AT 008 / Affitech, Generium - LARVOL DELTA

Genome-wide identification and functional characterization of natural antisense transcripts in Salvia miltiorrhiza. (PubMed, Sci Rep) - "And we found two miRNAs including miR156a and miR7208, might originate from NATs, NAT0112 and NAT0086. The results suggest that S. miltiorrhiza NATs might interact with STs, produce miRNAs, and be regulated by miRNAs. They potentially play significant regulatory roles in the biosynthesis of bioactive compounds."

Journal

The effects of NONRATT008453.2 on autophagy in genital tubercle fibroblasts of rats with hypospadias induced by dibutyl phthalate. (PubMed, Birth Defects Res) - "NONRATT008453.2 may have an influence on autophagy in the fibroblasts of the GT in DBP-induced hypospadiac rats."

Journal

Systematic Analysis of tRNA-Derived Small RNAs Discloses New Therapeutic Targets of Caloric Restriction in Myocardial Ischemic Rats. (PubMed, Front Cell Dev Biol) - "Furthermore, 55 tsRNAs were significantly regulated by CR pretreatment, among which five tsRNAs (tiRNA-His-GTG-004, tRF-Gly-TCC-018, tRF-Cys-GCA-022, tRF-Lys-CTT-026, tRF-Met-CAT-008) were randomly selected and verified by quantitative real-time polymerase chain reaction...In conclusion, our findings reveal that tsRNAs are potential therapeutic targets for CR pre-pretreatment to improve myocardial ischemic injury. This study provides new ideas for future research on elucidating the mechanisms of CR pretreatment in ameliorating myocardial ischemic injury."

Journal • Cardiovascular • Myocardial Ischemia • PCR

"Socio economic impact #Covid_19 @DrHarish139 @swarup58 @MinistryWCD @akshaykumar @hardikpandya7 @anandmahindra @gopalkagarwal @hvgoenka @hcmariwala @Dev_Fadnavis @ameyaprabhu @CharuPragya @TajinderBagga @bhargava_tarun @iffcoyogendra @ShelarAshish @udaykotak @BharatJ00889948" (@SocialTablez)

HEOR • Infectious Disease • Novel Coronavirus Disease

"#NationalInstituteOfIndustrialProperty (Instituto Nacional da Propriedade Industrial: INPI) Approves Substance Patent for #AskAt’s #EP4Antagonist (#AAT008) In Brazil https://t.co/sQbrFONdjq" (@1stOncology)

A facile polymerisation of magnetic coal to enhanced phosphate removal from solution. (PubMed, J Environ Manage) - "The FTIR spectrum showed successful adsorption of phosphate due to the formation of incipient peak at1008 cm. The Langmuir adsorption capacity of MUC-PANI is 147.1 mg PO/g at 25 °C and pH 5.0 (initial concentration 10-200 mg/L, dose 0.8 g/L). MUC-PANI is a cost-efficient compound for removal of phosphate because it is made from readily available coal."

Journal

Identification of a new Pyruvate kinase M2 isoform (PKM2) activator for the treatment of non-small cell lung cancer (NSCLC). (PubMed, Chem Biol Drug Des) - "Our results suggest that 0089-0022 activates PKM2 and thus is a promising anti-cancer therapeutic candidate in NSCLC."

Journal

Bioavailability and Metabolism of Raspberry Ketone with Potential Implications for Obesity Prevention (OR34-05-19). (PubMed, Curr Dev Nutr) - "Our findings are critical for elucidating the sites and mechanisms of action of RK for long-term management of diet-induced obesity. This work was supported by the NIH R01AT008933."

Journal

Population Duration of Breastfeeding and Prevalence of Bifidobacterium Longum Subspecies Infantis (OR01-01-19). (PubMed, Curr Dev Nutr) - "More studies are needed, particularly to determine whether species of Bifidobacterium other than B. infantis are sensitive to breastfeeding duration, and to understand the impact of different types of Bifidobacterium on infant health. NIH awards F32HD093185 (DHT), AT007079 (DAM), and AT008759 (DAM)."

Clinical • Journal

The Anti-obesity Effects of Direct Delivery of Resveratrol-encapsulated Liposomes to Inguinal White Adipose Tissue in Male APOE3Leiden.CETP Transgenic Mice (P21-006-19). (PubMed, Curr Dev Nutr) - "Nanoencapsulation increased R's solubility and enhanced its anti-obesity efficacy. NIH/NCCIH (Grant R15AT008733)."

Journal • Preclinical

Body Composition Changes in Female APOE3Leiden.CETP Transgenic Mice After 5-week Injection of Resveratrol-encapsulated Liposomes to Inguinal White Adipose Tissue (P21-041-19). (PubMed, Curr Dev Nutr) - "However longer treatment time might be necessary to see more prominent results. NIH/NCCIH (Grant R15AT008733)."

Journal • Preclinical

Eicosapentaenoic Acid Regulates Brown Adipose Tissue Function, Independently of UCP1 (FS11-01-19). (PubMed, Curr Dev Nutr) - "Additional studies are required to determine fuel or mitochondrial mechanisms by which energy expenditure is increased independently of UCP1. NIH/NCCIH grant # R15AT008879-01A1."

Journal

Transdermal Delivery of Nanoparticles Using Microneedles and Iontophoresis (P13-001-19). (PubMed, Curr Dev Nutr) - "We envision that combination of MN and iontophoresis could offer a clinical superiority over traditional, invasive injections for combating diseases and disorders. NIH (Grant R15AT008733)."

Journal

Microbiota Facilitates the Formation of the Aminated Metabolite of Tea Polyphenols Which Trap Deleterious Reactive Endogenous Metabolites (P06-022-19). (PubMed, Curr Dev Nutr) - "This finding opens a new window to understand the underlying mechanisms by which drinking tea could prevent the development of chronic diseases. We gratefully acknowledge financial support from NIH R01 grant AT008623 to this work."

Journal

"Definitely raising the bar for research presentations, highly recommend @AndrewMIbrahim ‘s #visualabstract @lat008_ @cabanam" (@JaymeCongdonMD)