aspirin / Generic mfg. - LARVOL DELTA

Assessing transfusion need in patients with type A aortic dissection with multiplate aggregometry. (PubMed, PLoS One) - "Multiplate® aggregometry can be a useful tool for evaluating platelet dysfunction and assessing transfusion need in ATAAD patients, thereby aiding in the optimization of treatment strategies."

Journal • Observational data • Retrospective data

Prevention of unfavorable fibrin clots and thrombo-embolic manifestations in patients with cardiovascular disease. (PubMed, Expert Rev Cardiovasc Ther) - "Anticoagulants (heparins, vitamin K antagonists, and direct oral anticoagulants), aspirin, and statins favorably modify fibrin clot characteristics, which might contribute to their efficacy in various clinical settings. Encouraging results suggest that also novel treatments not yet approved in cardiovascular disease, including factor XI inhibitors and lipoprotein (a) reducing agents, might be beneficial, in part through improved fibrin clot phenotype, which gives hope for reducing the residual risk of thromboembolism in cardiovascular disease which persists despite the recommended management."

Journal • Review • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Ischemic stroke • Myocardial Infarction • Peripheral Arterial Disease

Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH) (clinicaltrials.gov) - P1/2 | N=400 | Recruiting | Sponsor: Thomas Jefferson University | Not yet recruiting ➔ Recruiting

Enrollment open • Gynecology

Utility of the US Preventive Services Task Force for Preeclampsia Risk Assessment and Aspirin Prophylaxis. (PubMed, JAMA Netw Open) - "In this prospective cohort study of 5684 singleton pregnancies, 89% of the population was assessed as having increased risk (moderate or high) of preeclampsia by USPSTF criteria. These findings suggest that moderate risk factors in the absence of high risk factors show no or low value for estimating the risk of developing preeclampsia, leading to nonspecific recommendations of AP in the moderate risk category."

Journal • Observational data • Cardiovascular • Diabetes • Genetic Disorders • Gynecology • Hypertension • Immunology • Metabolic Disorders • Nephrology • Obesity • Renal Disease

Assessment of Preclinical Antioxidative and Anti-Inflammatory Activities of Cornus macrophylla Wall. Bark. (PubMed, Food Sci Nutr) - "In the in vivo anti-inflammatory assay, the ethyl acetate (EA) fraction showed activity of 68.3%, 79.7%, and 83.7% at dosages of 50, 100, and 200 mg/kg B.W. (Body weight) of all the mice decreased when treated with LPS while it increased when treated with aspirin, crude extract, dichloromethane (DCM), and EA, respectively...The EA fraction markedly increases the level of catalase (CAT) by 46.26, 41.12, and 39.37 units/mg proteins at doses of 100, 200, and 300 mg/kg body weight, respectively. In vivo results validated the in vitro results of different fractions of C. macrophylla."

Journal • Preclinical • Inflammation • CAT

Identifying Pharmacologic Regulators Of Brown Adipose Tissue In Humans (ENDO 2025) - "Our results show that the incidence of starting nine medications (inhaled fluticasone, hydrochlorothiazide, vitamin D3, vitamin D2, exemestane, aspirin, amlodipine, letrozole, pantoprazole) was higher in the BAT positive group compared to the BAT negative group (OR >1, p<0.05), indicating that usage of these medications was associated with BAT activation. On the other hand, the incidence of starting escitalopram was significantly lower in the BAT positive group versus BAT negative group, as shown previously by others (2). In summary, our unique longitudinal analyses on medication usage have unraveled candidate medications that can potentially be repurposed to activate BAT in humans."

Late-breaking abstract • Diabetes • Genetic Disorders • Obesity • Oncology • Type 2 Diabetes Mellitus

A Case Of Bilateral Diabetic Muscle Infarction In The Arm And Leg: An Unusual Presentation (ENDO 2025) - "Cases of DMI have been described before, but upper extremity involvement is much rarer, as is involvement of multiple muscle groups, especially in bilateral extremities. It is possible that the IV infiltration caused microvascular injury that precipitated the DMI in her forearm, in addition to the typical involvement of the thigh. Trauma has not been previously reported as a precipitating factor for DMI but is plausible in this case with a unique presentation."

Clinical • Late-breaking abstract • Cardiovascular • Dermatology • Diabetes • Immunology • Infectious Disease • Metabolic Disorders • Myositis • Pain • Renal Disease • Reperfusion Injury • Retinal Disorders • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus • Vasculitis

A Rare Case of Spontaneous Thyroid Hemorrhage Related to Anticoagulation Use and Multinodular Goiter (ENDO 2025) - "Apixaban was discontinued...Anticoagulation was stopped subsequently in another three months and aspirin was initiated...Cases of thyroid hemorrhage related to warfarin use have been reported in literature...Conservative management with serial imaging is appropriate, especially in the absence of airway symptoms. While fine needle aspiration may be considered, surgical evacuation is required for expanding hematomas or persistent respiratory symptoms."

