Alfenta (alfentanil) / Abbott - LARVOL DELTA

Anesthesia management for a case of acute myocardial infarction with moderate to severe aortic valve stenosis undergoing total gastrectomy (ASA 2025) - "During the operation, alfentanil was pumped to control stress reaction, and landiolol was used to control ventricular rate. After the operation, epidural analgesia was used, and the patient recovered smoothly and was discharged from the hospital."

Clinical • Anesthesia • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Heart Failure • Myocardial Infarction

Standardised Drug Provocation Testing in Perioperative Hypersensitivity (clinicaltrials.gov) - P=N/A | N=50 | Completed | Sponsor: University Hospital, Antwerp | Recruiting ➔ Completed | Trial completion date: Oct 2025 ➔ Jun 2025 | Trial primary completion date: Oct 2025 ➔ Jun 2025

Trial completion • Trial completion date • Trial primary completion date • Allergy • Immunology

Safety and efficacy of remimazolam combined with alfentanil in flexible fiberoptic bronchoscopy: A randomized controlled trial. (PubMed, J Int Med Res) - "It also shortened recovery time and improved both operator and patient comfort scores. These results support remimazolam plus alfentanil as a safe, effective, and well-tolerated alternative sedation regimen in this setting."

Clinical • Journal • Anesthesia • Cough • Hypotension • Pain • Respiratory Diseases

Expanding Fentanyl Analog Testing to Include Brain Specimens: Method Validation and Homogenate Stability Assessment. (PubMed, J Anal Toxicol) - "XXXXX recently added brain to its fentanyl analog testing method for 14 analogs (fluoroisobutyryl fentanyl, acetyl fentanyl, acryl fentanyl, alfentanil, butyryl fentanyl, carfentanil, fentanyl, para-fluorofentanyl, furanyl fentanyl, methoxyacetyl fentanyl, norcarfentanil, norfentanyl, sufentanil, and valeryl fentanyl) and 3 U-series drugs (U-47700, U-48800, and U-49900). Brain homogenate stability was improved when frozen and was not impacted by the addition of 1% sodium fluoride. The study herein provides insight into the feasibility of testing brain for fentanyl analogs and their stability under various storage conditions, contributing valuable data to the limited literature on brain toxicology testing."

Journal

Low-Dose Alfentanil Effectively Reduces the ED50 of Remimazolam for Loss of Consciousness in Pediatric Patients Undergoing General Anesthesia: A Study Using Up-and-Down Sequential Allocation Method. (PubMed, Drug Des Devel Ther) - "Compared with baseline values at T0, the MAP of pediatric patients in both groups decreased at T2 (P<0.05), but the reduction remained within 20% of the baseline values. Low-dose alfentanil (5 μg kg-1) significantly reduces the ED50 and ED95 of remimazolam for successful loss of consciousness during paediatric general anaesthesia induction and decreases the incidence of adverse reactions during remimazolam induced sedation."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Pain • Pediatrics • Psychiatry

Effective doses of alfentanil combined with propofol for gastroscopy in patients of different ages under Narcotrend monitoring: a prospective dose-finding study utilizing the up-and-down sequential allocation method. (PubMed, Perioper Med (Lond)) - "The ED50 of alfentanil combined with propofol for gastroscopy under Narcotrend monitoring were 5.39 µg/kg in the youth group and 5.69 µg/kg in the elderly group, respectively."

Journal • Anesthesia • Pain

Adverse Effects of Alfentanil versus Nalbuphine in Decompensated Cirrhotic Patients Undergoing Painless Gastroscopy: A Double-Blind, Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - "However, no significant differences existed in intraoperative or PACU complications, first-attempt induction success, dosage of etomidate-propofol, Aldrete score, induction time, operation time and awakening time (P > 0.05). Alfentanil demonstrates fewer postoperative complications and faster recovery than nalbuphine, potentially making it preferable for painless gastroscopy in decompensated cirrhosis."

