Apatone B (ascorbic acid/menadione)
/ Summa Health, IC-MedTech
- LARVOL DELTA
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April 05, 2022
Combination of Ascorbic Acid and Menadione Induces Cytotoxic Autophagy in Human Glioblastoma Cells.
(PubMed, Oxid Med Cell Longev)
- "Therefore, by upregulating oxidative stress, inhibiting mTORC1, and activating ULK1, AA converts MD-induced AMPK-dependent autophagy from nontoxic to cytotoxic. These results suggest that AA+MD or MD treatment in combination with autophagy inducers could be further investigated as a novel approach for glioblastoma therapy."
Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • BECN1
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