atenolol / Generic mfg. - LARVOL DELTA

Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Marshall University | Trial completion date: Dec 2024 ➔ Dec 2025 | Trial primary completion date: Apr 2024 ➔ Dec 2025

Trial completion date • Trial primary completion date • Cardiovascular • Hypertension

A Rare Cause of Hypergonadotropic Hypogonadism: H Syndrome (ESPE-ESE 2025) - "His current treatment includes methotrexate, tocilizumab, atenolol, hydrocortisone and tranexamic acid. Transitioning from paediatric to adult care poses additional challenges due to changing patient needs and a lack of literature on the condition. Early diagnosis is imperative to slow down disease progression and manage complications effectively."

Late-breaking abstract • Alopecia • Cardiomyopathy • Cardiovascular • Dermatology • Diabetes • Endocrine Disorders • Hematological Disorders • Hepatology • Hypertrophic Cardiomyopathy • Idiopathic Arthritis • Immunology • Metabolic Disorders • Nephrology • Otorhinolaryngology • Pediatrics • Rare Diseases • Renal Disease • Respiratory Diseases • Rheumatology • Sleep Apnea • Sleep Disorder • Type 1 Diabetes Mellitus

Elevated Risk of Life-Threatening Metabolic Acidosis with Combined Metformin and SGLT2 Inhibitor Therapy in the Elderly (ESPE-ESE 2025) - "Her home medications included Dapagliflozin 5 mg (started 6 months ago), Metformin XR 500 mg BID (started 8 years ago), Amlodipine, Atenolol, Hydrochlorothiazide, Olmesartan, and Rosuvastatin. Although it is often challenging to identify the exact cause of lactic acidosis, her clinical picture raised suspicion of metformin-induced lactic acidosis due to the initial failure to respond to fluid resuscitation and pressors, followed by improvement after CRRT, and a negative work-up for infection and other causes. 3There is a similar case presenting severe euglycemic ketoacidosis and lactic acidosis in a diabetic patient on chronic Dapagliflozin and Metformin therapy, which was triggered by poor oral intake and dehydration, ultimately requiring dialysis. Our case underscores the caution needed when using a combination of metformin and SGLT-2 inhibitors, especially in elderly T2D patients with decreased GFR."

Clinical • Alzheimer's Disease • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Dementia • Diabetes • Diabetic Nephropathy • Hypotension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Hypertension Secondary to Primary Hyperaldosteronism (ESPE-ESE 2025) - "Despite being on optimized doses of four antihypertensive drugs, including two diuretics (amlodipine 10 mg, losartan 100 mg, chlorthalidone 50 mg, hydralazine 100 mg, and spironolactone 300 mg), his blood pressure remained poorly controlled...Spironolactone was discontinued, and the patient maintained control with atenolol, losartan, and a reduced dose of amlodipine (5 mg)...Early diagnosis and appropriate treatment of primary hyperaldosteronism not only optimize blood pressure control but also correct electrolyte imbalances and significantly reduce long- term cardiovascular risks. A multidisciplinary approach remains essential for achieving the best outcomes."

Brain Cancer • Cardiovascular • Cervical Cancer • Endocrine Cancer • Endocrine Disorders • Hypertension • Obstructive Sleep Apnea • Oncology • Respiratory Diseases • Sleep Apnea • Sleep Disorder • Solid Tumor

Cardiac physiological changes induced by cardiovascular drugs from different chemical classes in zebrafish mirrored in mice: A predictive tool for comprehensive risk assessment. (PubMed, Indian J Pharmacol) - "Our findings highlight the zebrafish model's utility for early-phase cardiac risk assessment in drug discovery due to its high throughput capabilities and other beneficial features."

Journal • Preclinical • Cardiovascular

A Case of Beta Blocker and Calcium Blocker Overdose Managed With Veno-arterial Extracorporeal Circulation (ATS 2025) - "Case:A 40-year-old male presented to our hospital's emergency department after ingesting unknown quantities of metoprolol, diltiazem, and fluoxetine resulting in severe cardiogenic shock with bradycardia. The patient was treated with intravenous fluids, nor-epinephrine, epinephrine, dobutamine and placed on mechanical ventilation for supportive management of shock...CCB and more lipophilic BB such as propranolol are metabolized in the liver. The less lipophilic BB such as atenolol is excreted via the kidneys...This case adds to the limited literature on the use of VA ECMO as salvage therapy in severe cases of beta-blocker and calcium channel blocker overdose."