Adverse events • Clinical • Journal • Fibrosis • Immunology • Liver Cirrhosis • Pain

Comparison of Ciprofol Versus Propofol for the General Anaesthesia During Gynecological Day Surgery: A Prospective, Randomized, Double-Blind, Non-Inferiority Trial. (PubMed, Drug Des Devel Ther) - "Anesthesia induction in the ciprofol group: ciprofol 0.5 mg/kg was given intravenously within 1 minute, alfentanil 20 μg/kg was given intravenously within 30 seconds, mivacurium 0.2 mg/kg was given intravenously within 30 seconds, and anesthesia maintenance: ciprofol 1.25 mg/kg/h combined with alfentanil 40 μg/kg/h was given intravenously. However, the awakening time of the ciprofol group was significantly longer than that of the propofol group (7.57 vs 5.52 min). Ciprofol demonstrated non-inferior efficacy to propofol for gynecological day surgery anesthesia, while offering superior hemodynamic stability and reduced adverse effects."

Clinical • Head-to-Head • Journal • Anesthesia

Effect of alfentanil on rapid perioperative recovery in day surgery patients —— a randomized, double-blind, clinical comparative study (ChiCTR) - P4 | N=160 | Completed | Sponsor: Anqing Municipal Hospital; Anqing Municipal Hospital | Recruiting ➔ Completed

Trial completion • Gynecology

Different combinations of anesthetics in transperineal prostate biopsy in elderly men: A prospective, randomized, controlled monocentric trial (PubMed, Zhonghua Nan Ke Xue) - "For elderly male patients undergoing transperineal prostate biopsy under intravenous anesthesia with preservation of spontaneous breathing, the combined use of remimazolam and alfentanil can achieve more stable intraoperative hemodynamics, faster recovery from anesthesia and a lower incidence of perioperative adverse reactions, and produce an even better anesthetic effect with a small dose of propofol to suppress the body movement at the time of needle puncture."

Clinical • Journal • Anesthesia • CNS Disorders • Depression • Pain • Psychiatry

Effect of Different Sequences of Administration of Remimazolam and Alfentanil on Adverse Reactions During the Anesthetic Induction Period in Gynecological Day Surgery Patients (ChiCTR) - P4 | N=104 | Recruiting | Sponsor: Weifang People's Hospital; Weifang People's Hospital

New P4 trial • Anesthesia

Safety and efficacy of slow induction of amnesia analgesia with alfentanil combined with dexmedetomidine in elderly patients undergoing orthopedic surgery : a randomized, controlled study (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Hefei First People's Hospital; Hefei First People's Hospital

New trial • CNS Disorders • Musculoskeletal Diseases • Orthopedics

A Study on the Efficacy and Safety of Different Doses of Dexmedetomidine for Bronchoscopy in ASA Class III Patients (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Gansu Provincial Hospital; Gansu Provincial Hospital

New trial

Evaluating the efficacy and safety of lidocaine combined with alfentanil and propofol in painless gastroenteroscopy: a randomized, double-blind, controlled clinical trial. (ChiCTR) - P=N/A | N=240 | Recruiting | Sponsor: The First Affiliated Hospital of Baotou Medical College; The First Affiliated Hospital of Baotou Medical College

New trial • Pain

A Randomized, Double-Blind, Controlled Clinical Trial Evaluaing the Efficacy and Safety of Remimazolam-Alfentanil and Ciprofol-Alfentanil for Painless Fiberoptic Bronchoscopy (ChiCTR) - P4 | N=204 | Not yet recruiting | Sponsor: Xiangya Hospital, Central South University; Xiangya Hospital, Central South University

New P4 trial • Pain

Clinical application study of propofol combined with alfentanil anesthesia in tumor interventional surgery (ChiCTR) - P4 | N=202 | Not yet recruiting | Sponsor: Lishui Central Hospital; Lishui Central Hospital

