atenolol / Generic mfg. - LARVOL DELTA

Thyroiditis After Botox Injection to the Neck: A Case of Thyrotoxicosis Triggered by Aesthetic Treatment (ENDO 2025) - "She was prescribed NSAIDs and atenolol, and started on a 5-week tapering course of prednisone, leading to resolution of symptoms and normalization of thyroid tests. Subacute thyroiditis can be due to radiation, trauma, or infections; this case describes a rare instance of subacute thyroiditis following Botox injection into the platysmal bands...found that eyelid injections of Botox on a Hashimoto patient caused persistent TSH elevation despite adequate levothyroxine therapy, likely due to anti-Botox antibodies inducing anti-TSH-R antibodies inhibiting TSH-R signaling... Botox injections to the cervical area used for both aesthetic and medical purposes are generally considered benign, however, can rarely trigger a severe thyroiditis reaction. Patients should be informed of said risk and monitor for possible symptoms of thyrotoxicosis. Early recognition of subacute thyroiditis allows for prompt diagnosis and appropriate management."

Clinical • Aesthetic Medicine • Endocrine Disorders • Immunology • Infectious Disease • Inflammation • Mood Disorders • Movement Disorders • Solid Tumor

From Hashimoto's Thyroiditis to Graves' Disease: Autoimmune Thyroid Disease, a Dynamic Spectrum (ENDO 2025) - "After the initial diagnosis of hypothyroidism, the patient remained on levothyroxine for around 8 years...The patient was started on Methimazole for the treatment of GD and Atenolol for symptomatic management which helped improve symptoms...The patient was seen by an Oculoplastic specialist who started the patient on Teprotumumab for the treatment of severe thyroid eye disease... Autoimmune thyroid disorder is a spectrum with its dynamic nature stemming from the delicate balance of different characteristic antibodies. This case is a cardinal reminder of this, and it documents the rare but possible phenomenon of transitioning from a diagnosis of HT to GD. Furthermore, it underscores the importance of the close monitoring of thyroid studies and antibody profiles in patients with an autoimmune thyroid disease."

Endocrine Disorders • Grave’s Disease • Immunology • Ophthalmology • Thyroid Eye Disease

An Unusual Case of Catecholamine-Secreting Carotid Body Paraganglioma (ENDO 2025) - "She was started on doxazosin 2 mg and atenolol 25 mg oral daily for symptom control. HNPGLs are rarely associated with catecholamine hypersecretion. The prevalence of clinically significant catecholamine secreting HNPGLs has been estimated to be 7.7%-9.2%. However, this patient has bilateral carotid body PGLs with distinct metabolic activity."

Clinical • Cough • Endocrine Cancer • Endocrine Disorders • Gastrointestinal Disorder • Metabolic Disorders • Musculoskeletal Pain • Neuroendocrine Tumor • Oncology • Otorhinolaryngology • Pain • Respiratory Diseases • Solid Tumor • SYP

Elevated Risk of Life Threatening Metabolic Acidosis with Combined Metformin and SGLT2 Inhibitor Therapy in the Elderly (ENDO 2025) - "Her home medications included Dapagliflozin 5 mg (started 6 months ago), Metformin XR 500 mg BID (started 8 years ago), Amlodipine, Atenolol, Hydrochlorothiazide, Olmesartan, and Rosuvastatin. Although it is often challenging to identify the exact cause of lactic acidosis, her clinical picture raised suspicion of metformin-induced lactic acidosis due to the initial failure to respond to fluid resuscitation and pressors, followed by improvement after CRRT, and a negative work-up for infection and other causes.There is a similar case presenting severe euglycemic ketoacidosis and lactic acidosis in a diabetic patient on chronic Dapagliflozin and Metformin therapy, which was triggered by poor oral intake and dehydration, ultimately requiring dialysis. Our case underscores the caution needed when using a combination of metformin and SGLT-2 inhibitors, especially in elderly T2D patients with decreased"

Clinical • Alzheimer's Disease • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Dementia • Diabetes • Diabetic Nephropathy • Hypotension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Graves' Disease and Thyrotoxic Periodic Paralysis: A Case Series (ENDO 2025) - "Following development of hypothyroidism, he was placed on levothyroxine replacement, with no further recurrence of paralysis.Case 2: An 18 y.o. Caucasian male with a history of Graves' disease presented after multiple hospitalizations for hypokalemia and lower extremity weakness...He was restarted on methimazole as well as atenolol and advised on medical adherence... These cases highlight the under recognition of TPP in non-Asian populations in the United States, leading to delayed diagnosis and recurrent hospitalizations. Clinicians should maintain a high index of suspicion for TPP in young males with hypokalemia, and generalized weakness, particularly in the setting of undiagnosed or untreated hyperthyroidism. Prompt recognition and definitive treatment of hyperthyroidism is critical to preventing recurrent episodes and associated morbidity."

