ACXT-3102 / Accuronix Therap - LARVOL DELTA

Sigma-2-Erastin inhibits PC tumor growth through lipid ROS-DUSP6-MAPK signaling (AACR 2024) - "ACXT-3102, an orally administered conjugate of sigma-2 ligand and Erastin induces PCD of human PC by uniquely regulating apoptosis and ferroptosis together. Therefore, ACXT-3102 offers a novel and improved therapeutic strategy for treating patients of fatal human carcinomas, especially those, which are difficult to diagnose at an early stage."

Gastrointestinal Cancer • Oncology • Pancreatic Cancer • Solid Tumor • DUSP6 • GPX4

[VIRTUAL] Combined Inhibition of CXCR4 Signaling and System xc- Transporter Activity Induces Synthetic Lethality in T-ALL Cells By Suppressing Gsh and Inducing Ferroptosis (ASH 2020) - P2a | "Indeed, strong preclinical data demonstrating therapeutic activity of BL-8040, a potent CXCR4 antagonist, have led to a clinical trial of BL-8040 in combination with nelarabine for patients with relapsed/refractory T-ALL (NCT02763384)...Consistent with the hypothesis, treatment of T-ALL cells with ACXT-3102, a novel system xc- inhibitor, significantly enhanced BL-8040 killing of T-ALL cells in vitro. Collectively, these data suggest that T-ALL cells are sensitive to perturbations of the glutathione axis. Combined inhibition of CXCR4 signaling and system xc- activity exploits this vulnerability and presents a promising new therapeutic approach for T-ALL."

Acute Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Oncology • Pediatrics • T Acute Lymphoblastic Leukemia • Transplantation • CASP3

Investigational drug attacks synovial sarcoma, a rare type of tumor (Washington University School of Medicine in St. Louis) - "'Synovial sarcoma is responsible for about 10% of all sarcomas, and because sarcoma in general is rare, a lot of these patients - pediatric and adult - travel from all over the country to receive treatment at our specialized Sarcoma Center,' said oncologist Brian A. Van Tine, MD, PhD..."

Media quote

Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT3102. (PubMed, Clin Cancer Res) - "These findings demonstrate the translational potential of targeting redox homeostasis in ME1 null cancers, and establish the preclinical rational for a phase 1 trial of ACXT-3102 in synovial sarcoma patients."

Journal • Oncology • Sarcoma • Solid Tumor • Synovial Sarcoma • ME1