Asclera (polidocanol) / Merz Pharma - LARVOL DELTA

Experience in the Treatment of Toxic Adenomas Using Percutaneous Ablation Techniques in a Tertiary Care Unit (ENDO 2025) - "15 (88.2%) were treated with thiamazole and 7 (41.2%) with propranolol. 11(64.7%) were treated with chemical ablation (CA) with ethanol and polidocanol and 6(35.3%) with radiofrequency thermal ablation (RFT)... PA treatment represents an effective and safe alternative treatment for patients with TA. The greater volume reduction through RFT suggests better efficiency, but it is dependent on the learning curve."

Endocrine Disorders • Oncology • Pain

Marine-Lenhart Syndrome: Case Report (ENDO 2025) - "Thiamazole 30 mg/d and propranolol 20 mg/d were started. Percutaneous ablation of RTN was performed with 3% polidocanol 2 ml plus ethanol 1.5 ml and 8 mg intrathyroidal dexamethasone was administered in LTL... MLS is rare, but given the nature of the pathology, minimally invasive techniques can be implemented in its management combined with antithyroids to increase therapeutic efficacy."

Case report • Clinical • Alopecia • CNS Disorders • Endocrine Disorders • Fatigue • Grave’s Disease • Immunology • Insomnia • Movement Disorders • Sleep Disorder

Single-needle percutaneous foamed sclerotherapy using ultrasound and fluoroscopy guidance using "contrast washout technique" for the treatment of a slow-flow chest wall vascular malformation in a pediatric patient. (PubMed, J Surg Case Rep) - "We present the case of a 7-year-old child with a large, slow-flow VM on the right anterior chest wall, successfully treated with ultrasound- and fluoroscopy-guided foam sclerotherapy using polidocanol via the ``contrast washout'' technique. The procedure resulted in significant lesion resolution with no post-procedural pain. In addition to its effectiveness, this approach also spares patients from extensive surgical interventions, making it a valuable treatment option for pediatric VMs."

Journal • Pain • Pediatrics

Investigation of the sclerosing effect of increasing doses of polidocanol on pulmonary vessels: Experimental study (ERS 2025) - No abstract available

Cardiovascular • Pulmonary Embolism • Respiratory Diseases

THE DOUBLE-EDGED NEEDLE: GASTRIC ISCHEMIA FOLLOWING POLIDOCANOL INJECTION IN A REFRACTORY BLEEDING ULCER (UEGW 2025) - No abstract available

Cardiovascular

Sclerotherapy With Polidocanol Is Highly Effective for Treating Oral Cavernous Hemangiomas in Children. (PubMed, In Vivo) - "Sclerotherapy using polidocanol provides an effective, safe, and relatively simple treatment for hemangiomas in the oral cavity of children and may be recommended to replace the conventional pingyangmicine treatment."

Journal • Anesthesia • Oncology • Pain

Targeted Pre-Conditioning and Cell Transplantation in the Murine Lower Respiratory Tract. (PubMed, Am J Respir Cell Mol Biol) - "The detergent polidocanol was adapted for distal lung pre-conditioning, inducing intrapulmonary airway epithelial denudation by 5 and 24-hours post-delivery...These findings demonstrate the utility of bronchoscopically targeted pre-conditioning and cell delivery to the conducting intra-pulmonary airways. Thus providing an important framework for pre-clinical translation of approaches for engineered airway epithelial regeneration."

Journal • Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Transplantation

In Vitro Evaluation of Hydrogel Coils Combined with Liquid Embolic and Sclerosing Agents for Endovascular Embolization. (PubMed, Cardiovasc Intervent Radiol) - "In vitro, sclerosing agents disabled or damaged hydrogel coils. The combination of sclerosing agents and hydrogel coils might clinically have adverse effects, including the insufficient and non-target embolization."

Journal • Preclinical

Factors that Enhance the Stability of Polidocanol and Monoethanolamine Oleic Acid Foams, and Identification of the Optimal Foam-Creating Device. (PubMed, Cardiovasc Intervent Radiol) - "The half-lives of foams were prolonged by increasing their air ratio and by adding Gluc. Of the tested mixture devices, Hlic created foams with longer half-lives in the shortest time."

