Ab19 / Takeda - LARVOL DELTA

AB19: Interventions (EUSEM 2024) - No abstract available

A novel chemical proteomics approach toward the identification of kinase targets to sensitize tumour cells to the standard of care drug paclitaxel (AACR 2024) - "Our proof-of-concept was made with AB19, a chemoprobe designed with the scaffold of crizotinib, a MET receptor tyrosine kinase inhibitor. Taken together, the results suggest that AURKA is a unique target for sensitizing cells to paclitaxel and this novel chemical proteomics approach can be developed as a novel strategy to identify kinase inhibitors capable of significantly sensitizing cancer cells to standard of care drugs."

Late-breaking abstract • Tumor cell • Gastric Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • MET • mTOR

Taxonomic Re-Evaluation and Genomic Comparison of Novel Extracellular Electron Uptake-Capable Rhodovulum visakhapatnamense and Rhodovulum sulfidophilum Isolates. (PubMed, Microorganisms) - "Here, we reclassify two R. sulfidophilum isolates, strainAB26 and strain AB19, as Rhodovulum visakhapatnamense using taxonomic re-evaluation based on 16S and pufM phylogenetic analyses...Genome comparison led by transcriptomic data under pEEU reveals potential pEEU-relevant genes both unique to R. visakhapatnamense strains and shared within the R. sulfidophilum genomes. With these data we identify potential pEEU-important transcripts and how speciation may affect molecular mechanisms of pEEU in Rhodovulum species from the same environment."

Journal

B-AB19 - Provocative Cases Oral Abstracts (RHYTHM 2021) - "Provocative cases with ventricular arrhythmias in mind."

Clinical • Atrial Fibrillation • Cardiovascular