acenocoumarol / Generic mfg. - LARVOL DELTA

Argatroban anticoagulation for heparin induced thrombocytopenia after Heartmate 3 implantation: a single center experience (HEART FAILURE 2025) - "Limited data exist on the management of those patients (most of the published cases use bivalirudin (5–8))...Patients 1 and 2 were successfully bridged to acenocoumarol (International Normalized Ratio range 2-2.5) and discharged without hemocompatibility-related adverse events (Table)...Patients with previous coagulation disturbances may represent a subset of high-risk patients for worse outcomes after HIT regardless of the use of argatroban. It is challenging to distinguish which adverse events are attributable to HIT and argatroban, and which are inherent to LVADs, as these devices themselves carry a high risk of thromboembolism, bleeding, and morbi-mortality."

Clinical • Cardiovascular

Management of Acenocoumarol in Tunisian elderly population : Risk factors of overdose and bleeding. (PubMed, Ann Cardiol Angeiol (Paris)) - "The use of anticoagulants in the elderly requires a comprehensive assessment, including comorbidities, geriatric settings, and social environment."

Journal • Atrial Fibrillation • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Peptic Ulcer • Renal Disease • Venous Thromboembolism

In vitro-in vivo scaling of cytochrome P450-mediated metabolic clearance using a relative activity factor approach. (PubMed, Drug Metab Dispos) - "We selected multiple probe substrates for CYP1A2 (caffeine, tizanidine, phenacetin), CYP2C9 ((S)-acenocoumarol, glimepiride, lornoxicam, tolbutamide, (S)-warfarin), CYP2C19 ((S)-lansoprazole, omeprazole, pantoprazole), CYP2D6 (desipramine, metoprolol, nebivolol, tolterodine), and CYP3A4 (alprazolam, felodipine, midazolam, nisoldipine, sildenafil, triazolam) to calculate the representative RAF value for each P450 isoform based on the in vivo-to-in vitro clearance ratio of the multiple probe substrates...The fm values of the responsible P450 isoform(s) could be well predicted for mexiletine, tamsulosin, risperidone, celecoxib, and glibenclamide...By applying relative activity factor values obtained from multiple probe substrates, this study was able to quantitatively predict the in vivo clearances mediated by CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. This simple, practical method will help optimize metabolic clearances via the major cytochrome P450..."

Journal • Preclinical • CYP1A2 • CYP2C19 • CYP2C9 • CYP3A4

Impact of Ginkgo biloba drug interactions on bleeding risk and coagulation profiles: A comprehensive analysis. (PubMed, PLoS One) - "However, interactions with anticoagulants including direct oral anticoagulants and acenocoumarol, were not statistically significant in our analysis...Specific medications, including clopidogrel, aspirin, celecoxib, loxoprofen, nifedipine, and omeprazole, were significantly associated with the risk of bleeding and abnormal coagulation (p <  0.05). Interactions with ticagrelor, etoricoxib, insulin, omeprazole, and domperidone were associated with abnormal coagulation tests without affecting the reported bleeding. These findings underscore the critical need of evaluating potential interactions involving Ginkgo biloba extract drug interactions in clinical pratice, particularly when assessing bleeding risk and managing coagulation."

Journal • Observational data • Retrospective data • Hematological Disorders

Long-term left ventricular thrombosis resolution in patients receiving vitamin k antagonists: a multicenter observational study. (PubMed, Intern Emerg Med) - "Incidence of LVT resolution appeared to be higher at 12 than at 3 and 6 months of follow-up, and the rates of on-treatment acute arterial and bleeding events were low. Reduced left ventricular ejection fraction and left-ventricular aneurysm appeared to be associated with a lower rates of LVT resolution."

Journal • Observational data • Cardiovascular • Hematological Disorders • Ischemic stroke • Myocardial Infarction • Thrombosis • Venous Thromboembolism

Bowel obstruction and anticoagulation, is there a link? (APASL 2025) - "She was under treatment with Acenocoumarol for paroxysmal atrial fibrillation...Conclusion Our case offers two important implications for clinical practice. First, colonic intramural hematoma may occur in patients receiving anticoagulant therapy, while it remains rare and its endoscopic and radiological features remain poorly described in the literature."

