azithromycin / Generic mfg. - LARVOL DELTA

Zoliflodacin versus ceftriaxone plus azithromycin for treatment of uncomplicated urogenital gonorrhoea: an international, randomised, controlled, open-label, phase 3, non-inferiority clinical trial. (PubMed, Lancet) - P3 | "Zoliflodacin was non-inferior to ceftriaxone plus azithromycin for the treatment of uncomplicated urogenital gonorrhoea and had a similar safety profile. These data suggest a potential role for zoliflodacin as an effective oral treatment option for uncomplicated urogenital gonorrhoea."

Head-to-Head • Journal • P3 data • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Leukopenia • Neutropenia • Pain

Doxycycline vs Azithromycin in Combination with a Beta-lactam for the Treatment of Community-acquired Pneumonia in Hospitalized Patients (ASHP 2025) - No abstract available

Clinical • Combination therapy • Infectious Disease • Pneumonia • Respiratory Diseases

Evaluation of Oral Azithromycin Prescribing Practices at a Small Community Teaching Hospital (ASHP 2025) - No abstract available

Clinical

Evaluation of Azithromycin and Doxycycline in Severe Community-Acquired Pneumonia (ASHP 2025) - No abstract available

Infectious Disease • Pneumonia

Impact of Pharmacist Education on Ceftriaxone and Azithromycin Duration of Therapy for Community Acquired Pneumonia (ASHP 2025) - No abstract available

Infectious Disease • Pneumonia

Excess Durations of Azithromycin for Respiratory Infections Identifies Antimicrobial Stewardship Opportunities at a Multi-Site Health-System (ASHP 2025) - No abstract available

Infectious Disease • Respiratory Diseases

Medication use evaluation of long-term azithromycin use in a veteran population with COPD (ASHP 2025) - No abstract available

Clinical • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases

Azithromycin alters the microbiome composition, function and resistome in women with Chlamydia trachomatis infections. (PubMed, NPJ Biofilms Microbiomes) - "Our results show shifts in composition and function post-treatment that support persistent Ct, nonsynonymous Ct L22 amino acid substitutions that may be linked to azithromycin resistance, and significant endocervical increases in azithromycin resistance genes in Lactobacillus iners and Gardnerella vaginalis strains with moderate/high biofilm formation potential. These findings highlight the unintended ecological consequences of azithromycin treatment, including likely resistance gene propagation, emphasizing the need for novel treatment and microbiome-preserving strategies."

Journal • Infectious Disease

Antimicrobial resistance profiling of Salmonella and Escherichia coli isolates from conventional poultry farms in Hossana Town, Central Ethiopia. (PubMed, BMC Vet Res) - "Similarly, E. coli O157:H7 isolates demonstrated complete resistance to ampicillin and high (90%) resistance to cefotaxime and tetracycline. Both pathogens showed significant sensitivity to gentamicin and azithromycin...This investigation underscore the importance of further investigations into the factors contributing to resistance, as well as the development of integrated AMR surveillance systems. Molecular investigations are recommended to confirm the mechanisms of resistance and to inform policy decisions and implement evidence based interventions."

Journal

First-line treatment with low-dose ruxolitinib, pirfenidone, and low-dose calcineurin inhibitors leads to significant improvement in patients with bronchiolitis obliterans syndrome after allogeneic transplantation (ASH 2025) - "Traditional treatments for BOS rely on glucocorticoids combined with FAM regimens ( fluticasone + azithromycin + montelukast ) and calmodulin phosphatase inhibitors ( CNIs ), but they have limited efficacy with an even lower overall remission rate ( ORR ) and poor prognosis once progression to steroid-refractory cGVHD (SR-cGVHD) is achieved...Methods A retrospective analysis of 14 patients, 11 males and 3 females, with a median age of 19 years (7-54 years), who underwent hematopoietic stem cell transplantation combined with BOS at Henan Cancer Hospital from 2018 to 2025, including 6 cases of mild BOS, 3 cases of moderate BOS, 5 cases of severe BOS, Among them, 6 cases of mild, 3 cases of moderate, and 5 cases of severe BOS were treated with low-dose rucotinib ( 5 mg qd po) combined with piroxicam (200 mg tid po), small-dose CNI (half of the effective therapeutic concentration), and FAM first-line treatment...Conclusions In conclusion, the first-line treatment of BOS..."

