amlodipine/benazepril / Generic mfg. - LARVOL DELTA

Adrenal Vein Sampling and Surgical Outcomes in Mild Autonomous Cortisol Secretion: A Case Series (ENDO 2025) - "Dexamethasone suppression cortisol value was 5.7, and patient demonstrated no clinical features of overt Cushing's syndrome...Hypertension medications included amlodipine/benazepril 10-40mg, clonidine 0.1mg twice a day, and hydralazine 10mg 3 times a day...By 5/2023, BP continued improving to 129/78, BMI decreased to 29.7 and medications included amlodipine/benazepril 10-40mg, hydralazine 50mg 3 times daily, and doxazosin 4mg.Case 2:55yo male with a right adrenal nodule (1.0 × 0.6 cm)...At 2 months post-op, BP was well controlled on only nifedipine 30mg and doxazosin 4mg once daily...AVS guided adrenalX in MACS resulted in BP improvement and stable BMI, with varying degrees of antihypertensive reduction. AVS remains a promising tool for guiding surgical decisions in adrenal nodules with subclinical cortisol excess. With additional research the full potential of AVS in guiding adrenalX may be realized.*."

Clinical • Anemia • Cardiovascular • Cushing’s Disease • Endocrine Disorders • Hematological Disorders • Hypertension • Hypoglycemia • Pain

Bioequivalence Study of Single-Pill Capsule Formulation of Amlodipine Plus Benazepril in Healthy Chinese Subjects Under Fasting and Fed Conditions. (PubMed, Drug Des Devel Ther) - "The pharmacokinetic bioequivalence between the test and reference formulation in healthy individuals was confirmed under both fasting and fed states, meeting regulatory standards set for the study. Both drug formulations demonstrated safety and tolerability."

Clinical • Journal

Clinical efficacy of amlodipine and benazepril hydrochloride tablets in controlling morning blood pressure surge (MBPS) in patients with arteriosclerosis (ChiCTR) - P=N/A | N=225 | Completed | Sponsor: Shaoxing Central Hospital; Shaoxing Central Hospital

New trial • Atherosclerosis • Cardiovascular • Hypertension

Does Metabolic Syndrome Influence the Development and Progression of Lipid Laden Colon Polyps? (ACG 2024) - "His medications included atorvastatin, chlorthalidone, carvedilol, amlodipine-benazepril, and metformin. Research is needed to explore the progression of GI xanthomas in setting of metabolic disorders, and their risk of malignancy. Figure: Rectal polyps visualized, histologic report showed fragments of colonic mucosa with xanthomatous changes."

Cardiovascular • Colonic Polyps • Diabetes • Dyslipidemia • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Hepatology • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Oncology • Solid Tumor • Type 2 Diabetes Mellitus

ANGIOTENSIN II: A SALVAGE THERAPY IN CATECHOLAMINE-RESISTANT VASODILATORY SHOCK DUE TO CALCIUM CHANNEL BLOCKERS AND ACE INHIBITORS OVERDOSE (CHEST 2024) - "CASE PRESENTATION: A 54-year-old female with history of hypertension and depression presented to the hospital with hypotension and bradycardia after an intentional drug overdose of 60-day supply of Benazepril and Amlodipine...For persistent shock, vasopressin, phenylephrine, and epinephrine continued to be used without significant improvement... In patients with vasodilatory shock especially in the case of ace-inhibitor and calcium channel blocker overdose, the addition of angiotensin II to the regimen allows for catecholamine dose reductions and showing improvement in mean arterial pressures and hemodynamics leading to improved outcomes."

Cardiovascular • CNS Disorders • Depression • Hypertension • Hypotension • Psychiatry

Acute Declines in Estimated Glomerular Filtration Rate in Patients Treated With Benazepril and Hydrochlorothiazide Versus Amlodipine and Risk of Cardiovascular Outcomes. (PubMed, J Am Heart Assoc) - "Combined use of benazepril and amlodipine remains superior to benazepril and hydrochlorothiazide for cardiovascular outcomes, regardless of the magnitude of the decline in eGFR that occurred with initiation of therapy."

Journal • Cardiovascular • Hypertension • Renal Disease

Case report: A case of bradycardia triggered by diarrhea. (PubMed, Front Med (Lausanne)) - "He was on amlodipine, benazepril, metoprolol, furosemide and spironolactone. Clinicians should be alert to patients with hyperkalemia and maintain a high index of suspicion for BRASH syndrome. Timely diagnosis and comprehensive intervention are critical for better outcomes in managing patients with BRASH."

Journal • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Hypertension • Renal Disease

Drugs for hypertension. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Review • Cardiovascular • Hypertension

Evaluation of a miniature mass spectrometer based point-of-care-test method for direct analysis of amlodipine and benazepril in whole blood. (PubMed, J Pharm Biomed Anal) - "In summary, amlodipine has low sensitivity and can only be detected at higher concentrations, while benazepril has high sensitivity, good linearity, and even meets semi-quantitative requirements. The research results of this study are of great clinical significance for monitoring blood drug concentrations during hypertension medication, predicting drug efficacy, and customizing individualized medication plans."

