aspirin / Generic mfg. - LARVOL DELTA

Navigating Obstetric Anesthesia in Aortic Stenosis: A Case of Tailored Epidural and ICU Delivery (ASA 2025) - "Low-dose aspirin was initiated week 20. Delivery occurred in the CICU with early, slow-titrated fentanyl/ropivacaine epidural and assisted second stage to avoid Valsalva. Patient remained stable and was discharged after 24 hours of monitoring with her newborn at bedside."

Clinical • Anesthesia • Cardiovascular • Obstetrics

Bleeding Risks and Urgent Orthopedic Surgery: Navigating Infection, Anticoagulation, and Hemodynamic Instability in a Congenital Cardiac Patient (ASA 2025) - "Despite recent aspirin and rivaroxaban use, orthopedic surgery felt urgent necessity for hardware removal. Given Andexanet alfa unavailability, hematology and cardiac surgery prioritized bleeding risk and planned reversal with 4FPCC at 25 units/kg prior to incision.In the OR, purulent fluid was found around the hardware. She developed hypotension with blood loss. She was given transfusions and underwent successful wound-washout, transferred to PICU, and discharged post-op day 5 with aspirin."

Clinical • Surgery • Cardiovascular • Hematological Disorders • Hypotension • Infectious Disease • Orthopedics

Anesthetic Considerations for a Pregnant Patient with Immune Thrombocytopenia on Aspirin Therapy Undergoing Cesarean Delivery: A Case Report (ASA 2025) - "The patient stabilized postoperatively with favorable maternal and fetal outcomes. This case underscores the need to refine guidelines on anesthetic management of pregnant patients with ITP on aspirin therapy to improve individualized delivery planning."

Case report • Clinical • Anesthesia • Cardiovascular • Diabetes • Gestational Diabetes • Gynecology • Hematological Disorders • Hypertension • Immune Thrombocytopenic Purpura • Metabolic Disorders • Postpartum Hemorrhage • Thrombocytopenia • Thrombocytopenic Purpura

The Cuff Did It: A Benign Rash Mimic in a Diabetic Vascular Patient (ASA 2025) - "She was maintained on aspirin, with apixaban and clopidogrel appropriately held preoperatively. The cuff and IV were removed, the patient remained hemodynamically stable, and surgery proceeded without complication. This case highlights the importance of recognizing this rare but harmless dermatologic finding to avoid unnecessary alarm or intervention during anesthetic care."

Clinical • Anesthesia • Cardiovascular • Diabetes • Metabolic Disorders • Peripheral Arterial Disease • Type 1 Diabetes Mellitus

Effect of Aspirin on Grip Strength and Gait Speed in Community-Dwelling Older Adults in the ASPirin in Reducing Events in the Elderly (ASPREE) Study. (PubMed, J Gerontol A Biol Sci Med Sci) - "Low-dose aspirin use in relatively healthy older people did not affect gait speed or grip strength over time or reduce the risk of weakness and slowness."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia

Carotid artery stenting in JAK2 V617F-positive essential thrombocythemia with symptomatic internal carotid artery stenosis: a case report. (PubMed, Front Cardiovasc Med) - "Aggressive perioperative platelet and inflammation control, employing hydroxyurea, aspirin, and ticagrelor, was instrumental in mitigating the heightened thrombosis risk associated with the JAK2 V617F mutation. This case underscores that ET patients with the JAK2 V617F mutation face a substantial risk of thrombotic recurrence. It highlights the critical importance of rigorous preoperative platelet control, personalized antiplatelet therapy guided by pharmacogenomic principles, and multidisciplinary management in high-risk ET patients undergoing CAS."