Clinical • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Gastrointestinal Disorder • Hematological Disorders • Immunology • Inflammatory Arthritis • Ischemic stroke • Otorhinolaryngology • Pain • Rheumatoid Arthritis • Rheumatology

Double Trouble - A Case of Bilateral Adrenal Hemorrhage (ENDO 2025) - "Case:A 60 year old male with a history of hypertension, hyperlipidemia, transient ischemic attack on aspirin, and acid reflux came to the emergency room for worsening epigastric pain for weeks, unrelieved by antacid medications. He denied nausea, vomiting, diarrhea, or fevers, but recently took ibuprofen for the Flu...In our case, it was difficult to determine a cause and diagnose BAH due to non-specific symptoms, especially without the presence of AI. Early recognition is key as patients require monitoring for AI to reduce mortality."

Clinical • Cardiovascular • Dyslipidemia • Endocrine Disorders • Gastroesophageal Reflux Disease • Hematological Disorders • Hypertension • Infectious Disease • Nephrology • Pain • Renal Disease • Septic Shock • Thrombosis

TSH Secreting Adenoma vs. Thyroid Hormone Resistance (ENDO 2025) - "A total T4 was also obtained to rule out any condition in which there is decreased T4 binding to TBG, which would result in high free T4 with low total T4; both salicylates and certain NSAIDs can do this (the patient was taking aspirin and meloxicam). In conclusion, the more likely diagnosis therefore seems to be Resistance to Thyroid Hormone. Further diagnostic testing will be done to confirm that."

Cardiovascular • Chronic Obstructive Pulmonary Disease • Endocrine Disorders • Gastrointestinal Disorder • Immunology • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Otorhinolaryngology • Pain • Respiratory Diseases • Thyroid Gland Carcinoma

Refractory Painful Hashimoto's Thyroiditis (ENDO 2025) - "Treatment options include l-thyroxine, NSAIDs, or aspirin; however, if symptoms persist, surgical intervention may be necessary.Clinical Case A 23-year-old female G1P0 with PTSD was referred to endocrinology at 14 weeks gestational age for subclinical hypothyroidism and mild neck pain...Initial treatment with prednisone 40 mg daily for one week provided temporary relief, while NSAIDs were ineffective...In this case, the lack of response to glucocorticoids, along with normal CRP and ESR levels, led to the diagnosis. Surgery may be an option if other treatments do not adequately manage symptoms."

CNS Disorders • Dermatology • Endocrine Disorders • Fatigue • Infectious Disease • Musculoskeletal Pain • Oncology • Pain • Post-traumatic Stress Disorder • Pruritus

Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants (clinicaltrials.gov) - P1 | N=224 | Completed | Sponsor: Regeneron Pharmaceuticals | Active, not recruiting ➔ Completed

Trial completion

Salicylic Acid Engages Central Metabolic Regulators SnRK1 and TOR to Govern Immunity by Differential Phosphorylation of NPR1. (PubMed, bioRxiv) - "Under normal growth conditions, TARGET OF RAPAMYCIN (TOR) inhibits NPR1 through phosphorylation at Ser-55/59. This phosphorylation event activates NPR1 and facilitates its subsequent PTMs. Together, our results reveal an integral role of SA (the active metabolite of aspirin) in controlling central metabolic regulators SnRK1 and TOR to coordinate immune responses and growth through antagonistic modifications of NPR1."

Journal • Infectious Disease

Constructing a Preeclampsia Organoid Model to Elucidate the Mechanism of Aspirin. (PubMed, Hypertension) - "This study clarifies aspirin's multitarget mechanisms in alleviating preeclampsia, which include restoring the sFLT-1/PlGF balance, activating the PI3K-AKT-mTOR signaling pathway, optimizing mitochondrial function, and regulating CYP-mediated hormonal metabolism. These findings provide a mechanistic basis for aspirin's clinical effectiveness in preventing preeclampsia."

Journal • Cardiovascular • Gynecology • Hypertension • CYP19A1 • CYP1A1 • FLT1

Global Impact of Fixed-Dose Combination Therapies on Cardiovascular Mortality and Events, 2023-2050: A Modeling Study. (PubMed, J Am Coll Cardiol) - "SPC therapies could substantially accelerate progress on cardiovascular disease mortality by increasing use of preventive drugs, especially in settings where uptake is currently low."

Journal • Cardiovascular • Coronary Artery Disease • Heart Failure

Cost Savings of Switching to Aspirin for Thromboprophylaxis in Orthopaedic Trauma Patients: A Budget Impact Analysis. (PubMed, J Am Acad Orthop Surg) - "Our findings suggest that a widespread switch from enoxaparin thromboprophylaxis to aspirin would lead to more than $100 million in annual cost savings in the United States alone. Insurers stand to benefit most from this practice change. However, patients, especially those without insurance, would realize considerable savings from aspirin thromboprophylaxis."

