amikacin sulfate / Generic mfg. - LARVOL DELTA

Externally validated population pharmacokinetics of amikacin and evaluation of dosage regimen based on achieved serum concentrations in neonates. (PubMed, Antimicrob Agents Chemother) - "The current population PK model and external validation study have proven that the PK model built in the current study can be used to conduct reliable population simulations. IM injection can be an alternative route of administration for amikacin in neonates."

Journal • PK/PD data • Infectious Disease

Advanced therapeutic strategy for managing surgical site infections with natural nanoemulsion-antimicrobial combination. (PubMed, Front Pharmacol) - "However, it significantly enhanced the antimicrobial activity of amikacin, resensitizing resistant strains at safe concentrations...This study highlights chitosan nanoemulsion as an adjuvant therapy to combat antimicrobial resistance, enhance antibiotic efficacy, and improve SSI treatment outcomes. Further clinical studies are needed to optimize its use in patient care."

Journal • Infectious Disease • Inflammation • Pneumonia

Development of antibacterial drug + bacteriophage combination assays. (PubMed, JAC Antimicrob Resist) - "Time-kill curves (TKCs) were conducted at fosfomycin concentrations of 133, 50 and 5 mg/L, with and without phage...Amikacin and meropenem MIC50/90 (SD) values were 2/8 mg/L (<0.05-9.2) and 0.12/8 mg/L (<0.05-8.7), respectively...Microbroth methodologies based on ISO 2776-1:2019 lend themselves to be viable options for phage assessment, alone or in combination with antibiotics. The reproducibility of PmIC and familiarity of the methodology described allows for laboratory validation for phage and antibiotic combinations."

Journal

Bacteriological profile and antimicrobial resistance in sepsis cases in intensive care units in Lubumbashi: challenges and perspectives. (PubMed, Ann Clin Microbiol Antimicrob) - "This study highlights the high prevalence of Gram-negative bacteria and concerning resistance to first-line antibiotics, jeopardizing the effectiveness of empirical treatments. These findings underscore the urgency of strengthening microbiological surveillance, rationalizing antibiotic use, and implementing antimicrobial resistance control policies in the DRC. Developing treatment protocols tailored to local data and enforcing stricter antibiotic regulations are essential to improving sepsis management and reducing associated mortality."

Journal • Critical care • Infectious Disease • Pneumonia • Septic Shock

Inhibiting Amikacin Resistance in Multidrug-Resistant Bacteria with Cadmium and Pyrithione. (PubMed, Curr Microbiol) - "Furthermore, the combination inhibited amikacin resistance in carbapenem-resistant K. pneumoniae clinical isolates. These results add another cation to the arsenal of potential aminoglycoside adjuvants, which could be developed alone or in coordination complexes with ionophores to treat multidrug-resistant infections."

Journal • Review • Infectious Disease • Pneumonia • CD2

Nanopore-targeted sequencing: A new and effective technique for the diagnosis of non-tuberculous mycobacteria pulmonary disease. (PubMed, Int J Med Microbiol) - "The NTS sensitivity and specificity for predicting resistance to amikacin and clarithromycin were 42.9 %, 35.5 % and 98.8 %, 98.3 %, respectively. BALF specimens exhibit maximal sensitivity among different respiratory samples. Taken together, NTS is a novel, rapid, and efficient molecular diagnostic method for NTM-PD."

Journal • Infectious Disease • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases

Molecular epidemiological characteristics and risk factors analysis of Carbapenem-resistant Enterobacterales intestines colonization of neonates in Shenzhen region (PubMed, Zhonghua Yu Fang Yi Xue Za Zhi) - "All CRE isolates were resistant to penicillin, penicillinase inhibitors, cephalosporins, ertapenem and imipenem.The resistance rates of Escherichia coli to amikacin, levofloxacin was 1/14, 4/14, respectively. Risk factors for CRE colonization include the older age, length of hospital stay, tracheal intubation, invasive respiration, lumbar puncture, Apgar <7 score, and exposure to antibiotics. NDM5 is the predominant resistant gene in CRE isolated from neonatal patients feces in Shenzhen region.It is necessary to strengthen the screening of CRE colonization in neonate for prevention and control of CRE infection."

