acetazolamide / Generic mfg. - LARVOL DELTA

Altitude-Associated Central Apnea in Continuous Positive Airway Pressure Therapy. (PubMed, Sleep Sci) - "Currently, the first-line treatments are acetazolamide and oxygen supplementation. Conclusions  Changes in altitude should be considered in patients with OSA in PAP therapy, as it can occur in many occupations and in recreational travels."

Journal • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

A Rare Case of Vogt-Koyanagi-Harada (VKH) Disease, Graves' Disease, and Primary Ovarian Insufficiency (POI): Expanding the Spectrum of Multisystem Autoimmunity (ENDO 2025) - "She was treated with methimazole for two years, followed by radioiodine ablation (16 mCi). She developed hypothyroidism two months post-ablation and has since been euthyroid on levothyroxine... This case highlights a rare presentation of VKH, Graves' disease, and POI, suggesting that VKH may be part of a broader autoimmune polyglandular spectrum. Reports of VKH coexisting with hypothyroidism, diabetes, and adrenal insufficiency support this hypothesis. The HLA associations identified in VKH suggest a genetic predisposition."

Clinical • Cardiovascular • CNS Disorders • Dermatology • Diabetes • Endocrine Disorders • Grave’s Disease • Gynecology • Hypertension • Immune Modulation • Immunology • Inflammation • Metabolic Disorders • Nephrology • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Renal Disease • Uveitis • Vitiligo • Women's Health • IL2 • IL6

Facile synthesis of aminobiphenyl sulfonamides via Chan-Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors. (PubMed, Sci Rep) - "It was noted that 9d exhibited 8-fold more inhibitor potential as compared to standard inhibitor acetazolamide...Furthermore, the drug-ability of synthesized compounds was evaluated through SwissADME tools, and found that all the newly prepared derivatives successfully satisfied the drug-ability criteria. Molecular docking studies were conducted to identify the types of interactions between the synthesized ligands and the target proteins."

Journal • CNS Disorders • Epilepsy • Genetic Disorders • Glaucoma • Obesity • Oncology • Ophthalmology

Efficacy of ambulatory intravenous diuresis for chronic heart failure patients: Insights from the DEA-HF trial. (PubMed, ESC Heart Fail) - "In patients with congestion-refractory HF, an ambulatory strategy utilizing high-intensity weekly IV diuretic therapy achieved effective decongestion without major safety concerns. This escalated strategy may improve clinical outcomes and prevent hospitalizations of chronic HF patients who require diuresis intensification."

Journal • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease • NPPB

Dynamic intraoperative changes in intracranial pressure during venous stenting. (PubMed, J Neurointerv Surg) - "Initial management with acetazolamide yielded transient improvement; however, recurrent symptoms prompted further evaluation...Our findings emphasize the critical role of dynamic ICP monitoring in guiding venous stenting procedures for IIH and demonstrate the potential to refine treatment strategies for complex venous sinus stenoses, ultimately contributing to better clinical outcomes. neurintsurg;17/8/793/V1F1V1Video 1 Operative video demonstrating venous sinus stenting with concurrent ICP measurement."

Journal • Cardiovascular • CNS Disorders • Hypertension

Involuntary Eye Movements as a Clue to Diagnosis. (PubMed, Mov Disord Clin Pract) - No abstract available

Journal • Ataxia • Movement Disorders

GLP-1 Receptor Agonists in Idiopathic Intracranial Hypertension. (PubMed, JAMA Neurol) - "The control group included patients managed with conventional treatments, such as acetazolamide, topiramate, and dietary counseling, without GLP-1 RA exposure. GLP-1 RA therapy in IIH is associated with significant reductions in medication use, symptoms/signs, and procedural interventions, suggesting its potential as a management strategy. Further prospective studies are warranted to confirm these findings."