Journal • Cardiovascular • CNS Disorders • Essential Thrombocythemia • Hematological Disorders • Myeloproliferative Neoplasm • Oncology • Thrombocytosis • Thrombosis • JAK2

Sputum Eosinophil and Macrophage Changes After Aspirin Challenge in Patients With Nonsteroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease. (PubMed, Clin Transl Allergy) - "In N-ERD, sputum eosinophil percentage decreased after aspirin challenge regardless of administration route. In both N-ERD and ATA, sputum macrophage percentage decreased after oral aspirin challenge."

Journal • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Antiplatelet therapy and central nervous system hematomas: a cohort study using real-world data from the FAERS and vigiaccess databases. (PubMed, Int J Surg) - "We found a disproportionately significant association between antiplatelet therapy and CNS-related hematomas, with distinct patterns observed across drug types, patient demographics, and temporal profiles. These findings provide critical insights to inform risk stratification, clinical decision-making, and safety monitoring in patients undergoing antiplatelet therapy."

Journal • Real-world evidence • Atherosclerosis • Cardiovascular • CNS Disorders

Clinical Characteristics and Disease Burden of Wheat Allergy Dependent on Augmentation Factors in Recreationally Active and Trained Individuals. (PubMed, Scand J Med Sci Sports) - "In the diagnostic challenge tests, 90% reacted to wheat gluten alone in high doses or in combination with acetylsalicylic acid...Weight training may be less likely to trigger reactions than endurance activities. Timely diagnosis through challenge tests and comprehensive education and management effectively restore exercise participation and QOL."

Journal • Allergy • Dermatology • Immunology • Urticaria

A DOUBLE-EDGED PILL: ASPIRIN-INDUCED KOUNIS SYNDROME [WITHDRAWN] (CHEST 2025) - No abstract available

Cardiovascular

Addition of Dupilumab for Patients with Aspirin-Exacerbated Respiratory Disease who have Poor Response to Aspirin Therapy After Desensitization. (PubMed, J Allergy Clin Immunol Pract) - No abstract available

Journal • Chronic Rhinosinusitis With Nasal Polyps • Immunology • Nasal Polyps • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Postoperative Stroke Through a Patent Foramen Ovale in a Patient With Lung Cancer: A Case Report. (PubMed, Cureus) - "Treatment was initiated with aspirin on postoperative day 2, switched to apixaban after PFO confirmation. Perioperative strokes are often observed in patients with multiple underlying risk factors. In pulmonary resection, pulmonary vein stump thrombosis has been proposed as a causative mechanism, although PBE through PFO warrants consideration as an important alternative etiology because lung resection creates ideal conditions for PBE by combining increased venous thrombosis risk with elevated right heart pressures due to loss of the pulmonary vascular bed."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Diabetes • Hematological Disorders • Hypertension • Lung Cancer • Metabolic Disorders • Oncology • Solid Tumor • Thrombosis

Genetically predicted causal relationship between aspirin and colorectal cancer in individuals of European ancestry. (PubMed, Medicine (Baltimore)) - "Sensitivity results suggested the robustness of our findings. Our study reveals a causal relationship between aspirin and CRC, which provides a new basis for future clinical practice and CRC prevention and treatment research."

Causal relationship • Journal • Colorectal Cancer • Oncology • Solid Tumor

Estimating the long-term effects of aspirin for primary prevention. (PubMed, Eur Heart J) - No abstract available

Journal

Delayed Diagnosis Salicylate Toxicity With Confirmed Cerebrospinal Fluid Salicylate Concentration: A Case Report of Altered Mental Status Without Neuroglycopenia and With Coagulopathy. (PubMed, Cureus) - "Although we do not recommend routine CSF testing in salicylate toxicity cases, analysis of CSF could shed insight into salicylate-induced encephalopathy. This case illustrates that prompt recognition and treatment of toxicity is key, as delayed diagnosis can increase morbidity and mortality."

