amitriptyline / Generic mfg. - LARVOL DELTA

Effectiveness of AI-Guided Exercise and Pain Neuroscience Education for Fibromyalgia (FIBROIA) (clinicaltrials.gov) - P=N/A | N=50 | Recruiting | Sponsor: Marco Antonio Morales Osorio | Not yet recruiting ➔ Recruiting | Trial completion date: Jul 2025 ➔ Jul 2026 | Trial primary completion date: Apr 2025 ➔ Apr 2026

Enrollment open • Trial completion date • Trial primary completion date • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology

MRP-HAND: Multiprofen-CC to Reduce Pain in Hand Arthritis (clinicaltrials.gov) - P3 | N=42 | Not yet recruiting | Sponsor: McMaster University

New P3 trial • Immunology • Osteoarthritis • Pain • Rheumatology

EVALUATING THE SAFETY OF PHARMACOTHERAPY FOR IRRITABLE BOWEL SYNDROME: A META-ANALYSIS (DDW 2025) - "AEs were more varied for tricyclics (indicated for IBS global symptoms); for example, compared to placebo the three most common AEs with associated risk increases were drowsiness (14%), dry mouth (12%), and weight gain (9%) for amitriptyline, dry mouth (22%), flushing (18%), and constipation (17%) for desipramine, and fatigue (15%), dry mouth (3%) and blurry vision (1.5%) for doxepin...The NNH for linaclotide, lubiprostone, plecanatide, tegaserod, and tenapanor (indicated for IBS-C) was 27 (p < 0.01), 53 (p = 0.59), 58 (p < 0.01), 59 (p = 0.03), and 17 (p <0.01) respectively. The NNH for alosetron and eluxadoline (indicated for IBS-D) was 16 (p < 0.01) and 32 (p < 0.01). Ramosetron and rifaximin (indicated for IBS-D) had a negative risk difference, with the rate of withdrawal due to AEs higher in the placebo arm, so NNH was a negative, although statistically insignificant, value... Tricyclics, alosetron, and tenapanor are associated with a higher..."

Retrospective data • Constipation • Fatigue • Gastrointestinal Disorder • Xerostomia

SELECTIVE SEROTONIN REUPTAKE INHIBITORS AND TRICYCLIC ANTIDEPRESSANTS USE IN INFLAMMATORY BOWEL DISEASE PATIENTS MAY BE ASSOCIATED WITH POOR CLINICAL OUTCOMES (DDW 2025) - "Subjects were stratified into groups using commonly prescribed selective serotonin reuptake inhibitors (SSRI) (fluoxetine, citalopram, escitalopram, paroxetine, sertraline), tricyclic antidepressants (TCA) (amitriptyline, doxepin, imipramine, nortriptyline, desipramine), or monoamine oxidase inhibitors (MAOI) (selegiline, isocarboxazid, phenelzine, tranylcypromine) for at least one year. Herein we showed that SSRI and TCA use in IBD patients is associated with poor clinical outcomes in terms of requiring steroid therapy, hospitalization, and death. Some studies have suggested that this may be due to SSRI-induced dysbiosis which may lead to gut inflammation. MAOI use was not associated with statistically significant worsened outcomes however this may be due to insufficient power."

Clinical • Clinical data • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Pain • Psychiatry • Ulcerative Colitis

CYCLIC VOMITING SYNDROME AMONG PEDIATRIC PATIENTS IN THE UNITED STATES: PATIENT CHARACTERISTICS, TREATMENT PATTERNS, AND HEALTHCARE RESOURCE UTILIZATION (DDW 2025) - "Cyproheptadine (27.5%) and amitriptyline (12.7%) accounted for nearly all prophylaxis treatment, aligning with first-line recommendations for patients under and over 5 years of age, respectively. Guideline-recommended abortive medications sumatriptan and ondansetron were used by 5.7% and 61.4% of patients...Although patients eventually receive guideline-based treatments, diagnostic delays are experienced by most pediatric patients with CVS. Improved awareness of CVS should improve this gap in care."