Clinical • Atrial Fibrillation • Cardiovascular • Fatigue • Hematological Disorders • Hypertension • Hypotension • Ischemic stroke • Metabolic Disorders • SLC51B

Acute and Persistent Cardiovascular Effects of Menthol E-Cigarettes in Mice. (PubMed, J Am Heart Assoc) - "Exposure to menthol e-cigarette aerosols induces persistent cardiovascular autonomic imbalance in vivo. These findings raise the possibility of similar effects in humans using mentholated e-cigarettes."

Journal • Preclinical • Cardiomyopathy • Cardiovascular

Rheological Insight into the 3D Printability of Carboxymethyl Cellulose-Based Hydrogels. (PubMed, Gels) - "This study presents a comprehensive rheological analysis of the yielding and recovery properties critical for ensuring the printability of carboxymethyl cellulose (CMC)-based hydrogels incorporating atenolol, an antihypertensive agent, as the active ingredient...Additionally, the analysis of the Sequence of Physical Processes (SPP) during each deformation cycle provided deeper insight into oscillatory yielding behavior, emphasizing the role of elastic strains in determining printability. Overall, the study offers valuable understanding of the nonlinear viscoelastic behavior of CMC-based hydrogels, providing a framework for optimizing hydrogel formulations in DIW applications."

Journal

From Hashimoto's Thyroiditis to Graves' Disease: Autoimmune Thyroid Disease, a Dynamic Spectrum (ENDO 2025) - "TSH was then found to be consistently suppressed, even with weaning levothyroxine completely off...The patient was started on Methimazole for the treatment of GD and Atenolol for symptomatic management which helped improve symptoms...The patient was seen by an Oculoplastic specialist who started the patient on Teprotumumab for the treatment of severe thyroid eye disease... Autoimmune thyroid disorder is a spectrum with its dynamic nature stemming from the delicate balance of different characteristic antibodies. This case is a cardinal reminder of this, and it documents the rare but possible phenomenon of transitioning from a diagnosis of HT to GD. Furthermore, it underscores the importance of the close monitoring of thyroid studies and antibody profiles in patients with an autoimmune thyroid disease."

Endocrine Disorders • Grave’s Disease • Immunology • Ophthalmology • Thyroid Eye Disease

An Unusual Case of Catecholamine-Secreting Carotid Body Paraganglioma (ENDO 2025) - "She was started on doxazosin 2 mg and atenolol 25 mg oral daily for symptom control. HNPGLs are rarely associated with catecholamine hypersecretion. The prevalence of clinically significant catecholamine secreting HNPGLs has been estimated to be 7.7%–9.2%. However, this patient has bilateral carotid body PGLs with distinct metabolic activity."

Clinical • CNS Tumor • Cough • Endocrine Cancer • Endocrine Disorders • Gastrointestinal Disorder • Metabolic Disorders • Musculoskeletal Pain • Neuroendocrine Tumor • Oncology • Otorhinolaryngology • Pain • Respiratory Diseases • Solid Tumor • SYP

Graves' Disease and Thyrotoxic Periodic Paralysis: A Case Series (ENDO 2025) - "Following development of hypothyroidism, he was placed on levothyroxine replacement, with no further recurrence of paralysis.Case 2: An 18 y.o. Caucasian male with a history of Graves' disease presented after multiple hospitalizations for hypokalemia and lower extremity weakness...He was restarted on methimazole as well as atenolol and advised on medical adherence... These cases highlight the under recognition of TPP in non-Asian populations in the United States, leading to delayed diagnosis and recurrent hospitalizations. Clinicians should maintain a high index of suspicion for TPP in young males with hypokalemia, and generalized weakness, particularly in the setting of undiagnosed or untreated hyperthyroidism. Prompt recognition and definitive treatment of hyperthyroidism is critical to preventing recurrent episodes and associated morbidity.*."

Clinical • Endocrine Disorders • Grave’s Disease • Myositis

Elevated Risk of Life Threatening Metabolic Acidosis with Combined Metformin and SGLT2 Inhibitor Therapy in the Elderly (ENDO 2025) - "Her home medications included Dapagliflozin 5 mg (started 6 months ago), Metformin XR 500 mg BID (started 8 years ago), Amlodipine, Atenolol, Hydrochlorothiazide, Olmesartan, and Rosuvastatin. Although it is often challenging to identify the exact cause of lactic acidosis, her clinical picture raised suspicion of metformin-induced lactic acidosis due to the initial failure to respond to fluid resuscitation and pressors, followed by improvement after CRRT, and a negative work-up for infection and other causes.There is a similar case presenting severe euglycemic ketoacidosis and lactic acidosis in a diabetic patient on chronic Dapagliflozin and Metformin therapy, which was triggered by poor oral intake and dehydration, ultimately requiring dialysis. Our case underscores the caution needed when using a combination of metformin and SGLT-2 inhibitors, especially in elderly T2D patients with decreased*. .*"

