acyclovir / Generic mfg. - LARVOL DELTA

A novel molecularly imprinted 3D COF-based magnetic solid-phase extraction combined with UHPLC-MS/MS to detect trace residues of acyclovir, penciclovir and ganciclovir in animal-derived food. (PubMed, Food Chem) - "Afterwards, a MSPE-UHPLC-MS/MS method was developed, which stands out as the most sensitive approach yet for ACV, PCV, GCV measurements and has been successfully applied to analyze thirteen ready-to-eat chicken samples. Endogenous PCV was detected in two of these samples, demonstrating the potential of the proposed method as a valuable tool for monitoring antiviral drug residues and ensuring food safety."

Journal

Acyclovir-Induced Nephrotoxicity: A Case Report. (PubMed, Cureus) - "This case highlights the importance of close monitoring in patients receiving acyclovir, particularly those at an increased risk of nephrotoxicity. To ensure early detection and intervention, it is crucial to perform regular renal function assessments, especially within the first 48 hours of treatment."

Journal • Acute Kidney Injury • CNS Disorders • Nephrology • Renal Disease

A Case of Extramedullary Plasmacytoma Involving the Pancreas (ACG 2025) - "The patient began systemic treatment with daratumumab, lenalidomide, aspirin, acyclovir, and dexamethasone. Extramedullary plasmacytoma (EMP) of the pancreas is rare and often appears similar to pancreatic adenocarcinoma, typically causing jaundice and abdominal pain. Early and accurate diagnosis can lead to more effective treatment, reducing unnecessary surgeries and significantly improving outcomes.Figure: Pancreatic biopsy shows predominant population of atypical plasma cells that are CD138 positive: Hematoxylin and Eosin staining, magnification x 40 and x100. Figure: Immunostain CD138 Highlighting Plasma Cells, magnification x40"

Clinical • Anemia • Cardiovascular • Dyslipidemia • Endocrine Disorders • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Hepatology • Hypertension • Melanoma • Multiple Myeloma • Pancreatic Adenocarcinoma • Pancreatic Cancer • Plasmacytoma • Solid Tumor • CD38 • SDC1

Sub-150 nm drug nanocrystals produced using a milligram-scale media mill. (PubMed, Int J Pharm) - "Three model drugs (itraconazole, acyclovir, and amphotericin B) were processed under optimised conditions. Similarly, zeta potential measurements showed no significant differences between scales. Overall, the Mini Mill achieved an 85 % reduction in drug consumption without compromising key formulation attributes, positioning it as a practical and cost-effective tool for the early development of NCs-based formulations."

Journal

Infection Prophylaxis in CAR T-Cell Therapy (ICBMT 2025) - "NCCN and ASTCT guidelines support the use of acyclovir 400 mg PO twice daily or valacyclovir 500 mg PO twice daily for at least six months after CAR T infusion and until CD4 T -cell counts exceed 200/µL. Hepatitis B virus (HBV) management should include entecavir or tenofovir for at least 12 months in HBsAg -positive patients and longer if immunosuppression persists; anti -HBc–positive/HBsAg -negative patients may receive prophylaxis or undergo monthly HBV DNA monitoring...Alternatives include atovaquone 1500 mg daily, dapsone 100 mg daily (after G6PD testing), or monthly aerosolized pe ntamidine for those with sulfa allergy or intolerance. Fungal Fluconazole is recommended during periods of neutropenia until neutrophil recovery. High -risk patients — those with pre -infusion neutropenia, prior invasive fungal infection within six months, prior allo -HCT, grade ≥3 CRS/ICANS, or prolonged high -dose cortic osteroids (>72 h) —should receive mould -active..."

CAR T-Cell Therapy • Hematological Malignancies • Hepatitis B • Hepatology • Herpes Zoster • Immunology • Infectious Disease • Influenza • Meningococcal Infections • Neutropenia • Pertussis • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Tetanus • CD4

Nephrotoxicity and kidney outcomes in pediatric oncology patients. (PubMed, Nephrol Dial Transplant) - "Acute kidney injury (AKI) is common in children with cancer and is strongly associated with an increased risk of chronic kidney disease (CKD). Awareness is crucial for high-risk patients, particularly those receiving nephrotoxic medications, with a history of multiple AKI episodes or a prior nephrectomy. Comprehensive monitoring strategies should be implemented at diagnosis, during therapy, and during the post-treatment period to enable early detection and timely intervention, ultimately reducing the risk of AKI and its progression to CKD."

Journal • Acute Kidney Injury • Chronic Kidney Disease • Nephrology • Oncology • Pediatrics • Renal Disease

Comparative Case Series of Herpes Zoster in Older Immunocompromised Chinese Adults: Clinical, Immunological, and Treatment Profiles in Four Cases Over 60. (PubMed, Infect Drug Resist) - "Selected for their immunocompromised status and prior antiviral failure or renal concerns, patients received oral brivudine (125 mg once daily) with or without intravenous acyclovir, with outcomes assessed via clinical examination, pain scores, and laboratory monitoring over 7-14 days. Compared to previous use of other antivirals, brivudine was better tolerated and did not require renal dose adjustment. In summary, brivudine appears to be a promising option for elderly immunocompromised patients with herpes zoster, offering effective viral control, favorable safety, and improved clinical outcomes."

