acetazolamide / Generic mfg. - LARVOL DELTA

Trigeminal Neuralgia as a Rare Complication of Idiopathic Intracranial Hypertension. (PubMed, Case Rep Neurol) - "A treatment coupling acetazolamide and iterative lumbar punctures led to the regression of papilledema, but headaches were difficult to control...To our knowledge, this is the first case reported of trigeminal neuralgia associated with meningocele formation in IIH. Our case illustrates the great efficacy of venous stenting in IIH, and one may wonder whether earlier stenting could have avoided the subsequent development of meningoceles and subsequent neuralgia."

Journal • Cardiovascular • CNS Disorders • Hypertension • Neuralgia • Obesity • Pain

Authors' Reply: Acetazolamide and Renal Hemodynamics: Interplay between Tubuloglomerular Feedback and Renin-Angiotensin-Aldosterone System Adaptation. (PubMed, J Am Soc Nephrol) - No abstract available

Journal • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease

Acetazolamide and Renal Hemodynamics: Interplay between Tubuloglomerular Feedback and Renin-Angiotensin-Aldosterone System Adaptation. (PubMed, J Am Soc Nephrol) - No abstract available

Journal

The Role of Abdominal Circumference Reduction, NT-proBNP, and Body Weight in the Success of Decongestion: Insights from the COAF HF Trial Sub-Analysis (HEART FAILURE 2025) - "Waist circumference reduction and NT-proBNP changes are key predictors of decongestion success in ADHF patients receiving acetazolamide. Monitoring these parameters can help optimize decongestion evaluation and therapy."

Cardiovascular • Congestive Heart Failure • Heart Failure

Acetazolamide for ambulatory heart failure patients with diuretic resistance. (HEART FAILURE 2025) - "Treatment with acetazolamide in ambulatory HF with diuretic resistance can be safely used to control congestion, even of the setting of optimized therapy. No relevant clinical or biochemical disturbances were observed during long term therapy in very old patients with baseline renal dysfunction. Parameters of decongestion improved during therapy, although values did not reach statistically significance."

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension

PRACTICE-HF : an implementation study of an updated acute heart failure protocol. (HEART FAILURE 2025) - "Implementation of the protocol was successful as seen by an increase in the prescription of SGLT2-inhibitors (44.2 vs 20 % at discharge in HF(m)rEF patients and 29.4 vs 4 % in HFpEF P=0.001), pre-discharge installation of ≥3 evidence-based drug classes for HF with reduced ejection fraction (48.1 vs 34 %, P= 0.176), in-hospital use of acetazolamide (59.8 vs 0%, P<0.001) and in-hospital iv... A simple protocol based strategy of an updated AHF protocol improved adoption of several evidence based AHF interventions. This may translate into improved patient outcomes, against a minor increase in hospital duration."

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure

The role of acetazolamide in enhancing diuresis in acute decompensated heart failure: insights from a real-world retrospective cohort study (HEART FAILURE 2025) - "Patients were divided into two groups: those receiving acetazolamide plus furosemide (n = 38) and those on furosemide alone (n = 53). In this retrospective cohort, acetazolamide showed a trend toward increased diuresis in patients with ADHF and volume overload. The higher prevalence of congestion and longer hospital stays in the acetazolamide group may reflect greater initial disease severity. These findings underscore the need for further prospective studies to clarify the role of acetazolamide in optimizing decongestion in ADHF."

Real-world • Real-world evidence • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure

Combination oral acetazolamide and intravenous furosemide on acute decompensated heart failure (HEART FAILURE 2025) - No abstract available

Late-breaking abstract • Cardiovascular • Congestive Heart Failure • Heart Failure

FastPET: Evaluation of dynamic [15O]H2O Brain Perfusion based on a novel Fast Reconstruction Method (SNMMI 2025) - " The cohort included 6 healthy subjects that were scanned during rest and acetazolamide for the duration of 4 minutes leading to the total of 12 PET scans... The IDIF obtained using either OSEM or FastPET reconstruction showed a relative difference of approximately ±10% after the initial frames. The TAC using either method had a similar appearance including a relative difference ±7% or below. Evaluation of the mean perfusion estimate, K1, using a one-compartment model, the two reconstruction methods provide consistent results."

Cardiovascular • Vascular Neurology

Impact of GLP-1 receptor agonists on idiopathic intracranial hypertension clinical and neurosurgical outcomes: a propensity-matched multi-institutional cohort study. (PubMed, J Neurosurg) - "GLP-1-RAs may provide clinical benefits for patients with IIH, improving outcomes and reducing the need for invasive interventions. Future randomized, prospective studies are warranted to confirm these findings and optimize treatment strategies."