Anemia • Atrial Fibrillation • Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Myocardial Infarction • Oncology • Pain

Epidemiology And Clinical Features Of Vascular Liver Diseases Secondary To Myeloproliferative Disorders In Morocco: A Monocentric Experience (APASL 2025) - "Therapeutic management was instituted and consisted of Hydroxycarbamide for the myeloproliferative disorder for 12 patients (48 %). As for anticoagulants, only 15 patients (60 %) received acenocoumarol, among which 5 patients (20 %) switched to rivaroxaban... Despite their relatively low prevalence, vascular diseases of the liver represent a significant health problem in the field of liver disease. Our study shows that almost 20 % of these diseases are secondary to myeloproliferative disorders, mainly due to portal thrombosis, with a clear female predominance. Early management is necessary to reduce the risk of morbidity and mortality."

Clinical • Acute Myelogenous Leukemia • Anemia • Cardiovascular • Chronic Myeloid Leukemia • Essential Thrombocythemia • Fatigue • Fibrosis • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Leukemia • Liver Cirrhosis • Myelofibrosis • Myeloproliferative Neoplasm • Pain • Portal Hypertension • Thrombocytosis • Thrombosis • JAK2

Progressive coronary aneurysms in Kawasaki disease: A case report and long-term follow-up. (PubMed, Radiol Case Rep) - "Despite initial treatment with intravenous immunoglobulin, aspirin, low molecular weight heparin, and subsequent acenocoumarol therapy, the patient experienced progressive thrombosis of the intraventricular artery aneurysm over 3 years. This case underscores the critical need for early imaging, timely diagnosis, and long-term monitoring of KD patients, as coronary aneurysms may persist or progress despite prompt therapy. Rigorous follow-up, tailored anticoagulation strategies, and regular imaging are essential to minimize the risk of life-threatening cardiovascular complications."

Journal • Cardiovascular • Conjunctivitis • Hematological Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Thrombosis • Vasculitis

Avascular Necrosis of the Femoral Head in Patients with Antiphospholipid Syndrome: A Case Series. (PubMed, Hematol Rep) - "The patient was given clopidogrel and acenocoumarol. She was treated with acenocoumarol. AN is a rare clinical manifestation of APS, which may precede the diagnosis of APS for many years."

Journal • Cardiovascular • Genetic Disorders • Hematological Disorders • Immunology • Inflammatory Arthritis • Ischemic stroke • Obstetrics • Otorhinolaryngology • Rheumatology • Thrombosis • Vertigo • MTHFR

Hemorrhage risk associated with triple antithrombotic therapy: a focused real-world pharmacovigilance disproportional analysis study. (PubMed, BMC Cardiovasc Disord) - "This study highlights the elevated hemorrhage risk associated with TAT, particularly with rivaroxaban, while apixaban appears safer in terms of bleeding and mortality. These findings underscore the need for cautious monitoring of bleeding outcomes with anticoagulant regimens, particularly rivaroxaban combinations for optimizing patient outcomes. However, the signals obtained in this study need to be validated in future trials."

Adverse events • Clinical • Journal • Real-world evidence • Acute Coronary Syndrome • Cardiovascular • Hematological Disorders

Cost-effectiveness of direct oral anticoagulants in non-valvular atrial fibrillation. (PubMed, Gac Sanit) - "Based on the analysis of data from clinical practice and the similarity of results using several different techniques to adjust for bias associated with observational studies, we conclude that DOAC would be an efficient alternative for the treatment of patients with NVAF."

HEOR • Journal • Atrial Fibrillation • Cardiovascular

Clinical Outcome and Costs Based on the Degree of Vitamin K Antagonist Control for Non-Valvular Atrial Fibrillation. (PubMed, J Clin Med) - "The cost arising from patients with adequate control was lower than that for patients with inadequate control. Strategies to improve anticoagulation control could improve health outcomes and costs."

Clinical data • Journal • Atrial Fibrillation • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders

Treatment of functioning insulinoma using endoscopic ultrasound-guided radiofrequency ablation. (PubMed, Rev Esp Enferm Dig) - "Acenocoumarol was discontinued three days prior to the procedure and replaced with enoxaparin at 40 mg daily, with the basal anticoagulant therapy being restarted 24 hours after the procedure. Ten days later, the patient was diagnosed with an acute hematoma in the tail of the pancreas and gastric body, which led to clinical signs of hypotension and acute anemia, requiring the discontinuation of anticoagulation once again. Therefore, we believe that caution should be taken when managing anticoagulant therapy in patients undergoing endoscopic ultrasound (EUS)-guided radiofrequency ablation."

Journal • Hematological Disorders • Hypotension • Solid Tumor

Cost-effectiveness of apixaban in non-valvular atrial fibrillation (NVAF) based on effectiveness data from a Spanish study in clinical practice (real-world evidence). (PubMed, Expert Rev Cardiovasc Ther) - "The probability of apixabanbeing cost-effective ranges from 91.1% (vs dabigatran 150 mg), 97.8% (vsdabigatran 110 mg), and 100% (vs. rivaroxaban, edoxaban, and acenocoumarol). Based on the results of the FANTASIIA study, apixaban is acost-effective treatment (below a willingness to pay of €25,000 per QALYgained) compared to dabigatran, rivaroxaban, edoxaban, and acenocoumarol intreating patients with NVAF."

