AR28 / Azurity Pharma - LARVOL DELTA

Bone-Targeted Nanoparticle Drug Delivery System-Mediated Macrophage Modulation for Enhanced Fracture Healing. (PubMed, Small) - "The delivery of AR28, a glycogen synthase kinase-3 beta (GSK3β) inhibitor, via the TRAP binding peptide-NP (TBP-NP) expedites fracture healing...Longitudinal analysis of TBP-NP -mediated fracture healing reveals distinct spatial distributions of M2 macrophages, an increased M2/M1 ratio, and upregulation of anti-inflammatory and downregulated pro-inflammatory genes compared to controls. This work demonstrates the underlying therapeutic mechanism of bone-targeted NP DDS, which leverages macrophages as druggable targets and modulates M2 macrophage polarization to enhance fracture healing, highlighting the therapeutic benefit of this approach for fractures and bone-associated diseases."

Journal • Immunology • Musculoskeletal Diseases • Orthopedics • TRAP

Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study. (PubMed, Arthritis Res Ther) - "This study has demonstrated gout to be a risk factor for incident CKD stage ≥ 3. Further research examining the mechanisms by which gout may increase risk of CKD and whether optimal use of ULT can reduce the risk or progression of CKD in gout is suggested."

Clinical • Journal

Neoadjuvant treatment in a Mexican cohort of patients with locally advanced rectal cancer: Oncologic outcomes and prognostic factors. (ASCO-GI 2019) - "...Surgery: ultra-low anterior resection (AR) 48%, low AR 28% and abdominoperineal resection 24%... In pts with LARC the TNT is associated with high rates of pCR and favorable oncological outcomes. pCR and residual nodal disease after neoadjuvant therapy were strongly associated with recurrence and survival."

Biomarker • Clinical

Neoadjuvant treatment in a Mexican cohort of patients with locally advanced rectal cancer: Oncologic outcomes and prognostic factors. (ASCO-GI 2019) - "...Surgery: ultra-low anterior resection (AR) 48%, low AR 28% and abdominoperineal resection 24%... In pts with LARC the TNT is associated with high rates of pCR and favorable oncological outcomes. pCR and residual nodal disease after neoadjuvant therapy were strongly associated with recurrence and survival."

Biomarker • Clinical