Journal • Cardiovascular • CNS Disorders • Cognitive Disorders • Diabetes • Genetic Disorders • Hypertension • Metabolic Disorders • Pain

Procedural and patient-related factors play differential roles in postdural puncture headache. (PubMed, Turk J Med Sci) - "A lower volume of cerebrospinal fluid collected, higher frequency of previous headache attacks, diagnosis of idiopathic intracranial hypertension, and acetazolamide use were risk factors for the immediate-onset postdural puncture headache. This is the first study to detail the previous headache features in the development of postdural puncture headache and to extensively examine the risk factors for immediate and delayed postdural puncture headache. It was shown for the first time that patient-related factors may be more important in terms of the development of postdural puncture headache, and procedure-related factors gain importance in terms of its time of occurrence."

Journal • Observational data • Cardiovascular • CNS Disorders • Hypertension • Migraine • Pain

A case of bilateral stellate nonhereditary idiopathic foveomacular retinoschisis with 14-month follow-up: clinical features, OCT findings and treatment outcome. (PubMed, BMC Ophthalmol) - "Our findings suggest that bilateral SNIFR can occur in non-myopic females, although this patient did not respond to systemic and topical carbonic anhydrase inhibitors."

Journal • Inherited Retinal Dystrophy • Ophthalmology • Retinal Disorders

Development of new anticancer thiadiazole-sulfonamides as dual EGFR/carbonic anhydrase inhibitors. (PubMed, Future Med Chem) - "Enzymatic inhibition studies were conducted against EGFR and CA-IX, using erlotinib and acetazolamide as reference drugs. Compound 14 represents a promising dual EGFR/CA-IX inhibitor with selective anticancer activity. Further in vivo studies are warranted."

IO biomarker • Journal • Breast Cancer • Oncology • Solid Tumor • BAX • BCL2 • CA9 • CASP8 • CASP9 • EGFR

Management practices and surgical techniques for ab externo less invasive glaucoma surgery: a literature review and expert recommendations. (PubMed, Graefes Arch Clin Exp Ophthalmol) - "Management practices and surgical techniques for ab externo SBD vary, and surgeons must use their best clinical judgement based on the requirements of the individual patient. However, here we provide some recommendations for patient selection and pre-, peri- and post-surgical management based on the opinions of experts in the use of PRESERFLO MicroShunt, which we hope will prove useful in optimizing surgical outcomes."

Journal • Review • Glaucoma • Ophthalmology

Real-Life Experience of Semaglutide in the Treatment of Idiopathic Intracranial Hypertension: A Case Series (ESPE-ESE 2025) - "Acetazolamide therapy was maintained, and no recurrence of symptoms was noted...Due to polycystic ovary syndrome (PCOS), she was started on semaglutide, spironolactone, and metformin in 2022... Semaglutide represents a promising adjunct therapy for IIH, weight reduction and headache relief, potentially impacting intracranial pressure regulation."

Clinical • Cardiovascular • CNS Disorders • Diabetes • Genetic Disorders • Hypertension • Metabolic Disorders • Migraine • Obesity • Otorhinolaryngology • Pain • Polycystic Ovary Syndrome

Novel Near Infrared Dyes Targeting Carbonic Anhydrase IX for Fluorescence Imaging Applications. (PubMed, Invest Radiol) - "Several CAIX-targeting probes were synthesized to test the combinatory effect of different molecular vectors and dyes on the biological properties. All probes containing the C8-AZA targeting moiety displayed higher affinity and specificity to the target, while imaging efficacy in vivo was strongly influenced also by the structure of the labelling dye. All probes, and among them especially Dye1-C8-AZA, displayed efficient in vivo tumor accumulation. These results support further studies toward clinical testing of CAIX as suitable target for tumor fluorescence imaging and pave the way for future clinical applications."

Journal • Colon Adenocarcinoma • Colon Cancer • Colorectal Adenocarcinoma • Colorectal Cancer • Oncology • CA9

Chronic Mountain Sickness: A Comprehensive Review of Current Management and Proposals for Novel Therapies. (PubMed, High Alt Med Biol) - "Acetazolamide, enalapril, and medroxyprogesterone have lowered hematocrit and alleviated symptoms in human trials...Methylxanthines, adrenergic blockers, almitrine, and dopamine antagonists showed promise in murine and/or short-term human trials, highlighting the need for further long-term human trials...Topiramate may stimulate ventilation via acid-base modulation, thus providing therapeutic value. Similarly, the effect of aspirin and caffeine on ventilation may provide a low-cost, accessible intervention."