HEOR • Journal • Real-world evidence • Atrial Fibrillation • Cardiovascular

Simultaneous quantification of eighteen therapeutic oral anticoagulants, rodenticides, and antiplatelet agents by LC-MS/MS and its application in post-mortem forensic cases. (PubMed, J Pharm Biomed Anal) - "This research aimed to develop and validate a liquid chromatography-tandem mass spectrometry method capable of quantifying eighteen anticoagulant or antiplatelet compounds (apixaban, rivaroxaban, dabigatran, warfarin, acenocoumarol, fluindione, brodifacoum, bromadiolone, difenacoum, difethialone, chlorophacinone, coumatetralyl, flocoumafen, acetylsalicylic acid, clopidogrel, dipyridamole, ticagrelor, and ticlopidine) in a single run with simple sample preparation. Following validation, the method was applied to seven forensic cases with a known history of anticoagulant or antiplatelet agent use to prove the validity of the method. This method provides a valuable tool for legal contexts where precise determination of anticoagulant compound presence and concentration is required."

Journal

RENAL VEIN THROMBOSIS IN ACUTE PYELONEPHRITIS - RARE OR RARELY DIAGNOSED? (ISN-WCN 2025) - "She was discharged with oral anticoagulant (Apixaban 5mg twice daily) and IV antibiotics (Meropenem) was continued for a total of 14 days...Sl no Author Site of thrombosis Age/sex Comorbidity Thrombophilia Work up Culture Management Outcome 1 Bassilios et al (2004) Right renal V. IVC Pulmonary embolism 45/F T2D Homocysteine not done rest- negative Urine- Klebsiella Blood- Klebsiella IV heparin x 7 days Warfarin x 6 months Complete resolution 2 Novelli et al (2007) Right renal V. IVC 50/M Nil Not done Blood- MSSA percutaneous reopening of renal vein 6 month follow up - stable 3 Kumar et al (2008) Left renal V. IVC 59/M Nil Homocysteine high (32.77 umol/l) Urine- E Coli Heparin Warfarin partial resolution in 1 month Complete resolution in 3 months 4 Lurz et al (2017) Right renal V. IVC 35/F Recurrent UTI RSD HDN Negative Urine- Klebsiella Renal aspirate- Klebsiella Heparin Warfarin Not available 5 Assimakopoulos et al (2018) Right renal V. and branches IVC 71/M T2D Hernia..."

Acute Kidney Injury • Cardiovascular • Diabetes • Diabetic Nephropathy • Gastroenterology • Glomerulonephritis • Hematological Disorders • Immunology • Infectious Disease • Metabolic Disorders • Nephrology • Pain • Pulmonary Embolism • Respiratory Diseases • Thrombosis

Origanum vulgare and hemorrhagic risk, about a case (PubMed, Ann Cardiol Angeiol (Paris)) - "Oregano is an endemic plant widely used in Algeria, whose anti-inflammatory properties are well established. However, its side effects, toxicity, and risk of interaction when combined with medications are less known. The interaction between oregano and AVK (acenocoumarol) exists and deserves to be recognized and monitored, especially in a population with a traditional culture where the use of plants is common. This practice should be accompanied by national phytovigilance."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Sleep Disorder • CYP3A4

Anticoagulation versus Antiplatelets in Coronary Artery Ectasia and Acute Coronary Syndrome: A Systematic Review and Meta-analysis (AHA 2024) - "Pooled risk ratios were used to evaluate the effectiveness of anticoagulant therapy in CAE and ACS. We included 3 studies, including 1 randomized controlled trial and 2 observational studies, comprising a total of 441 patients, of whom 162 (36.7%) received anticoagulants, including vitamin K antagonists (warfarin and acenocoumarol) or direct oral anticoagulants (rivaroxaban, apixaban, and dabigatran). Our findings suggest that, among patients with CAE and ACS, anticoagulation does not reduce the risk of MACE or re-infarction as compared with no anticoagulation."

Retrospective data • Review • Acute Coronary Syndrome • Cardiovascular

Anticoagulation Status and Outcome in Cerebral Venous Thrombosis: A Single-Center Retrospective Study from South India. (PubMed, Ann Indian Acad Neurol) - "Maintenance of an intensive level of anticoagulation may not be required in patients with CVT and may be particularly true when a transient and treatable risk factor is the provoking etiology."

