ampicillin / Generic mfg. - LARVOL DELTA

Occurrence and Exposure Assessment of Antibiotics, Parabens and Potentially Toxic Elements in Groundwater Sources from Two Rural Communities in Nigeria. (PubMed, Environ Toxicol Chem) - "In Nigeria, however, monitoring and risk assessment data for EOCs such as Methylparaben (MeP), Ethylparaben (EtP), Propylparaben (PrP), Butylparaben (BuP), and antibiotics like ampicillin (AMP), chloramphenicol (CLP), ciprofloxacin (CIP), and metronidazole (MET) are scarce, especially in rural areas. Additionally, CIP exhibited high RQH (>1) across all age groups, ranging from 1.142 to 49.174. Findings from this study indicate that groundwater consumption in these communities poses significant health risks."

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A strain defined as a novel species in the Acinetobacter genus co-harboring chromosomal associated tet(X3) and plasmid associated bla NDM-1 from a beef cattle farm in Hebei, China. (PubMed, Front Cell Infect Microbiol) - "This strain was confirmed as a novel species of Acinetobacter genus, showing resistance to meropenem, ampicillin, ceftazidime, cefepime, gentamicin, kanamycin, fosfomycin, imipenem, ertapenem, and tetracycline. Despite carrying tet(X3), it remained susceptible to tigecycline, omadacycline, and doxycycline...Chromosomal tet(X3) was mediated by ISVsa3, forming a skeleton, ISVsa3-XerD-tet (X3)-res-ISVsa3. The co-occurrence of bla NDM and tet(X) in a novel species of the Acinetobacter genus hints that substantial undiscovered bacteria co-carrying high-risk ARGs are concealing in the agroecological system, which should cause particular concern."

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Vancomycin-Resistant Enterococcus Faecium Prosthetic Valve Endocarditis Treated with Daptomycin and Ampicillin Combination. (PubMed, J Assoc Med Microbiol Infect Dis Can) - "This case adds to the growing body of literature demonstrating the use of daptomycin and beta-lactam combination therapy for VRE bacteremia and endocarditis. Combination therapy may be an appropriate choice for select cases; however, reports of treatment failure warrant caution."

Journal • Cardiovascular

Higher-order epistasis drives evolutionary unpredictability toward novel antibiotic resistance. (PubMed, bioRxiv) - "Over eight million empirical fitness measurements were obtained under selection pressure with both a native antibiotic substrate (ampicillin) and a novel antibiotic (aztreonam), establishing the largest experimentally determined fitness landscape for antibiotic resistance to date. This integrated experimental and computational framework provides a foundation for predictive evolutionary pharmacology, enabling assessments of newly developed β-lactams or emerging β-lactamase variants for their potential contribution to ESBL evolution. Importantly, incorporating graph-theoretically informed evolutionary constraints can strategically disrupt evolutionary pathways, presenting a viable approach to mitigate the rise of antibiotic resistance."

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Sex-Specific Effects of the Gut Microbiome onHeterotopic Ossification inFibrodysplasia Ossificans Progressiva (ENDO 2025) - "To test the role of the gut microbiome in HO formation, we ablated the gut microbiome (GMA) in FOP mice starting at weaning using a broad-spectrum antibiotic cocktail (1 g/L ampicillin, 0.5 g/L metronidazole, 0.5 g/L neomycin, and 0.5 g/L vancomycin). Five candidate anti-inflammatory metabolites were differentially abundant in GMA vs. non-GMA mice, with higher levels in females and lower levels in males. These results suggest that microbially-derived metabolites may drive HO severity in FOP mice by a sex-specific mechanism, highlighting the potential role the gut microbiome or specific microbially derived products as therapeutic targets for FOP and potentially other HO conditions."

Immunology • Inflammation • Mood Disorders • Pain • Systemic Inflammatory Response Syndrome • PDGFRA

Necessity of the Gut Microbiome for Aspects of Metabolic Dysregulation in a Polycystic Ovary Syndrome Mouse Model (ENDO 2025) - "The gut microbiome was depleted using an oral antibiotic cocktail of vancomycin, ampicillin, and neomycin. While the gut microbiome was not required for acyclicity in a PCOS-like mouse model, it was required for key aspects of metabolic dysregulation implicated in the development of insulin resistance and type 2 diabetes, suggesting that the gut microbiome plays a role in PCOS pathology."

