amikacin sulfate / Generic mfg. - LARVOL DELTA

Cerebrospinal Fluid Exchange Combined with Intrathecal Antibiotic Injection for the Management of Severe Intracranial Infection Caused by Hypervirulent Klebsiella pneumoniae: A Case Report. (PubMed, Infect Drug Resist) - "Early cerebrospinal fluid exchange, combined with intrathecal amikacin injection, was initiated...Collectively, these findings provide novel insights and a valuable framework for developing future therapeutically efficacious strategies for the management of Hypervirulent Klebsiella pneumoniae. However, this regimen does not standard-of-care, and further evidence is required to establish its safety and clinical effectiveness."

Journal • CNS Disorders • Diabetes • Hepatology • Immunology • Infectious Disease • Metabolic Disorders • Myositis • Ocular Infections • Ocular Inflammation • Ophthalmology • Pneumonia

Epidemiology, resistance profiles, and risk factors of multidrug- and carbapenem-resistant Serratia marcescens infections: a retrospective study of 242 cases. (PubMed, BMC Infect Dis) - "This study reveals substantial differences in antimicrobial susceptibility between MDR and non-MDR S. marcescens isolates and highlights amikacin and sulfamethoxazole as potential treatment options against MDR strains. Didentified clinical risk factors-including prior hospitalization, kidney disease, and extensive antibiotic exposure-underscore the importance of early risk stratification and optimized antibiotic stewardship."

Journal • Retrospective data • Infectious Disease • Nephrology • Renal Disease • Respiratory Diseases

Etiological Profiles and Antibiotic Resistance of Urinary Tract Infections Among Different Age Categories in Children: A Retrospective Study of Xiamen Single-Center. (PubMed, Infect Drug Resist) - "Escherichia coli had a significantly lower rate of resistance to ampicillin than Klebsiella pneumoniae (p < 0.001), and both had a high rate of resistance to cephalosporins (over 95% to cefazolin), but a low rate of resistance to amikacin and furotoxin. Pseudomonas aeruginosa had 100% resistance to most cephalosporins, but less than 7% to ceftazidime, cefepime and piperacillin tazobactam. Enterococcus faecalis had over 90% resistance to Ampicillin, Penicillin, Linezolid and 91.53% to tetracycline. No Tigecycline/Vancomycin-resistant enterococci were found...Pediatric UTIs in Xiamen show gender-based pathogen differences, mainly gram-negative. Nitrofurantoin is preferred for mild cases, and the clinical selection should be individualized by combining the regional pathogen spectrum and drug sensitivity."

Journal • Retrospective data • Infectious Disease • Nephrology • Pediatrics • Pneumonia

First Case of Nocardia seriolae Infection in China Cultured Channel Catfish (Ictalurus punctatus). (PubMed, J Fish Dis) - "Drug sensitivity testing indicated susceptibility to commonly used antibiotics such as co-trimoxazole, doxycycline, enrofloxacin, florfenicol, amikacin and rifampicin. 100% mortality with 1 × 108, 1 × 107 and 1 × 106 cfu/mL in a 35-d challenge test period was observed, and the intraperitoneal injection median lethal dose (LD50) was 1.89 × 104 cfu/mL. This is the first isolation report of N. seriolae infection from cultured channel catfish, aiming to warn against the continuous host-range expansion of this pathogen, which is threatening the inland aquaculture industry."

Journal • Hepatitis C • Immunology • Infectious Disease • Inflammation • Sarcoidosis • AFF4

Child-Turcotte-Pugh score-based modified anti-tubercular treatment in patients with decompensated cirrhosis with tuberculosis: A two-year retrospective observational study from North India. (PubMed, Indian J Gastroenterol) - "As per our study, patients with decompensated cirrhosis tolerated the CTP-score-based modified ATT and almost 80% had a resolution of tuberculosis."

Journal • Observational data • Retrospective data • Fibrosis • Hepatology • Immunology • Infectious Disease • Liver Failure • Pulmonary Disease • Respiratory Diseases • Tuberculosis • RELA

