Alfenta (alfentanil) / Abbott - LARVOL DELTA

Pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates. (PubMed, Cochrane Database Syst Rev) - "Morphine may have little to no effect on PIPP or duration of ventilation (evidence very uncertain). Morphine may not increase the risk of hypotension and probably does not reduce the incidence of severe IVH. Alfentanil may reduce CHEOPS and heart rate change from baseline (evidence very uncertain). Meperidine may reduce BPS. Compared to midazolam, morphine may have little to no effect on PIPP scores, and may result in a large reduction in the duration of ventilation (evidence very uncertain). No studies reported on physiological and behavioural indicators or haemodynamic changes. Morphine may not reduce the incidence of severe IVH, compared to midazolam (low-certainty evidence). Compared to placebo, midazolam may reduce PIPP scores, and has little to no effect on the duration of ventilation or on the risk of severe IVH (low to very low-certainty evidence); ketamine may reduce CHEOPS change, and have little to no effect on heart rate change, or on mean arterial blood..."

Journal • Review • Critical care • Hypotension • Pain

Quantitative Prediction of Drug-Drug Interactions Arising from CYP3A4 Induction using Chimeric Mice with Humanized Liver. (PubMed, Xenobiotica) - "After repeated administration of rifampicin or efavirenz as CYP inducers to chimeric mice, the relative expression of human CYP3A4 in their livers was measured and plotted against the area under the concentration-time curve (AUC) of rifampicin and efavirenz, respectively, in plasma on the final day of administration. The intrinsic clearance was incorporated into a constructed physiologically based pharmacokinetic model, which successfully predicted the pk change of midazolam or alfentanil coadministered with a CYP inducer or not. The results confirmed that our approach is useful to improve the prediction accuracy of CYP3A4 induction in the preclinical phase."

Journal • Preclinical • CYP3A4

Observation on the Clinical Effect of Remimazolam Sulfonate Combined with Afentanil in Gastric and Colon Endoscopy under Painless Condition (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: Jiangxi Provincial People's Hospital; Jiangxi Provincial People's Hospital

New trial • Pain

The application of alfentanil in painless abortion surgery in plateau area (ChiCTR) - P=N/A | N=28 | Completed | Sponsor: Shannan Maternal and Child Health Hospital; Shannan Maternal and Child Health Hospital

New trial • Pain

The influence of alfentanil versus remifentanil combined with propofol or remimazolam on the incidence of hypoxemia during painless colonoscopy: A multicenter, prospective, 2×2 factorial design, randomized controlled study (ChiCTR) - P=N/A | N=1032 | Not yet recruiting | Sponsor: Drum Tower Hospital; Drum Tower Hospital

New trial • Pain

Analysis of the anesthetic effects of alfentanil combined with ciprofol for gynecological outpatient short operation (ChiCTR) - P=N/A | N=192 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Jinan University; The First Affiliated Hospital of Jinan University

New trial • Anesthesia

ED95 Dose of Alfentanil Combined with Remimazolam for Effective Analgesia in Painless Hysteroscopy: A Dose-Finding Study" (ChiCTR) - P4 | N=80 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Shan Tou University Medical College; The First Affiliated Hospital of Shan Tou University Medical College

New P4 trial • Gynecology • Pain

Alfentanil combined with dexmedetomidine for sedation and analgesia during dressing changes in patients with burns: a prospective, double-blind, randomized controlled study (ChiCTR) - P=N/A | N=62 | Completed | Sponsor: Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

New trial • Anesthesia • Thermal Injury

Application of different sedatives combined with afentanil in painless hysteroscopy (ChiCTR) - P=N/A | N=240 | Recruiting | Sponsor: Gansu Provincial Hospital; Gansu Provincial Hospital

New trial • Gynecology • Pain

Penehyclidine for prevention of postoperative nausea and vomiting in gynecological day surgery under remazolam-alfentanil general anesthesia: a randomized, double-blind, positive-controlled study (ChiCTR) - P=N/A | N=124 | Not yet recruiting | Sponsor: Weifang People's Hospital; Weifang People's Hospital

New trial • Anesthesia

Comparative study of alfentanil combined with remimazolam or propofol in hysteroscopic surger (ChiCTR) - P=N/A | N=80 | Completed | Sponsor: Meizhou People's Hospital; Meizhou People's Hospital

