aripiprazole / Generic mfg. - LARVOL DELTA

Insights into Ligand-Specific Activation Dynamics of Dopamine D2 Receptor Explored by MD Simulations. (PubMed, J Chem Inf Model) - "Here, the structural determinants underlying the response of D2R to binding of the endogenous agonist dopamine, the partial agonist aripiprazole, and the antagonist sulpiride are investigated at full atomistic resolution by molecular dynamics simulations. These structural changes are accompanied by a modulation of cholesterol interactions with the receptor. Our model suggests that aripiprazole might cause poor arrestin recruitment by modulating TM4 and TM5 down to the intracellular side through the destabilization of a hydrophobic binding pocket at TM5, in agreement with previous mutational data."

Journal • CNS Disorders • DRD2 • IL2

The plasma-derived exosomal Gomafu levels are associated with psychopathological symptoms and symptomatic remission in drug-naïve patients with first-episode schizophrenia. (PubMed, Eur Arch Psychiatry Clin Neurosci) - "All DFSZ patients received aripiprazole treatment...Plasma-derived exosomal Gomafu may be a biological biomarker for DFSZ. Further studies are warranted to elucidate the mechanisms linking Gomafu to schizophrenia pathophysiology."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Psychiatry • Schizophrenia

Pharmacologic Management of Skin-Picking Disorder: An Updated Review. (PubMed, J Acad Consult Liaison Psychiatry) - "Of the medications evaluated for use in SPD, SSRIs show the most promising results in terms of mitigating the severity and frequency of skin-picking symptoms. Although habit-reversal psychotherapy has traditionally been first-line treatment, SSRIs are now increasingly being used in combination with psychotherapy when a patient presents with SPD. N-acetyl cysteine has also been well-established in the treatment of SPD. Other classes of medications that have been studied in SPD include the use of antipsychotics (often combined with antidepressants) and naltrexone. Additional studies are indicated to further expand on the current research and definitively establish the role of the less common medications, such as antiepileptics, in SPD."

Journal • Review • CNS Disorders • Dermatology • Psychiatry

Psychopharmacological interventions among people who use Assisted Reproductive Technology (ART) - a scoping review. (PubMed, Reprod Biol Endocrinol) - "Evidence on the use of psychopharmacotherapy in ART primarily concerns women. Available literature indicates that psychopharmacotherapy for individuals undergoing ART frequently involves medications commonly used in general psychiatric practice, with a tendency toward lower dosing and a preference for serotonin reuptake inhibitors. However, this observation should be interpreted cautiously, as current evidence remains limited and further research is warranted to establish treatment patterns more conclusively. The variability in study designs and reporting standards further highlights the need for standardized methodologies and improved adherence to reporting guidelines to enhance the quality and applicability of future research."

Journal • Review • Bipolar Disorder • CNS Disorders • Depression • Gynecology • Infertility • Mental Retardation • Mood Disorders • Psychiatry • Sexual Disorders • NBN

Comparative Efficacy, Safety, and Tolerability of Xanomeline and Trospium Chloride versus Eight Atypical Antipsychotics for the Acute Treatment of Adults with Schizophrenia - A Network Meta-Analysis (ISPOR 2025) - "Xanomeline/trospium demonstrated improved clinical response and reduced weight gain compared with several existing oral antipsychotics."

Retrospective data • Anesthesia • CNS Disorders • Psychiatry • Schizophrenia

Recognition and treatment of attention deficit-hyperactivity disorder in patients with treatment-resistant burning mouth syndrome: a retrospective case study. (PubMed, Front Pain Res (Lausanne)) - "Algorithm-based pharmacotherapy using ADHD-effective medications (methylphenidate, atomoxetine, guanfacine, aripiprazole, venlafaxine, and duloxetine) was administered. ADHD is frequently comorbid in patients with treatment-resistant BMS, and ADHD-targeted pharmacotherapy may help alleviate pain, cognitive dysfunction, and brain perfusion abnormalities. These findings suggest that ADHD screening, diagnosis, and multidisciplinary management involving psychiatrists could play a crucial role in optimizing clinical outcomes in patients with BMS."