Clinical • HEOR • CNS Disorders • Depression • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Mood Disorders • Pain • Pediatrics • Psychiatry • Rare Diseases

CYCLIC VOMITING SYNDROME AMONG ADULTS IN THE UNITED STATES: PATIENT CHARACTERISTICS, TREATMENT PATTERNS AND HEALTHCARE RESOURCE UTILIZATION (DDW 2025) - "Guideline-recommended prophylactic medications for moderate-to-severe CVS (i.e., amitriptyline, topiramate, aprepitant, zonisamide and levetiracetam) were used by 0.5%–13% of patients at any time post-diagnosis. Guideline-recommended abortive medications sumatriptan and ondansetron were used by 8.3% and 72.4% of patients...Conclusion : This study highlights the significant clinical burden and HCRU associated with CVS in the US and the need to improve access to evidence-based treatments, and it suggests potential underreporting of CVS in healthcare records post-diagnosis. The novel use of NLP provided deeper insights into symptomatology and revealed the substantial length of diagnostic delay experienced by most patients with CVS."

Clinical • HEOR • CNS Disorders • Depression • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Mood Disorders • Pain • Psychiatry • Rare Diseases

Early-Onset Diabetic Neuropathy in a Teenager with Brittle Type 1 Diabetes: A Case Report (ESPE-ESE 2025) - "Symptoms significantly improved with optimized glycemic control and the initiation of amitriptyline (10 mg/day)...Maintaining rigorous glycemic control from the onset of diabetes is essential to prevent or delay the development of neuropathic complications. Conclusion : Early screening for diabetic neuropathy should be considered even in patients with recent-onset T1DM, as early intervention with glycemic optimization and symptomatic treatment can improve outcomes and prevent further complications."

Case report • Clinical • Diabetes • Diabetic Neuropathy • Endocrine Disorders • Hypoglycemia • Infectious Disease • Lipodystrophy • Metabolic Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Renal Disease • Retinal Disorders • Type 1 Diabetes Mellitus

Ecotoxicological implications of increased antidepressant concentrations in the Laurentian Great Lakes Basin, 2018-2023. (PubMed, Sci Total Environ) - "The greatest median increases corresponded to fluvoxamine (4.8-fold) and 10-hydroxyamitriptyline (4.7-fold)...The highest concentrations corresponded to the metabolite O-desmethylvenlafaxine (3113.98 ng L-1) and its parent drug venlafaxine (699.59 ng L-1) in 2022...We compared maximal MECs to ecotoxicological reference values and theorize a possible ecotoxicological impact when considering the overlap of maximal levels with ecotoxicological reference values cited in the scientific literature. We offer recommendations for next steps."

Journal • Infectious Disease • Novel Coronavirus Disease

MANAGING COMPLICATIONS IN PEDIATRIC EWING'S SARCOMA: PAIN CONTROL AND WOUND INFECTION FOLLOWING KNEE DISARTICULATION CASE REPORT (ASRA-SPRING 2025) - "Pain management with gabapentin (5mg/kg every 8 hours), amitriptyline (25mg once daily), and morphine (0.05mg/kg/dose every 4 hours) was ineffective...Therapeutic Intervention: For the second debridement procedure, the following anesthetic protocol was used: - Induction: Sevoflurane 8%, propofol 50 mg, fentanyl 30 mcg - Maintenance: Sevoflurane 2.5% - Regional anesthesia: Ultrasound-guided left anterior ischial and femoral nerve blocks using a linear probe and 30G needle Follow-up and Outcomes: Post-operatively, the patient stayed in the Post-Anesthesia Care Unit (PACU)...He required analgesics twice on the first postoperative day, none on the second day, and one dose of dipyrone on the third day...Peripheral nerve blocks are valuable in perioperative pain management for pediatric patients. This case illustrates the use of ultrasound-guided ischial and femoral nerve blocks with general anesthesia for surgical debridement, offering enhanced pain control, reduced opioid..."