Journal • CNS Disorders • Hematological Disorders • Infectious Disease • Pain

Mendelian randomization study: The association between pain, analgesics, and frailty. (PubMed, Medicine (Baltimore)) - "This bidirectional two-sample Mendelian randomization study included summary statistics of pain at different sites (headache, neck or shoulder pain, stomach or abdominal pain, hip pain, back pain, and knee pain), analgesics (aspirin, ibuprofen, paracetamol, and morphine), and frailty index. Findings suggest that common analgesic use (aspirin, ibuprofen, and paracetamol) may contribute to frailty risk, while frailty increases analgesic use. Results do not support using analgesic-based pain management for frailty improvement."

Journal • Back Pain • Musculoskeletal Pain • Pain

A Case of Extramedullary Plasmacytoma Involving the Pancreas (ACG 2025) - "The patient began systemic treatment with daratumumab, lenalidomide, aspirin, acyclovir, and dexamethasone. Extramedullary plasmacytoma (EMP) of the pancreas is rare and often appears similar to pancreatic adenocarcinoma, typically causing jaundice and abdominal pain. Early and accurate diagnosis can lead to more effective treatment, reducing unnecessary surgeries and significantly improving outcomes.Figure: Pancreatic biopsy shows predominant population of atypical plasma cells that are CD138 positive: Hematoxylin and Eosin staining, magnification x 40 and x100. Figure: Immunostain CD138 Highlighting Plasma Cells, magnification x40"

Clinical • Anemia • Cardiovascular • Dyslipidemia • Endocrine Disorders • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Hepatology • Hypertension • Melanoma • Multiple Myeloma • Pancreatic Adenocarcinoma • Pancreatic Cancer • Plasmacytoma • Solid Tumor • CD38 • SDC1

Primary Budd-Chiari Syndrome: A Silent Threat (ACG 2025) - "Due to her liver anatomy, she is not a candidate for TIPS procedure, and she was scheduled for outpatient routine paracentesis and listed for liver transplant and discharged with spironolactone, furosemide, enoxaparin, aspirin, and hydroxyurea. PBCS is extremely rare, ~ 1 case per million per year, more common in women 30-40s. (C) Showing multiple collaterals from chronic hepatic vein occlusion. (D) Yellow arrow showing intrahepatic IVC narrowing and red arrow showing engorgement corresponding to the CT images."

Cardiovascular • Essential Thrombocythemia • Fibrosis • Hepatology • Immunology • Infectious Disease • Myeloproliferative Neoplasm • Portal Hypertension • Rare Diseases • Thrombocytosis • Thrombosis

ATTEND: Randomized Phase III Trial of Tislelizumab and Chemotherapy With or Without Diphenhydramine in Advanced Non-Small Cell Lung Cancer (IASLC-WCLC 2025) - "Research has demonstrated that the concurrent use of non-steroidal anti-inflammatory drugs can significantly enhance the objective response rate in patients treated with nivolumab. Additionally, the co-administration of aspirin has been shown to lower the mortality rate among patients receiving immunotherapy. Furthermore, the H1 receptor antagonist loratadine has been found to improve survival outcomes for NSCLC...Patients are randomized (1:1) to receive either tislelizumab (200 mg) plus platinum-based doublet chemotherapy (pemetrexed 500 mg/m2 for non-squamous cell carcinoma or albumin-bound paclitaxel 260 mg/m2 for squamous cell carcinoma) every 3 weeks, with or without diphenhydramine (20 mg qd IM on day 0-2)...Secondary endpoints include objective response rate, overall survival, and toxicity profile. The ATTEND trial commenced in December 2024, and enrollment is ongoing across 19 centers in China."

Clinical • Metastases • P3 data • Lung Cancer • Lung Non-Squamous Non-Small Cell Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma

Bulk and surface engineered drug delivery system of repurposed drug enhances low-dose gemcitabine efficacy in pancreatic cancer. (PubMed, Int J Pharm) - "Aspirin (ASP), a repurposed NSAID, has been shown to sensitize PDAC cells to GEM through modulation of multiple oncogenic and inflammatory pathways. The study exemplifies how the control of polymorphic form, release kinetics, and surface engineering can overcome key limitations of combination chemotherapy. These findings highlight a novel NSAID based delivery platform with potential to improve outcomes in pancreatic cancer therapy through a rational, mechanism-driven sustained release approach."