Journal • Retrospective data • Cardiovascular • Hematological Disorders • Thrombosis

Real-World Data Cost-Effectiveness of Direct Oral Anticoagulants Compared With Acenocoumarol for the Management of Patients With Non-Valvular Atrial Fibrillation in Spain (ISPOR-EU 2024) - "Based on the analysis of data from clinical practice and the similarity of results using different techniques to adjust for the bias associated with observational studies, we conclude that DOACs would be an efficient alternative to acenocoumarol in the treatment of patients with NVAF in Spain."

Clinical • Cost effectiveness • HEOR • Real-world • Real-world evidence • Atrial Fibrillation • Cardiovascular

Gut Microbiome Diversity and Composition Correlates With Time in the Therapeutic Range in Patients on Warfarin Treatment: A Pilot Study. (PubMed, Arterioscler Thromb Vasc Biol) - No abstract available

Journal • Cardiovascular • Gastrointestinal Disorder • Hematological Disorders • Thrombosis

ROLE OF PHARMACOGENOMICS AND ACQUIRED FACTORS IN MAINTAINING STABLE ANTICOAGULATION FOLLOWING ACENOCOUMARIN IN STROKE PATIENTS (WSC 2024) - "Background and Aims Pharmacogenomics significantly influences drug metabolism, particularly in achieving stable anticoagulation critical for prevention of cardioembolic stroke and cerebral venous sinus thrombosis.In this study we highlight the impact of genetic variants of cytochrome P450 (CYP2C9*2/*3) and vitamin K epoxide reductase subunit 1 (VKORC1) with acquired factors,in maintaining anticoagulation stability with acenocoumarol treatment for patients with cardioembolic stroke and CVST. Bleeding and embolic complications were noted.The co relation of INR stability with comedication,diet,genotype and drug dose was studied.The predictors of unstable INR were evaluated using multivariate analysis. Results INR was stable in 47.8% and unstable in 52.2% of patients.Patients with mutant genotypes required low dose of acenocoumarin.The predictors of unstable INR were metallic valve (OR 4.07, 95% CI 1.23–13.49, P = 0.02), use of digoxin (OR 0.031, 95% CI 0.13–0.74, P =..."

Biomarker • Clinical • Cardiovascular • Hematological Disorders • Ischemic stroke • Thrombosis • CYP2C9

Analysis and categorization of pharmacotherapeutic queries received at a Valencia Drug Information Center (PubMed, Farm Comunitarios) - "Regarding classification, 90,0% of the inquiries about acenocoumarol were about drug interactions, while 33.3% of the inquiries about PPIs were related to commercialization...This information is valuable for improving the efficiency of responses at the DIS, providing uniformity, and reducing errors. Additionally, it provides a comprehensive database that facilitates the standardized integration of information."

Journal • Observational data

Profile and outcomes of patients presented with acute hemorrhage events in the Emergency Department. A single-center registry. (EUSEM 2024) - "Specifically, 21% were under treatment of acetylsalicylic acid, 21% acenocoumarol, 18.5% dabigatran, 16.2% apixaban, 14% rivaroxaban, 7% clopidogrel and 2.3% ticagrelor...Indeed, 22(62.8%) patients were transfused with RBC, 7(20%) patients with FFPs, 17(48.6%) patients received tranexamic acid, 4(11.4%) patients received vitamin K and 3(8.6%) patients received PCC...Intracranial, gastrointestinal and traumatic hemorrhage were associated with increased in-hospital mortality. As the use of NOACs is expanding and specific reversal agents become more widely available, the incorporation of protocolized strategies for the management of life-threatening hemorrhage in the ED is crucial."

Clinical • Atrial Fibrillation • Cardiovascular • Cerebral Hemorrhage • Chronic Kidney Disease • CNS Disorders • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Hematological Disorders • Hypertension • Metabolic Disorders • Mood Disorders • Nephrology • Renal Disease

Anticoagulant-Related Nephropathy as a Cause of Early Graft Dysfunction. (PubMed, Exp Clin Transplant) - "Anticoagulant-related nephropathy is an increasingly recognized entity, characterized by the presence of hematuria in the context of a supratherapeutic international normalized ratio with the development of secondary acute kidney injury, which may require renal replacement therapy and may progress to chronic kidney disease. We present the case of a 63-year-old patient who started anticoagulant therapy with acenocoumarol 2 months after her kidney transplant and presented with graft dysfunction concomitant to a supratherapeutic international normalized ratio."

Journal • Acute Kidney Injury • Chronic Kidney Disease • Nephrology • Transplantation