amisodin (PRG-A-01) / PRG S&Tech - LARVOL DELTA

Inhibition of SOD1 trimerization is a novel drug target for ALS disease. (PubMed, Transl Neurodegener) - "Our findings underscore the potential of targeting trimeric SOD1 in ALS treatment, positioning PRG-A-04 as a strong drug candidate for both familial and sporadic ALS."

Journal • Amyotrophic Lateral Sclerosis • CNS Disorders • SOD1

Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model. (PubMed, Commun Biol) - "Administration of PRG-A01 into the ALS model mouse resulted in significant improvement of muscle strength, motor neuron viability and mobility with extended lifespan. These results suggest that SOD1 misfolding/aggregation is a potent therapeutic target for SOD1 related ALS."

Journal • Preclinical • Amyotrophic Lateral Sclerosis • CNS Disorders • Neuroblastoma • Oncology • Solid Tumor • TARDBP