azithromycin / Generic mfg. - LARVOL DELTA

Streamlining antibiotic use in community acquired pneumonia: A quality improvement initiative. (PubMed, J Hosp Med) - "An order set backed by stewardship and hospitalists improves appropriate antibiotic use, showing that ongoing data-driven refinements can sustain stewardship and support the safety of shorter, narrower antibiotics for CAP in real-world care."

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

EVALUATION OF BRONCHOPULMONARY DYSPLASIA GUIDELINE ADHERENCE (WRMC 2026) - "The BPD bundle included: antenatal steroid exposure, surfactant administration according to criteria, maintenance of functional residual capacity (FRC) with CPAP until 32 weeks' postmenstrual age (PMA), limiting early postnatal steroids, avoiding inhaled steroids before 34 weeks' PMA, and no azithromycin... Evaluation of the implementation of a standardized BPD bundle revealed variable adherence improvements in FRC and inhaled steroid avoidance but persistent gaps in steroid practices. The observed increase in mortality post-bundle likely reflects confounding factors, illness severity, or incomplete implementation rather than a causal effect of the bundle itself. Systemwide process improvement is complex, low adherence in this cohort limited outcome conclusions."

Adherence • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases

FULMINANT RHABDOMYOLYSIS IN THE SETTING OF MYCOPLASMA PNEUMONIAE INFECTION IN AN IMMUNOCOMPETENT YOUNG ADULT: A CASE REPORT (WRMC 2026) - "The PCR panel returned positive for Mycoplasma pneumoniae, and he was promptly started on a three-day course of azithromycin...The patient was discharged in stable condition with plans for outpatient follow-up. Autoimmune genetic workup later revealed a heterozygous missense c.868C>T (p.Arg290Cys) mutation in the DYSFgene, which had not been previously described in the literature."

Case report • Clinical • Cardiovascular • Cough • Immunology • Infectious Disease • Mood Disorders • Musculoskeletal Pain • Myositis • Otorhinolaryngology • Pneumonia • Renal Disease • Respiratory Diseases

Sonographic Evaluation of an Inguinal Bubo from Bartonella henselae: A Case Report. (PubMed, Clin Pract Cases Emerg Med) - "As POCUS becomes the modality of choice for rapid assessment of soft tissue masses in the ED, familiarity with less common variants of soft tissue infections such as buboes can help with medical decision-making, risk stratification, and further workup. This sonographic description of a bubo caused by a common zoonotic infection will enable clinicians to familiarize themselves with their appearance."

Journal • Infectious Disease • Oncology

Impact of azithromycin treatment during early-life severe RSV bronchiolitis on airway and gut microbiomes and subsequent recurrent wheezing (AAAAI 2026) - P2/3 | "Mediation analysis revealed that gut Bifidobacterium reduction mediated the increased risk of post-RSV RW after antibiotic treatment (p<0.05). In an OVA-induced murine asthma model, whole fecal microbiota transplantation or supplementation of Bifidobacterium species derived from placebo-treated infants attenuated airway Conclusions Our findings provide mechanistic insights linking early antibiotic exposure, gut dysbiosis, and childhood respiratory outcomes, and suggest potential gut microbiome-targeted strategies to prevent childhood asthma after early-life RSV and antibiotic exposures."

Asthma • Immunology • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections

Asthma as an Immune Network Disorder: Observational Evidence for Non-Th2 Therapeutic Targets (AAAAI 2026) - "JAK inhibitors and G-CSF stimulators showed no Conclusions Calcineurin inhibitors demonstrate a consistent protective effect against asthma exacerbations while colchicine, TNF-ɑ inhibitors, azithromycin, and methotrexate showed encouraging signals that may only affect select phenotypes. These findings suggest that immunomodulation outside the canonical Th2 pathway may influence asthma outcomes."

Asthma • Immunology • Respiratory Diseases

Human Herpesvirus 6 (HHV-6)-Associated Longitudinally Extensive Transverse Myelitis Preceded by Mycoplasma pneumoniae Infection in an Immunocompetent Adult: A Report of a Unique Case. (PubMed, Cureus) - "High-dose intravenous corticosteroids, azithromycin, and intravenous ganciclovir were administered, leading to successful treatment with notable neurological improvement and the ability to walk with assistance at discharge. This case highlights the diagnostic challenges of HHV-6, an emerging pathogen that can cause serious CNS complications such as LETM in immunocompetent hosts. It also raises the possibility of a combined immunomodulatory and antiviral therapeutic approach, even in the presence of a concurrent infection."

