albendazole / Generic mfg. - LARVOL DELTA

Role of Topical Fumagillin 0.007% in the Management of Microsporidial Stromal Keratitis: Interventional Pilot Study with Literature Review. (PubMed, Ocul Immunol Inflamm) - "This pilot study investigated medical management, evaluating outcomes using topical fumagillin alone or in combination with topical voriconazole and oral albendazole. Clinical resolution occurred in all cases after 9.4 ± 5.2 months of treatment, with no recurrence over a 12.6 ± 3.4-month follow-up. The findings of this study support the potential of medical management for MSK, suggesting that topical fumagillin 0.007% may offer a viable treatment option for mild to moderate cases."

Journal • Glaucoma • Keratitis • Ocular Inflammation • Ophthalmology • Transplantation

Bony Hydatidosis of Femur Head - A Rare Case Report. (PubMed, J Orthop Case Rep) - "The patient was started on albendazole and after 3 months, surgical curettage and removal of cysts were performed with application of bone cement...High index of suspicion in endemic areas is required along with radiological and laboratory investigation to confirm the diagnosis. Timely and proper management can completely cure the patient without any residual pathology with full functional recovery."

Journal • Pain

Successful Treatment of Concurrent Cholangiohydatidosis with Obstructive Jaundice and Hepatothoracic Transit in a Pediatric Patient. (PubMed, European J Pediatr Surg Rep) - "Perioperative albendazole and antibiotic therapy was administered...Clinical presentation and laboratory findings are not specific and may simulate an obstructive jaundice and acute cholangitis of other etiology. ERCP with endoscopic papillotomy offers the advantage of a minimally invasive surgery, but it does not allow a definitive treatment of the whole problem and may be useful as a bridge procedure to drain the bile duct while awaiting definitive surgery."

Journal • Pain • Pediatrics

PEDIATRIC LIVER CYSTIC ECHINOCOCCOSIS IN KAZAKHSTAN (ESPID 2025) - "All patients underwent surgical treatment.The 23 patients did not receive albendazole (ABZ) after surgery.The duration of ABZ treatment was 28 days. Conclusions/Learning Points Understanding cyst stages is crucial for clinical,epidemiological,and economic reasons.The clinical management of CE in children in Kazakhstan could be enhanced by adopting the WHO-IWGE stepwise approach,potentially reducing the need for surgical intervention in uncomplicated cases."

Clinical

Moxidectin combination therapies for lymphatic filariasis: an open-label, observer-masked, randomised controlled trial. (PubMed, Lancet Infect Dis) - P3 | "In this study, single-dose MoxA was superior to IA for W bancrofti microfilaria clearance at 12 months and provided prolonged microfilaria clearance for most participants. These results suggest that MoxA could be a powerful tool to accelerate the elimination of lymphatic filariasis in Africa."

Journal • Inflammation

Black seed oil nanoemulsion containing albendazole against protoscoleces of Echinococcus granulosus: An in vivo study on C57BL/6 mice. (PubMed, Iran J Basic Med Sci) - "Additionally, after 60 days, the nanoemulsion containing albendazole showed 100% survival, while the survival rate was 50% for free albendazole, 75% for nanoemulsion without albendazole, and 37.5% for PBS. The nanoemulsion containing albendazole can be a promising treatment for hydatid cysts."

Journal • Preclinical

GALL BLADDER ASCARIASIS – AN UNWELCOME GUEST IN THE BILIARY TRACT (SSAT 2025) - "GB ascariasis is a surprise differential in patients with RUQ pain from endemic regions and management is usually not complicated.Ultrasonography images showing the worm as a echogenic, linear tubular structure with a hypoechoic center.MRCP image showing a linear filling defect in the gall bladder."

Gastroenterology • Hepatology • Infectious Disease • Pain

Impact of mass drug administration of ivermectin and albendazole on transmission of Wuchereria bancrofti lymphatic filariasis from 2001 to 2017 in Burkina Faso. (PubMed, Trop Med Int Health) - "Lymphatic filariasis transmission was interrupted in several health districts. Transmission assessment surveys showed a significant reduction of immunoparasitological indicators during program implementation. However, the country had to make efforts to reach the WHO target by 2020."

Journal

GALL BLADDER ASCARIASIS – AN UNWELCOME GUEST IN THE BILIARY TRACT (DDW 2025) - "Initial management is conservative treatment with antihelminthic agents once the worm is out of the biliary tract with either Albendazole 400mg as a single dose or Mebendazole 500 mg as a single dose. GB ascariasis is a surprise differential in patients with RUQ pain from endemic regions and management is usually not complicated."

Gastroenterology • Hepatology • Infectious Disease • Pain

Multi-omics insights into the response of the gut microbiota and metabolites to albendazole deworming in captive Rhinopithecus brelichi. (PubMed, Front Microbiol) - "This study emphasizes that deworming treatment has an impact on the gut microbiota and metabolic functions of R. brelichi. By exploiting the correlations between differential microbiota and metabolites, potential probiotics or prebiotics can be explored, thereby enhancing the efficiency of deworming and reducing its side effects."