Journal • Cardiovascular • Hypertension

Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial. (PubMed, BMC Med) - P4 | "The amlodipine/benazepril and benazepril/hydrochlorothiazide dual therapies were comparable in ambulatory systolic BP lowering. The former combination, compared with the latter, had a greater BP-lowering effect in the daytime and a lower incidence rate of dry cough."

Journal • Cardiovascular • Cough • Hypertension • Respiratory Diseases

Pharmacoeconomic evaluation of stroke and myocardial infarction prevention in hypertensive patients: Markov model based on the ACCOMPLISH trial. (PubMed, J Int Med Res) - "Compared with the hydrochlorothiazide + benazepril treatment regimen, the amlodipine + benazepril regimen showed greater economic benefits."

HEOR • Journal • Cardiovascular • Hypertension • Myocardial Infarction

Concurrent disorders of cats with diabetes mellitus and arterial systolic hypertension. (PubMed, J Feline Med Surg) - "Cats with DM and SH should be evaluated for the presence of chronic kidney disease, hyperthyroidism and functional adrenal masses. Treatment with amlodipine appears to be effective in lowering SABP in cats with DM and SH."

Journal • Cardiovascular • Diabetes • Diabetic Nephropathy • Endocrine Disorders • Hypertension • Metabolic Disorders • Nephrology • Renal Disease

Efficacy of single-pill combination in uncontrolled essential hypertension: A systematic review and network meta-analysis. (PubMed, Clin Cardiol) - "The results of the network meta-analysis showed that a total of 11 single-pill combination antihypertensive drugs were included, namely: Amlodipine/valsartan, Telmisartan/amlodipine, Losartan/HCTZ, Candesartan/HCTZ, Amlodipine/benazepril, Telmisartan/HCTZ, Valsartan/HCTZ, Irbesartan/amlodipine, Amlodipine/losartan, Irbesartan/HCTZ, and Perindopril/amlodipine. Based on Ranking Plot of the Network, we can conclude that single-pill combination antihypertensive drugs are superior to monotherapy, and ARB/CCB combination has better advantages than other SPC in terms of systolic blood pressure, diastolic blood pressure, blood pressure control rate, and diastolic response rate. However, due to the small number of some drug studies, the lack of relevant studies has led to not being included in this study, which may impact the results, and readers should interpret the results with caution."

Journal • Retrospective data • Review • Cardiovascular • Hypertension

Hiding in Plain Sight: Late Diagnosis of Primary Hyperaldosteronism in Patient with Atypical Presentation (ENDO 2023) - "His antihypertensive regimen included atenolol 25 mg daily and amlodipine-benazepril 10-40 mg daily...A 3-day dexamethasone suppression test was performed to exclude familial hyperaldosteronism or glucocorticoid remediable aldosteronism...He was started on eplerenone 25 mg twice daily and salt restriction with a goal of increasing the PRA above 1 ng/ml/hr.Discussion and It was initially thought that PHA represents 1% of all patients with primary HTN... It was initially thought that PHA represents 1% of all patients with primary HTN. However, more recent studies indicate that the prevalence is significantly higher. Additionally, the PAC in patients with PHA can fluctuate and patients can present with normokalemia, making the diagnosis more difficult to establish."

Clinical • Cardiovascular • Endocrine Disorders • Hypertension

Chlorthalidone Implicated in the Development of DKA HHS Overlap in a Patient With Type II Diabetes Mellitus (ENDO 2023) - "For hypertension, the patient was adherent with titrated doses of Amlodipine, Benazepril and Hydralazine and newly initiated on Chlorthalidone 25mg daily, 2 weeks prior...He was discharged on Glargine 30 units daily, Lispro 8 units three times daily with meals and Metformin 500mg BID...Abstracts presented at a news conference are embargoed until the date and time of the news conference. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.*"

Clinical • Cardiovascular • Diabetes • Dyslipidemia • Fatigue • Hematological Disorders • Hypertension • Metabolic Disorders • Type 2 Diabetes Mellitus

Angiotensin II Use in Treatment of Refractory Shock Due to Benazepril and Amlodipine Toxic Ingestion. (PubMed, J Pharm Pract) - "Isolated CCB overdoses have high complication rates and well-established treatments. Therefore, management of CCB and ACEi co-ingestion is typically driven by CCB poisoning algorithm. There are multiple reports of CCB and ACEi co-ingestions causing treatment-refractory shock. Therapeutic options are limited by toxicities and availability of salvage therapies. Ang II is a safe and highly effective option to manage these patients."

Journal • Cardiovascular • Critical care • Hypotension • Metabolic Disorders • Nephrology • Renal Disease

Initial combination therapy for hypertension in patients of African ancestry: a systematic review and meta-analysis. (PubMed, J Hypertens) - "An RCT including high-risk patients reported combined morbidity/mortality for hydrochlorothiazide (mg) 25 + benazepril 40 vs. amlodipine 10 + benazepril 40 of respectively 8.9% vs. 6.6% (n = 1414, risk ratio 1.35 [0.94;1.94]; all patients, N = 11 506, 1.23 [1.11;1.37]).We conclude that limited evidence supports CCB + ACEI rather than HCT + ACEI as first-line initial combination therapy in African ancestry patients with hypertension. CRD42021238529Video Abstract."