Whole-genome sequencing and machine learning reveal key drivers of delayed sputum conversion in rifampicin-resistant tuberculosis. (PubMed, Front Cell Infect Microbiol) - "Univariate analysis linked 2-month SCC failure to smear positivity, resistance to isoniazid, amikacin, capreomycin, and levofloxacin, and pre-XDR-TB status, though only smear positivity (aOR=2.41, P=0.008) and levofloxacin resistance (aOR=2.83, P=0.003) persisted as independent predictors in multivariable analysis. A Random Forest model achieved robust prediction of SCC failure (AUC: 0.86 ± 0.06 at 2 months; 0.76 ± 0.10 at 6 months), identifying levofloxacin resistance (feature importance: 6.37), embB_p.Met306Ile (5.94), and smear positivity (5.12) as top 2-month predictors, while katG_p.Ser315Thr (4.85) and gyrA_p.Asp94Gly (3.43) dominated 6-month predictions. These findings underscore smear positivity, levofloxacin resistance, and specific resistance mutations as critical drivers of SCC failure, guiding targeted RR-TB treatment strategies."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Recurrent Small Bowel Obstruction Secondary to Intestinal Tuberculosis: A Case Report and Review of the Literature (ACG 2025) - "A nasogastric tube was placed and the patient was started on IV rifampin, levofloxacin, amikacin, and linezolid...Intestinal TB may be difficult to diagnose as it can present similarly to pathologies such as intra-abdominal infection, IBD, or malignancy. Misdiagnosis rates of intestinal tuberculosis have been reported to be as high as 50-70%, even in countries with a high prevalence of tuberculosis."

Case report • Clinical • Review • Gastrointestinal Disorder • Hepatology • Infectious Disease • Respiratory Diseases • Tuberculosis

Comparison of clinical manifestations, antimicrobial susceptibility patterns, and carbapenem resistance determinants between Acinetobacter seifertii and Acinetobacter nosocomialis isolated in Taiwan. (PubMed, J Microbiol Immunol Infect) - "A. seifertii and A. nosocomialis exhibit distinct antimicrobial susceptibility profiles and carbapenem resistance mechanisms but share similar mortality rates. The ability of both species to act as reservoirs of carbapenem resistance highlights the importance of accurate identification, antimicrobial stewardship, and infection control strategies to mitigate the spread of resistant strains."

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Iron and Manganese Azooxime Complexes as Anti-Microbial Agents Against Antibiotics Resistant Wild Bacteria From Hospital Drainage. (PubMed, J Cell Mol Med) - "The strains were treated with various broad-spectrum antibiotics, namely, Penicillin G, Oxacillin, Cephalothin, Clindamycin, Erythromycin, Amoxyclav, Cefotaxime, Levofloxacin, Aztreonam, Imipenem, Amikacin, Ceftazidime, and found to be resistant against many of them, viz., Clindamycin, Ceftazidime, Erythromycin, Amoxyclav, and some others, thereby signifying that the molecular mechanism of action of the aforesaid complexes is multidimensional. These complexes were producing ROS in sufficient amounts that can cause lipid peroxidation, and subsequent damage to the bacterial cell membrane and translation machinery was found to be inhibited by RNA. Bacterial genomic DNA was also affected by the chelates, and this has been authenticated by the decreased genomic DNA concentration and presence of DNA debris on agarose gel electrophoresis of the DNA of bacterial cultures treated with the complexes."

Journal • CAT

Determining minimal inhibitory concentrations and antibiotic susceptibility for Enterobacterales by flow cytometry using reactive oxygen species as a marker. (PubMed, PLoS One) - "MICs of amikacins, aztreonams, cephalosporins (with or without a lactamase inhibitor), carbapenems, levofloxacin, polymyxin B, trimethoprim/sulfamethoxazole, and tigecycline were determined for six clinical carbapenem-resistant Enterobacterales isolates using conventional microbroth dilution assays and using FCM assessments in parallel. Further optimisation and validation of this FCM assay with additional bacteria strains with varying antibiotic susceptibilities are warranted. Future studies include assessing other organisms and antibiotic pairs."

Biomarker • Journal

Genomic characteristics and mechanisms of horizontal plasmid transfer in Klebsiella pneumoniae producing NDM-1 and IMP-4 carbapenemases (PubMed, Zhonghua Yi Xue Za Zhi) - "Klebsiella pneumoniae KP1050 was resistant to multiple antimicrobial agents, including carbapenems, and only susceptible to amikacin, tigecycline, and polymyxin. Knockout of key genes in the plasmid type Ⅳ secretion system revealed that the IncHI5-type IMP-4 plasmid was not an independently conjugative plasmid but could undergo horizontal transmission through conjugation with the assistance of the IncN-type NDM-1 plasmid. Interactions between plasmids can promote the spread of carbapenemase resistance genes."