Journal • Infectious Disease

Diagnosis and management of a rare case of isolated myocysticercosis of biceps brachii muscle: a case report. (PubMed, Ann Med Surg (Lond)) - "The cyst was eliminated via excision, followed by albendazole medication. Through this case report, we highlighted the approaches to therapy of myocysticercosis when the patient came with pain and swelling all over the body, particularly in an endemic location. Through this case report we highlight that it is important to consider the possibility of intramuscular cysticercosis, particularly in endemic regions when a patient presents with a swelling on their body."

Journal • Pain

Treatment of loiasis: a review of clinical management recommendations. (PubMed, Infect Dis Poverty) - "Inconsistencies between some recommendations were observed. There is an urgent need for internationally harmonized, evidence-based guidelines to address these inconsistencies, improve patient outcomes and minimize treatment-associated severe adverse events and fatalities."

Journal • Review • CNS Disorders

Double Trouble on the Lower Leg-Unique Human Coinfection with Echinococcus granulosus and Echinococcus multilocularis Without Liver Involvement. (PubMed, Pathogens) - "Albendazole therapy was started, and extensive surgical excision was performed. Both species were confirmed using PCR and sequencing from intraoperative samples. The current case shows that coinfection without liver involvement can occur, even in patients from low-incidence regions, which should be considered in the differential diagnosis of patients with unusual clinical presentation."

Journal • Infectious Disease • Pain

Silibinin enhanced the efficacy of albendazole in treating the muscular phase of experimental trichinellosis. (PubMed, Trop Anim Health Prod) - "The most significant improvements were recorded in the combined treatment group with a reduction rate of 69.95%, a significant reduction of inflammatory infiltrates (p < 0.05), and significant modulation of PDL1 local expression (p < 0.05). So, Silibinin (the major active ingredient of SM) showed anti-trichinellosis activity and enhanced the efficacy of ABZ against the muscular phase of the infection."

IO biomarker • Journal • Infectious Disease • Oncology

Imported Cutaneous Larva Migrans: Epidemiological, Clinical, and Therapeutic Aspects Analyzed in a Referral Tropical Medicine Unit in Barcelona. (PubMed, Am J Trop Med Hyg) - "Treatment was administered in 105 cases (98.1%), with albendazole used in 88 (83.8%), ivermectin in nine (8.6%), mebendazole in six (5.7%), and two cases lacking drug information (1.9%). A thorough epidemiological assessment, along with a detailed medical history and physical examination, facilitates early diagnosis and treatment. Currently, ivermectin and albendazole appear to achieve the highest cure rates with lower recurrence rates."

Journal

Alendronate repositioning as potential anti-parasitic agent targeting Trichinella spiralis inorganic pyrophosphatase, in vitro supported molecular docking and molecular dynamics simulation study. (PubMed, BMC Chem) - "Moreover, molecular dynamics simulation, through the analysis of RMSD, RMSF, RG, SASA and cluster analysis, proved the prolonged effective inhibition of ALN on T. spiralis inorganic pyrophosphatase, as an essential surface protein required for molting and developmental process of intestinal larval stages. Thus, ALN might be a valuable drug candidate for the treatment of trichinellosis and warrant further investigation in animal models of disease."

Journal • Preclinical • Hepatology • Infectious Disease • Osteoporosis • Rheumatology

Biomonitoring Livestock Antiparasitic Residues: Development of Fast Mass Spectrometric Methods for the Quantification of Ivermectin, Albendazole, and their Metabolites in Sheep Plasma and Feces. (PubMed, J Sep Sci) - "Also, these methods can contribute to the adjustment of the farm animal antiparasitic protocols, promoting the most effective utilization of the respective drugs while minimizing the risk of developing antiparasitic resistance. In a broader context, they may aid the advancement of veterinary medicine, offering practical solutions for monitoring the drug residues in farm animals and the derived products, and mitigating the risks associated with the extensive and uncontrolled utilization of antiparasitic drugs."

Journal • Infectious Disease

The process of residual calcification following antiparasitic treatment in the pig model of neurocysticercosis is dynamic. (PubMed, PLoS Negl Trop Dis) - "Calcification in NCC is a dynamic process that can be induced and monitored in naturally infected pigs. Eight months after treatment seems to be an optimal time point for assessing residual calcification."

Journal • Preclinical • CNS Disorders • Epilepsy

A Rare Case of Disseminated Strongyloidiasis Presenting as Polymicrobial Sepsis in a Patient With Lupus: A Diagnostic Conundrum (ATS 2025) - "He was started on systemic ivermectin and albendazole...Given the delay in diagnosis and associated higher mortality rates, screening for Strongyloides infection using stool studies before initiating immunosuppressive therapy should be considered, especially for people in endemic areas. This can help prevent fatal complications through early case detection."

Clinical • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Pulmonary Disease • Respiratory Diseases • Septic Shock

From Farm to Operating Table: Pulmonary Hydatidosis in a Sheep Herder (ATS 2025) - "He was diagnosed with cystic pulmonary hydatidosis and started on albendazole and praziquantel. Case studies associate untreated pulmonary hydatid disease with acute and chronic pulmonary embolism. This case illustrates the consequences of late detection of Echincoccus, including extended hospitalization, multiple thoracic surgeries and downstream complications."