Journal

Efficacy of sclerotherapy with pingyangmycin and polidocanol for venous malformations. (PubMed, Front Surg) - "None of the patients experienced serious adverse reactions. Sclerotherapy with pingyangmycin and polidocanol is a treatment modality for relieving the clinical symptoms of venous malformations, with good efficacy and few potential risks."

Journal • Pain

Targeted Pre-conditioning and Cell Transplantation in the Murine Lower Respiratory Tract (ATS 2025) - "Our group has successfully transplanted mouse primary or pluripotent stem cell (PSC)-derived basal cells into the tracheas of syngeneic recipient mice post-polidocanol (PDOC) injury... We find evidence of engraftment of primary tracheal BCs throughout the intrapulmonary airways but also within the alveolar space. This finding highlights the need for robust translational, pre-clinical models for cellular therapeutics within the lung to pair pre-conditioning and donor cell type for engraftment into the intended niche while minimizing off target injury or engraftment."

Preclinical • Anesthesia • Cystic Fibrosis • Genetic Disorders • Immunology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Transplantation

USE OF 50% DEXTROSE AS A SCLERO THERAPEUTIC AGENT FOR ESOPHAGEAL VARICES IN AN INFANT PRESENTED WITH HEMATEMESIS– A CASE REPORT WITH A VIDEO . (ESPGHAN 2025) - "Many agents are used in adult (e.g ethanolamine oleate,polidocanol, 99% alccohol) but not suitable and effective in infants...We are preparing patient for Living donar liver transplant. Conclusions Dextrose 50% works well as a sclerosing agents for bleeding oesophageal varices ."

Case report • Clinical • Video • Anemia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders

Anterograde spermatic vein sclerotherapy: Step-by-step Tauber procedure. (PubMed, J Pediatr Urol) - "Tauber's technique could be considered an appropriate option for the treatment of varicocele in the paediatric population."

Journal • Pediatrics

Combined Laser Therapy for Post-sclerotherapy Hyperpigmentation Following Nicolau Syndrome: A Case Report. (PubMed, Cureus) - "We report a case of a 40-year-old woman with Fitzpatrick skin type II, who developed longstanding hyperpigmentation in the right popliteal area following polidocanol sclerotherapy...Notable pigment clearance, full crust exfoliation, and restoration of normal skin tone were achieved without adverse effects. Independent expert evaluation and patient-reported outcomes confirmed the treatment's efficacy and high tolerability."

Journal

Application of ultrasound-guided microwave ablation combined with polidocanol injection in benign cystic-solid thyroid nodules and recurrence analysis. (PubMed, Discov Oncol) - "Ultrasound-guided MWA combined with polidocanol injection is more effective in treating benign cystic-solid thyroid nodules. This approach accelerates nodule ablation, significantly reduces nodule size, preserves thyroid function, lowers recurrence rates, and enhances overall safety."

Journal

Introducing the carbon footprint reduction index (CaFRI) as a software-supported tool for greener laboratories in chemical analysis. (PubMed, BMC Chem) - "Case studies using techniques such as spectrophotometry for polidocanol in ampoules, dispersive solid phase microextraction with HPLC/UV for ritonavir in human plasma, carbon quantum dots for molnupiravir in capsules, and homogenous liquid-liquid microextraction with HPLC/UV for favipiravir in human plasma demonstrated CaFRI's applicability in evaluating the carbon footprint across diverse analytical methods and matrices. These case studies illustrated that energy consumption and CO2 emissions are key criteria for CaFRI scores, with higher scores indicating more sustainable methods."

Journal

OPTIMAL INTERVAL FOR ARGON PLASMA COAGULATION FOLLOWING ENDOSCOPIC INJECTION SCLEROTHERAPY IN ESOPHAGEAL VARICES (DDW 2025) - "Background and Aim: The first-line treatment of esophageal varices (EV) in Japan is endoscopic injection sclerotherapy (EIS), and EIS with intra-variceal injection of ethanolamine oleate (EO) and para-variceal injection of polidocanol (aethoxysklerol: AS) is followed by argon plasma coagulation (APC) consolidation... Our findings suggest that APC consolidation following EIS is optimally performed as an outpatient procedure at least 15 days post-EIS to improve patient outcomes and reduce hospitalization duration."