Journal • Dermatology • Diabetes • Diabetic Nephropathy • Herpes Zoster • Immunology • Inflammatory Arthritis • Lupus • Metabolic Disorders • Pain • Renal Disease • Systemic Lupus Erythematosus • Varicella Zoster

Impact of kidney function on 200 days of antiviral prophylaxis for cytomegalovirus disease in CMV-seronegative recipients of CMV-seropositive donor kidneys Post hoc analysis of a randomized, phase 3 trial of letermovir versus valganciclovir prophylaxis. (PubMed, Am J Transplant) - P3 | "Adult CMV D+R- KTRs were randomized (1:1) post-transplant to letermovir 480 mg (with acyclovir and valganciclovir placebo) or valganciclovir 900 mg (with acyclovir and letermovir placebos) daily for 28-weeks (NCT03443869). In CMV D+R- KTRs, letermovir prophylaxis was associated with less CMV DNAemia compared to valganciclovir in participants with low kidney function during the 200-day prophylaxis period. CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov: NCT03443869, EudraCT: 2017-001055-30."

Journal • P3 data • Retrospective data • Cytomegalovirus Infection • Infectious Disease • Transplantation

A Rare Case of SDRIFE (Symmetrical Drug-Related Intertriginous and Flexural Exanthema) Induced by Systemic Acyclovir Use (EADV 2025) - No abstract available

Clinical

Charting the Neurotropism of Human Parvovirus B19 and Encephalitis: A Systematic Review of Existing Literature of 25 Years. (PubMed, Cureus) - "Acyclovir and intravenous immunoglobulin (IVIG) constituted the most common medications utilized, 13.01% each. Improvement was seen in 80.72% (67) after treatment. In light of recent publications, the shift in the trend of parvovirus B19 toward the central nervous system (CNS) is alarming. Despite limited information, the site of brain parenchymal involvement (parietal lobe, cerebellar hemispheres, corpus callosum, frontal lobe, and ventricles) and specific radiological findings such as hyperintensity on DWI and T2-weighted images, along with CSF PCR positivity and neurological symptoms, can point toward parvovirus encephalitis."

Journal • Review • Ataxia • Cardiovascular • CNS Disorders • Epilepsy • Infectious Disease • Movement Disorders • Pain • Pediatrics

Outpatient and Inpatient Management of Infants and Children With Eczema Herpeticum Diagnosed in the Emergency Department. (PubMed, Pediatr Dermatol) - "In this cohort, oral acyclovir outpatient management was not followed by disease progression or serious complications. These findings support that some mild EH cases may be managed without hospitalization, but further prospective studies are needed."

Journal • Atopic Dermatitis • Critical care • Dermatitis • Dermatology • Immunology • Keratitis • Ocular Inflammation • Ophthalmology • Pediatrics

Standarization and characterization of intravenous drug dilutions in critically ill pediatric patients. (PubMed, Farm Hosp) - "The physicochemical properties (osmolarity and pH) and vesicant nature of drugs are key factors contributing to the development of phlebitis in critically ill pediatric patients. Standardizing and characterizing drug dilutions will facilitate the selection of the most appropriate vascular access device, improving the safety and effectiveness of intravenous therapy."

Journal • Critical care • Pain • Pediatrics

An Atypical Case of Varicella Meningitis in a Young Immunocompetent Male Patient With a Possible Concomitant Case of Ramsay-Hunt Syndrome. (PubMed, Cureus) - "He was discharged on hospital day 4 and completed a total of 14 days of acyclovir 500mg three times a day. Additionally, we discuss the implications of intravenous acyclovir therapy in mild VZV meningitis in young immunocompetent individuals and the role oral valacyclovir therapy can play."

Journal • CNS Disorders • Herpes Zoster • Infectious Disease • Otorhinolaryngology • Pain • Varicella Zoster

A case report of zoster-induced Guillain-Barré syndrome: diagnostic challenges and potential role of pulse prednisone. (PubMed, Ann Med Surg (Lond)) - "The patient was initially treated with intravenous acyclovir for suspected herpes zoster myelitis but showed no improvement. This case underscores the diagnostic complexity of ZGBS and highlights prolonged pulse prednisone therapy as a viable alternative to IVIG in resource-constrained settings. Early diagnosis and tailored management are critical for optimizing recovery in rare conditions like ZGBS."

Journal • CNS Disorders • Herpes Zoster • Pain • Varicella Zoster

Epstein-Barr Virus Corneal Endotheliitis and Uveitis in a Patient With Extranodal Natural Killer/T-Cell Lymphoma. (PubMed, Cornea) - "EBV infection can cause severe corneal edema and uveitis. In patients with ENKTL, EBV should be considered a possible etiology of ocular involvement, and timely ophthalmic management may contribute to better visual outcomes."