HEOR • Journal • Cardiovascular • Musculoskeletal Diseases • Orthopedics • Respiratory Diseases • Venous Thromboembolism

Small intestinal bacteria accelerate aspirin-induced small intestinal injuries. (PubMed, Exp Mol Pathol) - "Enteric-coated, LDA-induced mucosal injuries in the small intestine are mainly caused by direct cytotoxicity of SA deacetylated by enterobacterial esterase in the small intestine."

Journal

Gut-Perm: Establishing and Validating a Meal-provoked Intestinal Permeability Test for Nutritional and Metabolic Health Clinical Research. (clinicaltrials.gov) - P=N/A | N=10 | Recruiting | Sponsor: Laval University

New trial

Formulation and Characterization of Multiparticulate System for Proton Pump Inhibitor using Combination Therapy for Peptic Ulcer. (PubMed, Recent Adv Drug Deliv Formul) - "The amla extract and esomeprazole magnesium enteric-coated granules with sustained release and negligible drug release in acidic pH were achieved. In the in vivo studies, the combination therapy demonstrated a significant positive effect in treating peptic ulcers in a rat ulcer model, as shown by assessments of various parameters such as ulcer index, total gastric juice acidity, hematological analysis, and histopathological evaluations."

Journal • Gastroenterology • Hematological Disorders • Peptic Ulcer

Acute digital ischemia in a child following a suspected arthropod bite: A case report. (PubMed, Medicine (Baltimore)) - "This case emphasizes the importance of considering arthropod bite-induced vascular injury as a rare but significant differential diagnosis in pediatric digital ischemia. Early recognition and conservative management can lead to favorable outcomes and avoid invasive interventions."

Journal • Cardiovascular • Dermatology • Hematological Disorders • Pediatrics

Coagulation and Fibrinolysis Dysregulation in β-Thalassemia Major: Potential Impact of Splenectomy and Medications on Thrombotic Risk. (PubMed, Clin Appl Thromb Hemost) - "No significant differences in PS, D-dimer, PT, INR, aPTT, fibrinogen, PC, TF, tPA or ADAMTS13 were found between β-thalassemia major patients taking and not taking aspirin. However, a higher platelet count (+37.1%) and PAI-1 level (+58.9%), along with a lower vWF level (-25.6%), were observed between these two groups (all p < 0.05).ConclusionElevation in PAI-1 and platelet count in splenectomized β-thalassemia major could increase the risk of having a thrombotic event. Medications may have significant interactions with blood coagulation in β-thalassemia."

Journal • Beta-Thalassemia • Genetic Disorders • PROS1

Efficacy and safety of recombinant human granulocyte colony-stimulating factor in patients with unexplained recurrent pregnancy loss: a protocol for a multicenter, randomized, double-blind, controlled trial. (PubMed, Trials) - P=N/A | "This trial aims to provide high-quality evidence on the efficacy and safety of G-CSF in the treatment of uRPL, particularly in the Chinese population where existing data are limited. The findings may support evidence-based recommendations and inform treatment decisions in a population where therapeutic options remain limited and controversial."

Clinical • Journal • Diabetes • Gestational Diabetes • Gynecology • Metabolic Disorders

What dose of aspirin for preventing pre-eclampsia? (PubMed, Drug Ther Bull) - No abstract available

Journal • Gynecology

Evaluating the efficacy of antiplatelet therapy in spontaneous coronary artery dissection: a scoping review. (PubMed, Cardiovasc Diagn Ther) - "There is no clear consensus regarding the optimum antiplatelet medication regimen and treatment duration for SCAD despite current American Heart Association (AHA) consensus guidelines recommending 12-month regimen of dual antiplatelet therapy (DAPT) consisting of a P2Y12 inhibitor and aspirin for patients following myocardial infarction (MI)...These adverse outcomes, primarily driven by increased non-fatal MI and unplanned percutaneous coronary interventions (PCIs), highlight the challenges of DAPT in SCAD management. In patients treated with antiplatelet therapy, adverse events that include unstable angina, mortality, and repeat revascularization were greater in patients with more aggressive antiplatelet therapy consisting for safety and efficacy of DAPT compared with these treated with SAPT."

Journal • Review • Acute Coronary Syndrome • Cardiovascular • Coronary Artery Disease • Myocardial Infarction

Identifying Aspirin as a Contributing Factor to Persistent Gout: A Case Report. (PubMed, Cureus) - "Despite following strict lifestyle practices and medication compliance, pharmacological therapies were rendered ineffective until aspirin was identified as a contributing factor to his gout. Optimizing his medication regimen resolved his gout attacks, which stresses the concept that clinicians must be diligent with lesser-known side effects of medication to improve patient outcomes."

Journal • Cardiovascular • Gout • Inflammation • Inflammatory Arthritis • Metabolic Disorders • Rheumatology