Journal • Retrospective data • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Cognitive Disorders • Depression • Developmental Disorders • Mood Disorders • Pain • Psychiatry

Antipsychotics cause reversible structural brain changes within one week. (PubMed, Neuropsychopharmacology) - "Within arms, participants were randomized to receive daily doses of either the active compound (Arm 1= amisulpride 400 mg/day, N = 24; Arm 2= aripiprazole 10 mg/day, N = 24) for one week, followed by placebo or vice versa. Short-term exposure to either one of two different antipsychotics results in a transient increase in striatal volume measured with T1-weighted MRI that normalizes rapidly on stopping treatment without cortical changes. Our findings suggest that striatal volumetric MRI differences detected in people with schizophrenia taking antipsychotics are, at least in part, attributable to pharmacological effects."

Clinical • Journal • CNS Disorders • Psychiatry • Schizophrenia

Not Just the Skin Rash: A Case of Coexistence of Macroprolactinoma and Metastatic Neuroendocrine Tumour (ESPE-ESE 2025) - "After psychiatric consultation, risperidone was switched to aripiprazole, leading to an improvement in prolactin levels (9,315 mU/L). 3. The combination of diarrhoea and a rash should alert the physician to the possibility of an underlying neuro-endocrine tumour."

Clinical • Metastases • Cardiovascular • CNS Disorders • Dermatology • Diabetes • Endocrine Cancer • Endocrine Disorders • Gastrointestinal Disorder • Heart Failure • Hypoglycemia • Metabolic Disorders • Neuroendocrine Tumor • Oncology • Pain • Pituitary Gland Carcinoma • Psychiatry • Schizophrenia • Solid Tumor • Type 2 Diabetes Mellitus • PRL

Cost-Effectiveness Analysis of Xanomeline and Trospium Chloride for Schizophrenia in the United States (ISPOR 2025) - "Our findings suggest that xanomeline and trospium chloride is not cost-effective as maintenance treatment for schizophrenia in the U.S. We found that xanomeline and trospium chloride would be cost-effective at $150,000/QALY if the total healthcare costs for a three-month cycle did not exceed $5,950."

Cost effectiveness • HEOR • CNS Disorders • Mental Retardation • Metabolic Disorders • Psychiatry • Schizophrenia

Aripiprazole intestinal side effects in flies. (PubMed, Lab Anim (NY)) - No abstract available

Adverse events • Journal

N-acetylcysteine enhances the antipsychotic effect of aripiprazole in the neurodevelopmental rat model of schizophrenia. (PubMed, Pharmacol Biochem Behav) - "The schizophrenia-like behavior was induced in Sprague-Dawley male pups in the neonatal days p5-p16 by repeated administration of the glutathione synthesis inhibitor L-butionine-(S,R)-sulfoximine (BSO) given together with the dopamine reuptake inhibitor 1-[2-[Bis-4(fluorophenyl)methoxy]ethyl]-4-3-(3-phenylpropyl) (GBR 12909)...Moreover, repeated co-treatment with low doses of ARI with NAC also reversed schizophrenia-like behavior in the neurodevelopmental rat model of schizophrenia. The above results indicated that NAC enhanced the action of ARI in the used neurodevelopmental rat model of schizophrenia, and the mechanism of action of the used drugs in this model is discussed."

Journal • Preclinical • CNS Disorders • Cognitive Disorders • Psychiatry • Schizophrenia

Sulfhemoglobinopathy and Hemolytic Anemia Resulting in Acute Hypoxic Respiratory Failure Secondary to Isobutyl Nitrite Inhalation (ATS 2025) - "Case: A 36-year-old man with history of schizophrenia on paliperidone and aripiprazole presented to clinic with subacute nausea, vomiting, and hypoxia requiring Emergency Department evaluation and subsequent admission...Typical agents include but are not limited to acetanilide, phenacetin, nitrates, nitroglycerine, trinitrotoluene, metoclopramide, methylene blue, and sulfur compounds. Isobutyl nitrite, was also implicated as the driver of hemolytic anemia. This case illustrates a rare, but clinically impactful, diagnosis of sulfhemoglobinemia secondary to inhaled isobutyl nitrite."

Anemia • Cardiovascular • CNS Disorders • Heart Failure • Hematological Disorders • Hepatology • Infectious Disease • Pain • Pneumonia • Psychiatry • Pulmonary Embolism • Respiratory Diseases • Schizophrenia

A neuroimmune pathway drives bacterial infection. (PubMed, Sci Adv) - "Delayed administration of pramipexole, a dopamine agonist, mitigates lethality in bacterial sepsis mouse models. Conversely, the dopamine antagonist aripiprazole exacerbates sepsis mortality. Dysregulation of the dopamine-ACOD1 axis correlates with sepsis severity in patients, indicating a potential therapeutic target for modulating this neuroimmune pathway."