Clinical • Endocrine Disorders • Grave’s Disease • Myositis

Paradigm Shift in the Management of Infantile Hemangiomas in the Beta-blocker Era: A Retrospective Cohort Study. (PubMed, J Am Acad Dermatol) - "At tertiary centers, treatment was initiated in a majority of patients. This represents an important shift in the management practices of IH, moving away from the traditional hands-off approach prior to the emergence of beta blockers for IH."

Journal • Retrospective data • Oncology • Pediatrics

In brief: Low-dose chlorthalidone (HemiClor) for hypertension. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Cardiovascular • Hypertension

Quantifying cross-linking strength in sodium starch glycolate and its impact on tablet disintegration and dissolution. (PubMed, Eur J Pharm Biopharm) - "The tablet disintegration and API dissolution of these SSG grades were evaluated for a wet granulation formulation with atenolol...The findings of this study show that understanding the type of cross-link and the SXL of SSG can support formulators with the development of good, robust formulations, in line with a quality-by-design approach. The provided case study shows that formulators can make their formulations more robust to stress exposure before, during or after tablet manufacturing by using an SSG grade with phosphorous cross-links, thereby limiting the risk of product failure."

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3D-Printed Boron-Nitrogen Doped Carbon Electrodes for Sustainable Wastewater Treatment via MPECVD. (PubMed, Nanomicro Lett) - "Electrochemical characterization demonstrated that the optimized electrodes performed significantly better, achieving 4.7-, 4-, and 6.5-fold increases in the degradation rates of atenolol, metoprolol, and propranolol, respectively, during electrochemical oxidation. These results highlight the efficacy of the integrated fabrication and simulation approach in producing high-performance electrodes for sustainable wastewater treatment applications."

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Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids. (PubMed, Transl Psychiatry) - "Notably, one of the genes in identified loci (RRP1B) was found to be a target of the approved drug Atenolol suggesting potential for drug repurposing. Overall, our findings suggest that taking interaction between genetic variants and psychosocial factors into account and including genetically diverse populations can lead to novel discoveries for serum lipids."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Exploring the relationship between atenolol use and depression: A network pharmacology approach using NHANES data. (PubMed, J Affect Disord) - "Our findings indicate a positive correlation between atenolol use and depression, particularly among individuals in the middle-aged demographic. It is important to monitor the mental health of patients when prescribing atenolol."

Journal • Cardiovascular • CNS Disorders • Depression • Mood Disorders • Psychiatry • ADRB2 • DRD2 • SLC6A3

Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2. (PubMed, J Med Chem) - "High-affinity substrates included berberine, pentamidine, and amisulpride, while epinephrine and atenolol had the highest Vmax. However, machine learning classifiers using 15 parameters allowed 69 to 87% correct prediction. The large number of substrates indicates a possibly broad role of multidrug and toxin extrusion (MATE) transporters in pharmacokinetics and drug interactions."

Journal • SLC22A1

Atenolol, alone or in combination with PTH, has a modest effect on bone in female C57BL/6J mice. (PubMed, JBMR Plus) - "However, propranolol, a non-selective β-blocker, has been widely used in rodent models. In summary, we found little effect of atenolol alone or in combination with PTH, which may be related to relative selectivity of atenolol for β1AR over β2AR, the predominant βAR in bone. Future studies should test whether longer term atenolol may improve microarchitectural parameters with PTH co-treatment."

Journal • Preclinical • Osteoporosis • Rheumatology

Myocarditis in Cats with Feline Infectious Peritonitis Can Be Cured with GS-441524 and Symptomatic Cardiovascular Treatment. (PubMed, Animals (Basel)) - "Myocarditis can be a clinical feature of FIP and present with different cardiologic manifestations. FIP-induced myocarditis can be cured with GS-441524 in combination with symptomatic cardiovascular treatment including pimobendan, clopidogrel, furosemide, or atenolol, depending on the clinical presentation."

