AT446 / Astellas - LARVOL DELTA

Sunlight-driven rapid and facile synthesis of Silver nanoparticles using Allium ampeloprasum extract with enhanced antioxidant and antifungal activity. (PubMed, Saudi J Biol Sci) - "UV-Vis spectrum showed absorption peak at 446 nm which confirmed the formation of AgNPs...krusei. Results showed that sunlight driven nanoparticle synthesis of AgNPs is rapid, facile and exhibit enhanced antioxidant and antifungal activity."

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One-Pot Synthesis of Fluorescent Nitrogen and Sulfur-Carbon Quantum Dots as a Sensitive Nanosensor for Trimetazidine Determination. (PubMed, Luminescence) - "The achieved N, S-CQDs have strong emission at 446 nm upon excitation at 370 nm and a high quantum yield of 58.5%. The method was tested in compliance with the ICH guidelines. The results obtained were statistically compared to those given by a reported method showing no significant variations regards accuracy and precision."

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Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments. (PubMed, J Biomed Nanotechnol) - "The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine...The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments. This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects."

Journal • Cardiovascular • Hematological Disorders • Thrombosis

A Novel Eplerenone Ecofriendly Fluorescent Nanosensor Based on Nitrogen and Sulfur-Carbon Quantum Dots. (PubMed, J Fluoresc) - "The produced N, S-CQDs have a small particle size in the range of 4.7 nm with a high quantum yield (58.5%) and high emission intensity at 446 nm under excitation wavelength of 370 nm. The limit of detection and quantitation were 0.05 and 0.15 μM, respectively. The assay of EPL by this approach was successfully done in drug formulations and in spiked human serum samples."

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Shrimp shells extracted chitin in silver nanoparticle synthesis: Expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells. (PubMed, Int J Biol Macromol) - "Ultraviolet visible spectroscopy (UV-Vis spec) study indicated that the development of AgNPs present in the colloidal solution was single peak at 446 nm...The upregulated apoptotic related proteins Bax, cytochrome-c, caspase-3, caspase-9, PARP and downregulated anti-apoptotic related proteins Bcl-2 and Bcl-xl in cancer cells, confirmed the anticancer potential of AgNPs. These findings suggest that the AgNPs possess significant anticancer activity against HepG2 cells which could play major role in the therapeutic drug development to treat cancer in future."

Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Hepatology • Oncology • Solid Tumor • BCL2 • BCL2L1 • CASP3 • CASP9 • PARP1

Reduction of Opioids Prescribed Upon Discharge After Total Knee Arthroplasty Significantly Reduces Consumption: A Prospective Study Comparing Two States. (PubMed, J Arthroplasty) - "Based on our results, the institution of state regulations aimed at decreasing the quantity and refills of postoperative opioids led patients to consume less opioids following TKA. Many patients are prescribed more opioids than they require which increases their consumption and can increase the risk for diversion, addiction, and misuse."

Clinical • Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Pain

Nitrogen-Doped Carbon Dots from Averrhoa carambola Fruit Extract as a Fluorescent Probe for Methyl Orange. (PubMed, Sensors (Basel)) - "The AC-NCDs exhibited the maximum emission intensity at 446 nm with 360 nm excitation wavelength...The pH 5 maintained higher quenching efficiency while other pH values slightly decreased the quenching efficiency. Incoming applications, the AC-NCDs can be used in various important fields, especially for environmental protection."

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A Trinuclear Zinc Coordination Cluster Exhibiting Fluorescence, Colorimetric Sensitivity, and Recycling of Silver Ion and Detection of Cupric Ion. (PubMed, Inorg Chem) - "Compound 1 displays distinctive sensing of Ag through the fluorescence quenching effect at 576 nm and signal augment at 446 nm over 11 kinds of cations in the absence of interference...The orange color of 1 changes to colorless during the mixing of a small amount of Ag, revealing its potential practical application in naked-eye detection of Ag. Furthermore, 2 exhibits obvious fluorescence emission at 448 nm (λ = 380 nm) and selectively responds to Cu over 11 kinds of metal ions with the fluorescence "turn-off" owing to the formation of 3 in ethanolic solution; it also has a detection limit of 0.0226 μM."

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Astellas, Audentes merger may lead to new exon-skipping treatments for MD (Muscular Dystrophy News Today) - "Astellas Pharma recently agreed to acquire Audentes Therapeutics, a move it expects will result in faster development of potentially best-in-class therapies for rare neuromuscular diseases, including muscular dystrophy (MD)....Audentes had also started developing and testing AT466, an experimental treatment for myotonic dystrophy type 1....The transaction, worth $3 billion, is expected to take place early this year."

M&A

Biosynthesis of silver nanoparticles using Sida acuta extract for anti-microbial actions and corrosion inhibition potential. (PubMed, Environ Technol) - "...The as-synthesized reaction mixture of Ag-NPs was found to exhibit an absorbance band at 446-447 nm, by an UV/VIS spectrophotometer, which is a characteristic of Ag-NPs due to the surface plasmon resonance absorption band...The IR spectra confirmed the bio-fabrication of the Ag-NPs displayed the existence of conceivable functional groups responsible for the bio-reduction and capping. The antimicrobial actions were measured and the zone of inhibition was compared with some standard antibiotics."

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