atenolol / Generic mfg. - LARVOL DELTA

MANAGEMENT OF SEVERE HYPERTHYROIDISM IN HOSPITALIZED PATIENTS (WRMC 2026) - "Propranolol, atenolol and metoprolol were considered equipotent. In summary, published HR targets were often not achieved at discharge, and most discharge β-blocker doses were well below the maximum doses (150-200 mg/d) recommended in ATA guidelines. recurrent HT was frequent among pts whose primary treatment was ATDs or who received RAI or Tx >1m after discharge. In conclusion, 1) β blockade was frequently inadequate for HR control on discharge, and 2) recurrent HT in hospitalized pts with severe HT is common unless definitive treatment with surgery or RAI is undertaken within 1m of discharge."

Clinical • Endocrine Disorders

MULTIMODAL MANAGEMENT OF LEFT VENTRICULAR NON-COMPACTION CARDIOMYOPATHY WITH CONDUCTION DISEASE AND NKX2-5 VARIANT: A CASE STUDY (WRMC 2026) - "Atenolol was considered for arrhythmia and mood stabilization...Her two daughters, ages 19 and 17, are currently asymptomatic and undergoing clinical screening. The pedigree supports autosomal dominant inheritance with variable expressivity and incomplete penetrance, consistent with known NKX2-5–associated cardiac phenotypes."

Case study • Clinical • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • CNS Disorders • Congestive Heart Failure • Heart Failure • Ventricular Tachycardia

Granule size-dependent biotransformation of organic micropollutants in aerobic granular sludge under different bioconversion conditions. (PubMed, J Hazard Mater) - "Eight OMPs (sulfamethoxazole, atenolol, furosemide, benzotriazole, trimethoprim, diclofenac, metoprolol, and gabapentin) showed biotransformation efficiencies above 10 % under at least one condition. This study is the first to assess OMP biotransformation across AGS size fractions, highlighting the combined effects of granule size and bioconversion conditions. The findings provide insights for optimizing AGS systems, including potential granule size adjustments, to enhance OMP biotransformation and reduce environmental impacts."

Journal

Delayed cardiovascular collapse in poisoning due to amlodipine, atenolol, tamsulosin and insulin. (PubMed, Clin Toxicol (Phila)) - No abstract available

Journal • Cardiovascular

Case Report: Transient myocardial thickening in a cat secondary to acute cholangiohepatitis. (PubMed, Front Vet Sci) - "Atenolol was added to the outpatient medical management for cholangiohepatitis, consisting of broad-spectrum antimicrobials, hepatoprotectants, and antiemetic/gastroprotective agents. Over the course of 84 days, five follow-up evaluations were performed, during which hepatic values normalized, cTnI and NT-proBNP returned to reference ranges, and myocardial dimensions and vertebral heart score normalized. Unlike most reports in which TMT is identified after congestive signs develop, this case was recognized earlier, on the basis of an abrupt biomarker surge during apparent clinical improvement."

Journal • Anesthesia • Cholangiocarcinoma • Hepatitis C • Infectious Disease • TNNI3

Bilateral Epicardial Coronary Microfistulas With Anomalous Deviation. (PubMed, JACC Case Rep) - "This case contributes to the growing recognition of coronary microfistulas as a rare but clinically meaningful cause of type 2 myocardial infarction, emphasizing the diagnostic value of coronary angiography and reinforcing the importance of individualized conservative management in such diffuse presentations of fistulas."

Journal • Cardiovascular • Coronary Artery Disease • Diabetes • Endocrine Disorders • Hypertension • Metabolic Disorders • Myocardial Infarction • Pain • Psychiatry • Type 2 Diabetes Mellitus

Psychosis as the Initial and Main Presentation of Graves' Disease: A Case Report from Saudi Arabia. (PubMed, Cureus) - "She was treated with carbimazole and atenolol, alongside low-dose olanzapine (5 mg daily). Endocrine screening should be routinely performed in new-onset psychosis to identify reversible causes such as thyrotoxicosis. Early recognition and treatment of underlying hyperthyroidism ensures rapid psychiatric recovery and prevents unnecessary prolonged antipsychotic use."

Journal • CNS Disorders • Endocrine Disorders • Grave’s Disease • Ophthalmology • Psychiatry

Combined Neutron and X-Ray Diffraction Study of Ibuprofen and Atenolol Adsorption in Zeolite Y. (PubMed, Molecules) - "These results provide a microscopic model describing the fundamental host-guest interactions in FAU zeolites. This structural understanding is an essential step towards the potential use of zeolitic materials in environmental remediation and complex guest sequestration."

Journal

Systematic Identification and Recognition Analysis of Beta1-Adrenergic Receptor Targeting Material Basis in Tibetan Medicine Formula Bawei Chenxiang Powder. (PubMed, J Mol Recognit) - "So, in this work, we engineered a fusion protein by linking the kinase domain of epidermal growth factor receptor (EGFR) to the C-terminus of β1-AR, which was subsequently immobilized onto the ibrutinib-modified silica gels. Following column preparation by packing the β1-AR immobilized silica into a stainless-steel column, the specificity and stability of β1-AR column were evaluated through the retention behavior analysis of atenolol, esmolol, and metoprolol for characterization...These confirmed the reliability of the screened compounds by the immobilized β1-AR. To our knowledge, this work establishes the first systematic identification of BWCP's bioactive components targeting β1-AR, providing a pharmacological foundation for developing novel cardiovascular therapeutics derived from this traditional formulation."

Journal • Cardiovascular • EGFR

2-(4-Hy-droxy-phen-yl)acetamide. (PubMed, IUCrdata) - "In the extended structure, N-H⋯O hydrogen bonds organize mol-ecules into stacks propagating along [100], with additional hydrogen bonding linking neighboring parallel stacks. A survey of known structures indicates that the structures of 2-phenyl-acetamide mol-ecules with any substitution at the 4-position on the phenyl ring can demonstrate different orientations for the acetamide group ranging from the -NH2 group directed almost completely outward to the -NH2 group directed almost completely inward."

Journal

RaP-AF: Rate Control in Patients With Atrial Fibrillation (clinicaltrials.gov) - P=N/A | N=13 | Completed | Sponsor: National Taiwan University Hospital | Active, not recruiting ➔ Completed | N=50 ➔ 13

Enrollment change • Trial completion • Atrial Fibrillation • Cardiovascular

Fate, chlorination kinetics, and comprehensive risk assessment of pharmaceuticals and personal care products in drinking water distribution systems. (PubMed, J Contam Hydrol) - "Four compounds (atenolol, sulpiride, paroxetine, and nadolol) exhibited pseudo-first-order kinetics with residual chlorine, while the others exhibited significant resistance to chlorination...Ecological risk assessment revealed ibuprofen posed a moderate ecological risk, a risk quotient (RQ) of 0.335, while triclocarban presented a high ecological risk (RQ = 4.6031)...Among the detected PPCPs, meclofenamic acid was identified as the compound of highest concern, with average relative risk indices exceeding >10-4. These findings provide critical insights into the fate and transformation of PPCPs in drinking water systems and offer scientific guidance for optimizing treatment processes and risk management strategies."

Journal

Investigation of the aggregation and assembly mechanisms of trace organic compounds and dissolved organic matter using a combined approach of molecular dynamics simulations and experiments. (PubMed, J Environ Manage) - "Four scenarios (Sce) were designed: (i) Sce-1 including atenolol (ATL) and DOM; (ii) Sce-2 including ATL, sulfamethoxazole (SMZ), carbamazepine (CBZ) and DOM; (iii) Sce-3 with the same composition as Sce-1 under an electric field; and (iv) Sce-4 excluding tannic acid (TAN) and humic acid (HA). Fluorescence analysis showed 25.8 % peak intensity reduction. Electric fields disrupt clusters and enhance oxidant-mediated TrOC removal, while pre-removing of bridging molecules reduces cluster size for efficient elimination."

Journal

Schiff-based metal complexes of atenolol: Synthesis, characterization, molecular docking and biological evaluation. (PubMed, Pak J Pharm Sci) - "The imine Schiff based derivatives of atenolol and their metal complexes exhibit good biological efficacy as well as multi modal effects when compared to the frequently prescribed drug, atenolol."

Journal • Oncology

Perinatal Management of Andersen-Tawil Syndrome Using a Wearable Cardioverter-Defibrillator: A Case Report. (PubMed, J Obstet Gynaecol Res) - "At 36 weeks, atenolol and flecainide were introduced, and a wearable cardioverter-defibrillator (WCD) was applied, further reducing arrhythmias. Postpartum, arrhythmias increased again, highlighting the importance of surveillance. This case demonstrates that combined pharmacological therapy and temporary WCD use may represent a safe and effective perinatal management strategy in high-risk pregnancies complicated by ATS."

Journal • Cardiovascular • Ventricular Tachycardia

Capillary blood microsampling and LC-Orbitrap analysis for adherence monitoring of cardiovascular drugs: method development, cross-validation, and patient proof-of-concept using VAMS and Capitainer-B. (PubMed, Talanta) - "Amlodipine, atenolol, atorvastatin, bisoprolol, carvedilol, clopidogrel, diltiazem, lercanidipine, metoprolol, nebivolol, prasugrel, rosuvastatin, salicylic acid, simvastatin hydroxy acid, and verapamil were included. In a proof-of-concept involving 30 patients, finger-prick concentrations from VAMS and Capitainer-B were interchangeable, supporting the suitability of these adherence workflows but reference ranges for capillary blood remain necessary to enable routine clinical interpretation. In summary, this work established a reliable, LC-Orbitrap-based microsampling platform for monitoring adherence and identified stability issued amongst others that guide future method selection and development."