Gastroenterology

TYPER: Transdermal Radiofrequency V ERASER Versus Polidocanol Sclerotherapy for Reticular Veins and Telangiectasias (clinicaltrials.gov) - P=N/A | N=46 | Completed | Sponsor: Science Valley Research Institute

New trial • Varicose Veins

Sclerotherapy with polidocanol as a treatment for aneurysmal bone cyst: A systematic review. (PubMed, J Clin Orthop Trauma) - "Other interventions, like absolute alcohol gel and Denosumab, showed potential but with varying outcomes. While percutaneous sclerotherapy with polidocanol has been prominently effective in managing aneurysmal bone cysts, further studies are required to identify the most effective and least invasive treatment strategies to optimize outcomes and minimize complications in clinical practice."

Journal • Review • Cardiovascular • Pain

Closing the Gap: Use of Polidocanol to Study Human Airway Epithelial Repair. (PubMed, Am J Respir Cell Mol Biol) - No abstract available

Journal

Comparing venous wall effects using empty vein ablation (EVA) technique by VELEXTM Catheter, endovenous laser ablation (EVLA) and foam sclerotherapy (FS) in an animal model. (PubMed, J Vasc Surg Venous Lymphat Disord) - "EVA demonstrated better results in vein wall damage compared with EVLA and FS, both in intima and media layers."

Journal • Preclinical • Varicose Veins

Spaghetti with meatballs or noodles: Microscopic structure of sclerosant-induced thrombus, sclerocoagulum and superficial venous thrombosis. (PubMed, Phlebology) - "Sclerothrombus samples were generated in vitro following incubation of whole blood or platelet-rich plasma with detergent sclerosants sodium tetradecyl sulphate (STS) or polidocanol (POL)...SVT contained a smooth fibrin mesh of relatively thick fibrin strands with scarce branching and fewer microparticles.ConclusionThe three entities of sclerothrombus, sclerocoagulum and SVT are distinct and distinguishable entities. Whilst sclerothrombus and SVT demonstrate features of a fibrin clot, sclerocoagulum is haemolysed blood containing disorganised fibrin strands."

Journal • Cardiovascular • Hematological Disorders • Thrombosis • Varicose Veins

Novel Low-Tech Vocal Fold Injury and Inoculation Methods Reveal Innate Permeability of Vocal Fold Epithelium in a Mouse Model (COSM 2025) - "Intraperitoneal (IP) naphthalene (NAPH) and topical polidocanol (PDOC) are two methods of injuring mouse airways... High-dose NAPH consistently injures mouse VFs. OA is a viable method of VF inoculation. VF epithelium is permeable, even without injury."

Preclinical

Development of a Polidocanol-based Human In Vitro Model to Explore Airway Epithelial Repair. (PubMed, Am J Respir Cell Mol Biol) - "While naphthalene is known to specifically induce club cell depletion in mouse airways, it failed to do so in phBECs. In conclusion, using fully differentiated phBECs treated with PDOC, we successfully established and thoroughly characterized a human in vitro system that will facilitate studies of mechanisms involved in susceptibility to injury as well as human airway repair and regeneration."

Journal • Preclinical • Pulmonary Disease • Respiratory Diseases • CDKN1A • KRT17

Complications and recurrence rates following aspiration sclerotherapy for adult hydrocele and spermatocele in the Helsinki Metropolitan Area (AUA 2025) - "Sclerosant used was in 97% of the cases polidocanol... Aspiration sclerotherapy is a safe treatment for adult hydrocele and spermatocele, with a low rate of complications. However, multiple treatments are often required, and surgery may sometimes be necessary. The retrospective design and loss to follow-up limit the certainty of these results."

Clinical • Infectious Disease • Urology