AN-0128 / Pfizer - LARVOL DELTA

Halogenated Dipyridine Alkaloids from Actinoalloteichus cyanogriseus and Its Mutant Strain upon Precursor Feeding. (PubMed, J Nat Prod) - "Nineteen uncovered 2,2'-dipyridine alkaloids (1-19), along with six previously reported analogues (20-25), were isolated from the wild strain Actinoalloteichus cyanogriseus OUCMDZ-413 and its mutant strain CRM005...The molecular structures of these compounds were determined through spectroscopic analysis. Notably, the novel compounds showed cytotoxicity against the HCT-116, B16, and K562 tumor cell lines, with IC50 values ranging from 0.16 to 11 μM."

Journal • Oncology

Ring Expansion of Cyclic Boronates via Oxyboration of Arynes. (PubMed, J Am Chem Soc) - "A series of 2-aryl-1,3,2-dioxaborolane derivatives were reacted with aryne precursors in the presence of CsF to give the corresponding ring-expanded seven-membered borinic acid esters via selective boron-oxygen bond activation. Preliminary experimental mechanistic studies and density functional theory (DFT) calculations suggest that this unprecedented aryne oxyboration proceeds through the formation of boron ate complexes of arylboronates with CsF, followed by aryne insertion into the boron-oxygen bond."

Journal