azithromycin / Generic mfg. - LARVOL DELTA

Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study) (clinicaltrials.gov) - P1 | N=108 | Completed | Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) | Active, not recruiting ➔ Completed | Trial completion date: Dec 2025 ➔ May 2025 | Trial primary completion date: Dec 2025 ➔ May 2025

Trial completion • Trial completion date • Trial primary completion date

Taiwan consensus on pulmonary chronic graft-versus-host disease: A joint statement from the Taiwan Society of Blood and Marrow Transplantation (TBMT) and Taiwan Society of Pulmonary and Critical Care Medicine (TSPCCM). (PubMed, Br J Haematol) - "The fluticasone-azithromycin-montelukast (FAM) regimen has demonstrated notable efficacy in stabilizing lung function. Emerging therapies such as ruxolitinib, belumosudil, abatacept and axatilimab offer promising benefits for refractory cases, whereas lung transplantation is a viable last resort for advanced disease...This consensus report highlights the importance of standardized PFT surveillance, early intervention and individualized immunosuppressive strategies. Future research should focus on refining diagnostic biomarkers and optimizing therapeutic approaches to improve patient outcomes."

Journal • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Critical care • Graft versus Host Disease • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Transplantation

A Silent Invader: Asymptomatic Rhodococcus Infection Unmasked in A Patient with Ectopic ACTH-Dependent Cushing's Syndrome. (PubMed, Eur J Case Rep Intern Med) - "This case highlights the diagnostic complexity of incidental pulmonary nodules in immunocompromised patients, reinforcing the need for thorough microbiological investigation even in the absence of infection symptoms.It illustrates a rare, asymptomatic presentation of Rhodococcus infection in the context of ectopic ACTH-dependent Cushing's syndrome, a scenario not widely reported in the literature.Practical is given guidance on managing opportunistic infections and evaluating ectopic ACTH sources, aiding internists in navigating similar diagnostic and therapeutic challenges in complex endocrine-infectious overlaps."

Journal • Cardiovascular • Cushing’s Disease • Diabetes • Endocrine Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Oncology

Clinical Efficacy of Qingke Mixture in Treating Mycoplasma Pneumonia in Children: A Randomized Controlled Trial. (PubMed, Int J Gen Med) - "The incidence of adverse events was low in both groups, with no statistically significant difference. Qingke Mixture combined with azithromycin significantly improves clinical outcomes in children with MPP, enhancing efficacy while maintaining safety."

Clinical • Journal • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases • CD4 • CD8 • CXCL8 • IL6

Multi-anatomical site prevalence of Mycoplasma genitalium infection, resistance and association with coinfections: a prospective study in MSM with HIV. (PubMed, JAC Antimicrob Resist) - "The cure rate for non-susceptible M. genitalium infection was satisfactory with moxifloxacin or minocycline but not with azithromycin. genitalium RAM prevalence is high in MSM with HIV, in whom rectal infection and C. trachomatis/N. gonorrhoeae coinfections are common."

Journal • Human Immunodeficiency Virus • Infectious Disease

HEMOPERICARDIAL TAMPONADE AS A RESULT OF AZITHROMYCIN-INDUCED WARFARIN TOXICITY (CHEST 2025) - No abstract available

Critical care

1118: COPD Management: Advanced Pharmacological Options (CHEST 2025) - "This session will address medication class selection in COPD highlighting considerations for newly approved options (ensifentrine and dupilumab) and how they fit in with existing therapies. Review the evidence for ensifentrine, roflumilast, and azithromycin and provide a framework for drug selection 3. Learn about the currently available and emerging biologic therapeutics in the management of COPD"

Metastases • Chronic Obstructive Pulmonary Disease • Eosinophilia • Immunology • Respiratory Diseases

COMPARATIVE OUTCOMES OF AZITHROMYCIN VS AZITHROMYCIN AND ROFLUMILAST IN ADVANCED COPD: A MULTICENTER RETROSPECTIVE ANALYSIS (CHEST 2025) - No abstract available

Metastases • Retrospective data • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases

COMPARATIVE OUTCOMES OF BETA-LACTAM PLUS AZITHROMYCIN VS FLUOROQUINOLONE IN HOSPITALIZED PATIENTS: A RETROSPECTIVE ANALYSIS OF THE MIMIC IV DATABASE (CHEST 2025) - No abstract available