Journal • Infectious Disease • Pneumonia

Evaluation of Bcr/cflA Targeted Efflux Inhibitory Potential of 2-Hydroxy-4-Methoxybenzaldehyde Against Proteus mirabilis. (PubMed, Indian J Microbiol) - "HMB treatment down-regulated efflux genes expression and enhanced antibiotic susceptibility, particularly against amikacin, chloramphenicol, kanamycin, and polymyxin-B, highlighting its therapeutic role in combating antibiotic resistance in P. mirabilis. The online version contains supplementary material available at 10.1007/s12088-024-01284-9."

Journal • Infectious Disease

A Rare Case of Exophiala Dermatitidis Isolation in a Patient with Non-Cystic Fibrosis Bronchiectasis: Colonization or True Infection? (PubMed, Diagnostics (Basel)) - "Given clinical stability and the absence of systemic signs, initial therapy included oral voriconazole, levofloxacin, doxycycline, and inhaled amikacin. This case underscores the need for further research on fungal colonization in NCFB and the development of evidence-based treatment guidelines. Further studies are needed to clarify the pathogenic significance, optimal management, and long-term outcomes of E. dermatitidis in non-CF chronic lung diseases."

Journal • Breast Cancer • Bronchiectasis • Chronic Cough • Cough • Cystic Fibrosis • Gastrointestinal Disorder • Genetic Disorders • Immunology • Infectious Disease • Non‐Cystic Fibrosis Bronchiectasis • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Tumor

Efficacy of Gentamicin irrigation for the prevention of surgical site infection in brain surgery: A randomized controlled study. (PubMed, Clin Neurol Neurosurg) - "Gentamicin irrigation did not demonstrate a significant advantage over normal saline irrigation in preventing postoperative surgical site infections when intravenous antibiotics were concurrently administered in neurosurgical patients."

Journal • CNS Disorders • Infectious Disease

Research Note: Isolation and genomic characterization of Avibacterium paragallinarum from the Hubei Province, China. (PubMed, Poult Sci) - "Antimicrobial susceptibility testing revealed that all isolates exhibited resistance to tetracycline and lincomycin and sensitivity to levofloxacin. The isolates demonstrated varying degrees of resistance to other antibiotics, including erythromycin, doxycycline, cefotaxime, florfenicol, polymyxin B, spectinomycin, and amikacin...Notably, no genetic divergence was detected in resistance or virulence determinants among the 12 isolates. Overall, our study provides valuable data for the clinical management of A. paragallinarum and offers insights into its pathogenicity and antibiotic-resistance mechanisms for future studies."

Journal • Respiratory Diseases

Molecular Characterization and Antibiograms of Nontuberculous Mycobacterium Infections in Kashgar, China. (PubMed, Curr Microbiol) - "All slowly growing mycobacteria isolates exhibited the highest resistance rate against doxycycline (83.3%, 5/6), but most strains were sensitive to clarithromycin, rifabutin, amikacin, ciprofloxacin, moxifloxacin, rifampin, and trimethoprim-sulfamethoxazole. The prevalence of NTM isolates in Kashgar presents a very specific features and some rarely reported species constitute big proportions. Amikacin and moxifloxacin may represent effective therapeutic options for NTM infections in Kashgar."

Journal • Infectious Disease • Nontuberculous Mycobacterial Disease • Respiratory Diseases

Antimicrobial Susceptibility Patterns of Uropathogens: A Retrospective Study at a Primary Care Hospital in Ghana. (PubMed, Health Sci Rep) - "Amikacin exhibited the lowest resistance rate (4.4%), making it a strong candidate for empirical therapy. Multi-drug resistance (MDR) was demonstrated by 72.7% of bacterial isolates, with Klebsiella spp and Escherichia coli showing the highest MDR rates. The identified patterns of antimicrobial resistance highlight the critical importance of careful antibiotic selection to effectively manage urinary tract infections."

Journal • Retrospective data • Infectious Disease • Nephrology

Drug-associated hearing impairment in children: a disproportionality analysis of the FDA adverse event reporting system. (PubMed, Front Pharmacol) - "The top three medications with the highest ROR were vinblastin [N = 6 cases, ROR = 86.72 (34.15-220.19)], risedronate [N = 3 cases, ROR = 73.59 (20.24-267.63)], and amikacin [N = 11 cases, ROR = 71.31 (36.40-139.72)]. The top 3 drugs with the highest number of reports were carboplatin [N = 125 cases, ROR = 18.41 (15.27-22.21)], cisplatin [N = 78 cases, ROR = 31.24 (24.59-39.70)], and vincristine [N = 56 cases, ROR = 6.32 (4.83-8.27)]...Our findings suggest that nearly half of the 56 drugs linked to hearing impairment signals in children are not currently labeled with ototoxicity warnings. Consequently, further research is required to evaluate the association of these medicines with this risk."