Clinical • Alzheimer's Disease • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Dementia • Diabetes • Diabetic Nephropathy • Hypotension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Sotalol: A new alternative in medically-resistant pediatric POTS (PAS 2025) - "Patient 1 is an 18-year-old female with POTS that was treated with atenolol and fludrocortisone until she contracted COVID-19...Patient 3 is a 17-year-old female with POTS treated with metoprolol, midodrine, and ivabradine... All 3 patients were started on sotalol twice per day. This treatment provided heart rate control in these patients after they became treatment-resistant to other therapies following a viral infection or some unknown etiology. Sotalol caused an average decrease in heart rate of 98.7 bpm, and a standing heart rate of 100 bpm or less for all 3 patients, with remission of their tachycardia symptoms."

Clinical • Cardiovascular • Epstein-Barr Virus Infections • Genetic Disorders • Hypotension • Infectious Disease • Novel Coronavirus Disease • Pediatrics

Factors influencing nurses' knowledge and competence in warfarin-drug and nutrient interactions and patient counseling practices. (PubMed, BMC Med Educ) - "The study highlights significant gaps in nurses' knowledge of warfarin interactions, particularly with certain drugs and foods, and underscores the need for targeted education and training. However, the study is limited by its reliance on self-reported data and a convenience sampling approach, which may impact generalizability. Strengthening nurses' understanding of warfarin management, especially regarding high-risk interactions, is essential for improving patient safety and the efficacy of anticoagulant therapy. Future initiatives should focus on structured educational programs, introducing interactive e-learning modules, regular workshops, and case-based training, as well as promoting multidisciplinary teamwork to enhance nurses' competency in warfarin counseling and patient care."

Journal • Cardiovascular • Gastrointestinal Disorder

ABBV-712-induced cardiac pathology in rats is related to off-target-driven acute vasodilation, tachycardia, and increased cardiac contractility. (PubMed, Toxicol Sci) - "Telemetry-instrumented rats were administered ABBV-712 with or without atenolol to investigate effects of co-dosing on hemodynamic parameters and cardiac pathology. These effects were unrelated to TYK2 inhibition. This report is an example of a cross-functional mechanistic investigation into the pharmacologic cause of an identified cardiovascular toxicity."

Journal • Preclinical • Cardiovascular • Myocardial Infarction • TYK2

Efficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials. (PubMed, Vascul Pharmacol) - "We found no evidence of benefit from β-blocker treatment for patients with TAA. More robust RCTs are needed to establish evidence-based recommendations."

Clinical data • Journal • Retrospective data • Cardiovascular • Genetic Disorders

A CASE REPORT OF SWALLOWING INDUCED ATRIAL TACHYCARDIA - Travis Hanson (ACC 2025) - "This 46-year-old male with palpitations, intermittent chest pain, and lightheadedness while swallowing was diagnosed with SIAT. The patient's symptoms have been well managed with metoprolol and diltiazem."

Case report • Clinical • Cardiovascular • Pain

Minimal Physiologically-Based Pharmacokinetic Modeling of Atenolol and Metoprolol Absorption in Malnourished Rats. (PubMed, Eur J Drug Metab Pharmacokinet) - "This study demonstrated advantageous use of mPBPK modeling with malnutrition primarily altering drug absorption in this animal model. Also, our analysis offers a blend of known and assumed components assembled mechanistically to suggest a reasonable interpretation of the PK profiles."

Journal • PK/PD data • Preclinical

INTEGRATIVE FRAMEWORK FOR ALZHEIMER'S DISEASE DRUG REPURPOSING: GENETIC SUBTYPES, COGNITIVE EFFECTS, AND UNSUPERVISED LEARNING (ADPD 2025) - "Oli -M45 subtype had highest significance (8.49) and mean similarity score (0.96), featuring Vinblastine formulations targeting TUBA1A/B...Amitriptyline, Fluoxetine, Glucosamine, and Atenolol showed differing responses by risk group within subtypes. This study introduces an innovative approach to AD drug repurposing leveraging unsupervised learning algorithms, enabling precision medicine and subtype -driven strategies. Moreover, the observed differential medication responses across brain cell -type driv en subtypes highlight the potential of genetic subtype -driven treatme nt strategies in advancing personalized therapies for AD."