Case report • Clinical • Anesthesia • Ewing Sarcoma • Infectious Disease • Neuralgia • Oncology • Osteosarcoma • Pain • Pediatrics • Sarcoma • Solid Tumor

PERCUTANEOUS CRYONEUROLYSIS FOR SUBACUTE TRAUMATIC LOWER EXTREMITY AMPUTATION PAIN (ASRA-SPRING 2025) - "At 5 weeks follow-up by telephone, the patient reported her stump pain had returned and was being treated with acetaminophen, amitriptyline, gabapentin, and oxycodone. This case highlights the potential of ultrasound- guided percutaneous cryoneurolysis for managing subacute pain in challenging clinical scenarios in which local anesthetic based nerve blocks fail to provide sufficient duration of analgesia. Given the resource intensive nature of percutaneous cryoneurolysis, further research is indicated to optimize its integration into pain management protocols."

Anesthesia • Cardiovascular • Pain • Pulmonary Embolism • Respiratory Diseases

ULTRASOUND-GUIDED COMMON PERONEAL NERVE BLOCK AND SCAR INFILTRATION FOR CHRONIC POSTOPERATIVE NEUROPATHIC PAIN: A CASE REPORT (ASRA-SPRING 2025) - "Minimal residual pain at the nailing site wasmanaged conservatively with oral analgesics (T.Amitriptyline 5 mg at bedtime for 5 days, followed by 10mg at bedtime, and Tablet with combination of 100 mg ofaceclofenac, 325 mg of paracetamol, and 15mg ofserratiopeptidase for 3 days) and physiotherapy.Follow-up at three months confirmed sustained pain reliefand functional improvement.ResultsThis case underscores the efficacy of ultrasound-guided nerve blocksand scar infiltration in addressing chronic postoperative neuropathicpain. Ultrasound-guided peripheralnerve blocks and scar infiltration have been explored as effectiveinterventional strategies to alleviate chronic postoperative pain. Thiscase report discusses a patient with chronic neuropathic painfollowing tibia and fibula fracture surgery, emphasizing the role oftargeted pain management techniques."

Case report • Clinical • Fibrosis • Immunology • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Neuralgia • Orthopedics • Pain

PELVIC PAIN CAUSED BY BERTOLOTTI SYNDROME (ASRA-SPRING 2025) - "Prior Treatments: non-steroidal anti-inflammatory drugs, acetaminophen, methocarbamol, cyclobenzaprine, oxycodone, corticosteroids, topiramate, amitriptyline, duloxetine, venlafaxine, vaginal diazepam, and pelvic floor physical therapy...At the time of initial evaluation, patient was only using ibuprofen as it provided minimal benefit and was tolerated better than other medications...She was started on baclofen 10mg and phenazopyridine 100 mg three times daily as needed...In a patient with chronic pelvic/low abdominal pain unrelated to organic urogynecologic and gastrointestinal pathologies, consider referred pain from Bertolotti Syndrome pseudoarticulation. Early identification may help avoid prolonged pain, effects on mental health, and decrease further sequelae of degenerative spine disease in the surrounding levels [2] [3]."

Back Pain • Gastrointestinal Disorder • Gynecology • Lumbar Back Pain • Musculoskeletal Pain • Neuralgia • Pain • Pruritus

Effects of Commonly Prescribed Medications on Sleep: A Review of the Literature. (PubMed, Mayo Clin Proc) - "This review synthesizes literature on how commonly prescribed medications-antihypertensives, statins, antidepressants, levothyroxine, proton pump inhibitors, phosphodiesterase type 5 inhibitors, and metformin-affect sleep...Antidepressants have mixed effects; some increase somnolence (trazodone, amitriptyline), whereas others are associated with insomnia (bupropion) and may worsen restless legs syndrome (mirtazapine)...Phosphodiesterase type 5 inhibitors like sildenafil may exacerbate severe obstructive sleep apnea, warranting caution. Metformin does not appear to interfere with sleep, with some studies suggesting a limited benefit. Clinicians should carefully consider these medication effects to balance therapeutic benefits with potential sleep-related adverse effects."