Adverse events • Journal

Epidemiological and molecular characterisation of carbapenemase-producing Pseudomonas aeruginosa from a tertiary care hospital, India. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Antibacterial susceptibility profiling revealed high resistance to β-lactams (e.g. cefepime (40.2%), ceftazidime (42.4%)) and fluoroquinolones (ciprofloxacin (36.5%), levofloxacin (38.9%)), while colistin (84.4%) and amikacin (83.1%) retained high efficacy. These findings highlight a high burden of carbapenem resistance, driven by blaNDM-1 and its combinations, with significant clinical and infection control implications. Robust antibacterial stewardship and targeted surveillance in high-risk departments are imperative to curb the spread of these highly resistant pathogens."

Journal • Gene Therapies • Infectious Disease

A retrospective study: management of Rhizobium radiobacter-associated bloodstream infections in pediatric hematology and oncology patients. (PubMed, Rev Assoc Med Bras (1992)) - "In this first pediatric case series utilizing antibiotic lock therapy, effective treatment, strict isolation, and surveillance screenings led to favorable clinical outcomes for Rhizobium radiobacter-associated bloodstream infections in children with hematologic and oncologic conditions."

Journal • Retrospective data • Hematological Disorders • Hematological Malignancies • Infectious Disease • Oncology • Pediatrics

Identification of two novel bacterial strains as the putative cause of black mouth disease in farmed Strongylocentrotus intermedius. (PubMed, J Invertebr Pathol) - "Antimicrobial susceptibility tests indicated that both SIBMPM04 and SIBMIT01 were sensitive to chloramphenicol, florfenicol, imipenem, kanamycin, levofloxacin and polymyxin B. SIBMPM04 was sensitive to gentamycin and amikacin, and SIBMIT01 was sensitive to norfloxacin and sulfamethoxazole. Laboratory-based artificial infection tests showed that sea urchins infected with either SIBMPM04 or SIBMIT01 alone exhibited typical pathological symptoms of BMD in a dosage-dependent manner, and synergistic pathogenicity was observed when both bacterial strains were present. The observations from this study not only enrich information on these pathogens in sea urchins but also support the hypothesis that BMD may be induced by the synergistic action of multiple bacterial strains in sea urchins, leading to the rapid progression of disease symptoms."

Journal • Gastrointestinal Disorder • Infectious Disease

Understanding the Microbiology of Chronic Otitis Media (AAO-HNSF 2025) - "Regarding the bacterial spectrum, Corynebacterium amycolatum showed 100% susceptibility to cefotaxime, tetracycline, and linezolid, with 83% resistance to levofloxacin. Pseudomonas were susceptible to gentamicin, amikacin, cefepime, ceftazidime, and meropenem, but resistant to cephalothin, ceftriaxone, and fosfomycin...aureus was highly susceptible to vancomycin, nitrofurantoin, trimethoprim/sulfamethoxazole, linezolid and 33% resistance to ciprofloxacin and erythromycin. Corynebacterium amycolatum was the most common isolated microorganism.we found an increase antibiotic resistance to commonly used drugs such as fluoroquinolones, macrolides and penicillins. Corynebacterium amycolatum was the most common isolated microorganism.we found an increase antibiotic resistance to commonly used drugs such as fluoroquinolones, macrolides and penicillins. This study highlights the need for targeted therapy based on local resistance patterns. Further research on biofilms and fungal..."

Otorhinolaryngology

Molecular detection of virulence genes and antimicrobial resistance in Salmonella isolates from avian and human sources in northeastern Algeria. (PubMed, Acta Microbiol Immunol Hung) - "This study highlights the significant role of avian-derived Salmonella as a reservoir of antibiotic resistance and virulence genes, posing a serious threat to public health.Antibiotic resistance profiling revealed that avian isolates exhibited complete resistance (100%) to ampicillin, penicillin and cephalothin, followed by a high resistance rate of 98% to cefalexin and ceftriaxone...Moderate resistance (76%-46%) was observed against ceftriaxone, kanamycin, cefotaxime, gentamicin, trimethoprim-sulfamethoxazole, nalidixic acid, streptomycin, and chloramphenicol. Low resistance levels were detected for tetracycline, ciprofloxacin, and amikacin, at 26%, 20%, and 6.6%, respectively.These findings along with the widespread presence of virulence genes (spvA, spiC, spvC, and pefA) in both human and poultry isolates, underscore the potential for cross-species transmission and the urgent need for enhanced surveillance. The regional findings from Annaba and Constantine emphasize..."