Journal • Infectious Disease • Pneumonia

Molecular and Computational Insights of Novel Mutations in Aminoglycoside-Modifying Genes of P. aeruginosa. (PubMed, Mol Biotechnol) - "The docking analysis calculated different binding energy scores of -7.6, -7.1, -8.3, -7.1, and -7.1 kcal/mol for the aac(6)-Ib wild protein and antibiotics, including Gentamicin, Tobramycin, Amikacin, Kanamycin, and Streptomycin, respectively. In the case of mutated proteins and antibiotics, binding energies of -6.8, -6.1, -7.3, -6, and -5.6 kcal/mol were calculated. The dynamic stability of the docked complex was examined using molecular dynamics simulations, and the results indicate that the docked complexes maintain their stability throughout the simulation time frame."

Journal

Prevalence, Clinical Characteristics, and Mortality Impact of Metallo-β-Lactamase-Producing Enterobacter Cloacae Complex Infections: A Retrospective Cohort Study. (PubMed, J Glob Antimicrob Resist) - "MBL-producing ECC infections are associated with high antibiotic resistance, increased healthcare resource utilization, and significantly higher mortality, particularly in bloodstream infections. The predominance of blaNDM among MBL genes aligns with recent regional trends. These findings underscore the urgent need for enhanced surveillance, rapid diagnostics, and targeted management strategies to address this emerging threat."

Journal • Retrospective data • Infectious Disease

Synergistic antibacterial effects of postbiotics combined with linezolid and amikacin against nosocomial pathogens. (PubMed, Front Cell Infect Microbiol) - "In conclusion, postbiotic-antibiotic combinations, especially with linezolid and amikacin, present promising low-toxicity, synergistic therapeutic strategies. These results lay a strong foundation for advancing microbiome-based adjunct therapies to combat AMR in clinical settings."

Journal • Infectious Disease

Investigation into Antibiotic Resistance Profiles of Staphylococcus aureus Among Chronic Rhinosinusitis Patients and Multifaceted Analysis of Factors Influencing Methicillin-Resistant Staphylococcus aureus Infection. (PubMed, Infect Drug Resist) - "MRSA strains exhibited significantly higher resistance rates to cefoxitin, amikacin, ciprofloxacin, and six other antibiotic classes compared to MSSA strains (all P<0.05), with resistance exceeding 50% for fluoroquinolones and macrolides. Clinicians should prioritize targeted screening for high-risk patients, optimize antibiotic stewardship, and enhance postoperative nasal function management. Implementing a multifaceted approach-including early risk assessment, standardized antibiotic use, and intensified follow-up care-can effectively mitigate MRSA infection risks and improve overall treatment outcomes for CRS patients."

Journal • Infectious Disease • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Antimicrobial susceptibility patterns of Escherichia coli from various clinical sources. (PubMed, Antimicrob Steward Healthc Epidemiol) - "There were high sensitivity rates to Amikacin, Tigecycline, and Imipenem by (97.49%), (90.87%), and (90.35%), respectively, while there were high resistance rates to Norfloxacin, Ampicillin, and Cefotaxime by (93.67%), (79.60%), and (71.65%), respectively. Antibiotics, including imipenem, amikacin, and nitrofurantoin, demonstrated the highest efficacy against E. coli isolates. Nalidixic acid, cefexime, and ceftriaxone showed efficacy against E. coli; nevertheless, several clinical isolates exhibited resistance."

Journal • Gastrointestinal Disorder

Intraperitoneally Administered Vancomycin Results in Suboptimal Serum and Peritoneal Effluent Drug Levels in Patients with PD-related Peritonitis. (PubMed, Indian J Nephrol) - "Patients received IP Vancomycin 15 mg/kg Q96H and amikacin 2 mg/kg while awaiting culture reports. In patients with PD-related peritonitis, intermittent intraperitoneal administration of 15 mg/kg of vancomycin every 96 h does not achieve the recommended serum and dialysate levels of vancomycin. There is an urgent need for pharmacokinetic studies on commonly used IP antibiotics in the PD population to facilitate correct dose recommendations."

Journal • Chronic Kidney Disease • Nephrology • Renal Disease

Prevalence and epidemiologic features of nontuberculous mycobacteria causing persistent surgical site infections in Bangladesh. (PubMed, IJID Reg) - "Resistance to amikacin, ciprofloxacin, and clarithromycin was noted for M. abscessus and M. fortuitum. NTM represented by M. abscessus and M. fortuitum were revealed to be a significant cause of persistent SSIs of various patient groups in Bangladesh, associated with specific types of surgery."

