albuterol HFA (APC-2000) / DMK Pharma - LARVOL DELTA

Trends in avascular necrosis and related arthroplasties in hospitalized patients with systemic lupus erythematosus and rheumatoid arthritis. (PubMed, Semin Arthritis Rheum) - "We report a breakpoint in rising SLE-AVN after 2011, which may relate to newer steroid-sparing therapies (i.e., belimumab). AVN-associated arthroplasties decreased in SLE and RA. Fewer AVN-associated arthroplasties were noted for Black patients and those with Medicaid, indicating potential disparities. Further research should examine treatment differences impacting AVN and arthroplasty rates."

Journal • Immunology • Inflammatory Arthritis • Lupus • Orthopedics • Rheumatoid Arthritis • Rheumatology • Systemic Lupus Erythematosus

Trends, Sociodemographic and Clinical Factors Associated with Avascular Necrosis and Related Arthroplasties in Hospitalized Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis (ACR Convergence 2023) - "In contrast, there was an initial increase followed by a tendency to decline in SLE-AVN (APC 2000-2011: 1.96* APC 2011-2019 -2.05), with a decrease in the proportion of arthroplasties over time (APC -2.03*, Figure 2 ). We report an initial increasing trend of SLE-AVN followed by a tendency to decline, which may relate to newer steroid-sparing therapies (i.e., Belimumab approval in 2011). There was an overall declining trend of AVN-associated arthroplasties in both SLE and RA. AVN hospitalizations were more likely to be younger and of the Black race."

Clinical • Addiction (Opioid and Alcohol) • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Coronary Artery Disease • Dyslipidemia • Genetic Disorders • Heart Failure • Hematological Disorders • Hypertension • Immunology • Inflammatory Arthritis • Lupus • Nephrology • Nicotine Addiction • Orthopedics • Peripheral Arterial Disease • Pulmonary Disease • Renal Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Systemic Lupus Erythematosus

RECENT AND PROJECTED TRENDS IN ANAL CANCER INCIDENCE AMONG PERSONS WITH HIV IN THE US (CROI 2023) - "Absolute incidence and calendar trends varied by US region, ranging from 27.2/100,000 in the Northeast (APC2000-2010=7.9% [CI, -0.3 to 16.7], APC2010-2016=-21.5% [CI, -35.0 to -5.2]), 58.5/100,000 in the South (APC2000-2016=-2.5% [CI, -6.0 to 1.0]), 74.3/100,000 in the West (APC2000-2016=-4.1% [CI, -6.4 to -1.7]), to 97.1/100,000 in the Midwest (APC2000-2016=-2.2% [CI, -7.3 to 3.3]). In the US (particularly, in the Northeast and West), anal cancer incidence among PWH is decreasing, while the absolute incidence and relative risk was highest in the Midwest. Geographic variation in incidence and temporal trends may reflect regional differences in the HIV epidemic and care dynamics and anal cancer screening practices."

Anal Carcinoma • Gastrointestinal Cancer • Human Immunodeficiency Virus • Immunology • Infectious Disease • Oncology • Solid Tumor

Colorectal Cancer Annual Percent Change Incidence Analysis in 40-49 and 50-54 Year-Olds Utilizing 2000-2016 SEER 18 Data and Stratified by Histology (ACG 2019) - "All results were statistically significant except Age 50-54 colon AC APC 2000-2016 (0.27%) and Age 50-54 CRC CN APC 2008-2012 (-1.09%). Age 40-49 overall CRC APC was 1.45% from 2000-2016. Colon AC APC was 1.08% from 2000-2016, and rectal AC APC was 1.49% 2000-2016. Age 50-54 overall CRC APCs was 1.06% from 2000-2016."