Journal • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor

A Rare Case of Giant Cell Arteritis Presenting With Progressive Dysphagia and Lingual Infarction (ACG 2025) - "Temporal artery biopsy revealed bilateral transmural inflammation, consistent with GCA, though giant cells were not seen.Treatment included prednisone 60 mg daily and aspirin 81 mg daily. First-line therapy includes high-dose steroids and aspirin, but refractory cases may require advanced treatments like tocilizumab.GCA should be considered in elderly patients presenting with dysphagia and systemic symptoms, even in the absence of classic features. Prompt recognition and treatment are essential, making rare presentations valuable in improving patient care."

Clinical • Cardiovascular • Gastrointestinal Disorder • Giant Cell Arteritis • Immunology • Inflammation • Otorhinolaryngology • Vasculitis

BTK inhibitors potently impair platelet aggregation as a class effect independent of BTK specificity or dose in CLL and MCL. (PubMed, J Clin Exp Hematop) - "We investigated whether BTKi impaired platelet aggregation and adhesion in a drug- or dose-dependent manner in patients with CLL and MCL who received ibrutinib, acalabrutinib, or pirtobrutinib. Although the sample size was small, our results suggest the potential of impaired platelet adhesion as a candidate biomarker for estimating bleeding risk in patients receiving BTKi. Second, in BTKi-treated patients requiring anti-platelet agents, BTKi dose reduction may be considered, irrespective of BTK selectivity of the drug or whether aspirin or a P2Y12 receptor inhibitor is used."

Journal • Chronic Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Lymphoma • Mantle Cell Lymphoma • Oncology

Clinical and biological determinants of multimodal metronomic chemotherapy efficacy in chemo-refractory gastrointestinal cancers. (PubMed, Int J Cancer) - P=N/A | "Multimodal MC was administered continuously, combining low doses of capecitabine, cyclophosphamide, and aspirin. The presence of liver metastases, baseline plasmatic levels of Ang2 and CXCL14, as well as the induction of PD1 on T-cells are potential biomarkers for efficacy. These results feature a potential subset of diseases where MC might be a promising cost-effective and well-tolerated therapeutic option."

IO biomarker • Journal • Gastrointestinal Cancer • Oncology • Solid Tumor • ANGPT2 • CD4 • CD8 • CXCL14 • PD-1

NCI-2019-01192: Aspirin and Rintatolimod With or Without Interferon-alpha 2b in Treating Patients With Prostate Cancer Before Surgery (clinicaltrials.gov) - P2 | N=12 | Active, not recruiting | Sponsor: Roswell Park Cancer Institute | Recruiting ➔ Active, not recruiting | N=30 ➔ 12 | Trial primary completion date: Nov 2026 ➔ Jun 2025

Biomarker • Enrollment change • Enrollment closed • Trial primary completion date • Genito-urinary Cancer • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Solid Tumor

Pharmacokinetics of dexamethasone in tuberculosis meningitis. (PubMed, medRxiv) - "This pharmacokinetic study was nested in a randomised controlled trial comparing the safety of high-dose rifampicin (oral, 35 mg/kg; intravenous, 20 mg/kg) plus linezolid, with or without aspirin, vs standard-dose rifampicin (10 mg/kg) for adults with HIV-associated TBM...Eight (18%) participants were on efavirenz-based ART and five (11%) were on a lopinavir/ritonavir-based regimen...This pharmacokinetic analysis of dexamethasone in adults with HIV-associated tuberculosis meningitis found high oral clearance (131 L/h), likely due to a drug-drug interaction with rifampicin. High-dose rifampicin had no additional effect on dexamethasone exposure compared with standard dose."

Journal • PK/PD data • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis