Asclera (polidocanol) / Merz Pharma - LARVOL DELTA

Morphological features of the great saphenous vein in patients with chronic venous disease of the lower extremities undergoing the most common endovenous treatment techniques. (PubMed, Pol Merkur Lekarski) - " The severity of structural changes in the great saphenous vein in patients with chronic venous disease of the lower extremities following ultrasoundguided microfoam sclerotherapy was significantly lower compared to endovenous high-frequency electric welding in automatic mode and endovenous laser ablation, resulting in less favorable conditions for the qualitative development of the fibrous process."

Journal

Use of Sclerotherapy in the Treatment of Intranasal Hemangiomas: Case Report and Review of the Literature (AAOMS 2025) - "Polidocanol is often preferred for smaller, superficial lesions due to its milder effects, while bleomycin is used for slow-flow vascular malformations with a favorable safety profile.This case report describes a 52-year-old female with a nasal hemangioma severe enough to obstruct her right nostril. PMID: 26723834. Photo after sclerotherapy treatment Photo before sclerotherapy treatment"

Case report • Clinical • Review • Cardiovascular • CNS Disorders • Fibrosis • Hematological Disorders • Immunology • Ischemic stroke • Thrombosis

Evaluation of Chemical Ablation in Benign Thyroid Nodules: Experience in a Mexican Cohort (ATA 2025) - "Patient records were reviewed to assess outcomes following treatment with lauromacrogol or polidocanol.ResultsA total of 26 patients (22 women [84.6%] and 4 men [15.4%]) were followed for a median of 10.5 months (range: 1–30 months)...It demonstrated a high success rate and significant volume reduction rate in most patients. Compared to more invasive treatments like surgery or radiofrequency ablation, chemical ablation offers a cost-effective alternative with lower risk of complications and overtreatment."

Endocrine Cancer • Oncology • Solid Tumor • Thyroid Gland Carcinoma

Evaluation of the tolerance and efficacy of a shampoo and a spray containing polidocanol in patients with anti-cancer treatment and suffering of trichodynia and scalp discomfort sensations (EADV 2025) - No abstract available

Clinical • Oncology

Transdermal radiofrequency (V ERASER®) plus polidocanol sclerotherapy versus polidocanol sclerotherapy alone for the treatment of reticular veins and telangiectasias. A randomized controlled trial (TYPER trial). (PubMed, Phlebology) - "Quality of life improved, with pain reduction in 40% and 55% of patients in the right and left lower limbs, respectively (p = .030 and p = .002).ConclusionTransdermal radiofrequency was not superior to standard of care polidocanol sclerotherapy. Both methods improved quality of life, particularly in reducing pain associated with varicose veins."

Journal • Pain • Varicose Veins

Investigation of the sclerosing effect of increasing doses of polidocanol on pulmonary vessels: Experimental study (ERS 2025) - No abstract available

Cardiovascular • Pulmonary Embolism • Respiratory Diseases

Ophthalmic and Central Retinal Artery Occlusion after Polidocanol Injection. (PubMed, Ophthalmol Retina) - No abstract available

Journal • Ophthalmology • Retinal Disorders

Therapeutic efficacy of the polidocanol versus pingyangmycin in the treatment of maxillofacial vascular disorders. (PubMed, Phlebology) - "The adverse reaction rate, cure rate, effective rate and total effective rate of patients with lymphatic vessel malformation were 94.00%, 54.00%, 84.00% and 94.00% respectively. The adverse reaction rate, cure rate, effective rate and total effective rate of venous malformation patients were 95.83%, 75.00%, 91.67% and 100.00%, respectively.ConclusionPolidocanol injection is better than Pingyangmycin in the treatment of maxillofacial vascular disorders, and the drug is milder, less adverse reactions and higher safety."

