Hospital

New trial • Pain

The optimal interval time for programmed intermittent epidural bolus of 0.075% ropivacaine hydrochloride and 4 μg/ml alfentanil hydrochloride for labor epidural analgesia: A biased coin up-and-down sequential allocation trial (ChiCTR) - P=N/A | N=40 | Not yet recruiting | Sponsor: The General Hospital of the Northern Theater Command of the People's Liberation Army of China; The General Hospital of the Northern Theater Command of

New trial • Pain

The use of Fospropofol disodium and Propofol Combined with Low-Dose Alfentanil in Gastrointestinal Endoscopy: A Randomized Controlled Study (ChiCTR) - P=N/A | N=156 | Not yet recruiting | Sponsor: The People's Hospital of Fengqing; The People's Hospital of Fengqing

New trial • Pain

Study on the effective dose of alfentanil combined with ciprofol in inhibiting intraoperative body movement responses in patients undergoing breast lump resection. (PubMed, Front Med (Lausanne)) - P1 | "The ED50 of alfentanil combined with ciprofol for intravenous anesthesia to suppress movement during breast lumpectomy is 13.396 μg/kg, and the ED₉₅ is 15.752 μg/kg. http://www.chictr.org.cn, ChiCTR2500109829."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Psychiatry

RAA-TS: A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery (clinicaltrials.gov) - P4 | N=50 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Xinxiang Medical College

New P4 trial • Anesthesia

The Efficacy of Remimazolam on Incidence of Hypoxia During Sedated Transvaginal Oocyte Retrieval: A Multicenter Randomized Controlled Trial. (clinicaltrials.gov) - P=N/A | N=400 | Recruiting | Sponsor: Diansan Su

New trial • Infertility • Sexual Disorders

Association between preoperative anxiety and ciprofol requirements in women undergoing surgical abortion: a prospective observational study. (PubMed, Front Med (Lausanne)) - P4 | "Anesthesia was induced with 5 μg/kg alfentanil and 0.3 mg/kg ciprofol. These results indicate that anxiety may be a relevant factor to consider during sedation management for surgical abortion. ChiCTR2500108366 (Chinese Clinical Trial Registry, www.chictr.org.cn)."

Journal • Observational data • Anesthesia • Mood Disorders • Psychiatry

Pharmacokinetics of CYP2C19- and CYP3A4-Metabolized Drugs in Cirrhosis Using a Whole-Body PBPK Approach. (PubMed, Pharmaceutics) - " We constructed a physiologically based pharmacokinetic (PBPK) model that incorporates six drugs, including omeprazole, lansoprazole, midazolam, ondansetron, verapamil, and alfentanil, which are metabolized primarily by CYP2C19 or CYP3A4. The clinical dosing regimens of the CYP2C19 substrate omeprazole and the CYP3A4 substrate ondansetron were optimized for use in cirrhotic patients. The developed PBPK model successfully predicted the pharmacokinetics of CYP2C19 and CYP3A4 substrates in both healthy individuals and cirrhotic patients and can be effectively used for dose optimization in cirrhotic populations."

Journal • PK/PD data • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis • CYP2C19 • CYP3A4

Comparison of the effective dose of alfentanil for percutaneous thermal ablation in subcapsular versus non-subcapsular hepatocellular carcinoma: a prospective dose-finding study utilizing the up-and-down sequential allocation method. (PubMed, BMC Anesthesiol) - No abstract available

Journal • Hepatocellular Cancer • Oncology • Solid Tumor

Effects of penehyclidine hydrochloride or droperidol combined with dexamethasone on preventing postoperative nausea and vomiting after remimazolam-alfentanil general anesthesia for gynecological day surgery. (PubMed, BMC Anesthesiol) - No abstract available

Journal • Anesthesia

Combination of remazolam and alfentanil on hemodynamics, postoperative cognitive function, and adverse cardiovascular events in elderly patients undergoing laparoscopic cholecystectomy: a randomized controlled trial. (PubMed, Front Pharmacol) - P=N/A | "While promising, these findings warrant confirmation in larger, multicenter trials. https://www.chictr.org.cn/showproj.html?proj=210389, Identifier ChiCTR2300077536."

Adverse events • Journal • Anesthesia • Cardiovascular • CNS Disorders • Cognitive Disorders • Hypotension

Effects of Adding Different Drugs for Preventing Cough Induced by Bronchoscopic Spraying of Local Anesthetics (clinicaltrials.gov) - P=N/A | N=108 | Completed | Sponsor: National Taiwan University Hospital | Recruiting ➔ Completed

Trial completion • Anesthesia • Cough • Pulmonary Disease • Respiratory Diseases

Patient-Controlled Sedation in Port Implantation (PACSPI 2)-A Randomised Clinical Trial. (PubMed, Acta Anaesthesiol Scand) - P4 | "EDITORIAL COMMENT: This randomised clinical trial found that adding patient-controlled sedation with propofol-alfentanil to standard local anaesthesia for subcutaneous venous port implantation does not have an impact on pain scores or patient satisfaction. Additional studies focusing on patients experiences and safety are recommended before implementing propofol-alfentanil patient-controlled sedation. Trial Registration: EudraCT number: 2021-003821-31; ClinicalTrials.gov identifier: NCT05688384."

Journal • Anesthesia • Oncology • Pain