Preclinical • Cardiovascular • Diabetes • Endocrine Disorders • Infertility • Metabolic Disorders • Obesity • Polycystic Ovary Syndrome • Sexual Disorders • Type 2 Diabetes Mellitus

Association between farm-level antimicrobial usage and antimicrobial resistance in Escherichia coli isolates from healthy swine in ten farms in Japan. (PubMed, J Vet Med Sci) - "In addition, for many antimicrobial-resistant strains, an association was found with the use of single or multiple antimicrobial classes other than the corresponding class: resistance to ampicillin and kanamycin in the sow group and resistance to ampicillin, cefazolin, cefoxitin, cefotaxime, tetracycline, chloramphenicol, streptomycin, kanamycin, gentamicin and nalidixic acid in the fattening group. In the case of the association with the noncorresponding class, most of the E. coli isolates were multidrug resistant, suggesting that there is a high possibility of coselection on farms and that reducing the use of multiple antimicrobial agents may be effective at decreasing antimicrobial resistance."

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Isolation and Genetic Profiling of Yersinia enterocolitica Strains from Diarrheal Samples of Iranian Children Under 5: PCR Ribotyping Insights. (PubMed, Microb Pathog) - "Resistance to ampicillin was 100%. High resistance to nitrofurantoin and ceftazidime was observed. Twenty-five isolates of Y. enterocolitica were analyzed by PCR ribotyping method, which identified 3 SR. The outbreak of highly pathogenic Y. enterocolitica 1B/O:8 in Iran may be a serious threat to the public health of Iran."

Journal • Gastroenterology • Gastrointestinal Disorder • Pain

Probiotic potential and safety assessment of bacteriocinogenic Enterococcus faecalis CAUM157. (PubMed, Front Microbiol) - "Various enzymes and antimicrobial resistance genes that confer resistance to aminoglycosides, lincosamides, macrolides, streptogramins A and B, and tetracyclines were also identified. Additionally, the ST21 MLST typing of the strain, along with the identified niche factors and the lack of resistance to vancomycin and ampicillin, highlights its apparent safety. The results of this study suggest that strain CAUM157 may be a potential probiotic candidate in the food and feed industries."

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Ampicillin administration and the incidence of severe acute kidney injury in patients with sepsis. (PubMed, Ren Fail) - "Early ampicillin administration within 48 h of ICU admission is associated with reduced severe AKI and improved short-term renal outcomes in septic patients. Further studies are needed to confirm these findings."

Journal • Retrospective data • Acute Kidney Injury • Infectious Disease • Nephrology • Renal Disease • Septic Shock

Fabrication, spectroscopic inspection, biological evaluation of some transition metal complexes with bis- azomethine ligand and γ-ray irradiation dose effect. (PubMed, Sci Rep) - "The finding showed that the parent metal complexes demonstrated promising antimicrobial activity against gram -ve (Escherichia coli) and gram + ve (Staphylococcus aureus) bacterial species and two fungal species (Candida albicans and Aspergillus nigar) as well. The complexes exhibited greater antimicrobial potency than Ampicillin and Nystatin."

Journal • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor

Aliphatic Disinfection Byproducts Induced Antibiotic Resistance in Escherichia coli through Cell Wall Alteration. (PubMed, Environ Sci Technol) - "The results showed that most treated bacteria developed resistance to cell wall-targeting antibiotics such as ampicillin and fosfomycin, with resistance levels increasing by 1.16- to 6.39-fold, higher than for other classes of antibiotics. Nontargeted ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis further confirmed the cell wall structure alteration by the increased proportion of noncanonical d-amino acids in peptidoglycan, the major component of the cell wall, potentially explaining the observed resistance to cell wall-targeting antibiotics. Collectively, this study highlights the risk of aliphatic DBPs-induced antibiotic resistance, likely driven by alterations in the bacterial cell wall."