Cachexia • Cardiovascular • Cough • Eosinophilia • Hematological Disorders • Hepatology • Infectious Disease • Pain • Pruritus • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases

Eosinophilic Fasciitis With Pulmonary Granulomas: A Mimicker of Sarcoidosis (ATS 2025) - "She subsequently developed associated persistent, peripheral eosinophilia, concerning for parasitic infection, and was diagnosed and treated for Strongyloides infection with ivermectin and albendazole...She was treated with low-dose prednisone, as she could not tolerate higher doses, and Cellcept...Raynaud's phenomenon, dysphagia, positive ANA, and systemic sclerosis-specific autoantibodies are not generally present in EF. This case highlights the challenge of differentiating EF from other disorders, such as SS and Sarcoidosis, as it may impact therapeutic management."

Cardiovascular • Dermatology • Eosinophilia • Eosinophilic Granulomatosis With Polyangiitis • Fibrosis • Gastrointestinal Disorder • Hematological Malignancies • Herpes Zoster • Hypereosinophilic Syndrome • Immunology • Infectious Disease • Langerhans Cell Histiocytosis • Monoclonal Gammopathy • Musculoskeletal Pain • Novel Coronavirus Disease • Oncology • Pain • Rare Diseases • Rheumatology • Sarcoidosis • Scleroderma • Systemic Sclerosis • Varicella Zoster • Vasculitis

From Liver to Lungs: A Rare Case of Hepatopulmonary Fistula Following Hepatic Abscess Rupture (ATS 2025) - "Broad-spectrum antibiotics (metronidazole, ceftriaxone, later escalated to piperacillin-tazobactam) and albendazole were initiated...Aspirate cultures grew gram-negative rods and gram-positive cocci, leading to vancomycin and meropenem...Despite maximal vasopressor (norepinephrine, vasopressin, epinephrine) and inotropic support (dobutamine), she experienced refractory hypoxemia and worsening multiorgan failure...The CT findings of gas-filled hepatic abscesses suggested anaerobic infection, and the absence of travel history reduced suspicion of a parasitic cause, guiding broad-spectrum antibiotic coverage for likely polymicrobial infection. This case ultimately underscores the importance of early recognition, comprehensive imaging, and balancing aggressive and conservative management, with a need for standardized guidelines in HPF care for critically ill patients."

Clinical • Cardiovascular • Cough • Endocrine Disorders • Fatigue • Hepatology • Hypertension • Infectious Disease • Musculoskeletal Pain • Oncology • Pain • Respiratory Diseases • Septic Shock

How Bronchoscopy Helped Uncover Acute Eosinophilic Pneumonia Behind a Mask of Community-acquired Pneumonia (ATS 2025) - "Patient was admitted and treated for community-acquired pneumonia with ceftriaxone and azithromycin...Patient ultimately improved on IV methylprednisolone and oral prednisone of varying doses adjusted according to oxygen requirements, respiratory status, eosinophil count, and CRP. He was also treated with albendazole for Strongyloides IgG positive status...Significant peripheral eosinophilia is often absent, making it harder to assess improvement and guide steroid dosing. Most patients improve with steroid treatment, with doses adjusted according to clinical picture."

Anorexia • Cough • Eosinophilia • Eosinophilic Granulomatosis With Polyangiitis • Immunology • Infectious Disease • Interstitial Lung Disease • Langerhans Cell Histiocytosis • Pneumonia • Rare Diseases • Respiratory Diseases • Vasculitis

Uncommon Presentation of Pulmonary Echinococcosis With a Bacterial Superinfection in a Non-endemic Region (ATS 2025) - "The patient was discharged on a course of amoxicillin-clavulanic acid with close follow-up. Upon follow-up, echinococcal serology was positive, eosinophilia had resolved, and albendazole therapy was initiated for suspected echinococcal cyst...Peripheral eosinophilia can be a helpful diagnostic tool when evaluating for cyst spillage, as it is not typically expected in uncomplicated cysts nor pyogenic abscesses. This case highlights the importance of considering rare parasitic infections, even in non-endemic regions, as increased immigration can lead to increased prevalence of tropical diseases, even when initial diagnoses seem straightforward."

Cough • Eosinophilia • Hepatology • Infectious Disease • Oncology • Pain • Rare Diseases • Respiratory Diseases • Tuberculosis

The Sleeping Beauty: Pulmonary Echinococcosis Manifesting After Two Decades of Dormancy (ATS 2025) - "Postoperatively, she was treated with albendazole for 12 months, due to the risk of recurrence or dissemination...This case underscores the complexity of diagnosing pulmonary echinococcosis in non-endemic areas, especially with negative serology. Echinococcal serological tests have limited sensitivity, especially in patients with isolated pulmonary involvement. The prolonged latency period in this patient suggests that E. granulosus can remain dormant for extended periods, only manifesting clinically decades after last exposure."

Infectious Disease • Septic Shock