New trial

Cardiac arrest during anesthesia induction for corneal transplantation in a Down syndrome patient (Euroanaesthesia 2025) - "Sevoflurane, combined with alfentanil, propofol and succinylcholine may have exacerbated parasympathetic dominance, leading to the event. 2022; 32(5):609–616. doi:10.1111/pan.14416"

Clinical • Anesthesia • Cardiovascular • Developmental Disorders • Genetic Disorders • Hypotension • Ophthalmology • Transplantation

Inhaled milrinone: an option in patients with pulmonary hypertension in non-cardiac surgery (Euroanaesthesia 2025) - "There are no evidence-based recommendations on the use of specific inhaled pulmonary vasodilators in the intraoperative period for non-cardiac surgery.Case Report: We present a case of a 51 year-old woman with severe type IV pulmonary hypertension (PSAP 70 mmHg) chronically treated with sildenafil that underwent emergent laparotomic incisional hernia repair...Anesthetic induction was performed with alfentanil, ketamine and etomidate and maintenance was carried out with sevoflurane and remifentanil perfusion...In its inhaled form, milrinone causes selective pulmonary vasodilation, improving the V/Q ratio. Additionally, it has positive inotropic properties, increasing cardiac output, while minimizing adverse effects such as hypotension3."

Clinical • Surgery • Anesthesia • Cardiovascular • Gastroenterology • Hypotension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Optimizing sedation in endoscopic retrograde cholangiopancreatography: validation of a pharmacodynamic response surface model (Euroanaesthesia 2025) - "An existing NLMAZ response surface model has been validated for predicting patient responses to sedation with a triple-drug combination of midazolam, alfentanil, and propofol during endoscopic procedures. However, individual variability and procedural factors such as positioning influenced the model's predictive accuracy.Conclusion(s): The NLMAZ model is a valuable tool for optimizing sedation in ERCP. While effective, further studies with larger datasets are needed to refine predictions and explore the impact of positional and physiological factors on sedation depth."

PK/PD data • Anesthesia

Perioperative cardiac arrest and the chain of survival (Euroanaesthesia 2025) - "He was diagnosed with diabetic ketoacidosis (DKA), which resolved within 54 hours of treatment.He underwent an emergency arthroscopic washout for septic arthritis under general anaesthesia with Propofol and Alfentanil...A prolonged downtime of 90 minutes followed with ROSC achieved after two doses of Alteplase...Persistent bradycardia complicated by sepsis precluded pacing. He succumbed on day 37 due to multiple organ failure with sepsis, AKI and recurrent cardiac arrests contributing. This case highlights severe cardiovascular complications in poorly controlled diabetes exacerbated by emergency surgery and infection.Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality for diabetes patients."

Anesthesia • Atherosclerosis • Cardiovascular • Diabetes • Hypotension • Immunology • Infectious Disease • Metabolic Disorders • Myocardial Infarction • Orthopedics • Rheumatology • Septic Shock

Challenges in airway management of a child with severe esophageal caustic stricture and undiagnosed dynamic airway obstruction (Euroanaesthesia 2025) - "He had sialorrhea, nocturnal cough and was fed via a gastrostomy.After inhalation induction and insertion of an intravenous (IV) catheter, 0.2mg alfentanil and 20mg propofol were administered...Intubation with a 3.5mm tube with a stylet under direct laryngoscopy was uneventful: omega-shaped epiglottis, no identification of arytenoid cartilages, modified Cormack-Lehane 2a.General anaesthesia was maintained with sevoflurane.After intubation, bronchospasm occurred and was treated with inhaled bronchodilators.The oesophageal opening was not identified endoscopically...2023; 76(6):643-644.Learning Points: Difficult airway and high risk of respiratory complications should be expected in children with caustic injuries1. A timely multidisciplinary evaluation is essential to ensure safe anaesthesia."

Clinical • Anesthesia • Cough • Fibrosis • Immunology • Pediatrics • Respiratory Diseases

Airway management challenges in a patient with advanced head and neck cancer: a case report (Euroanaesthesia 2025) - "Sedation was induced with alfentanil and propofol, and topical lidocaine was applied. Proactive evaluation, imaging, and a multidisciplinary team are critical to managing high-risk cases.Learning Points: Airway management in patients with malignancy and radiotherapy requires proactive evaluation, advanced tools, and multidisciplinary collaboration. Contingency planning is key, as even asymptomatic patients may develop critical obstruction."