Journal • Cardiovascular • Infectious Disease • Inflammation • Novel Coronavirus Disease • TNNI3

Immobilized lipase in the resolution of racemic atenolol - a possible key to sustainable pharmaceuticals synthesis. (PubMed, Int J Biol Macromol) - "What is more, it was established that a higher enzyme loading resulted in greater catalytic activity, providing over 30 % higher performance after 10 reusability cycles. High enzymatic activity and enantioselectivity demonstrated by the produced system was proved in dynamic kinetic resolution of atenolol reaching over 55 % reaction yield, that was over 40 % higher as free counterpart, and attaining 100 % enantiomeric excess for the final (S)-atenolol ester."

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Advanced electrochemical detection and profiling of the antihypertensive drug atenolol via a SPION-activated carbon nanocomposite interface. (PubMed, Nanoscale Adv) - "With a low detection limit (LOD) of 0.401 μM, the sensor offers precise quantification of ATN, making it a promising tool for improving patient care. High selectivity, reproducibility, and excellent recovery in complex pharmaceutical matrices further highlight the potential of this sensor for biomedical and clinical applications."

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Non-operation room anesthesia during polypectomy in colonoscopy for a patient with pattern of Wolff-Parkinson White (Euroanaesthesia 2025) - "He was treated in that period with atenolol 50mg x 2 and denied ablation...We used dexmedetomidine 3 mcg/kg + ketamine 2 mg/kg i/v for NORA. Adenosine, procainamide, and amiodarone were kept on standby...Our case aims to highlight that proper medical knowledge combined with appropriate precautions can avoid sympathetic stimulation. They are the key to a successful outcome in patients with WPW syndrome undergoing sedation during colonoscopy."

Clinical • Aesthetic Medicine • Anesthesia • Cardiovascular • CNS Disorders • Movement Disorders

Anesthetic management of pheochromocytoma surgery. Case series (Euroanaesthesia 2025) - "PM: doxazosin, nifedipine, propranolol...PM: doxazosin, atenolol, nifedipine...PM: doxazosin, nifedipine, bisoprolol...Arterial hypotension occurred in all patients but was rapidly resolved with fluid therapy comprising objective infusion rates and intermittent boluses of phenylephrine. No patients required vasopressor infusion. Clevidipine is an intravenous calcium antagonist with rapid onset and a short half-life, which could be an optimal antihypertensive agent in the treatment of pheocromocytoma1​.​​​"

Clinical • Surgery • Anesthesia • Cardiovascular • Dermatology • Endocrine Cancer • Genetic Disorders • Hypertension • Hypotension • Movement Disorders • Neurofibromatosis • Oncology • Pain • Solid Tumor

Performance evaluation of ceramic and polymeric membrane application in hybrid system (membranes + O3/UV) for pharmaceutical and personal care products (PPCPs) removal from hospital wastewater. (PubMed, J Hazard Mater) - "The order of degradation rate is carbamazepine > trimethoprim > atenolol > acetaminophen > sulfamethoxazole > caffeine. Analysis of degradation pathways and toxicity suggests that transformation products formed during membrane + O3/UV hybridized process are environmentally benign and do not pose significant health risks."

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Clinical factors and prognostic outcomes of hyperthyroidism induced by immune checkpoint inhibitor therapy. (ASCO 2025) - "Inclusion criteria encompassed patients aged 18 years or older treated with ICIs (e.g., pembrolizumab, nivolumab, atezolizumab, cemiplimab) between January 1, 2013, and December 31, 2024. Patients with a history of thyroid disorders or Levothyroxine use were excluded...In patients with hyperthyroidism, 31.3% initiated metoprolol, 9.5% initiated propranolol, and 6.0% initiated atenolol for symptom management...Among all ICIs, atezolizumab (OR: 1.32; 95% CI: 0.82–2.13; p = 0.25) showed the strongest trend toward hyperthyroidism, followed by durvalumab (OR: 1.24; 95% CI: 0.75–2.05; p = 0.39), pembrolizumab (OR: 1.23; 95% CI: 0.81–1.87; p = 0.34), and nivolumab (OR: 1.22; 95% CI: 0.80–1.86; p = 0.37)... ICI-induced hyperthyroidism, while less common, has a significant impact on patient outcomes, including mortality. Identifying high-risk cancer subtypes and implementing proactive management, including beta-blocker therapy for symptom control, are critical steps to mitigate..."

