Anisina (ATM-3507) / Kazia - LARVOL DELTA

[VIRTUAL] Tropomyosins are critical mediators of CD8+ T cell synaptic actomyosin organization. (IMMUNOLOGY 2021) - "Importantly, treatment with an inhibitor of Tpm3.1, ATM3507, severely impacts the organization of T cell synaptic actin structures. Our aim is to examine the role that tropomyosins play in the organization of T cell synaptic actin and actomyosin structures and to determine their importance for effector function."

Immunology • CD8

Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents. (PubMed, Br J Cancer) - "Combined targeting of Tpm3.1/actin and microtubules is a promising treatment strategy for ovarian cancer that should be further tested in clinical settings."

Journal • Oncology • Ovarian Cancer • Solid Tumor • CCND1 • CDKN1A

Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1. (PubMed, Sci Rep) - "CD spectroscopy and thermal melts using Tpm3.1 peptides containing the C-terminus, the N-terminus, and a combination of the two forming the overlap junction at the interface of adjacent Tpm3.1 dimers, show that ATM-3507 shifts the melting temperature of the C-terminus and the overlap junction, but not the N-terminus. Molecular dynamic simulation (MDS) analysis predicts that ATM-3507 integrates into the 4-helix coiled coil overlap junction and in doing so, likely changes the lateral movement of Tpm3.1 across the actin surface resulting in an alteration of filament interactions with actin binding proteins and myosin motors, consistent with the cellular impact of ATM-3507."

Journal • Oncology

Indigenizing and Decolonizing the Teaching of Psychology: Reflections on the Role of the Non-Indigenous Ally. (PubMed, Am J Community Psychol) - "In this article, I survey the existing literature on Indigenizing and decolonizing psychological curriculum and share ways in which I have integrated Indigenous content into my psychology courses. I also reflect upon the successes, questions, and ongoing challenges that have emerged as I worked in collaboration with first Anisinaabek First Nations and then Mi'kmaw/L'nu First Nations."

Journal