New P4 trial • Anesthesia

Remimazolam Besylate-Alfentanil Combination for Pain-Free Colonoscopy: Clinical Outcomes and Influencing Factors (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: Zhongyi Northeast International Hospital Co., Ltd; Zhongyi Northeast International Hospital Co., Ltd

New trial • Pain

The effect of propofol combined with alfentanil target-controlled infusion compared with intermittent bolus injection in gastroenteroscopy (ChiCTR) - P4 | N=188 | Recruiting | Sponsor: Affiliated Hospital of Yan'an University; Affiliated Hospital of Yan'an University

New P4 trial

A comparative study of the anesthetic effect of Alfentanil versus Sufentanil in laryngeal microsurgery (ChiCTR) - P=N/A | N=92 | Recruiting | Sponsor: Ziyang Central Hospital; Ziyang Central Hospital

New trial • Anesthesia • Otorhinolaryngology

Efficacy and safety of remimazolam besylate combined with alfentanil for the induction and maintenance of general anesthesia in obese patients (ChiCTR) - P4 | N=330 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University

New P4 trial • Anesthesia • Obesity

Pharmacodynamics study of remimazolam besylate in anxious patients undergoing gastroscopy: a biased-coin design up-and-down sequential allocation trial. (PubMed, BMC Anesthesiol) - P=N/A | "When combined with 5 µg/kg alfentanil, the ED50 and ED90 of remimazolam besylate for inhibiting body movement response within two minutes of gastroscopy in anxious patients were 0.175 mg/kg and 0.251 mg/kg, respectively. Anxiety increased the requirement for remimazolam besylate in patients undergoing gastroscopy, but it did not increase the risk of prolonged discharge time or adverse effects."

Clinical • Journal • PK/PD data • Mood Disorders • Psychiatry

Evaluation of Therapeutic Opioids in Hair of Neonatal and Pediatric Patients. (PubMed, Drug Test Anal) - "These patients were treated with medically approved novel synthetic opioids (fentanyl, remifentanil, sufentanil, or alfentanil) and traditional opioids (morphine, methadone, and hydromorphone) during their clinical treatment. The metabolite ratio of β-hydroxyfentanyl to fentanyl was particularly well suited for children and neonatal patients. In conclusion, concentration ranges, metabolite ratios, and dose correlations of the studied opioids in pediatric hair were established, providing insights into opioid incorporation pathways."

Journal • Pediatrics

Effect of Sedation/Analgesia During Colonoscope on Abdominal Pain After Examination. (PubMed, Asian J Anesthesiol) - "Optimal S/A with midazolam and alfentanil decreases the severity and duration of postcolonoscopic abdominal pain."

Journal • Anesthesia • Hypotension • Mood Disorders • Pain • Psychiatry

Comparison of fentanyl and alfentanil in combination with atropine for premedication of dogs undergoing radiotherapy. (PubMed, Vet Anaesth Analg) - "Since the two protocols produced comparable clinical effects and were both found suitable for dogs undergoing repeated radiotherapy, fentanyl is recommended over alfentanil in countries where it is licensed."

Journal • Anesthesia • CNS Disorders • Ophthalmology

Optimizing adjuvant strategies for sevoflurane-related emergence delirium: a Bayesian network meta-analysis in pediatric surgery. (PubMed, Front Pharmacol) - "Among all interventions, dexmedetomidine combined with alfentanil was the most effective in reducing ED risk for tonsillectomy/adenoidectomy, achieving a SUCRA ranking of 94.63% (logRR = -2.82). Targeted use of dexmedetomidine-based combinations was found to be particularly effective across various surgeries, while fentanyl and propofol-midazolam combinations excelled in specific contexts. This study underscores the importance of tailoring anesthetic adjuvant strategies to specific surgical sites to reduce the risk of ED in pediatric patients, and provides a valuable reference for optimizing anesthetic care in this vulnerable population."

Journal • Retrospective data • Review • Anesthesia • CNS Disorders • Gastroenterology • Ophthalmology • Otorhinolaryngology • Pediatrics