IO biomarker • Journal • Infectious Disease • Inflammation • Septic Shock • CD14 • CREB1 • DRD2 • MAPK3 • MYD88 • PD-L1 • TLR4

Standardization challenges in antipsychotic drug monitoring: insights from a national survey in Chinese TDM practices. (PubMed, Clin Chem Lab Med) - "Urgent standardization of Chinese TDM practices is needed, including harmonized systems and traceable calibrators. While commercial kits enhance result consistency, further efforts are required to harmonize performance across manufacturers. Lyophilized materials are optimal for EQA due to their stability and ease of transport. These findings offer actionable insights to improve the quality and comparability of antipsychotic TDM in clinical practice."

Journal • CNS Disorders

Investigation of the Protective Effects of Aripiprazole on Methylphenidate-induced Neurotoxicity in Rats. (PubMed, Mol Neurobiol) - "Biochemical analyses indicated that ARP decreased oxidative stress markers, including malondialdehyde (MDA) and myeloperoxidase (MPO), while enhancing levels of glutathione and the expression of brain-derived neurotrophic factor (BDNF), nuclear factor erythroid 2-related factor 2 (NRF2), and protein kinase B (Akt) in hippocampus. Aripiprazole reduces behavioral and biochemical deficits from chronic MPH use in rats, suggesting it may help mitigate adverse effects of long-term MPH treatment."

Journal • Preclinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Epilepsy • Inflammation • Psychiatry • BDNF • MPO

A Key Opinion Leader Survey of Major Depressive Disorder (MDD) with Anhedonia in Canada on Frequency, Management, and Burden of MDD With Prominent Anhedonia (ISPOR 2025) - "Escitalopram is the preferred first-line treatment for MDD patients with PA. Aripiprazole, bupropion, and brexpiprazole were identified as adjunct treatments; however, no clear consensus emerged on the best option for patients... Managing MDD with anhedonia is complex and requires a tailored approach, which is currently hindered with no available anhedonia-specific MDD treatments and guidelines."

CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • Suicidal Ideation

Real-World Patient Persistence and Adherence: A Comparison Of Long Acting Injectables and Oral Antipsychotics Used For The Treatment Of Schizophrenia in a Canadian Adult population (ISPOR 2025) - "Individuals above 15 years of age were included based on their first claim for either LAI or oral formulations of risperidone, paliperidone and aripiprazole from January 2021 to April 2023. In the Canadian population studied, persistence and adherence on LAIs was statistically-significantly higher compared to their oral formulations. Strategies that support improved treatment persistence and adherence in schizophrenia patients could reduce relapse rates and improve overall patient trajectories."

Adherence • Clinical • Real-world • Real-world evidence • CNS Disorders • Psychiatry • Schizophrenia

Carbon Materials in Voltammetry: An Overview of Versatile Platforms for Antidepressant Drug Detection. (PubMed, Micromachines (Basel)) - "Moreover, the combination of voltammetric approaches with the unique characteristics of carbon and its derivatives has led to the development of powerful electrochemical sensing tools for detecting antidepressant drugs, which are highly desirable in healthcare, environmental monitoring, and the pharmaceutical industry. In this review, carbon-based materials, such as glassy carbon and boron-doped diamond, and a wide spectrum of carbon nanoparticles, including graphene, graphene oxides, reduced graphene oxides, single-walled carbon nanotubes, and multi-walled carbon nanotubes were described in terms of the sensing performance of agomelatine, alprazolam, amitriptyline, aripiprazole, carbamazepine, citalopram, clomipramine, clozapine, clonazepam, desipramine, desvenlafaxine, doxepin, duloxetine, flunitrazepam, fluoxetine, fluvoxamine, imipramine, nifedipine, olanzapine, opipramol, paroxetine, quetiapine, serotonin, sertraline, sulpiride, thioridazine, trazodone, venlafaxine,..."

Journal • Review • CNS Disorders • Depression • Mood Disorders • Personality Disorder • Psychiatry

Mirtazapine Is Associated With Shorter Hospital Stay in Pediatric Avoidant Restrictive Food Intake Disorder-A Retrospective Chart Review. (PubMed, Int J Eat Disord) - "In our highly controlled environment, all patients reached a comparable target weight, but patients treated with mirtazapine did so faster. Further research should investigate the clinical effects and underlying mechanisms of mirtazapine in patients with ARFID."