Clinical • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Transplantation

Rhabdomyolysis in patients taking isocitrate dehydrogenase inhibitors for R/R Acute Myeloid Leukemia (ASH 2025) - "She was started on treatment with azacitidine, venetoclax, and magrolimab and achieved MRD-negative CR after cycle 1, then went on to complete 6 cycles of therapy, followed by 4 cycles of maintenance therapy with combination decitabine/cedazuridine and venetoclax prior to relapse. She was then treated with combination decitabine/cedazuridine, venetoclax, and ivosidenib...Azacitidine was discontinued after C33, at which time she continued on enasidenib monotherapy...She was on a stable dose of atorvastatin at the time of this event and had recently started azithromycin for symptoms of upper respiratory tract infection...al 2015). We hypothesize that rhabdomyolysis observed with IDH inhibitors may reflect a convergence of metabolic stressors, particularly in susceptible populations such as elderly patients with low muscle mass, and those on concomitant statins."

Clinical • Acute Myelogenous Leukemia • Brain Cancer • Constipation • Gastroenterology • Gastrointestinal Disorder • Glioma • Hematological Disorders • Hematological Malignancies • Hepatology • Infectious Disease • Leukemia • Musculoskeletal Pain • Myelodysplastic Syndrome • Respiratory Diseases • Solid Tumor • Thrombocytopenia • IDH1 • IDH2

A rare case of gelatinous transformation of the bone marrow secondary to untreated hypothyroidism and congestive heart failure (ASH 2025) - "He was empirically treated with cefepime and azithromycin for presumed sepsis...He was started on levothyroxine 25 mcg, Jardiance 10 mg, and spironolactone 25 mg for HFpEF...Diagnosing GTBM requires a high index of suspicion and exclusion of other pancytopenia causes. Early recognition and treatment of the underlying disorder can reverse both GTBM and associated cytopenias."

Clinical • Aplastic Anemia • Cardiovascular • Congestive Heart Failure • Endocrine Disorders • Heart Failure • Hematological Malignancies • Human Immunodeficiency Virus • Immunology • Infectious Disease • Pituitary Gland Carcinoma • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock • IL2

Babesiosis masquerading as ITP in a patient with CLL (ASH 2025) - "Patient's home medications included only ramipril and metoprolol succinate...Patient was started on atovaquone and azithromycin...And patient was diagnosed with Babesiosis. This case highlights how Babesiosis can masquerade as ITP and present as severe thrombocytopenia without any symptoms suggestive of infection."

Clinical • Cardiovascular • Chronic Lymphocytic Leukemia • Coronary Artery Disease • Dyslipidemia • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Metabolic Disorders • Thrombocytopenia • HP

Babesia induced cytokine storm: A rare cause of secondary hemophagocytic lymphohistiocytosis (ASH 2025) - "Initially, this was thought to be a tick-borne illness such as anaplasmosis and doxycycline was empirically started...Treatment with Dexamethasone and Etoposide was initiated per HLH-94 guidelines (Henter et al., 2007)...The tick panel was positive for Babesia, and antibiotics were switched to Azithromycin and Atovaquone...Early identification can prevent further spread including CNS spread and prevent the need for hematopoietic stem cell transplants. Screening tools like HScore distinguish hemophagocytic syndromes such as HLH from sepsis or acute hematologic malignancies, allowing for earlier HLH diagnosis and improved outcomes (Fardet et al., 2014)."