Journal • Infectious Disease • Nontuberculous Mycobacterial Disease • Respiratory Diseases

A Practice-Based and Expert-Driven Consensus on the Management of Respiratory and Non-Respiratory Adverse Events Associated with Amikacin Liposome Inhalation Suspension (ALIS) (IDWeek 2025) - No abstract available

Adverse events • Infectious Disease

Luciferase reporter mycobacteriophage (TM4::GeNL) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complex. (PubMed, J Clin Microbiol) - "Mycobacterium abscessus (MAB) infections are challenging to treat due to high-level resistance to anti-tuberculosis drugs, carbapenems, fluoroquinolones, and tetracyclines. Clarithromycin and amikacin are considered cornerstone drugs for MAB treatment due to their superior efficacy; however, assessing clarithromycin susceptibility typically takes 7 to 14 days because of inducible macrolide resistance...All clarithromycin-resistant isolates carried full-length inducible erythromycin ribosomal methylase-41 [erm(41)] gene, and none had rrl (23S rRNA) mutations...In addition, LRM-DST results for bedaquiline, moxifloxacin, imipenem, linezolid, and cefoxitin correlated well with Sensititre DST...We developed a novel luciferase reporter mycobacteriophage (LRM) based phenotypic DST method using TM4::GeNL to assess MAB drug susceptibility based on metabolic inhibition rather than growth. LRM-DST significantly reduces the DST turnaround time to 48 h and provides rapid assessment..."

Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Adverse effects associated with Kanamycin, Amikacin, Capreomycin and Bedaquiline -a VigiAccess™ study. (PubMed, Afr Health Sci) - "Therefore, VigiAccess™ provides a good platform for reporting and awareness of specific adverse effects associated with MDR-TB therapy. This is a vital stepping stone for further research."

Adverse events • Journal • Dermatology • Infectious Disease • Otorhinolaryngology • Pruritus • Pulmonary Disease • Respiratory Diseases • Tuberculosis

MIKA: Research of the Consequences on the Digestive Tract Following the Proposed Treatments for a Urinary Infection in Children (clinicaltrials.gov) - P=N/A | N=200 | Recruiting | Sponsor: Centre Hospitalier Intercommunal Creteil | Trial completion date: Jan 2025 ➔ Jul 2026 | Trial primary completion date: Jan 2025 ➔ Jul 2026

Trial completion date • Trial primary completion date • Infectious Disease • Nephrology • Urology

Hospital acquired drug resistant pathogens infections in patients with viral respiratory tract infections: a retrospective study. (PubMed, BMC Infect Dis) - "The drug resistance rate of P. aeruginosa to third-generation cephalosporins (such as ceftriaxone and cefotaxime) exceeds 89%, but it has relatively higher sensitivity to ceftazidime (71.7%) and cefepime (69.6%)...pneumoniae shows resistance rates of 53.3% to imipenem and 46.7% to meropenem, with over 50% resistance to levofloxacin and ciprofloxacin. Effective agents include sulfamethoxazole (68.9% susceptible), tigecycline (64.4%), chloramphenicol (62.2%), and amikacin (62.2%)...baumannii was highly resistant to nearly all tested antibiotics, showing only partial susceptibility to minocycline (59.5%) and trimethoprim-sulfamethoxazole (38.1%). Among the seven ML models, the neural network (NN) achieved the best predictive performance. The SHAP method revealed the top 15 predictive variables by importance ranking, including length of stay (LOS), cholinesterase (CHE), age, albumin (ALB), etc."

Journal • Retrospective data • Infectious Disease • Influenza • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Dynamic injectable photothermal/chemotherapeutic hydrogel for prevention and treatment of local wound infections. (PubMed, J Biomater Appl) - "Herein, a dynamic injectable photothermal/chemotherapeutic hydrogel has been facilely established through mixing gellan gum (GG), indocyanine green (ICG) and amikacin (AMI) aqueous solutions at 80°C and cooling to room temperature...These exceptional physicochemical properties and combined effects of chemotherapy and PTT facilitated the satisfactory in vitro biocompatibility and antibacterial capability as well as wound healing acceleration ability. Therefore, such a dynamic injectable photothermal/chemotherapeutic hydrogel paves the way toward easily clinical transformation for prevention and treatment of local wound infections."

Journal • Infectious Disease

Clinical features, antimicrobial susceptibilities, treatment characteristics and outcomes of paediatric Acinetobacter lwoffii bacteremia: a case series. (PubMed, Eur J Clin Microbiol Infect Dis) - "Acinetobacter lwoffii remains an important pathogen of hospital-acquired bacteraemia in hospitalised children. Treatment with broad-spectrum beta-lactam antibiotics, either as monotherapy or combined with amikacin or colistin, appears effective."

Journal • Infectious Disease • Pediatrics