Journal • Review • CNS Disorders • Endocrine Disorders • Fatigue • Gastroenterology • Gastroesophageal Reflux Disease • Insomnia • Movement Disorders • Obstructive Sleep Apnea • Respiratory Diseases • Restless Legs Syndrome • Sleep Disorder

Intervening Mechanisms of Amitriptyline Combined With Domperidone on Functional Dyspepsia Rats. (PubMed, Neurogastroenterol Motil) - "The combination of amitriptyline and domperidone relieves anxiety and depression, improves gastrointestinal motility by targeting the 5-HT2BR, PLCβ2, and IP3R signaling pathways, and modulates the gut microbiota. This integrated approach alleviates FD symptoms through multiple mechanisms and pathways, presenting a promising therapeutic strategy."

Journal • Preclinical • CNS Disorders • Depression • Dyspepsia • Gastrointestinal Disorder • Mood Disorders • Psychiatry • ANO1

Amitriptyline Versus Placebo in Addition to Speech Pathology for Inducible Laryngeal Obstruction: A Double-blind Randomised Controlled Trial (ATS 2025) - "In this double-blind randomised controlled trial, speech pathology effectively reduced ILO symptoms, laryngeal hypersensitivity, the impact of voice problems on patients' quality of life and anxiety and depression scores, with no additional benefit from concurrent amitriptyline."

Clinical • CNS Disorders • Depression • Immunology • Mood Disorders • Otorhinolaryngology • Psychiatry • Pulmonary Disease

Multidisciplinary Management of ARDS, Pulmonary Emboli, and Bronchopleural Fistula Following Multidrug Ingestion (ATS 2025) - "This was caused by an intentional polysubstance overdose, including amitriptyline, a tricyclic antidepressant (TCA)...It also highlights the life-sustaining role of ECMO in cases of pediatric respiratory failure. In this case VA-ECMO via central cannulation allowed the patient to be liberated from positive pressure ventilation and ultimately provided time for recovery."

Acute Respiratory Distress Syndrome • Cardiovascular • CNS Disorders • Depression • Pediatrics • Psychiatry • Pulmonary Embolism

Role of Ceramide in SARS-CoV-2 Spike Protein-amplified Acute Lung Injury (ATS 2025) - "ASM was inhibited by amitriptyline or endothelial-specific conditional Smpd1 knockout mice... In a model of S1-amplified ALI, characterized by excess Ang2, activation of ASM on endothelial cells may drive acute lung injury pathogenesis via formation of ceramide rich platforms on microvascular endothelial cells. Acknowledgements: Seyed Ali Mousavi-Aghdas, Katrina Kopf, and Arjun Singh are equal contributors to this abstract."

Acute Lung Injury • Acute Respiratory Distress Syndrome • Anesthesia • Infectious Disease • Inflammation • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Physiologically based pharmacokinetic modelling predicts altered maternal pharmacokinetics of amitriptyline during pregnancy. (PubMed, Br J Clin Pharmacol) - "With this model, we added valuable information on AMI pharmacokinetics during pregnancy (increased AMI concentration, decreased NOR concentration). For clinical practice the treating physician should be aware that despite active moiety serum concentration comparable to before pregnancy, tolerability may be affected due to increased AMI serum concentrations and as consequence increased anticholinergic effects. To keep the risk of therapy discontinuation during pregnancy low, we suggest performing therapeutic drug monitoring, especially to check the AMI serum concentration."

Journal • PK/PD data • CNS Disorders • Depression • Psychiatry

Intravenous Ketamine Infusion for Managing Chronic Postoperative Pain After Inguinal Herniorrhaphy: A Case Report. (PubMed, J Pain Palliat Care Pharmacother) - "The patient reported persistent pain despite multiple pharmacological treatments, including amitriptyline, gabapentin, and codeine, as well as nerve blocks and nonpharmacological interventions like acupuncture. This case aligns with the 2018 consensus guidelines on ketamine use in chronic pain and contributes to the growing body of evidence supporting its efficacy in CPSP management. While this therapy demonstrated remarkable clinical benefits, further research is essential to establish optimal protocols and long-term outcomes for ketamine use in chronic postoperative pain."