Journal • Retrospective data • CNS Disorders • Depression • Mood Disorders • Pediatrics • Psychiatry

Unmasking a Rare Adverse Event: Olanzapine-Induced Diabetic Ketoacidosis in a Type 1 Diabetes Mellitus Patient (ENDO 2025) - "Olanzapine represents 36% of the associated antipsychotics, followed by aripiprazole at 24%, risperidone at 24%, clozapine at 12%, and quetiapine at 4%. Clinicians should closely monitor susceptible patients, considering the continuation of SGA treatment alongside proper diabetes management or screening protocols for metabolic complications.*. .*"

Adverse events • Clinical • CNS Disorders • Diabetes • Epilepsy • Metabolic Disorders • Mood Disorders • Psychiatry • Rare Diseases • Type 1 Diabetes Mellitus

Aripiprazole Use as a Cause for Dopamine Agonist Failure in the Treatment of Prolactinomas (ENDO 2025) - "We report the first case of aripiprazole competing with cabergoline and reducing its efficacy in the treatment of a giant prolactinoma, as evidenced by an immediate and marked rise in serum prolactin (approx. In addition, all patients on dual aripiprazole and DA therapy for prolactinomas should be closely monitored, especially if there are risk factors for tumour aggressiveness.*. .*"

CNS Disorders • Depression • Mental Retardation • Mood Disorders • Oncology • Pituitary Gland Carcinoma • Psychiatry • PRL

Cabergoline Induced Psychosis in a Patient with Macroprolactinoma (ENDO 2025) - "He was started on cabergoline 1 mg twice weekly, levothyroxine 100 mcg daily, and hydrocortisone (20 mg in the morning and 10 mg in the evening)...The patient was treated with Valproate and Quetiapine...Discontinuing cabergoline typically leads to symptom resolution, though atypical antipsychotics (e.g., clozapine, aripiprazole) and mood stabilizers (e.g., lithium, valproate) have been used to manage symptoms in some cases2...*. .*"

Clinical • CNS Disorders • Endocrine Disorders • Hematological Disorders • Hypotension • Immunology • Mental Retardation • Nephrology • Oncology • Otorhinolaryngology • Pain • Psychiatry • Pulmonary Disease • Renal Disease • Respiratory Diseases • Vertigo • DRD2

Oral Adverse Effects of Antipsychotic Medications: A Case/Noncase Analysis of EudraVigilance Data. (PubMed, Oral Dis) - "Antipsychotics significantly affect oral health, highlighting the need for preventive dental care and interventions to reduce these effects and improve patient well-being."

Adverse events • Journal • CNS Disorders • Dental Disorders • Mental Retardation • Movement Disorders • Psychiatry • Xerostomia

Increased risk of hepatic steatosis in young adults treated for first-episode psychosis; a retrospective study (EASL 2025) - "Exposition to olanzapine, aripiprazole or quetiapine is associated with a higher FLI and cardiometabolic risk. These results describe an increase over time in the risk of hepatic steatosis in young people experiencing a first psychotic episode, possibly related to the cardiometabolic deterioration following the introduction of psychiatric pharmacotherapy. Better understanding of the hepatic risks associated with psychotropic medication and of the psychotic disorder itself is essential to minimize possible hepatic complications in young people experiencing a first episode of psychosis."

Retrospective data • CNS Disorders • Hepatology • Psychiatry

Glecaprevir/pibrentasvir in chronic HCV: an integrated analysis of patients on concomitant opioids, antipsychotics and cardiovascular medications (EASL 2025) - "While the effect of G/P on the exposures of these concomitant medications is expected to be small, herein we analyze the safety and tolerability of a subset of concomitant medications including antipsychotics (aripiprazole, quetiapine, risperidone, paliperidone, lurasidone, clozapine), cardiovascular agents (statins, beta-blockers, calcium-channel blockers, hypertensives) and opioids (fentanyl, oxycodone and hydrocodone). This integrated pooled analysis demonstrated that G/P when concomitantly administered with medications such as those belonging to the antipsychotic (aripiprazole, quetiapine, risperidone, paliperidone, lurasidone, clozapine), cardiovascular (statins, beta-blockers, calcium-channel blockers, hypertensives) and opioid class, was safe, well tolerated, and demonstrated high efficacy and adherence."

Clinical • Breast Cancer • Cardiovascular • CNS Disorders • Fibrosis • Hepatitis C • Hepatology • Immunology • Oncology • Solid Tumor