Asclera (polidocanol) / Merz Pharma - LARVOL DELTA

Application of ultrasound-guided microwave ablation combined with polidocanol injection in benign cystic-solid thyroid nodules and recurrence analysis. (PubMed, Discov Oncol) - "Ultrasound-guided MWA combined with polidocanol injection is more effective in treating benign cystic-solid thyroid nodules. This approach accelerates nodule ablation, significantly reduces nodule size, preserves thyroid function, lowers recurrence rates, and enhances overall safety."

Journal

Introducing the carbon footprint reduction index (CaFRI) as a software-supported tool for greener laboratories in chemical analysis. (PubMed, BMC Chem) - "Case studies using techniques such as spectrophotometry for polidocanol in ampoules, dispersive solid phase microextraction with HPLC/UV for ritonavir in human plasma, carbon quantum dots for molnupiravir in capsules, and homogenous liquid-liquid microextraction with HPLC/UV for favipiravir in human plasma demonstrated CaFRI's applicability in evaluating the carbon footprint across diverse analytical methods and matrices. These case studies illustrated that energy consumption and CO2 emissions are key criteria for CaFRI scores, with higher scores indicating more sustainable methods."

Journal

OPTIMAL INTERVAL FOR ARGON PLASMA COAGULATION FOLLOWING ENDOSCOPIC INJECTION SCLEROTHERAPY IN ESOPHAGEAL VARICES (DDW 2025) - "Background and Aim: The first-line treatment of esophageal varices (EV) in Japan is endoscopic injection sclerotherapy (EIS), and EIS with intra-variceal injection of ethanolamine oleate (EO) and para-variceal injection of polidocanol (aethoxysklerol: AS) is followed by argon plasma coagulation (APC) consolidation... Our findings suggest that APC consolidation following EIS is optimally performed as an outpatient procedure at least 15 days post-EIS to improve patient outcomes and reduce hospitalization duration."

Gastroenterology

TYPER: Transdermal Radiofrequency V ERASER Versus Polidocanol Sclerotherapy for Reticular Veins and Telangiectasias (clinicaltrials.gov) - P=N/A | N=46 | Completed | Sponsor: Science Valley Research Institute

New trial • Varicose Veins

Sclerotherapy with polidocanol as a treatment for aneurysmal bone cyst: A systematic review. (PubMed, J Clin Orthop Trauma) - "Other interventions, like absolute alcohol gel and Denosumab, showed potential but with varying outcomes. While percutaneous sclerotherapy with polidocanol has been prominently effective in managing aneurysmal bone cysts, further studies are required to identify the most effective and least invasive treatment strategies to optimize outcomes and minimize complications in clinical practice."

Journal • Review • Cardiovascular • Pain

Targeted Pre-conditioning and Cell Transplantation in the Murine Lower Respiratory Tract (ATS 2025) - "Our group has successfully transplanted mouse primary or pluripotent stem cell (PSC)-derived basal cells into the tracheas of syngeneic recipient mice post-polidocanol (PDOC) injury... We find evidence of engraftment of primary tracheal BCs throughout the intrapulmonary airways but also within the alveolar space. This finding highlights the need for robust translational, pre-clinical models for cellular therapeutics within the lung to pair pre-conditioning and donor cell type for engraftment into the intended niche while minimizing off target injury or engraftment."

Preclinical • Anesthesia • Cystic Fibrosis • Genetic Disorders • Immunology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Transplantation

Closing the Gap: Use of Polidocanol to Study Human Airway Epithelial Repair. (PubMed, Am J Respir Cell Mol Biol) - No abstract available

Journal

Comparing venous wall effects using empty vein ablation (EVA) technique by VELEXTM Catheter, endovenous laser ablation (EVLA) and foam sclerotherapy (FS) in an animal model. (PubMed, J Vasc Surg Venous Lymphat Disord) - "EVA demonstrated better results in vein wall damage compared with EVLA and FS, both in intima and media layers."

