AMG 458 / Amgen - LARVOL DELTA

Discovering novel therapies in the treatment of osteosarcoma (AACR 2022) - "These drugs are: BRL-15572 (dihydrochloride), PH-797804, Apalutamide (ARN-509), AMG-458, Ipatasertib (GDC-0068), Mifepristone, Prucalopride, VU 0361737, Olopatadine HCl, and AZ 3146. The in vitro test results are promising and provide the groundwork to proceed with in vivo testing on orthotopic xenograft models. These models will be used for drug testing of the narrowed drug agents, with tumor growth inhibition and survival time of the drug treatment group monitored against a control group without drug exposure. Results from in vivo testing will be proposed for future clinical trials for treating pediatric osteosarcoma."

Lung Cancer • Oncology • Osteosarcoma • Sarcoma • Solid Tumor