Journal • Achromatopsia • Epstein-Barr Virus Infections • Hematological Disorders • Hematological Malignancies • Infectious Disease • Lymphoma • Natural Killer/T-cell Lymphoma • Ocular Inflammation • Oncology • Ophthalmology • T Cell Non-Hodgkin Lymphoma • Uveitis

Herpes simplex virus disease in infants younger than 90 days: a British Paediatric Surveillance Unit study. (PubMed, Arch Dis Child) - "Infants with neonatal HSV can present without fever, SEM lesions or elevated infection markers; treatment delay is subsequently common. Outcomes remain poor with high case-fatality rates and long-term morbidity. Clinicians should have a low threshold for empirically testing for and treating herpes in unwell neonates."

Journal • Herpes Simplex • Infectious Disease • Pediatrics • Septic Shock

Biological evaluation and molecular docking studies of novel aza-acyclic nucleosides as putative antimicrobial, anticancer, and antioxidant agents. (PubMed, BMC Chem) - "This study aimed to synthesize new aza-acyclic nucleosides (aza-acyclovir) and evaluate the efficacy of these synthetic compounds as potential antimicrobial, anticancer, and antioxidant agents...Despite exhibiting lower radical scavenging activity than ascorbic acid (an antioxidant compound used as a standard), Compound 1 from the novel synthetic aza-acyclic nucleosides showed a higher reduction capacity, which was dose-dependent. Overall, we report newly synthesized compounds that show promising antimicrobial, anticancer, and antioxidant effects."

Journal • Lung Cancer • Oncology • Solid Tumor

Decrease in SinglePlex Viral PCRs Use and acyclovir utilization following implementation of The BioFire Meningitis/Encephalitis Panel at A Tertiary Care Cancer Center. (PubMed, J Clin Virol Plus) - "In the post-intervention period, the number of targeted viral tests was reduced by 64.9 % (703 to 247 PCRs), and the total number of patients treated with acyclovir was reduced by 29.1 % (82 patients vs 45 patients) with a reduction in the duration of therapy from 7.33 days to 4.47 days in the post-intervention period (p < 0.0274). The implementation of the M/E panel contributed to a reduction in the number of singleplex PCR tests performed and a reduction in the utilization and duration of acyclovir therapy in our cancer patient population."

Journal • CNS Disorders • Infectious Disease • Oncology

Intralesional acyclovir versus cryotherapy in treatment of plantar warts: A randomized controlled trial. (PubMed, J Am Acad Dermatol) - "Intralesional acyclovir is a promising therapeutic modality for plantar warts, demonstrating similar efficacy to cryotherapy, but the procedure is significantly more painful."

Journal • Dermatology • Pain

In vitro study: No displacement of bilirubin-albumin binding by erythromycin, azithromycin, acyclovir, or ganciclovir. (PubMed, Pediatr Int) - No abstract available

Journal • Preclinical • Infectious Disease

Herpes Simplex Virus Type-1 Infection as a Trigger for Pemphigus Vulgaris. (PubMed, Cureus) - "Treatment with acyclovir only modestly improved the lesions. Anti-desmosome antibodies were positive, and an oral biopsy showed PV features. Treatment with prednisolone followed by rituximab (RTX) resulted in significant improvement."

Journal • Dermatology • Gastrointestinal Disorder • Herpes Simplex • Immunology • Infectious Disease • Pain • Pemphigus Vulgaris • Vitiligo

Factors associated with mortality in immunocompromised children with varicella. (PubMed, BMC Pediatr) - "Multiple complications and a neutrophil/lymphocyte (NLR) ratio > 3.3 were associated with a significantly higher risk of death in immunocompromised children with varicella."

Journal • Retrospective data • Dermatology • Hematological Disorders • Hematological Malignancies • Infectious Disease • Oncology • Pediatrics • Pneumonia • Respiratory Diseases • Solid Tumor • Varicella Zoster

Neurotoxic effects of acyclovir: impacts on oxidative stress, inflammation, and neurotransmitter dynamics in male Wistar rats. (PubMed, Metab Brain Dis) - "Acyclovir impaired motor function, muscle strength, and memory by inducing derangement of the brain's oxidative markers, cytokines, and neurotransmitter levels."

Journal • Preclinical • Inflammation • CAT • IL10 • IL1B • IL6 • TNFA

Duration of Intravenous Acyclovir in Adults and Children with Suspected Herpes Simplex Virus Encephalitis at an Institution with the BioFire FilmArray Meningitis/Encephalitis Panel (IDWeek 2025) - No abstract available

Clinical • Herpes Simplex • Infectious Disease

Efficacy and safety results from the Phase 2 clinical trial of pritelivir versus foscarnet for treatment of acyclovir-refractory and/or resistant mucocutaneous HSV infections in immunocompromised subjects (IDWeek 2025) - No abstract available

Clinical • P2 data • Herpes Simplex • Infectious Disease