Retrospective data

Human Babesiosis: The Past, Present, and Future. (PubMed, Expert Rev Mol Med) - No abstract available

Journal • Review

COMPARISON OF EFFECTS BETWEEN ROFLUMILAST AND AZITHROMYCIN IN MANAGEMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (CHEST 2025) - No abstract available

Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Australian Gonococcal Surveillance Program, 1 January to 31 March 2025. (PubMed, Commun Dis Intell (2018)) - "The antibiotics reported represent current or potential agents used for the treatment of gonorrhoea, and include ceftriaxone, azithromycin, ciprofloxacin and penicillin. More recently, gentamicin and tetracycline are included in the AGSP Annual Report...In these regions, an oral treatment regimen comprising amoxycillin, probenecid, and azithromycin was recommended. However, since January 2023, increasing reports of penicillin-resistant N. gonorrhoeae in the Northern Territory have changed treatment recommendations to align with the majority of Australia.1 Additional data on other antibiotics are reported in the AGSP Annual Report. The AGSP has a programme-specific quality assurance process."

Journal • Infectious Disease

In Vitro Analysis of Azithromycin's Effect on J774 Murine Macrophages Challenged with Aspergillus fumigatus: Azithromycin Improves Macrophage Response to Aspergillus fumigatus. (PubMed, Immunol Lett) - "These findings suggest AZM enhances macrophage function, boosting anti-inflammatory responses and improving fungal clearance."

Journal • Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases • IFNG • IL13 • IL4 • IL6

AD-CAP: Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia (clinicaltrials.gov) - P4 | N=1120 | Not yet recruiting | Sponsor: Mayo Clinic

New P4 trial • Infectious Disease • Pneumonia • Respiratory Diseases

Fulminant Macrolide-Resistant Mycoplasma pneumoniae Pneumonia in a Young Adult: A Case Report. (PubMed, Cureus) - "Despite repeated negative rapid antigen tests for M. pneumoniae, the patient was suspected of having MRMP pneumonia based on the Japanese Respiratory Society (JRS) scoring system and bilateral pneumonia resistant to amoxicillin/clavulanate and azithromycin, which led to the administration of levofloxacin infusion. Hydrocortisone was administered as treatment for severe CAP...The diagnosis and treatment strategy resulted in early improvement. This case highlights the diagnostic approach for MRMP and the clinical course of severe ARDS associated with MRMP."

Journal • Acute Respiratory Distress Syndrome • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Necrotizing Mediastinal Mass and Cavitary Pneumonia From Probable Co-infection With Epstein-Barr Virus and Mycoplasma pneumoniae. (PubMed, Cureus) - "The antibiotic regimen was modified to include azithromycin, resulting in marked clinical improvement. Repeat CT scans at two weeks and three months showed a reduction in the size of the necrotic mass. The patient was subsequently discharged home in stable condition and has remained well."

Journal • Cough • Epstein-Barr Virus Infections • Infectious Disease • Pain • Pediatrics • Pneumonia • Respiratory Diseases

Antimicrobial resistance in Neisseria gonorrhoeae in nine sentinel countries within the World Health Organization Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP), 2023: a retrospective observational study. (PubMed, Lancet Reg Health West Pac) - "Minimum inhibitory concentrations (MICs, mg/L) values were determined for ceftriaxone, cefixime, azithromycin, gentamicin, and ciprofloxacin using Etest (bioMérieux). Novel antimicrobials for gonorrhoea treatment are critical; zoliflodacin and gepotidacin are promising. WHO, Global Fund."

Journal • Observational data • Retrospective data • Infectious Disease

Malignant Peritoneal Mesothelioma Masquerading as Sclerosing Mesenteritis (ACG 2025) - "The patient was then started on prednisone to treat suspected sclerosing mesenteritis...Given her positive response to therapy, she was started on azithromycin as maintenance therapy for sclerosing mesenteritis...After receiving 4 cycles of pemetrexed and cisplatin with complications, the patient acknowledged that her cancer was incurable and prioritized maintaining her quality of life. This case highlights the diagnostic challenges of MPM in its early stage because it can resemble sclerosing mesenteritis in terms of symptoms and imaging findings. Accurate diagnosis with close follow-up to monitor the patient's symptoms and imaging findings in response to therapy is essential for improved patient outcomes."