Journal • Cardiovascular • Pain

THE DOUBLE-EDGED NEEDLE: GASTRIC ISCHEMIA FOLLOWING POLIDOCANOL INJECTION IN A REFRACTORY BLEEDING ULCER (UEGW 2025) - No abstract available

Cardiovascular

Neovascularisation in flexor carpi ulnaris tendinopathy: novel combined sclerosing therapy and eccentric training of the forearms in athletics' wrist pain. (PubMed, BMJ Case Rep) - "Sclerosing therapy using polidocanol under power and laser Doppler guidance was initiated, with immediate decrease of capillary blood flow by 25% with resolution of the neovascularisation in power Doppler. Immediately following sclerosing, the patient's reported pain level on the VAS was reduced from 9/10 to 4/10. Following a short period of rest, eccentric training of the forearm muscle was initiated over 12 weeks with functional complete recovery and complete resolution of wrist pain."

Journal • Pain

Consensus on Sclerotherapy for Patients With Hereditary Hemorrhagic Telangiectasia-Related Epistaxis. (PubMed, JAMA Otolaryngol Head Neck Surg) - "Experts in using specific sclerotherapy agents (sodium tetradecyl sulfate and polidocanol), both in liquid or foam form, participated in surveys...While not formal treatment guidelines, these statements offer valuable insights for clinicians seeking to adopt or align with expert recommendations. Further validation and research are encouraged to ensure these consensus statements improve patient care and outcomes."

Journal • Anesthesia • Cardiovascular • Hematological Disorders

Is Injectable Sclerotherapy with Polidocanol Foam Effective for Treating Hemorrhoids in Patients with Severe Anemia? (PubMed, J Anus Rectum Colon) - "Two patients experienced recurrence of prolapse symptoms during the one-year follow-up period and subsequently underwent hemorrhoidectomy. The use of Polidocanol foam in injectable sclerotherapy demonstrates highly promising effects in patients suffering from severe anemia caused by hemorrhoids."

Journal • Anemia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders

Experience in the Treatment of Toxic Adenomas Using Percutaneous Ablation Techniques in a Tertiary Care Unit (ENDO 2025) - "15 (88.2%) were treated with thiamazole and 7 (41.2%) with propranolol. 11(64.7%) were treated with chemical ablation (CA) with ethanol and polidocanol and 6(35.3%) with radiofrequency thermal ablation (RFT)... PA treatment represents an effective and safe alternative treatment for patients with TA. The greater volume reduction through RFT suggests better efficiency, but it is dependent on the learning curve."

Endocrine Disorders • Oncology • Pain

Marine-Lenhart Syndrome: Case Report (ENDO 2025) - "Thiamazole 30 mg/d and propranolol 20 mg/d were started. Percutaneous ablation of RTN was performed with 3% polidocanol 2 ml plus ethanol 1.5 ml and 8 mg intrathyroidal dexamethasone was administered in LTL... MLS is rare, but given the nature of the pathology, minimally invasive techniques can be implemented in its management combined with antithyroids to increase therapeutic efficacy."

Case report • Clinical • Alopecia • CNS Disorders • Endocrine Disorders • Fatigue • Grave’s Disease • Immunology • Insomnia • Movement Disorders • Sleep Disorder

Single-needle percutaneous foamed sclerotherapy using ultrasound and fluoroscopy guidance using "contrast washout technique" for the treatment of a slow-flow chest wall vascular malformation in a pediatric patient. (PubMed, J Surg Case Rep) - "We present the case of a 7-year-old child with a large, slow-flow VM on the right anterior chest wall, successfully treated with ultrasound- and fluoroscopy-guided foam sclerotherapy using polidocanol via the ``contrast washout'' technique. The procedure resulted in significant lesion resolution with no post-procedural pain. In addition to its effectiveness, this approach also spares patients from extensive surgical interventions, making it a valuable treatment option for pediatric VMs."

Journal • Pain • Pediatrics

Sclerotherapy With Polidocanol Is Highly Effective for Treating Oral Cavernous Hemangiomas in Children. (PubMed, In Vivo) - "Sclerotherapy using polidocanol provides an effective, safe, and relatively simple treatment for hemangiomas in the oral cavity of children and may be recommended to replace the conventional pingyangmicine treatment."

