AER-271 / Aeromics, Simcere - LARVOL DELTA

Neuroprotective Effects of AER-271 in a tMCAO Mouse Model: Modulation of Autophagy, Apoptosis, and Inflammation. (PubMed, Inflammation) - "Finally, a comparative assessment of the effects of AER-271 and TGN-020 in mitigating apoptosis and microglial polarization in ischemic mice revealed neuroprotective effects with no significant difference in efficacy. This study provides essential insights into the neuroprotective mechanisms of AER-271 in cerebral ischemia-reperfusion injury, offering potential clinical applications in the treatment of ischemic cerebrovascular disorders."

Journal • Preclinical • Cardiovascular • CNS Disorders • Inflammation • Ischemic stroke • Reperfusion Injury • Vascular Neurology • AQP4 • NLRP3

Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271. (PubMed, Glia) - "Importantly, AER-271 did not affect AQP4 localization to the astrocytic endfeet, nor have any effect in AQP4 deficient mice. Since acute pharmacological inhibition of AQP4 directly decreased glymphatic flow in wild-type but not in AQP4 deficient mice, we foresee AER-271 as a new tool for manipulation of the glymphatic system in rodent brain."

Journal • CNS Disorders • AQP4

The Tolerability, Safety, and PK Characteristics of SIM1910-09 in Healthy Chinese Volunteers (clinicaltrials.gov) - P1 | N=68 | Completed | Sponsor: Jiangsu Simcere Pharmaceutical Co., Ltd. | Recruiting ➔ Completed

Trial completion • Cardiovascular • Ischemic stroke • IL6 • TNFA

Aquaporins: important players in the cardiovascular pathophysiology. (PubMed, Pharmacol Res) - "AQPs are differentially expressed in different cardiovascular tissues and participate in water transmembrane transport, cell migration, metabolism, inflammatory response, etc. The aberrant expression of AQPs highly correlates with the onset of ischemic heart disease, myocardial ischemia-reperfusion injury, heart failure, etc. Despite much attention to the regulatory role of AQPs in the cardiovascular system, the translation of AQPs into clinical application still faces many challenges, including clarification of the localization of AQPs in the cardiovascular system and mechanisms mediating cardiovascular pathophysiology, as well as the development of cardiovascular-specific AQPs modulators.Therefore, in this study, we comprehensively reviewed the critical roles of AQP family proteins in maintaining cardiovascular homeostasis and described the underlying mechanisms by which AQPs mediated the outcomes of cardiovascular diseases. Meanwhile, AQPs serve as important..."

Journal • Review • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Inflammation • Myocardial Ischemia • Reperfusion Injury