Journal • Preclinical • Varicose Veins

Spaghetti with meatballs or noodles: Microscopic structure of sclerosant-induced thrombus, sclerocoagulum and superficial venous thrombosis. (PubMed, Phlebology) - "Sclerothrombus samples were generated in vitro following incubation of whole blood or platelet-rich plasma with detergent sclerosants sodium tetradecyl sulphate (STS) or polidocanol (POL)...SVT contained a smooth fibrin mesh of relatively thick fibrin strands with scarce branching and fewer microparticles.ConclusionThe three entities of sclerothrombus, sclerocoagulum and SVT are distinct and distinguishable entities. Whilst sclerothrombus and SVT demonstrate features of a fibrin clot, sclerocoagulum is haemolysed blood containing disorganised fibrin strands."

Journal • Cardiovascular • Hematological Disorders • Thrombosis • Varicose Veins

Novel Low-Tech Vocal Fold Injury and Inoculation Methods Reveal Innate Permeability of Vocal Fold Epithelium in a Mouse Model (COSM 2025) - "Intraperitoneal (IP) naphthalene (NAPH) and topical polidocanol (PDOC) are two methods of injuring mouse airways... High-dose NAPH consistently injures mouse VFs. OA is a viable method of VF inoculation. VF epithelium is permeable, even without injury."

Preclinical

Development of a Polidocanol-based Human In Vitro Model to Explore Airway Epithelial Repair. (PubMed, Am J Respir Cell Mol Biol) - "While naphthalene is known to specifically induce club cell depletion in mouse airways, it failed to do so in phBECs. In conclusion, using fully differentiated phBECs treated with PDOC, we successfully established and thoroughly characterized a human in vitro system that will facilitate studies of mechanisms involved in susceptibility to injury as well as human airway repair and regeneration."

Journal • Preclinical • Pulmonary Disease • Respiratory Diseases • CDKN1A • KRT17

Complications and recurrence rates following aspiration sclerotherapy for adult hydrocele and spermatocele in the Helsinki Metropolitan Area (AUA 2025) - "Sclerosant used was in 97% of the cases polidocanol... Aspiration sclerotherapy is a safe treatment for adult hydrocele and spermatocele, with a low rate of complications. However, multiple treatments are often required, and surgery may sometimes be necessary. The retrospective design and loss to follow-up limit the certainty of these results."

Clinical • Infectious Disease • Urology

Polidocanol ablation in midventricular obstructive cardiomyopathy: novel approach and early outcomes. (PubMed, J Invasive Cardiol) - "Polidocanol ablation was safe and effective as a minimally invasive option for managing MVOHCM, providing noteworthy procedural advantages. However, additional multicenter trials are needed to validate its use and establish standardized protocols."

Journal • Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy • Obstructive Hypertrophic Cardiomyopathy

Successful Treatment of a Rapidly Enlarging Mandibular Aneurysmal Bone Cyst With Sclerotherapy and Intralesional Curettage. (PubMed, Cureus) - "This case highlights the potential benefits of combining polidocanol sclerotherapy and intralesional curettage for the treatment of jaw ABCs. Further research is needed to determine the optimal application and follow-up of this approach."

Journal • Cardiovascular • Oncology

The Initial Exploration of Polidocanol Sclerotherapy for the Treatment of Axillary Osmidrosis: A Retrospective Study. (PubMed, Dermatol Surg) - "Polidocanol sclerotherapy may provide an effective and safe treatment with longer efficacy compared to toxin, which is an effective and safe option for AO treatment."

Clinical • Journal • Retrospective data

Klippel-Trenaunay syndrome with multiorgan vascular involvement and gastrointestinal bleeding: A case report and literature review. (PubMed, Medicine (Baltimore)) - "Endoscopic therapy can provide significant benefits for patients with KTS complicated by long-term gastrointestinal bleeding. However, KTS cannot currently be cured, and early diagnosis, standardized evaluation, and regular follow-up are key to the collaborative management and treatment of KTS patients."