Journal • CNS Disorders • Cough • Epstein-Barr Virus Infections • Infectious Disease • Pneumonia • Respiratory Diseases

Salmonella enteritidis: a rare pathogen in a polymicrobial acute prosthetic joint infection following total hip arthroplasty treated with double debridement, antibiotics, and implant retention (DAIR). (PubMed, J Surg Case Rep) - "She received a 3-month course of antibiotics including per os (PO) azithromycin and intravenous (IV) ceftriaxone that was switched to IV meropenem. Salmonella organism is an atypical isolate in PJI. In the absence of a primary cause and in the context of acute infection, double DAIR is a viable option to salvage the prosthesis when a dual approach of aggressive intraoperative debridement and postoperative antibiotics coverage is employed."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Association Between Antibiotic Use in Acute Bronchiolitis and Childhood Asthma Inception (RSVVW 2026) - "Sensitivity analysis demonstrated similar trends. Antibiotic use during early-life acute (mostly RSV) bronchiolitis was associated with an increased risk for preschool asthma inception, with azithromycin showing the strongest association."

Clinical • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections

Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children (clinicaltrials.gov) - P3 | N=370 | Recruiting | Sponsor: University of Alabama at Birmingham | Trial completion date: Jul 2026 ➔ Jul 2028 | Trial primary completion date: Feb 2026 ➔ Jul 2027

Trial completion date • Trial primary completion date • Infectious Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections

Dual Mycobacterial Infection: Rare Coinfection of Mycobacterium tuberculosis and Nontuberculous Mycobacteria. (PubMed, Cureus) - "However, concurrent sputum cultures subsequently grew Mycobacterium abscessus and later Mycobacterium avium complex, prompting the addition of amikacin, cefoxitin, and azithromycin based on infectious disease consultation. This case illustrates the diagnostic and therapeutic challenges inherent to MTB-NTM coinfection, where distinguishing true NTM disease from colonization is critical, and underscores the importance of multidisciplinary management."

Journal • Gastrointestinal Disorder • Infectious Disease • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Macrolides for the prevention of bronchopulmonary dysplasia in preterm neonates. (PubMed, Cochrane Database Syst Rev) - "The use of macrolides, specifically azithromycin, for the prevention of BPD in very preterm infants at high risk of developing BPD, may result in little to no difference in BPD at 36 weeks' PMA, defined as requiring oxygen or respiratory support at 36 weeks' PMA. They may result in a slight reduction in death before discharge and a reduction in gastrointestinal upset. There may be little to no difference between groups in hepatic dysfunction, prolonged QTc and cardiac arrhythmias, or pyloric stenosis. Importantly, azithromycin may reduce the use of postnatal steroids to prevent or treat BPD prior to discharge."

Clinical • Journal • Review • Bronchopulmonary Dysplasia • Cardiovascular • Hepatology • Liver Failure • Pulmonary Disease • Respiratory Diseases

Azithromycin therapy for prevention of chronic lung disease of prematurity (AZTEC): a randomised placebo-controlled trial. (PubMed, Health Technol Assess) - "Limitations include the (limited) missed oxygen reduction tests, inadequate collection of respiratory support data and lower-than-anticipated baseline sampling. This synopsis presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number 16/111/106."

Clinical • Journal • Bronchopulmonary Dysplasia • Gastrointestinal Disorder • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Retinal Disorders • Retinopathy of Prematurity

Exploring heterogeneity in treatment effects: The impact and interaction of asset-based wealth and mass azithromycin distribution on child mortality. (PubMed, PLoS One) - P4 | "Our findings demonstrate a wealth gradient in child mortality, with the highest mortality rates observed among households and communities in the lowest wealth quintiles. These disparities were consistent across both AZ-treated and placebo groups, suggesting that the role of AZ in health disparities may be limited to addressing gaps in treatment access rather than broader wealth-related disparities. While the study may have been underpowered to detect modest interaction effects, AZ appeared to offer similar benefits across economically diverse communities, with no evidence suggesting enhanced benefits for disadvantaged communities or for prioritizing treatment based on wealth status. Further work is needed to address the wealth-related disparities in child mortality in these communities."

Clinical • Heterogeneity • Journal

Bullous Myringitis in an Adult With Chronic Noise Exposure. (PubMed, J Community Hosp Intern Med Perspect) - "The treatment was escalated to include high-dose steroids, azithromycin, valacyclovir, and daily aspiration of effusion. His symptoms improved, and he was discharged with oral antibiotics and scheduled follow-up. This case highlights the complexity of diagnosing BM that complicates AOM in an adult and the importance of detailed history, underlying past medical conditions pertinent to early diagnosis, consideration of less common pathogens, and comprehensive treatment."