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Prevalence and characterization of ESBL-producing diarrheagenic Escherichia coli from the poultry industry in Shanghai, China. (PubMed, Front Microbiol) - "The results indicated a detection rate of E. coli at 15.67%, with the isolates exhibiting high resistance to the tested antibiotics, particularly ampicillin (AMP),nalidixic acid (NAL), chloramphenicol (CHL), and tetracycline (TET)...Among these isolates, 20.45% were ESBL-producing E. coli, which exhibited higher resistance to first- through fourth-generation cephalosporins, such as cefazolin (CFZ),cefuroxime (CXM), and cefotaxime (CTX)...The findings from this study reveal that ARGs are widely distributed among ESBL-producing E. coli strains. STs with the same serotypes and FumC-FimH (CH) types showed high genetic relatedness in single-nucleotide polymorphism (SNP)-based phylogenetic analysis, highlighting the need for enhanced surveillance to prevent further transmission."

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Listeria rhombencephalitis in the postpartum period. (PubMed, BMJ Case Rep) - "The patient was treated with an 8 week course of ampicillin and gentamicin and was discharged home with residual, though improving, hemiparesis and cranial neuropathy. This case highlights the importance of considering Listeria rhombencephalitis in postpartum women with neurologic deficits and fever, even in the absence of meningeal signs. It also emphasises the crucial role of early diagnosis and treatment in reducing mortality and the severity of neurologic sequelae."

Journal • CNS Disorders • Infectious Disease • Pain • Pneumonia • Respiratory Diseases

Molecular characterization of multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolated from Sonali chicken meat in Bangladesh. (PubMed, Sci Rep) - "Antimicrobial susceptibility testing by disc diffusion method revealed complete resistance to ampicillin (100%), with high resistance to erythromycin (87.59%) and third-generation cephalosporins. Furthermore, the lowest resistance was observed for amoxicillin-clavulanate (3.01%)...Significant positive correlations were observed among β-lactamase genes, highlighting the complexity of resistance mechanisms. Our results demonstrate the necessity of judiciously using antibiotics in Sonali chickens to prevent the emergence of resistant bacterial strains."

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A non-enzymatic doxycycline absorbance sensor based on manganese-doped zinc sulfide nanoparticles coated with chitosan. (PubMed, PLoS One) - "The need for doxycycline detection is urgent because it is a vital antibiotic extensively utilized to combat bacterial diseases in humans and animals, and it is now at the forefront of the global battle against antibiotic resistance. The sensor also obtains excellent selectivity when testing with other analytes, including glucose, amoxicillin, tetracycline, penicillin, ampicillin, and cephalexin. The capabilities of these ZnS: Mn/Chitosan-based sensors mark a significant advancement in antibiotic monitoring, offering promising applications in clinical settings for patient care and environmental surveillance, thereby playing a critical role in curbing the spread of antibiotic resistance globally."

Journal • Infectious Disease

Fosfomycin resistance in extended-spectrum beta-lactamase producing Escherichia coli isolated from urinary tract-infected patients in a tertiary care hospital. (PubMed, J Med Microbiol) - "Resistance to other antibiotics, such as nalidixic acid (98%) and ampicillin (93%), was notably high. Fosfomycin remains a highly effective treatment option for ESBL-producing E. coli UTIs in Northern Haryana, India, with low resistance rates observed. However, the emergence of fosfomycin resistance, albeit minimal, highlights the need for continuous surveillance and rational use of antibiotics to combat the growing threat of antimicrobial resistance."

Journal • Infectious Disease • Nephrology

Detection and Correlation of Virulence Determinants of Ampicillin Resistant Isolates of Salmonella Typhimurium. (PubMed, Indian J Microbiol) - "Plasmids, stn and inv A gene were more closely associated with virulence as compared to pef and spv C genes. As these isolates were virulent and exhibited resistance to ampicillin, the spread of such isolates may result in a serious threat to human and animal health."

Journal • Infectious Disease

Prevalence, Etiological Patterns and Factors Associated with Bacteraemia Among Febrile Children with Sickle Cell Anaemia in Jinja Regional Referral Hospital, Uganda. (PubMed, Infect Drug Resist) - "Blood cultures should be prioritized. Ampicillin and gentamicin were ineffective, whereas cloxacillin, cefotaxime, and other antibiotics with demonstrated sensitivity are recommended as empiric alternatives."

Journal • Anemia • Cardiovascular • Genetic Disorders • Hematological Disorders • Infectious Disease • Influenza • Pneumonia • Respiratory Diseases • Sickle Cell Disease

Probiotic properties of Lactiplantibacillus plantarum KS2020 with GABA producing ability. (PubMed, Food Sci Biotechnol) - "plantarum KS2020 exhibited no resistance to antibiotics such as ampicillin, erythromycin, clindamycin, tetracycline, or chloramphenicol. Therefore, Lb. plantarum KS2020 is confirmed as a safe probiotic with GABA-producing potential, suggesting its potential for developing novel probiotic-based functional foods."