Case report • Clinical • Metastases • Anesthesia • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Head and Neck Cancer • Oncology • Otorhinolaryngology • Solid Tumor • Squamous Cell Carcinoma

The effects of topical pharyngeal anaesthesia on patient tolerance and recovery time following gastroscopy under sedation (Euroanaesthesia 2025) - "Propofol was the mainstay of sedation, adjunct medications included midazolam, alfentanil and fentanyl. Given that this study was conducted in a small hospital with a limited sample size, the generalisability of these results is uncertain. As such, larger-scale studies are necessary to validate these findings."

Clinical • Anesthesia

Application effect of cyclopropofol in endoscopic retrograde cholangiopancreatography under nasal high-flow oxygen therapy in elderly patients (ChiCTR) - P4 | N=108 | Completed | Sponsor: First Affiliated Hospital of Gannan Medical University; First Affiliated Hospital of Gannan Medical University | Recruiting ➔ Completed

Trial completion • Gastroenterology • Pain

Effects of remimazolam combined with high-dose alfentanil on early postoperative cognitive function and sleep in elderly patients undergoing flexible bronchoscopy (ChiCTR) - P=N/A | N=186 | Recruiting | Sponsor: Beilun District People's Hospital of Ningbo; Beilun District People's Hospital of Ningbo

New trial

The Median Effective Concentration (EC50) of Alfentanil Combined with Propofol Closed-Loop Targeted Infusion in Super-Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP). (PubMed, Drug Des Devel Ther) - "The EC50 of alfentanil combined with propofol by closed-loop target-controlled infusion during ERCP in super-elderly patients is 36.52ng/mL. At this concentration level, the patients can be satisfied with surgical anesthesia and maintain relatively stable hemodynamics."

Clinical • Journal • Anesthesia

Population Pharmacokinetics of Alfentanil in Children. (PubMed, J Clin Pharmacol) - "These regimens should be prospectively evaluated to ensure their safety and confirm their efficacy. Overall, this study provides valuable insights into pharmacokinetics and dosing of alfentanil in children."

Journal • PK/PD data • Anesthesia • Pain • Pediatrics

Pharmacokinetics and Pharmacodynamics of Analgesic and Anesthetic Drugs in Patients During Cardiac Surgery With Cardiopulmonary Bypass: A Narrative Review. (PubMed, Anesth Analg) - "The breakdown of studies by main topic was as follows: propofol (9 articles), sevoflurane (4), remifentanil (3), isoflurane (2), fentanyl (2), and sufentanil (2), and alfentanil (1). The clinical implication of the altered drug responses after CPB remains challenging in this high-risk population. Key takeaways include the necessity of considering patient-specific factors, utilizing objective monitoring tools, and recognizing potential drug alterations due to CPB."

Journal • PK/PD data • Anesthesia • Cardiovascular • Pain

Safety of remimazolam in deep sedation during flexible fiberoptic bronchoscopy: a prospective, randomized controlled trial. (PubMed, BMC Anesthesiol) - P4 | "During the maintenance of elderly patients under deep sedation with FFB, remimazolam exhibited superior safety than propofol, particularly in terms of respiratory depression and cardiovascular inhibition."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Pain • Psychiatry

HISPANIC PATIENTS WITH IBD WHO UNDERWENT BOWEL RESECTION ARE LESS LIKELY TO RECEIVE ALL-CAUSE OPIOID AND NON-OPIOID AGENTS USED IN MULTIMODAL PAIN MANAGEMENT (SSAT 2025) - "Medications, which were identified using RXNORM codes, assessed included opioids (weak/strong), NSAIDs, gabapentin/pregabalin, antispasmodics, TCAs, and SSRIs. Among 70,654 IBD patients, non-Hispanic whites (NHW) comprised 49.4% (34,922), Hispanics 16.2% (11,457), and non-Hispanic blacks (NHB) 11.9% (8,431). These findings emphasize differences in all-cause pain management among IBD patients undergoing bowel resections. Hispanic patients consistently used fewer opioids and non-opioid pain medications compared to NHW patients, despite similar resection rates. Our findings may reflect differences in disease severity, pain perception, or healthcare access on the basis of ethnicity.Table 1."

Clinical • Addiction (Opioid and Alcohol) • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Pain • Ulcerative Colitis