Journal • Crohn's disease • Gastroenterology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Otorhinolaryngology • Pain • Vertigo

Front Line Ibrutinib Without Corticosteroids for Newly Diagnosed Chronic Graft-versus-Host Disease (clinicaltrials.gov) - P2 | N=10 | Completed | Sponsor: National Cancer Institute (NCI) | Active, not recruiting ➔ Completed

Trial completion • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology

Microbiological analysis and whole-genome sequencing of Neisseria gonorrhoeae from the microbiological failures in the international, zoliflodacin, phase 3, clinical trial for treatment of uncomplicated urogenital gonorrhoea: a retrospective, genomic, observational study. (PubMed, Lancet Microbe) - "In the zoliflodacin phase 3, randomised controlled trial, 23% of the zoliflodacin microbiological failures and the single ceftriaxone and azithromycin microbiological failure had different gonococcal strains at TOC versus baseline, which suggests reinfections and not treatment failures. In addition, 59% of the zoliflodacin microbiological failures, all in anogenital sites, had no obvious microbiological explanation based on the low zoliflodacin MICs, previous pharmacodynamic studies, and no evidence of resistance selection after zoliflodacin therapy. A reinfection as the cause for these microbiological failures could not be excluded. We recommend that WGS is implemented in future randomised controlled trials for gonorrhoea treatment to further evaluate possible microbiological failures, exclude reinfections (to avoid underestimating the cure rates), and characterise antimicrobial resistance determinants."

Journal • Observational data • P3 data • Retrospective data • Infectious Disease

Thymoquinone from Lichen Dirinaria frostii (Tuck.): A New Promising Antimicrobial Compound. (PubMed, Curr Microbiol) - "Thymoquinone showed significant bactericidal activity compared to the standard antibiotics azithromycin, streptomycin, and erythromycin in a dose-dependent manner. This study demonstrates occurrence of thymoquinone from D. frostii as a novel finding and opens new possibilities for its therapeutic applications in the future."

Journal • Cholera

LONG TERM B CELL APLASIA POST CD19 TARGETING CART CELLS IN PAEDIATRIC PATIENTS: IMPLICATIONS ON LUNG STATUS (EBMT 2026) - "Patients with bronchiectasis commenced chest physiotherapy and antibiotic prophylaxis with azithromycin. In this cohort, 10/48 patients in durable remission post CAR T, with BCA and need for immunoglobulin replacement but without further anti-cancer therapy developed respiratory symptoms prompting imaging despite regular immunoglobulin supplementation, 3 of the imaged patients showed new bronchiectasis, 4 had other abnormal findings. Our data support structured respiratory monitoring to optimise long-term care in this vulnerable population."

CAR T-Cell Therapy • Clinical • Acute Lymphocytic Leukemia • Bone Marrow Transplantation • Bronchiectasis • Chronic Cough • Chronic Graft versus Host Disease • Cough • Graft versus Host Disease • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Pediatrics • Pulmonary Disease • Respiratory Diseases

MANAGEMENT OF SEVERE PULMONARY COMPLICATIONS FOLLOWING HSCT IN A PATIENT WITH Β-THALASSEMIA: A CASE REPORT ON SUCCESSFUL TREATMENT OF CMV PNEUMONIA, DAH, AND BOS (EBMT 2026) - "She underwent a matched unrelated donor (9/10 HLA-matched) allo-HSCT following a myeloablative conditioning regimen (fludarabine, busulfan, cyclophosphamide, ATG). GVHD prophylaxis included tacrolimus, methotrexate, mycophenolate mofetil, and pre-emptive infusions of umbilical cord-derived mesenchymal stromal cells (UC-MSCs)...The early post-transplant course was complicated by steroid-refractory, grade III acute GVHD (skin and gut), which was successfully managed with a second-line regimen of ruxolitinib, CD25 monoclonal antibody, budesonide, and additional UC-MSCs...Initial anti-CMV therapy (acyclovir/foscarnet) failed, indicating a refractory infection...Treatment with the FAM regimen (fluticasone, azithromycin, montelukast) combined with further cycles of UC-MSCs resulted in significant clinical and radiological improvement by day +220... This complex case illustrates the cascade of severe complications—refractory aGVHD, life-threatening CMV pneumonia with DAH, and..."