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Bacterial Spectrum and Antimicrobial Resistance Patterns of External Ocular Infections Among Patients Attending Dilla University General Hospital Ophthalmic Clinic, Southern Ethiopia. (PubMed, Can J Infect Dis Med Microbiol) - "Most bacteria have shown resistance to penicillin and ampicillin. Hence, antimicrobial susceptibility tests better monitor the empirical treatment of external eye infections."

Journal • Infectious Disease • Ocular Infections • Ophthalmology

Antimicrobial resistance of Escherichia coli and associated factors in pet dogs from Cajamarca city (Peru). (PubMed, Res Vet Sci) - "The prevalence of resistance to streptomycin [STR] (61 %) and ampicillin [AMP] (53 %) was categorized as "very high". In comparison, resistance to cephalexin [CEP] (47 %), sulfamethoxazole/trimethoprim [SXT] (41 %), gentamicin [GEN] (40 %), and tetracycline [TET] (33 %) was categorized as "high", and resistance to enrofloxacin [ENR] (10 %) was classified as "low"...The risk of acquiring STR resistance in E. coli was higher in adult dogs than in younger ones (OR 2.304 [95 % CI: 1.012-5.244], p = 0.047). Regarding SXT, the likelihood of E. coli acquiring resistance in females was higher than in males (OR 3.987 [95 % CI: 1.672-9.088], p = 0.002), and cohabitation with other animal species was also a risk factor (OR 3.468 [95 % CI: 1.258-9.562], p = 0.016)."

Journal • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus

Histological Analysis of Root Surface Treatment with Tetracycline and Ampicillin in the Repair Process of Rat Teeth Subjected to Delayed Replantation. (PubMed, J Clin Med) - " It is concluded that, in an aseptic environment, the use of topical antibiotics such as ampicillin and tetracycline in the treatment of the root surface during replantation of teeth stored in milk is beneficial to the periodontal repair process and root resorption. Notably, ampicillin demonstrated superior efficacy in mitigating inflammatory root resorption and better periodontal ligament reattachment."

Journal • Preclinical

Antibiotic susceptibility patterns of Salmonella isolates from clinical, food, and environmental sources in Addis Ababa and surrounding towns, Ethiopia. (PubMed, Microbiol Spectr) - "Resistance to trimethoprim-sulfamethoxazole and chloramphenicol was noted in 24.6% and 19.7% of isolates, respectively. Azithromycin resistance was also sensible at 27.9%. In contrast, ciprofloxacin showed relatively low resistance at 8.2%...Gentamicin (3.3%), ceftriaxone (6.6%), and amoxicillin-clavulanic acid (9.8%) remained largely effective, showing low resistance rates...High antimicrobial resistance, especially to ampicillin and tetracycline, highlights the urgent need for improved surveillance, rational antibiotic use, and infection control...This study provides a comprehensive analysis of Salmonella isolates from clinical, food, and environmental samples in Addis Ababa and nearby towns, offering current data on antimicrobial resistance patterns. By using updated laboratory standards and sampling diverse sources, the findings highlight the urgent need for improved food safety practices, sanitation, and antimicrobial stewardship."

Journal • Infectious Disease

Prevalence and risk factors of antimicrobial resistance patterns of Staphylococcus spp. and E. coli in rodents and shrews at human-animal interfaces in Chattogram, Bangladesh. (PubMed, PLoS One) - "isolates were 100% resistant to oxacillin, oxytetracycline, metronidazole, and cefixime. Again, E. coli isolates were 100% resistant to metronidazole followed by ampicillin and cefixime (98.0%), sulfamethoxazole + trimethoprim (97.0%), amoxicillin and doxycycline (96.0%), streptomycin (95.0%). Only gentamycin was sensitive against both bacterial isolates...Our findings indicate a significant prevalence of AMR Staphylococcus spp. and E. coli in urban rodents and house shrews, suggesting their potential role as reservoirs and disseminators of AMR, hence posing a risk to human and animal health."

Journal • Preclinical • Infectious Disease