Checkpoint inhibition • Clinical • Colon Cancer • Colorectal Cancer • Endocrine Disorders • Endometrial Cancer • Genito-urinary Cancer • Hematological Malignancies • Kidney Cancer • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • Renal Cell Carcinoma • Solid Tumor

Identification of potentially effective drugs for metabolic dysfunction-associated steatotic liver disease against liver cirrhosis: In-silico drug repositioning-based retrospective cohort study. (PubMed, PLoS One) - "This study is limited to drugs registered in the Korean NHIS, potentially excluding other relevant candidates. Additionally, the absence of dietary and genetic data in the NHIS database may introduce residual confounding. Lastly, as the study population consists solely of Korean adults, the findings may not be generalizable to other populations."

Journal • Retrospective data • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease

Ivabradine and atenolol overdose managed with renal replacement therapy: A case report. (PubMed, Am J Emerg Med) - "Toxicity was successfully managed with supportive care including atropine boluses and an epinephrine infusion. Renal replacement therapy (RRT) was employed to enhance atenolol elimination, yet serial drug levels revealed a significant reduction in ivabradine concentrations without a corresponding effect on atenolol levels. This case suggests a potential role for RRT in severe ivabradine poisoning and underscores the need for further research into optimal management strategies."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypotension

Bridging in vitro and clinical data: Experimental insights into the IC50 variability of dolutegravir as an organic cation transporter 2 inhibitor. (PubMed, Drug Metab Dispos) - "Similar uptake time dependency was observed with other inhibitors (cimetidine and pyrimethamine). However, the extent of variability differed among metformin, N1-methylnicotinamide, atenolol, frovatriptan, and sumatriptan, likely reflecting differences in cellular kinetics...DDI predictions using in vitro IC50 values suggested repeated dolutegravir administration could raise the area under the curve of OCT substrates, such as atenolol, nadolol, and sulpiride beyond regulatory thresholds...SIGNIFICANCE STATEMENT: This study identified experimental conditions affecting the IC50 variability of dolutegravir as an organic cation transporter 2 inhibitor. These findings offer valuable insights for improving in vitro to in vivo drug-drug interaction predictions and optimizing inhibition experiments for transporter-mediated drug-drug interactions."

Clinical data • Journal • Preclinical • SLC22A2

Integrative Approaches in the Management of Hypertrophic Cardiomyopathy: A Comprehensive Review of Current Therapeutic Modalities. (PubMed, Biomedicines) - "Beta-blockers, including atenolol and nadolol, are considered the first-line treatment due to their ability to reduce heart rate and myocardial contractility and enhance diastolic filling. Non-dihydropyridine calcium channel blockers, such as verapamil and diltiazem, are utilized as second-line agents when beta-blockers are ineffective or contraindicated...Recent advancements in cardiac myosin modulators, such as Mavacamten and Aficamten, offer targeted therapies by modulating myosin-actin interactions to reduce LVOT gradients and improve symptoms, with promising results from clinical trials...Ultimately, the treatment and prevention of atrial fibrillation and sudden cardiac death are two key points of HCM management in both obstructive and non-obstructive forms. This review aims to provide an overview of current pharmacological and invasive strategies, as well as emerging therapies, in the management of HCM."

Journal • Review • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Gene Therapies • Hypertrophic Cardiomyopathy

Enhanced Removal of Common Wastewater-Derived Trace Organic Contaminants in Vertical-Flow Constructed Wetlands Amended with Fe(III)-EDTA. (PubMed, ACS Environ Au) - "Our results indicate that Fe-EDTA contributed to the degradation of carbamazepine and sulfamethoxazole under the studied flow regimes. The more readily degradable compounds atenolol and trimethoprim were removed with >97% efficiency in both control and amended columns, regardless of flow. This column study positively correlates Fe-EDTA with improved removal efficiencies of environmentally recalcitrant TrOCs without affecting readily degradable TrOCs."

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