ALB-127158 / Curia - LARVOL DELTA

Computational prediction of analog compounds of the membrane protein MCHR1 antagonists ALB-127158 and KRX-104130. (PubMed, J Bioenerg Biomembr) - "Known MCHR1 antagonists include BMS-830216, GW-856464, NGD-4715, ALB-127158, and AMG 076, but many have failed phase-I clinical studies. In addition, all ligands remained stable in putative binding site. It has been suggested that PV-002757495233 and Z1922310273 compounds can be evaluated as MCHR1 antagonists when all these outputs are considered in melting pots."

Journal • Cardiovascular • Genetic Disorders • Metabolic Disorders • Obesity