Alzheimer's Disease • CNS Disorders • TUBA1A

Association between beta-1-adrenoceptor blockade and risk of Raynaud's phenomenon: Mendelian randomisation study. (PubMed, J Scleroderma Relat Disord) - "The effect of beta-1-adrenoceptor blockers (e.g. bisoprolol, atenolol) on Raynaud's phenomenon remains unclear. We found no genetic evidence to support a causal association between beta-1-adrenoceptor blockade and Raynaud's phenomenon risk in either direction. Randomised controlled trials are required to confirm the safety of beta-1-adrenoceptor blockers in people with Raynaud's phenomenon."

Journal • Cardiovascular • Immunology • Rheumatology • Scleroderma • Systemic Sclerosis

The Interplay Between Hypocalcemia and Atrioventricular Nodal Blocking Agents in Inducing a Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH)-Like Phenomenon With Serial Serum Drug Concentrations. (PubMed, Cureus) - "Serum drug concentrations on admission revealed therapeutic levels of atenolol and supratherapeutic levels of amlodipine and telmisartan, despite no overdose. Given the increasing use of these medications, awareness of BRASH-like phenomena driven by electrolyte disturbances is essential. Further studies are needed to clarify the mechanisms and optimal management strategies for these conditions."

Journal • Acute Kidney Injury • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Diabetes • Endocrine Disorders • Hypertension • Hypotension • Metabolic Disorders • Nephrology • Renal Disease

The Effectiveness of Liquid-Phase Microextraction of Beta-Blockers from Aqueous Matrices for Their Analysis by Chromatographic Techniques. (PubMed, Molecules) - "The aim of this research is to test the effectiveness of two green liquid-phase microextraction procedures, such as dispersive liquid-liquid microextraction (DLLME) and solidification of floating organic droplet microextraction (SFOME) for the selective extraction of eight beta-blockers (atenolol, nadolol, pindolol, acebutolol, metoprolol, bisoprolol, propranolol, and betaxolol) from aqueous matrices for their analysis by gas chromatography (GC) or liquid chromatography (LC). Good limits of detection (0.13 to 0.69 µg/mL for GC and 0.07 to 0.15 µg/mL for HPLC) and limits of quantification (0.39 to 2.10 µg/mL for GC and 0.20 to 0.45 µg/mL for LC) were obtained. The developed procedures were successfully applied to the analysis of selected beta-blockers in wastewater samples, proving their applicability to the real samples."

Journal • Cardiovascular • Hypertension

Toward a personalized chronotherapy of blood pressure. (PubMed, Biomed J) - "Personalized optimization of treatment timing to best match a healthy circadian BP pattern is recommended, guided by chronobiological analyses of ABPM data collected over several days in view of the large day-to-day variability in all features of the 24-hour BP rhythm."

Journal

Unveiling transformation processes of cardiovascular pharmaceuticals in wastewater based on nontarget screening. (PubMed, Water Res) - "To fill this knowledge gap, nontarget screening combined with batch experiments were employed to reveal the transformation of five cardiovascular pharmaceuticals (atenolol, metoprolol, propranolol, bezafibrate and candesartan) in aerobic activated sludge. Furthermore, the predicted results suggested that about 30 % TPs have higher persistence and bioaccumulation than parent compounds while about 40 % TPs harbored higher toxicity than parent compounds of cardiovascular pharmaceuticals. Collectively, this study unveiled the fate and transformation pathways of five cardiovascular pharmaceuticals and summarized the specific transformation patterns for them in aerobic activated sludge, which is theoretically useful to effectively remove pharmaceuticals from wastewater."

Journal • Cardiovascular

Psoriasiform rash possibly induced by oral propranolol in a 12-month-old girl with infantile hemangioma: a case report and literature review. (PubMed, Dermatol Reports) - "Infantile hemangiomas are the most common soft-tissue tumors in children, with propranolol, a non-cardioselective β-blocker, considered the first-line treatment for complicated cases. The patient was switched to atenolol, which resulted in improvement of the hemangioma and complete resolution of the skin lesions. This case highlights the rare but significant risk of psoriasiform eruptions associated with β-blocker therapy in infants, emphasizing the need for careful recognition and monitoring of this potential adverse effect in pediatric patients treated for infantile hemangiomas."

Journal • Dermatology • Immunology • Oncology • Pediatrics • Psoriasis