Journal • Review • Cardiovascular • Congestive Heart Failure • Fatigue • Heart Failure • Hematological Disorders • Hypertension • Polycythemia Vera • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

The impact of acetazolamide and dronabinol on the physiological endotypes responsible for obstructive sleep apnea. (PubMed, Sleep Med) - "Mechanistically, our findings suggest that medium and high doses of Aceta-Dro primarily reduce OSA severity by lowering loop gain, while the efficacy of the low dose was due to improved airway collapsibility."

Journal • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs. (PubMed, Biotechnol Appl Biochem) - "Notably, compound 6 showed strong inhibitory activity against hCA I (Ki = 9.12 ± 2.21 nM; acetazolamide (AZA) = 26.54 ± 3.11 nM) and hCA II (Ki = 17.54 ± 7.74 nM; AZA = 21.73 ± 2.42 nM), whereas compound 4 exhibited superior AChE inhibition (Ki = 9.58 ± 2.22 nM; TAC = 23.12 ± 2.05 nM). The chemical structures of the synthesized compounds were characterized using advanced spectroscopic techniques, including FT-IR, 1H-NMR, and 13C-NMR spectroscopy."

Journal • Alzheimer's Disease • CNS Disorders • Pain

Stereotactic radiosurgery for uveal melanoma – long-term outcomes and volumetric analysis (ESTRO 2025) - "Prophylaxis was based on acetazolamide peroral medication... Stereotactic radiosurgery with minimally invasive retrobulbar anesthesia and akinesia is feasible with low acute toxicity. Bulbus preservation is high, however, visual acuity has deteriorated."

Surgery • Anesthesia • Eye Cancer • Melanoma • Oncology • Solid Tumor • Uveal Melanoma

The Use of Airway Pressure Release Ventilation in a Patient With Severe Respiratory Alkalosis Following Intubation (ATS 2025) - "Typical management includes use of acetazolamide, although its use has not been shown to reduce mortality in ventilated patients...Here we present a novel method to control respiratory alkalosis with high Thigh to minimize releases, and a low Phigh, which results in lower minute ventilation. Using invasive ventilation modes that maintain oxygenation but reduce ventilation may be worth considering in the future in patients with difficult to control respiratory alkalosis."

Clinical • Intubation • Acute Respiratory Distress Syndrome • Addiction (Opioid and Alcohol) • Anesthesia • Cardiovascular • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Heart Failure • Immunology • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases

Diuretic Prescriptions During Postnatal Maturation in Extremely Preterm Infants Admitted to United States Children's Hospitals (ATS 2025) - "We identified all prescriptions of acetazolamide, bumetanide, chlorothiazide, diuretic combinations, ethacrynic acid, furosemide, hydrochlorothiazide, mannitol, metolazone and spironolactone between NICU admission and hospital discharge. Both furosemide and chlorothiazide are highly prescribed during postnatal age ranges that may span periods of dynamically changing diuretic clearance. High prescription periods occurred earliest for furosemide, whereas chlorothiazide was prescribed most often at discharge. Furosemide and chlorothiazide should be prioritized in developmental pharmacology research to ensure appropriate clinical dosage adjustments throughout infant maturation and appropriate dosage selection in clinical trials evaluating their safety and effectiveness in preterm populations."

Clinical • Prematurity • Pediatrics • Pulmonary Disease • Respiratory Diseases

Acetazolamide use in postoperative CSF leak prevention: A literature review. (PubMed, Am J Otolaryngol) - "Acetazolamide shows promise in the prevention of postoperative CSF leaks and in certain trauma contexts. However, further studies should establish standardized protocols and optimize dosing regimens. Future research should also focus on long-term outcomes and the management of adverse effects to fully elucidate the benefits and limitations of acetazolamide in these clinical settings."

Journal • Review • Cardiovascular • CNS Disorders • Hypertension • Mood Disorders • Novel Coronavirus Disease • Otorhinolaryngology

Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma (clinicaltrials.gov) - P1 | N=10 | Completed | Sponsor: University of Chicago | Recruiting ➔ Completed | N=60 ➔ 10 | Trial completion date: Oct 2026 ➔ Mar 2025 | Trial primary completion date: Oct 2026 ➔ Mar 2025

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Brain Cancer • CNS Tumor • Glioblastoma • Glioma • Malignant Glioma • Oncology • Solid Tumor

The effect of glucagon-like peptide-1 agonists on ocular parameters in idiopathic intracranial hypertension patients: a retrospective study. (PubMed, Eye (Lond)) - "This study suggests that GLP-1 agonists effectively reduce BMI, a major risk factor for IIH. Moreover, our analysis of seven patients from the combined therapy group suggests that GLP-1 agonists allow for a reduction in acetazolamide dosage in the treatment of IIH without changing the clinical outcome."

Journal • Retrospective data • Cardiovascular • CNS Disorders • Hypertension • Obesity