Journal • Cardiovascular • CNS Disorders • Hypertension • Ophthalmology • Pain

Novel Derivatives of 3-Amino-4-hydroxy-benzenesulfonamide: Synthesis, Binding to Carbonic Anhydrases, and Activity in Cancer Cell 2D and 3D Cultures. (PubMed, Int J Mol Sci) - "Additionally, the activity of compounds on the viability of three cancer cell lines-human glioblastoma U-87, triple-negative breast cancer MDA-MB-231, and prostate adenocarcinoma PPC-1-was established using the MTT assay and compared to CAIX-selective and non-selective comparative compounds U-104 and acetazolamide...U-87 and PPC-1 spheroids became looser in the presence of compound 9, while the growth of MDA-MB-231 spheroids was slower compared to the control. Compound 21 reduced the growth of U-87 and MDA-MB-231 3D cultures, with no significant effect on PPC-1 spheroids."

Journal • Brain Cancer • Breast Cancer • Glioblastoma • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Solid Tumor • Triple Negative Breast Cancer • CA9

Systemic Carbonic Anhydrase Inhibitors in Common Ophthalmic Diseases: A Scoping Review from A Clinical Standpoint. (PubMed, Curr Ophthalmol Rep) - "It's important to be aware of potential side effects and ensure the correct usage of oral CAIs, especially in individuals with other systemic diseases. A tailored evaluation of risks and benefits carried out for each individual, particularly in case of prolonged usage, should decrease the risk of adverse events."

Journal • Review • Cardiovascular • CNS Disorders • Glaucoma • Hypertension • Macular Edema • Ophthalmology

Optimizing decongestion with adding oral acetazolamide in acute heart failure : fact or myths? (ESC-WCC 2025) - No abstract available

Cardiovascular • Congestive Heart Failure • Heart Failure

Oral acetazolamide in acute heart failure: effects on renal function and clinical outcomes (ESC-WCC 2025) - No abstract available

Clinical • Clinical data • Cardiovascular • Congestive Heart Failure • Heart Failure

Acetazolamide as an adjunct to loop diuretics in decongesting patients with acute decompensated heart failure: a systematic review and meta-analysis (ESC-WCC 2025) - No abstract available

Retrospective data • Review • Cardiovascular • Congestive Heart Failure • Heart Failure

Efficacy and safety of oral acetazolamide in patients with decompensated heart failure: hospital phase of open-label prospective randomized multicenter study ORION-A (ESC-WCC 2025) - No abstract available

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure

Acetazolamide plus Atomoxetine Changed Chemosensitivity in Obesity Hypoventilation Syndrome (ERS 2025) - No abstract available

Genetic Disorders • Obesity • Respiratory Diseases

Effect of acetazolamide on 24-hour blood pressure in highlanders with obstructive sleep apnea: a randomized, placebo-controlled, double-blinded (ERS 2025) - No abstract available

Clinical • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Effect of acetazolamide on obstructive sleep apnea in highlanders: a randomized, placebo-controlled, double-blinded crossover trial (ERS 2025) - No abstract available

Clinical • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Semi-Solid Extrusion 3D Printing of Pediatric Acetazolamide Formulation: Impact of the Spatial Arrangement of Extruded Material on Quality Attributes. (PubMed, J Pharm Sci) - "This study provides a quantitative assessment of how spatial material distribution in SSE 3D printing affects the CQAs of printed dosage forms. The findings highlight the need to optimize structural parameters to balance mechanical stability and dissolution characteristics, ensuring pharmaceutical compliance."

Journal • Pediatrics

Risk Reduction of Recurrent Spontaneous Cerebrospinal Fluid Leaks with Postoperative Intracranial Pressure Management (AAO-HNSF 2025) - "There is no strong evidence to support the use of postoperative CSF pressure-reducing interventions in reducing the risk of recurrent lateral skull base sCSF leaks after repair."

Cardiovascular • CNS Disorders • Hypertension

Neuroschistosomiasis: rare CNS infection in a preschool-aged child. (PubMed, BMJ Case Rep) - "The patient demonstrated an excellent therapeutic response to serial CSF drainage, empirical praziquantel, acetazolamide and corticosteroid treatment. The child gradually improved without neurological sequelae. Prompt diagnosis and treatment are crucial for a favourable outcome and minimising the risk of permanent neurological impairment."