Journal

Prevalence of Shiga toxin-producing Escherichia Coli O157 in Moroccan food and antimicrobial resistance profiles of the strains isolated. (PubMed, World J Microbiol Biotechnol) - "All isolates were resistant to amoxicillin/clavulanic acid, 11/14 (78.6%) were resistant to streptomycin, 10/14 (71.4%) were resistant to tobramycin, 9/14 (64.3%) were resistant to ertapenem and piperacillin, 8/14 (57.1%) were resistant to cefotaxime and 7/14 (50.0%) were resistant to ampicillin and ceftazidime. All isolates were sensitive to amikacin, ceftazidime/avibactam, gentamicin, imipenem, nitrofurantoin and trimethoprim/sulfamethoxazole. Results indicate food producers and sellers may need further training in good hygiene rules, highlighting the importance of implementing strict quality control to ensure food safety."

Journal

Drug development studies supporting zileuton as a parenteral adjuvant to attenuate antibiotic-associated nephrotoxicity. (PubMed, Antimicrob Agents Chemother) - "Different dosing strategies of zileuton to attenuate vancomycin-, polymyxin B-, and amikacin-associated nephrotoxicity were evaluated in rats over 10 days. This would allow the optimal use of glycopeptides, polymyxins, and aminoglycosides to treat difficult infections. Further studies are warranted to repurpose zileuton as a nephroprotectant."

Journal • Infectious Disease

Population-based microbiological characterization of Nocardia strains causing invasive infections during a multiyear period in a large Canadian healthcare region. (PubMed, Microbiol Spectr) - "Nocardia species were highly susceptible to amikacin, trimethoprim-sulfamethoxazole, moxifloxacin, and linezolid. Imipenem resistance only occurred in N. farcinica complex and N. nova complex strains, and ceftriaxone resistance only occurred in the former. Species-level Nocardia identification using MALDI-TOF MS and 16S sequencing improves understanding of these organisms' unique roles in invasive disease."

Journal • Immunology • Infectious Disease • Respiratory Diseases • Rheumatology

Characterization of Carbapenemase-producing Enterobacterales isolated from patients returning from Sub-Saharan Africa, France, 2015-2022. (PubMed, J Antimicrob Chemother) - "This study provides a comprehensive characterization of CPE isolated from patients returning from SSA. WGS allowed the identification of major circulating clones, their associated resistance genes, and their susceptibility to last-resort antibiotics."

Journal • Infectious Disease • Pneumonia

Heterogeneity among Mycobacterium avium complex species isolated from pulmonary infection in Taiwan. (PubMed, Microbiol Spectr) - "AST showed that clarithromycin and amikacin had high susceptibility rates against M. intracellulare clade A, M. intracellulare subsp...intracellulare, and M. avium, while linezolid and moxifloxacin exhibited higher resistance...Although international guidelines recommend macrolide, ethambutol, and rifampin for treating MAC pulmonary disease, our study highlights the importance of considering species identification and regional AST results when selecting anti-mycobacterial agents.IMPORTANCEThere are more than 10 (sub)species within the Mycobacterium avium complex...Indeed, we encountered poorer treatment outcomes when facing Mycobacterium avium pulmonary infections compared to other species causing pulmonary infections. Individualized anti-mycobacterial therapy should focus on each species responsible for pulmonary disease."

Heterogeneity • Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Epidemiological factors associated with the prevalence of mobile genetic elements, and antimicrobial resistance patterns in Klebsiella pneumoniae of farm environments in Bangladesh. (PubMed, BMC Med Genomics) - "Regarding resistance patterns, the highest resistance was observed to ertapenem (90.6%) and ampicillin (84%), while complete sensitivity was noted to several antibiotics, including amikacin and tigecycline. Importantly, these also carry serious implications for human health, as resistance genes may transfer to clinical settings, exacerbating the burden of AMR. Strengthening environmental and agricultural policies through a One Health approach is essential to mitigate the public health threat posed by antimicrobial resistance."

Journal • Infectious Disease • Pneumonia