atorvastatin immediate-release/losartan potassium delayed release (HL 040) / Yuhan Corp, Yuhan Corp, Daewoong Pharma - LARVOL DELTA

Integrated Multiomics Analysis Sheds Light on the Mechanisms of Color and Fragrance Biosynthesis in Wintersweet Flowers. (PubMed, Int J Mol Sci) - "In this study, we chose the wintersweet genotypes HLT040 and HLT015 as the research materials, and studied the co-regulatory mechanism of color and fragrance of wintersweet through metabolomics and transcriptomics...In the yeast one-hybrid assay, we found that CpERF7 was able to interact with the promoter of CpANS1, while CpbHLH50 and CpMYB21 interacted with the promoter of CpTPS4. This study provides a theoretical basis for understanding the co-regulatory mechanism of color and fragrance in wintersweet."

Journal

Low-dose atorvastatin, losartan, and particularly their combination, provide cardiovascular protection in isolated rat heart and aorta (Heart Vessels) - Rat model showed important vasodilatory activity of low-dose ATORVA, losartan & particularly their combination; The effects of the low-dose combination were accompanied by & probably at least partly achieved by, anti-inflammatory & nitric oxide pathways; Results could be valuable for the development of new vascular protective strategies focusing on a low-dose regimen of statins & sartans & particularly their combination

Preclinical-animal • Dyslipidemia