AB-510 / Angiocrine - LARVOL DELTA

Thrombospondin-1 Deficient Exacerbates the Pathogenesis of Imiquimod-Induced Psoriasis (EADV 2024) - "Introduction & Objectives: Psoriasis is a chronic, relapsing inflammatory skin disorder, characterized by as silver scaling erythematous plaques due to epidermal hyperplasia, aberrant differentiation of keratinocytes, and increased angiogenesis. Our findings underscore TSP-1 ’ s pivotal regulatory role in IMQ-induced psoriasiform skin inflammation, thus, wu suggested that TSP-1 may act as an important endogenous negative regulator of psoriasis pathogenesis and may be developed as a novel therapeutic strategy of psoriasis."

Dermatitis • Dermatology • Immunology • Inflammation • Psoriasis • IL17A • IL23A • THBS1

FSH promotes the proliferation of sheep granulosa cells by inhibiting the expression of TSP1. (PubMed, Anim Biotechnol) - "In contrast, TSP1 mimetic peptide, ABT510, offsets the proliferation of sheep granulosa cells. Different signaling pathway inhibitors all promoted FSH-inhibited TSP1 expression, but each inhibitor had different effects on TSP1. Among them, the PI3K and ERK pathway inhibitors significantly promoted TSP1 expression and inhibited the proliferation of sheep granulosa cells."

Journal • THBS1