ARQ 680 / Merck (MSD) - LARVOL DELTA

Harnessing retinoic acid metabolism-related genes to identify lung adenocarcinoma subtype and establish a risk model for predicting prognosis and drug therapy response. (PubMed, Comput Biol Chem) - "RAMRGs serve as useful biomarkers to predict prognosis in LUAD patients, and may guide the immunotherapy regimen."

IO biomarker • Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CYP17A1 • IGF2BP1 • IGFBP1 • TP53

Unveiling the impact of interferon genes on the immune microenvironment of triple-negative breast cancer: identification of therapeutic targets. (PubMed, Front Bioinform) - "The TNBC prognostic signature comprising four interferon genes (STXBP1, LAMP3, CD276, and POLR2F) was identified, with their expression significantly correlated with the infiltration abundance of multiple immune cells and the drug sensitivity of 30 diverse drugs (ARQ-680, Fluphenazine, and Chelerythrine, etc.). In the prognostic signature and the ceRNA axes, STXBP1, RBPMS-AS1, and FAM198B-AS1 were first reported as potential biomarkers of TNBC. These findings have the potential to provide new insights into the mechanisms driving TNBC tumorigenesis and development."

Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • CD276 • CD63 • LAMP3 • LIFR • MIR455 • POLR2F • RBPMS • XBP1

Identification of different lung adenocarcinoma subtypes in combination with antidiuretic hormone-related genes and creation of an associated index to predict prognosis and guide immunotherapy. (PubMed, Comput Biol Chem) - "This study provided potential prognostic biomarkers for LUAD and might facilitate the development of effective immunotherapy strategies for LUAD patients."

IO biomarker • Journal • Tumor mutational burden • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • DKK1 • IGFBP1 • TMB

IL27 and IL1RN are causally associated with acute pancreatitis: a Mendelian randomization study. (PubMed, Aging (Albany NY)) - "IL1RN was identified as a risk factor for acute pancreatitis (AP), but IL27 was found to be a protective factor for AP."

Journal • Pancreatitis • IL1R2 • IL1RN