Journal • Anesthesia • Oncology • Pain

Targeted Pre-Conditioning and Cell Transplantation in the Murine Lower Respiratory Tract. (PubMed, Am J Respir Cell Mol Biol) - "The detergent polidocanol was adapted for distal lung pre-conditioning, inducing intrapulmonary airway epithelial denudation by 5 and 24-hours post-delivery...These findings demonstrate the utility of bronchoscopically targeted pre-conditioning and cell delivery to the conducting intra-pulmonary airways. Thus providing an important framework for pre-clinical translation of approaches for engineered airway epithelial regeneration."

Journal • Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Transplantation

In Vitro Evaluation of Hydrogel Coils Combined with Liquid Embolic and Sclerosing Agents for Endovascular Embolization. (PubMed, Cardiovasc Intervent Radiol) - "In vitro, sclerosing agents disabled or damaged hydrogel coils. The combination of sclerosing agents and hydrogel coils might clinically have adverse effects, including the insufficient and non-target embolization."

Journal • Preclinical

Factors that Enhance the Stability of Polidocanol and Monoethanolamine Oleic Acid Foams, and Identification of the Optimal Foam-Creating Device. (PubMed, Cardiovasc Intervent Radiol) - "The half-lives of foams were prolonged by increasing their air ratio and by adding Gluc. Of the tested mixture devices, Hlic created foams with longer half-lives in the shortest time."

Journal

Efficacy of sclerotherapy with pingyangmycin and polidocanol for venous malformations. (PubMed, Front Surg) - "None of the patients experienced serious adverse reactions. Sclerotherapy with pingyangmycin and polidocanol is a treatment modality for relieving the clinical symptoms of venous malformations, with good efficacy and few potential risks."

Journal • Pain

Targeted Pre-conditioning and Cell Transplantation in the Murine Lower Respiratory Tract (ATS 2025) - "Our group has successfully transplanted mouse primary or pluripotent stem cell (PSC)-derived basal cells into the tracheas of syngeneic recipient mice post-polidocanol (PDOC) injury... We find evidence of engraftment of primary tracheal BCs throughout the intrapulmonary airways but also within the alveolar space. This finding highlights the need for robust translational, pre-clinical models for cellular therapeutics within the lung to pair pre-conditioning and donor cell type for engraftment into the intended niche while minimizing off target injury or engraftment."

Preclinical • Anesthesia • Cystic Fibrosis • Genetic Disorders • Immunology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Transplantation

USE OF 50% DEXTROSE AS A SCLERO THERAPEUTIC AGENT FOR ESOPHAGEAL VARICES IN AN INFANT PRESENTED WITH HEMATEMESIS– A CASE REPORT WITH A VIDEO . (ESPGHAN 2025) - "Many agents are used in adult (e.g ethanolamine oleate,polidocanol, 99% alccohol) but not suitable and effective in infants...We are preparing patient for Living donar liver transplant. Conclusions Dextrose 50% works well as a sclerosing agents for bleeding oesophageal varices ."

Case report • Clinical • Video • Anemia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders

Anterograde spermatic vein sclerotherapy: Step-by-step Tauber procedure. (PubMed, J Pediatr Urol) - "Tauber's technique could be considered an appropriate option for the treatment of varicocele in the paediatric population."

Journal • Pediatrics

Combined Laser Therapy for Post-sclerotherapy Hyperpigmentation Following Nicolau Syndrome: A Case Report. (PubMed, Cureus) - "We report a case of a 40-year-old woman with Fitzpatrick skin type II, who developed longstanding hyperpigmentation in the right popliteal area following polidocanol sclerotherapy...Notable pigment clearance, full crust exfoliation, and restoration of normal skin tone were achieved without adverse effects. Independent expert evaluation and patient-reported outcomes confirmed the treatment's efficacy and high tolerability."

Journal

Application of ultrasound-guided microwave ablation combined with polidocanol injection in benign cystic-solid thyroid nodules and recurrence analysis. (PubMed, Discov Oncol) - "Ultrasound-guided MWA combined with polidocanol injection is more effective in treating benign cystic-solid thyroid nodules. This approach accelerates nodule ablation, significantly reduces nodule size, preserves thyroid function, lowers recurrence rates, and enhances overall safety."

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