Journal • Review • Gastroenterology • Gastrointestinal Disorder • Varicose Veins

Dosing and Tolerability of Deoxycholic Acid Vs. Polidocanol in the Treatment of Neurofibromatosis Type 1 Cutaneous Neurofibromas (clinicaltrials.gov) - P1 | N=20 | Completed | Sponsor: Massachusetts General Hospital | Recruiting ➔ Completed | Trial completion date: Sep 2024 ➔ Jan 2025 | Trial primary completion date: Apr 2024 ➔ Jan 2025

Trial completion • Trial completion date • Trial primary completion date • Genetic Disorders • Neurofibromatosis • Solid Tumor • NF1

Effectiveness of Double Balloon Enteroscopy in the Diagnosis and Treatment of Small Bowel Varices. (PubMed, Diagnostics (Basel)) - "Endoscopic therapy for small bowel varices included injection sclerotherapy in eight cases (six with cyanoacrylate and two with polidocanol) and injection sclerotherapy plus hemoclipping in one case. SB varices can present a diagnostic challenge for clinicians. DBE is a valuable tool for both the diagnosis and management of small bowel varices."

Journal • Gastrointestinal Disorder • Rare Diseases

PROMISING RESULTS OF ULTRASOUND GUIDED FOAM SCLEROTHERAPY FOR TREATING CHRONIC VENOUS ULCERS. (PubMed, J Vasc Surg Venous Lymphat Disord) - "Most patients with chronic venous ulcers (CEAP 6) treated with foam sclerotherapy achieved healing or significant improvement within 52 weeks. Healing was highly influenced by time until treatment, ulcer size, reduced dorsiflexion of the ankle and/or lymphedema presence and use of compression therapy."

Journal • Cardiovascular • Hypertension • Inflammation • Venous Ulcer

Clinical observation on prognosis of mixed hemorrhoids treated with polidocanol injection combined with automatic elastic thread ligation operation. (PubMed, World J Gastrointest Surg) - "For patients with mixed hemorrhoids, the therapeutic effect achieved by using polidocanol injection combined with RPH was better. The wounds of the patients healed faster, the postoperative pain was milder, QOL improved, and the incidence of complications was lower, and the short-term and long-term prognosis was good."

Journal • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Pain

The Efficacy of Percutaneous Renal Puncture Injection of Group A Streptococcal Sclerosant in the Treatment of Simple Renal Cysts (ChiCTR) - P=N/A | N=180 | Sponsor: The First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese Hospital); The First Affiliated Hospital of Jinan University (Guangzhou

New trial

Investigation of the sclerosing effect of increasing doses of polidocanol on pulmonary vessels: Experimental study. (PubMed, Medicine (Baltimore)) - "In our study, a single injection of 0.5 mL 2% polidocanol via the femoral vein. Animal lungs, congestion in pulmonary vessels, emphysematous changes, and intra-alveolar hemorrhage were found. As a result, our study demonstrated pulmonary vascular damage with increasing doses of polidocanol. So, the dose of polidocanol should be used in a limited manner."

Journal • Anesthesia • Cardiovascular • Hematological Disorders • Pulmonary Embolism • Respiratory Diseases

A new therapy for microcystic lymphatic malformations: the combination of intralesional laser thermolysis and percutaneous sclerotherapy. (PubMed, Front Cell Dev Biol) - "Minor complications included circumscribed skin blisters, postoperative non-infectious fever, transient skin edema, pigmentation, and slight depressions of localized skin. The treatment of intralesional laser thermolysis combined with traditional sclerotherapy is considered as a safe, feasible and effective therapy in treating microcystic LMs."

Journal • CNS Disorders • Depression • Psychiatry

Attempted ablation of an orbital cyst in a dog with 1% polidocanol using fluoroscopy and contrast cystography. (PubMed, Vet Ophthalmol) - "Contrast cystography may be useful to verify catheter position and demonstrate cyst margins prior to injection. This case report highlights the importance of complete conjunctival excision during enucleation."

Journal • Glaucoma • Inflammation • Ophthalmology

Sclerotherapy and Candida Antigen in Treatment of Common Warts (clinicaltrials.gov) - P=N/A | N=75 | Not yet recruiting | Sponsor: Sohag University

New trial • Dermatology