alphataxin / Alpha-1 Biologics - LARVOL DELTA

Alphataxin, a Small-Molecule Drug That Elevates Tumor-Infiltrating CD4 T Cells, in Combination With Anti-PD-1 Therapy, Suppresses Murine Renal Cancer and Metastasis. (PubMed, Front Oncol) - P2/3 | "Lung metastasis was present in monotherapy, but significantly reduced in combination-treated mice. Orally available Alphataxin, the first and only drug developed to increase CD4 T cells, in combination with anti-PD-1, is a powerful therapeutic method that provides long-term remission in renal cell carcinoma and potentially other T cell-responsive cancers by increasing the number of CD4 tumor-infiltrating T cells."

Combination therapy • Journal • Preclinical • Genito-urinary Cancer • Immune Modulation • Immunology • Inflammation • Kidney Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor • CD4 • CD8 • TNFA • TNFRSF1B