AZ-17 / Allozyne - LARVOL DELTA

Hydroxychloroquine in hospitalized COVID-19 patients: Real world experience assessing mortality. (PubMed, Pharmacotherapy) - "We report from a large retrospective multinational database analysis of COVID-19 outcomes with HCQ and overall mortality in hospitalized patients. There was no statistically significant increase in mortality and mortality/arrhythmia with HCQ or HCQ/AZ."

Clinical • Journal • Real-World Evidence • Atrial Fibrillation • Cardiovascular • Infectious Disease • Novel Coronavirus Disease

WEE1 Inhibitor MK-1775 and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors (clinicaltrials.gov) - P1/2; N=128; Not yet recruiting; Sponsor: National Cancer Institute (NCI)

New P1/2 trial • Biosimilar • Oncology

[VIRTUAL] Both 17q12 duplication and deletion detected in the patient with normal phenotype and their segregation in family with variably affected members (ESHG 2020) - "This case supports hypothesis that 17q12 duplications are stable and may segregate in a family for several generations. Supported by: 00064203, NF-CZ11-PDP-3-003-2014, AZV17-29423A"

Clinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Developmental Disorders • Diabetes • Epilepsy • Mental Retardation • Metabolic Disorders

Identification of novel HNF1B mRNA splicing variants and their qualitative and semi-quantitative profile in selected healthy and tumor tissues (NCRI 2019) - "We identified 45 ASVs, of which 43 were novel. The spectrum and relative quantity of expressed ASVs mRNA differed among the analyzed tissue types. Four HNF1B transcripts, including two known (3p, D7_8) and two novel (D7, D8) ASVs with unknown biological functions, were detected in all the analyzed tissues."

Clinical

Isolation, characterization, and effect of phosphate-zinc-solubilizing bacterial strains on chickpea (Cicer arietinum L.) growth. (PubMed, Saudi J Biol Sci) - "strain AZ5 and Bacillus sp. strain AZ17 can serve as effective microbial inocula for chickpea, particularly in the rain-fed area."

Journal