Case report • Clinical • Acute Graft versus Host Disease • Beta-Thalassemia • Bone Marrow Transplantation • Genetic Disorders • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

BUSULFAN ASSOCIATED PULMONARY TOXICITY AND INFECTIOUS COMPLICATIONS FOLLOWING AUTOLOGOUS SCT IN A 3-YEAR-OLD CHILD WITH NEUROBLASTOMA (EBMT 2026) - "Background: High-dose busulfan/melphalan (Bu/Mel) remains a standard conditioning regimen for autologous stem cell transplantation in high-risk neuroblastoma but is associated with significant organ toxicity, particularly hepatic and pulmonary injury...A treatment with Defibrotide, Ganciclovir and Azithromycin was initiated...We started a treatment with Sildenafil, Macitentan, Epoprostenol in addition to Methylprednisolone pulse therapy and antifibrotic treatment with Nintedanib, Hydroxychloroquin and Azithromycin...We started a treatment with Sildenafil, Macitentan, Epoprostenol in addition to Methylprednisolone pulse therapy and antifibrotic treatment with Nintedanib, Hydroxychloroquin and Azithromycin...We started a treatment with Sildenafil, Macitentan, Epoprostenol in addition to Methylprednisolone pulse therapy and antifibrotic treatment with Nintedanib, Hydroxychloroquin and Azithromycin... This case illustrates the complex interplay between infectious..."

Clinical • Acute Respiratory Distress Syndrome • Cardiovascular • Cystic Fibrosis • Cytomegalovirus Infection • Gastroenterology • Genetic Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Interstitial Lung Disease • Neuroblastoma • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock • Solid Tumor

MYCOBACTERIUM ABSCESSUS AS A COMPLICATION OF IMMUNOSUPPRESSION AFTER ALLOGENEIC STEM CELL TRANSPLANTATION FOR CONGENITAL NEUTROPENIA (EBMT 2026) - "Despite treatment with systemic corticosteroids, ruxolitinib, ibrutinib, antiviral agents, and antifungal therapy for a probable invasive pulmonary aspergillosis infection, respiratory status continued to decline.By day +190, the patient presented with septic shock, for which invasive mechanical ventilation (IMV), fluid expansion and vasopressor therapy were required...BAL and blood cultures were positive for M. abscessus massiliense, confirming invasive pulmonary disease with bacteremia.Treatment consisted of intravenous amikacin, tigecycline, imipenem, and TDM guided azithromycin and clofazimine, in addition to ongoing antifungal therapy... This case illustrates how Mabs can emerge insidiously in pediatric alloSCT recipients, mimicking more common post-transplant complications and progressing rapidly to severe invasive infection. The patient's gradual recovery underscores the importance of early recognition, aggressive multidrug therapy, and careful reassessment of..."

Graft versus Host Disease • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Neutropenia • Nontuberculous Mycobacterial Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock • Transplantation • CSF3R

CLINICAL CHARACTERISTICS AND TREATMENT RESPONSE OF NON-INFECTIOUS PULMONARY COMPLICATIONS FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION: A SINGLE-CENTER RETROSPECTIVE ANALYSIS (EBMT 2026) - "Commonly used drugs included calcineurin inhibitors (tacrolimus/cyclosporine), corticosteroids, JAK inhibitors (e.g., ruxolitinib), and components of the "FAM" regimen (fluticasone, azithromycin, montelukast). NIPCs following HSCT are a significant complication affecting long-term quality of life. Their clinical presentation is often nonspecific and coexists with chronic GVHD in other organs. Exertional dyspnea is a core symptom, while obstructive patterns on PFTs and air trapping on CT are key diagnostic clues."

Retrospective data • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Cough • Graft versus Host Disease • Hematological Malignancies • Immunology • Leukemia • Pulmonary Disease • Respiratory Diseases • Transplantation

BENEFITS OF A MULTIDISCIPLINARY COMMITTEE FOR THE TREATMENT OF CHRONIC GVHD: CASE REPORTS AS A PARADIGM FOR COLLABORATIVE CARE (EBMT 2026) - "Together with the Dermatology Department, tocilizumab was initiated—monthly at first and later every three months—with clinical improvement beginning after the second dose...She was re-evaluated, and recovery was optimized through respiratory physiotherapy, FAM therapy, optimization of bronchodilator therapy with closed triple therapy (LABA/LAMA/ICS), and temporarily increasing azithromycin to 600 mg for six days, followed by a return to the previous dose of 250 mg three days per week. Prednisone was gradually discontinued, and immunoglobulins were administered every three weeks... The GVHD committee at our hospital reflects a collaborative effort among various specialists focused on the management of patients with this condition. We believe that this kind of multidisciplinary approach provides clear clinical benefit among patients with GVHD, particularly in cases with several organs involved."

Case report • Clinical • Asthma • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Dermatology • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Neutropenia • Ophthalmology • Respiratory Diseases

Unlocking New Avenues: Azithromycin Vs Erythromycin in Pre-term, Pre-mature Rupture of Membrane Management (clinicaltrials.gov) - P1 | N=250 | Completed | Sponsor: District Headquarters Teaching Hospital Sahiwal

New P1 trial