Journal • Cardiovascular • CNS Disorders • Hypertension • Infectious Disease • Pain • Pediatrics

Design, Synthesis, and In Vitro Anticancer Evaluation of Thiazole-Based Chalcones Linked to Sulfanilamide as Tumor-Associated Carbonic Anhydrase IX and XII Inhibitors. (PubMed, J Med Chem) - "Compound 5u emerged as the most potent, exhibiting strong inhibition of hCA IX/XII, outperforming acetazolamide and SLC-0111. ADME predictions indicated good solubility and oral bioavailability, while DFT calculations supported its electronic stability. These results highlight 5u as a promising lead for dual hCA IX/XII-targeted cancer therapy."

Journal • Preclinical • Breast Cancer • Colon Cancer • Colorectal Cancer • Melanoma • Oncology • Solid Tumor • CA9

Electro: Diuretic Strategies in Patients With Heart Failure and Kidney Dysfunction (KSN 2025) - "More recently, adjunctive therapies such as acetazolamide have been explored...Emerging clinical research emphasizes novel therapeutic strategies, including alternative administration routes such as subcutaneous diuretic formulations and outpatient intravenous diuretic clinics, which may reduce hospitalization rates. This presentation will comprehensively review the fundamental mechanisms underlying diuretic therapy, current management strategies for diuretic resistance, and recent clinical trial findings, providing practical guidance for clinicians managing patients with concurrent HF and CKD."

Clinical • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease

Comprehensive molecular docking on the AlphaFold-predicted protein structure proteome: identifying target protein candidates for puberulic acid. (PubMed, J Toxicol Sci) - "However, performance was limited for certain targets, such as carbonic anhydrase II with acetazolamide, where the binding pocket was broad, leading to inaccurate docking results...This in silico framework enables hypothesis-driven identification of potential target proteins for toxicants or therapeutics and offers a useful tool for predictive toxicology, particularly when experimental data are limited. The pipeline is available at: https://github.com/toxtoxcat/reAlldock."

Journal • SLC5A1 • TOP2A

Synthesis and evaluation of thiazolyl coumarin drug conjugates as carbonic anhydrase isozyme inhibitors by using integrated invitro and insilico approaches. (PubMed, Sci Rep) - "Surpassing its standard inhibitor acetazolamide...The comprehensive experimental and computational analyses supported the conclusion that the synthesized hybrid compounds possess the potential to act as inhibitors against different types of carbonic anhydrases. Overall, this study will open new avenues for the development of dual inhibitors of CAII and CAXII, displaying versatile therapeutic applications."

Journal • Preclinical • CA9

Nerve-Sparing Approach to the Lateral Sphenoid Sinus Recess in a Patient With Multiple Sphenoid Encephaloceles. (PubMed, Ear Nose Throat J) - "Intraoperatively, 2 discreet skull-base defects were encountered, each with exposed dural tissue that were then repaired with septal cartilage underlay grafts and overlay mucosal grafts. The patient started acetazolamide in the postoperative period and recovered without the recurrence of cerebrospinal fluid leak."

Journal • CNS Disorders • Otorhinolaryngology • Pain • Respiratory Diseases • Sinusitis

Synthesis, in vitro evaluation and computational modelling of benzene sulfonamide derivatives as Dickkopf 1 inhibitors for anticancer drug development. (PubMed, Sci Rep) - "Among all the synthesized derivatives (5a-5j), the compound 5d was found to possess highest antioxidant activity (90.7397 ± 0.0732 µg/mL) comparable to vitamin C (95.1571 ± 0.057 µg/mL) and also exhibited maximum inhibition against CA-II with an IC50 value of 0.00690 ± 0.1119 µM, indicating that 5d is significantly more potent as compared to standard i.e., acetazolamide IC50 = 0.9979 ± 0.0024 µM...All the experimental and computational results reveals the excellent potential of 5d as a candidate medicine in future. Conclusively, the current study may lead to the new therapeutic strategies for the treatment of cancer associated with the aberrant expression of CA-II and less explored DDK1 target."

Journal • Preclinical • Lung Cancer • Oncology • Solid Tumor • DKK1