Esophageal Cancer • Fibrosis • Mesothelioma • Peritoneal Mesothelioma • Solid Tumor

A Rare Case of Hepatitis B Reactivation in a Patient Treated With Regorafenib for Gastrointestinal Stromal Tumor: A Case Report (ACG 2025) - "She was started on azithromycin, ethambutol, and rifampin...Tenofovir was initiated but discontinued due to Fanconi syndrome; she was transitioned to entecavir...This case underscores the importance of routine HBV screening and prophylaxis prior to initiating immunosuppressive or targeted cancer therapies. Early identification and management of HBV reactivation are crucial to prevent life-threatening hepatic complications.Figure: HBV Viral Load Timeline"

Case report • Clinical • Stroma • Breast Cancer • Cough • Fibrosis • Gastrointestinal Cancer • Gastrointestinal Stromal Tumor • Hepatitis B • Hepatology • Immunology • Infectious Disease • Liver Failure • Nephrology • Oncology • Respiratory Diseases • Sarcoma • Solid Tumor

A Rare Case of Immune Checkpoint Inhibitor Esophagitis Due to Pembrolizumab (ACG 2025) - "We describe a case of grade 3/4 pembrolizumab-induced esophagitis and mucositis in a patient receiving treatment for stage IIA breast adenocarcinoma.Case Description/ A 72-year-old female with triple-negative, poorly differentiated stage IIA breast adenocarcinoma achieved complete response to neoadjuvant therapy (doxorubicin, cyclophosphamide, and pembrolizumab)...Her symptoms proved refractory to empiric therapies including azithromycin, nystatin, fluconazole, micafungin, and saline gargles...Flexible laryngoscopy confirmed ulcerative mucositis with concomitant laryngopharyngitis.Pembrolizumab was discontinued, and she was initiated on prednisone 1 mg/kg, achieving significant pain improvement within one week...Treatment with fluconazole and pantoprazole was initiated...Management includes acid suppression (PPIs, H2 blockers), mucosal protectants (sucralfate), and corticosteroids for moderate to severe cases. This case highlights the need for clinician awareness of rare..."

Checkpoint inhibition • Clinical • Breast Cancer • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Mucositis • Oncology • Triple Negative Breast Cancer

Is It Time to Consider Hydroxyurea as a Potential Therapeutic Option in the Management of Malignant Pertussis - A Case Report and Literature Review. (PubMed, Cureus) - "A diagnosis of malignant pertussis, based on the severe paroxysmal cough, significant lymphocytosis, and progressive respiratory symptoms, was established, and treatment was initiated with azithromycin and hydroxyurea (20 mg/kg/day) under intensive supportive care. Early administration in hemodynamically stable patients may reduce the need for invasive procedures; however, its use in more severe cases requiring urgent leukoreduction may be limited due to the delayed onset of action. This case adds to the limited number of reported instances where hydroxyurea was successfully used as a noninvasive leukoreductive option in malignant pertussis."

Journal • Cardiovascular • Cough • Hypertension • Infectious Disease • Pertussis • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Mass azithromycin distributions: balancing childhood mortality and antimicrobial resistance. (PubMed, Lancet Infect Dis) - No abstract available

Journal

Mass azithromycin distributions: balancing childhood mortality and antimicrobial resistance - Authors' reply. (PubMed, Lancet Infect Dis) - No abstract available

Journal

Babesiosis-induced warm autoimmune hemolytic anemia, from infection to hemolysis: a case report. (PubMed, J Med Case Rep) - "Given the increasing prevalence of tick-borne illnesses, physicians should have a high index of suspicion for concurrent warm autoimmune hemolytic anemia in patients with babesiosis and anemia not improving with typical therapies. In addition, the interplay between babesiosis and warm autoimmune hemolytic anemia underscores the need for clinicians to consider infectious etiologies in the workup of this disease."

Journal • Review • Anemia • Autoimmune Hemolytic Anemia • Hematological Disorders • Immunology • Infectious Disease

3D collagen high-throughput screen identifies drugs that induce epithelial polarity and enhance chemotherapy response in colorectal cancer. (PubMed, Commun Biol) - "A retrospective analysis of patient data demonstrated that the use of azithromycin in patients undergoing treatment for CRC with irinotecan had improved the 5 year survival compared to the chemotherapy alone. These results highlight the importance of morphological screens to identify novel drug candidates and synergistic mechanisms."

Journal • Colorectal Cancer • Oncology • Solid Tumor • CDH1 • TJP1