ASP2205 / Astellas - LARVOL DELTA

Effect of a 5-HT receptor agonist on urethral closure mechanism in healthy women. (PubMed, Neurourol Urodyn) - "ASP2205, a serotonin 5-HT receptor agonist, does not increase the urethral pressure and it is therefore unlikely that 5-HT receptor agonists can be used as a treatment for stress urinary incontinence. ASP2205 was less well tolerated than the high dose of duloxetine."

Clinical • Journal

Effect of ASP2205 fumarate, a novel 5-HT receptor agonist, on urethral closure function in rats. (PubMed, J Pharmacol Sci) - "In contrast, ASP2205 (0.3 mg/kg i.v.) did not change the resting urethral pressure in rats. These results indicate that ASP2205 can enhance the pudendal nerve-mediated urethral closure reflex via the 5-HT receptor, resulting in the prevention of involuntary urine loss."

Journal • Preclinical