Journal • Anesthesia • Gastroenterology • Pain

Comparing Efficacy of Gabapentin and Amitriptyline in Chronic Pain Management: A Systematic Review of Randomized Controlled Trials (ISPOR 2025) - "This systematic review demonstrated that gabapentin has comparable or superior efficacy to amitriptyline in chronic pain management. Future research should focus on specific subpopulations to determine whether certain groups respond better to one medication and assess the long-term effectiveness of the studied drugs and other first-line treatments for chronic pain to gain a more comprehensive understanding of optimal pain management strategies."

Clinical • Review • Pain

Carbon Materials in Voltammetry: An Overview of Versatile Platforms for Antidepressant Drug Detection. (PubMed, Micromachines (Basel)) - "Moreover, the combination of voltammetric approaches with the unique characteristics of carbon and its derivatives has led to the development of powerful electrochemical sensing tools for detecting antidepressant drugs, which are highly desirable in healthcare, environmental monitoring, and the pharmaceutical industry. In this review, carbon-based materials, such as glassy carbon and boron-doped diamond, and a wide spectrum of carbon nanoparticles, including graphene, graphene oxides, reduced graphene oxides, single-walled carbon nanotubes, and multi-walled carbon nanotubes were described in terms of the sensing performance of agomelatine, alprazolam, amitriptyline, aripiprazole, carbamazepine, citalopram, clomipramine, clozapine, clonazepam, desipramine, desvenlafaxine, doxepin, duloxetine, flunitrazepam, fluoxetine, fluvoxamine, imipramine, nifedipine, olanzapine, opipramol, paroxetine, quetiapine, serotonin, sertraline, sulpiride, thioridazine, trazodone, venlafaxine,..."

Journal • Review • CNS Disorders • Depression • Mood Disorders • Personality Disorder • Psychiatry

Effects of Pharmacological Treatment on Telomere Length and the Expression of Telomerase/Shelterin-Related Genes in Rat Models of Autism. (PubMed, J Mol Neurosci) - "Using the valproic acid (VPA, 500 mg/kg) rodent model, this study aimed to assess the impact of three drugs commonly used in ASD treatment (amitriptyline, risperidone, and nooclerin) on telomere length and the expression of telomerase/shelterin-related genes (Dkc1, Gar1, Pot1a, Pot1b, Tep1, Terc, Terf2ip, Tert, Tinf2, Tnks, Tpp1, Trf1, and Trf2) in blood cells, the prefrontal cortex, and hippocampus of VPA-exposed Wistar rats. Long telomeres in male blood cells were associated with reduced anxiety, while a positive correlation was found between Tpp1 expression and stereotypical behavior in both male and female VPA rats. These findings suggest that nooclerin and risperidone influence telomere length and gene expression related to the telomere-telomerase complex in a sex-dependent manner, offering insights into the neurobiological mechanisms underlying ASD."

Journal • Preclinical • Autism Spectrum Disorder • Genetic Disorders • Mood Disorders • Psychiatry • DKC1 • TERF1 • TERF2 • TINF2 • TPP1

Serotonin syndrome induced through a combination of oxycodone and amitriptyline: A case report. (PubMed, Psychiatry Clin Neurosci) - No abstract available

Journal

Treatment with antidepressant drugs and hyponatremia: a network meta-analysis. (PubMed, J Endocrinol Invest) - "These data appear useful on clinical grounds, in order to increase the awareness regarding the possibility that antidepressants induce hyponatremia and to encourage regular serum sodium monitoring."

Journal • Retrospective data • Review • Cardiovascular • Heart Failure

Combined speech pathology and amitriptyline treatment for vocal cord dysfunction. (ANZCTR) - P3 | N=50 | Completed | Sponsor: LaTrobe University | Recruiting ➔ Completed

Trial completion • Otorhinolaryngology