Cytokine storm • Bone Marrow Transplantation • Cardiovascular • Coronary Artery Disease • Hematological Malignancies • Hemophagocytic lymphohistiocytosis • Hepatology • Immunology • Infectious Disease • Rare Diseases • Septic Shock • Thrombocytopenia • IL2 • IL2RA

Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial (ASH 2025) - P3 | "ACSseverity was defined a priori as mild (no oxygen (O2) use or RBC transfusion), moderate (O2 use ortransfusion), or severe (bilevel positive airway pressure (BiPAP) use, intubation, or pediatric intensive careunit (PICU) transfer). 271 patients enrolled (median age 15[11,18] years, 51% male; 74% HbSS/Sb°; 76% onHydroxyurea (HU)...Across all sites, 96% of patients receivedantibiotics (50% ceftriaxone, 28% ampicillin-sulbactam, 7% vancomycin, 11% other) and 82% receivedazithromycin. Site-level use ranged from 0-100% for ceftriaxone and 50-100% for azithromycin... ACS remains common in patients with SCD-VOE (20%), with 14% of ACS diagnosed duringtheir hospital stay. Two-thirds of subjects who developed ACS had a CXR done in the ED that wasnegative. ACS may have been missed in patients who did not get a CXR, and radiographic changes oftenlag behind symptoms."

Clinical • P3 data • Addiction (Opioid and Alcohol) • Cardiovascular • Cough • Genetic Disorders • Hematological Disorders • Pain • Respiratory Diseases • Sickle Cell Disease

Tailoring Nanoparticle Surfaces Empowered by Multivariate Techniques for Detection of Multiple Antibiotic Fingerprints in Real Samples Using Hand-Held Colorimetric Signal Readout. (PubMed, ACS Appl Mater Interfaces) - "With 100% accuracy, the sensor array successfully discriminates between eight antibiotics (amoxicillin, azithromycin, neomycin, streptomycin, chloramphenicol, ofloxacin, fluconazole, and ciprofloxacin), with detection limits ranging from 1.7 to 8.3 μM. Further, for the real-time applications, we have developed prototypes for colorimetric analysis and also modified the previously developed 96-well plate reader, which functions similarly to the UV-visible absorption spectrophotometer. These on-site sensing methods, with straightforward preparation, quick response, exceptional sensitivity, and consistently stable high-throughput signal output, show significant potential for practical use in food forensics and for environmental remediation."

Journal

The single-center retrospective analysis of steroid-free rmap regimen (ruxolitinib, montelukast, azithromycin, and pirfenidone) treating moderate-to-severe bronchiolitis obliterans syndrome (BOS). (ASH 2025) - "The steroid-free RMAP regimen demonstrated promising efficacy in moderate-to-severe BOS,enabling rapid steroid withdrawal while improving quality of life and long-term survival. However, giventhe small sample size and retrospective design, further prospective studies are warranted for validation."

Retrospective data • Bone Marrow Transplantation • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Autoimmune hemolytic anemia: An underrecognized contributor to anemia and hemolysis in babesiosis infection (ASH 2025) - "Most received the standardantibiotic regimen of atovaquone, azithromycin and doxycycline. Data was analyzed for 406 patients. Median age was 73 (range 2 to 103) with a malepredominance (67.5%; 264/406). Asplenia was seen in 10.7% (42/406), and 32.5% (127/406) had Lyme-coinfection."

Anemia • Autoimmune Hemolytic Anemia • Hematological Disorders • Immunology • Infectious Disease

Impact of biannual azithromycin on weight-for-age z-score among infants in the AVENIR cluster-randomised trial. (PubMed, BMJ Paediatr Open) - "These findings align with prior large-scale trials that demonstrated mortality benefits but no sustained effects of azithromycin on growth. Taken together, the results suggest that while azithromycin MDA reduces childhood mortality, it is unlikely to provide medium-term improvements in weight gain, highlighting the need for complementary nutritional interventions to address undernutrition in similar settings."