Journal • Cardiovascular

Different beta-blockers for preventing arrhythmic events in patients with long QT syndrome: a network meta-analysis. (PubMed, Front Med (Lausanne)) - "In LQT1, nadolol was superior to propranolol (RR = 0.59, 95% CI: 0.39-0.90) and had the highest probability of being the optimal treatment (SUCRA = 0.92). In LQT2 patients, nadolol not only shows a superiority trend but also has a significant dose-effect relationship, supporting its clinical priority; in LQT3 patients, nadolol exhibits a significant dose-dependent risk reduction trend, though no statistically significant differences in efficacy were observed among all beta-blockers. Additionally, LQT3 patients should be cautious of the potential risks associated with atenolol."

Journal • Retrospective data • Cardiovascular

Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) (clinicaltrials.gov) - P4 | N=240 | Not yet recruiting | Sponsor: Weill Medical College of Cornell University

New P4 trial • Cardiovascular • Congestive Heart Failure • Heart Failure

Effects of Bariatric Surgery on the Pharmacokinetics of Cardiovascular Drugs: A Systematic Review and Meta-Analysis. (PubMed, Obes Surg) - "Bariatric surgery can significantly impact the pharmacokinetics of cardiovascular drugs, especially atorvastatin and beta-blockers, highlighting the need for individualized dose adjustments and therapeutic monitoring. These findings provide essential evidence for optimizing cardiovascular pharmacotherapy in post-bariatric surgery patients, supporting the development of tailored dosing guidelines."

Journal • PK/PD data • Retrospective data • Review • Cardiovascular • Genetic Disorders • Obesity

Blocking SUDEP With a Beta Blocker: Atenolol Reduces Seizure-Related Mortality. (PubMed, Epilepsy Curr) - No abstract available

Journal • CNS Disorders • Epilepsy

Chronic stress promotes pancreatic ductal adenocarcinoma progression via complement C5a-recruited myeloid-derived suppressor cells. (PubMed, Cancer Immunol Immunother) - "The effect was abrogated by the C5aR1 antagonist PMX-53, identifying C5a as a critical mediator of MDSC accumulation. Intervention with the ADRB1 antagonist atenolol in PDAC mice significantly reduced serum/tumoral C5a levels, diminished splenic/intratumoral MDSCs proportions, and attenuated tumor growth. Our findings propose that targeting the SNS-driven complement-MDSCs axis represents a promising strategy for PDAC patients."

IO biomarker • Journal • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • PD-L1 • TGFB1

HEART-BEAT: Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease (clinicaltrials.gov) - P2/3 | N=350 | Enrolling by invitation | Sponsor: Gødstrup Hospital | Not yet recruiting ➔ Enrolling by invitation

Enrollment open • Cardiovascular • Coronary Artery Disease • Heart Failure

Comparison of low- and high-pressure balloon valvuloplasty in dogs with severe pulmonary valve stenosis. (PubMed, J Vet Cardiol) - "No significant difference between LP and HP catheters was observed in PS severity reduction or myocardial injury. High-pressure catheters offer no added benefit over LP catheters for treating severe PS in dogs without annular hypoplasia."

Journal • TNNI3

Warm autoimmune hemolytic anemia following epstein-barr virus reactivation: An uncommon clinical association (ASH 2025) - "His only medications were atenolol and atorvastatin, and he denied use of herbal supplements or over-the-counter drugs... Warm AIHA is most commonly idiopathic but can also occur secondary to various conditions, including rheumatologic diseases (e.g., systemic lupus erythematosus), chronic lymphoblastic leukemia, non-Hodgkin's lymphoma, certain medications (e.g., cephalosporins, piperacillin), and infections...Initial corticosteroid therapy varies widely during the first 72 hours, ranging from 1–2 mg/kg of prednisone every 8–12 hours to high-dose intravenous methylprednisolone (250–1000 mg/day)...In cases refractory to steroids, additional therapies such as mycophenolate mofetil or sirolimus may be considered. This case highlights a rare presentation of warm AIHA likely triggered by EBV reactivation, an association that is infrequently reported in the literature."

Clinical • Anemia • Autoimmune Hemolytic Anemia • Chronic Lymphocytic Leukemia • Cytomegalovirus Infection • Dyslipidemia • Epstein-Barr Virus Infections • Hematological Malignancies • Hepatology • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Leukemia • Lupus • Lymphoma • Non-Hodgkin’s Lymphoma • Pulmonary Disease • Rheumatology • Systemic Lupus Erythematosus • HP

Exploring the link between osteoporosis and stroke risk: An exploratory study based on 2017-2018 NHANES clinical data and bioinformatics analysis. (PubMed, PLoS One) - "There is a significant positive correlation between Osteoporosis and stroke risk. LILRA5, HNRNPL and AGBL3 could be key genes common to both diseases, and Cyclopenthiazide, Neostigmine bromide, and R-atenolol could be potential drugs for intervention."

Clinical data • Journal • Cardiovascular • Osteoporosis • Rheumatology