avitriptan (BMS-180048) / BMS - LARVOL DELTA

Antimigraine Drug Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells. (PubMed, Int J Mol Sci) - "Activation of AhR in reporter gene assays was observed for Avitriptan and to a lesser extent for Donitriptan, while other triptans were very weak or no activators of AhR. Collectively, we show that Avitriptan is a weak ligand and activator of human AhR, which induces the expression of CYP1A1 in a cell-type specific manner. Our data warrant the potential off-label therapeutic application of Avitriptan as an AhR-agonist drug."

Journal • CNS Disorders • Colorectal Cancer • Gastrointestinal Cancer • Migraine • Oncology • Solid Tumor • AHR

A domino reaction for generating β-aryl aldehydes from alkynes by substrate recognition catalysis. (PubMed, Nat Commun) - "Remarkably, molecular recognition of the ligand and the substrate via hydrogen bonding plays a key role in this step. Control experiments indicate that the reaction further proceeds via 1,4-addition of an arene nucleophile to the unsaturated aldehyde intermediate and subsequent decarboxylation."

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