Clinical • Journal

Penicillin remains an effective agent against Group A Streptococcus in low- and middle-income countries: A systematic review and meta-analysis of antibiotic resistance and associated genes. (PubMed, S Afr Med J) - "This review comprehensively characterises the latest evidence on the prevalence of antibiotic resistance in Strep A in LMICs. Strep A in LMICs continues to be highly susceptible to antibiotics in vitro, primarily to penicillins. Strep A macrolide resistance patterns in LMICs are similar to those observed in high-income countries. The findings of this review may serve to inform effective treatment decisions and public health interventions."

Clinical • Journal • Retrospective data • Review

Estimating macrolide antibiotics use in a typical region of Taihu Lake Basin, China through wastewater-based epidemiology. (PubMed, Environ Geochem Health) - "The concentrations of four MLs-erythromycin, roxithromycin, azithromycin, and clarithromycin-were determined. A significant increase in antibiotic usage was observed in January 2023 that the other sampling months, accompanying with low ambient temperatures. The data set on MLs consumption provides valuable insights for evaluating antibiotic usage patterns under varying temporal and climatic conditions."

Journal

Nanocurcumin: An Innovative Strategy to Combat Virulence and Methicillin Resistance in Staphylococcus aureus Isolated from Burn Wounds. (PubMed, Iran J Med Sci) - "The 50 selected isolates were resistant to cefoxitin, amoxicillin, benzylpenicillin, ampicillin/sulbactam, piperacillin/tazobactam, cloxacillin, oxacillin, and azithromycin. No significant changes were seen in fnbA and ftsZ. Nanocurcumin inhibits S. aureus virulence and resistance genes, reducing biofilm formation and toxin production, but lacks effect on fnbA and ftsZ, requiring further research."

Journal • Infectious Disease

Molecular Epidemiology and Antibiotic Resistance of Sheep-Derived Mannheimia haemolytica in Northwestern China. (PubMed, Animals (Basel)) - "Antibiotic susceptibility testing showed sensitivity to ciprofloxacin, azithromycin, gentamicin, and levofloxacin, while resistance was observed for tiamulin and enrofloxacin. These findings indicate a high prevalence and strong pathogenicity of ovine M. haemolytica in Shaanxi, underscore the presence of key resistance traits, and provide a genomic and pathogenic reference to guide region-specific surveillance, therapeutic decisions, and vaccine-oriented control in small ruminant herds. Importantly, these results highlight the need for region-specific monitoring and judicious antibiotic use, which are essential to forestall the spread of resistant strains and to ensure sustainable disease management strategies."

Journal • Respiratory Diseases

SWIFT: Sanitation, Water, and Instruction in Face-washing for Trachoma I/II (clinicaltrials.gov) - P3 | N=47605 | Completed | Sponsor: University of California, San Francisco | Active, not recruiting ➔ Completed | N=340000 ➔ 47605 | Trial completion date: Dec 2025 ➔ Dec 2024

Enrollment change • Trial completion • Trial completion date • Ophthalmology

Genomic diversity and antimicrobial resistance of Vibrio cholerae isolates from Africa: a PulseNet Africa initiative using nanopore sequencing to enhance genomic surveillance. (PubMed, Microb Genom) - "AMR gene analysis revealed genes associated with resistance to trimethoprim in 96% of isolates and genes associated with resistance to quinolones in 83%, while genes associated with resistance to azithromycin, rifampicin and tetracycline remained low (≤7%). The widespread presence of genes associated with resistance to trimethoprim and quinolones raises concerns for treatment efficacy, although azithromycin and tetracycline remain viable options. WGS enables precise identification of species and genotyping, reinforcing PulseNet Africa's pivotal role in advancing genomic surveillance and enabling timely public health responses to cholera outbreaks."

Journal • Cholera • Infectious Disease