Combination therapy • Journal • Retrospective data • Review • Diabetes • Hypertension

[VIRTUAL] Initial combination therapy for hypertension in patients of African ancestry: a systematic review and meta-analysis (ESC 2021) - "Initial combination therapy with CAB+ACEI/ARB (vs Diuretics+ACEI/ARB; 7 comparisons) also resulted in comparable blood pressures (n=2266; SBP: −0.49[95% CI, −0.87 to −0.12] and DBP −0.55[−0.97 to −0.14]); but CAB+ACEI/ARB showed less adverse effects (hypokalaemia, hyperglycaemia), and a trend toward reduced cardiovascular disease and mortality (n=1414; mean follow up 3 y; Amlodipine/Benazepril vs HCT/Benazepril, combined cardiovascular disease and mortality (6.6 vs 8.9%, P=0.10), without significant differences in Stroke (2.2 vs 2.1%, P=0.97), or heart failure (1.7 vs 2.2%, P=0.50).CONCLUSION In relatively young AA patients with uncomplicated hypertension, initial dual combination therapy including CAB, Diuretics, or Diuretics+CAB results in comparable blood pressures, but adverse metabolic effects are lower without a diuretic. Knowledge gaps include data on biomarkers to replace race/ancestry, data by sex and in the elderly, and end point data, including on Diuretic/CAB..."

Combination therapy • Retrospective data • Review • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension

Cardiovascular Benefits of Angiotensin Converting Enzyme Inhibition plus Calcium Channel Blockade in Patients Achieving Tight Blood Pressure Control and with Resistant Hypertension. (PubMed, Am J Hypertens) - P3 | "Combination therapy adding a calcium channel blocker, rather than hydrochlorothiazide, to an angiotensin converting enzyme inhibitor was more effective in preventing composite cardiovascular events even in hypertensive patients achieving aggressive systolic blood pressure targets as well as in those with apparent resistant hypertension. Our findings add support that most patients, including those following contemporary clinical guidelines, will benefit from this combination."

Clinical • Journal • Cardiovascular • Hypertension • Myocardial Infarction

Real-World Data Approaches for Early Detection of Potential Safety and Effectiveness Signals for Generic Substitution: A Metoprolol Extended-Release Case Study. (PubMed, J Clin Pharmacol) - "Compared to amlodipine-benazepril, which also had a first-approved generic at the same time, market share data showed that metoprolol succinate had lower utilization and more prescriptions written as dispense as written. This analytic framework can be implemented to actively monitor new generic formulations for potential bioequivalence failures. Signals from these analyses require confirmation (eg, via pharmacometric analyses) to be informative for regulatory action."

Clinical • Journal • Real-World Evidence

Comparative effectiveness of generic and brand-name medication use: A database study of US health insurance claims. (PubMed, PLoS Med) - "In this study, we observed that use of generics was associated with comparable clinical outcomes to use of brand-name products. These results could help in promoting educational interventions aimed at increasing patient and provider confidence in the ability of generic medicines to manage chronic diseases."

HEOR • Journal • Reimbursement

Prior Medications and the Cardiovascular Benefits From Combination Angiotensin-Converting Enzyme Inhibition Plus Calcium Channel Blockade Among High-Risk Hypertensive Patients. (PubMed, J Am Heart Assoc) - "When combined with an angiotensin-converting enzyme inhibitor, amlodipine provides cardiovascular risk reduction superior to hydrochlorothiazide, largely regardless of prior medication use. These findings add further support for the initial use of this combination regimen among high-risk hypertensive patients."

Clinical • Journal

Optimal combination treatment strategy in hypertension (KSN 2019) - "ACE inhibitor / ARB + CCB Versus Diuretics In the ACCOMPLISH study, benazepril-amlodipine combination was compared to the benazepril- hydrochlorothiazide combination in high risk patients. For this reason, in the meta-analyses that compared ACE inhibitor and ARB on various cardiovascular outcome, the performance of ACE inhibitor was better than ARB. From this available scientific evidence, it is tempting to speculate that the combination of ACE inhibitors (but not ARBs) with CCB provides effective protection from clinical events."

THE HIDDEN NEOPLASM: A CASE OF PARAGANGLIOMA (AACE 2019) - "His blood pressure at that time was also noted to be 152/88 (heart rate of 79, respiratory rate of 16, and temperature of 98F), and he was started metoprolol in addition to his amlodipine and benazepril that he had already been taking. Discussion : There are approximately 500 to 1600 cases of paragangliomas/pheochromocytomas diagnosed each year, but studies involving autopsies revealed a greater prevalence, suggesting that many tumors go undiagnosed. Conclusion : This case illustrates how paragangliomas can remain hidden and highlights the need for better diagnostic studies to further identify paragangliomas early."

Clinical