acyclovir / Generic mfg. - LARVOL DELTA

Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes. (PubMed, J Adv Res) - "Antimycin A emerges as a promising lead candidate for the development of antiviral therapies against alpha-herpesvirus infections."

Journal • Herpes Simplex • Infectious Disease

Herpes Simplex Virus and Drug Resistance - Comprehensive Update on Resistance Mutations and Implications for Clinical Management: A Narrative Review. (PubMed, Clin Microbiol Infect) - "This dataset paves the way to harmonize reporting of DRMs for diagnostic labs and to accelerate genotypic DST interpretation through aggregated data. Ongoing large-scale data collection of genotypic, phenotypic, and clinical data is crucial for evidence-based management of HSV antiviral resistance and clinical guidelines."

Journal • Review • Epstein-Barr Virus Infections • Herpes Simplex • Infectious Disease

Disseminated Varicella-Zoster Virus in a Patient on Pegloticase and Mycophenolate Mofetil for Gout. (PubMed, Cureus) - "She was, therefore, started on acyclovir, and she clinically improved. In this case, our patient became profoundly immunosuppressed with the MMF-pegloticase regimen, which led to disseminated VZV. This case sheds light on the serious risks associated with this drug regimen."

Journal • Atrial Fibrillation • Cardiovascular • Dermatology • Diabetes • Gout • Herpes Zoster • Hypotension • Inflammatory Arthritis • Metabolic Disorders • Rheumatology • Type 2 Diabetes Mellitus • Varicella Zoster

[Translated article] The need for prolonged antiviral use to prevent recurrences of herpes simplex virus ocular disease: A systematic review. (PubMed, Farm Hosp) - "Prolonged use of antivirals protects from ocular, non-ocular recurrences and stromal keratitis safely. The effects on visual acuity are not known."

Journal • Herpes Simplex • Keratitis • Ocular Inflammation • Ophthalmology

NEONATAL HERPES IN THE UK : WHAT IS THE LONG-TERM OUTLOOK FOR AFFECTED INFANTS? (ESPID 2025) - "All infants received initial treatment with IV aciclovir 23/41 subsequently received six months or more prophylactic oral aciclovir...Conclusions/Learning Points Over a quarter of surviving infants with neonatal herpes in this UK study had neurodevelopmental impairment at 2 years of age. Cinicians should be aware that infants with neonatal herpes infections can have long-term neurodevelopmental sequelae, and that those with HSV-2 infections may be at greater risk than those with HSV-1."

Infectious Disease

OUTCOMES OF ANTENATAL ANTIVIRAL SUPPRESSIVE THERAPY AT 36 WEEKS GESTATION IN A LARGE COHORT OF PREGNANT PERSONS WITH GENITAL HERPES SIMPLEX VIRUS (ESPID 2025) - "Background To decrease rates of cesarean section for active herpes simplex virus (HSV) genital lesions and HSV transmission to infants, several international organizations recommend offering mothers with a history of genital HSV acyclovir prophylaxis at or beyond 36 weeks' gestation...A total of 8 (0.03%) infants went on to develop neonatal HSV. Conclusions/Learning Points Continued emphasis should be placed on ascertaining a history of genital HSV and using antenatal antiviral suppressive therapy to lower cesarean section rates and prevent genital and neonatal HSV."

Herpes Simplex • Infectious Disease

Secondary Immunodeficiency in Marginal Zone Lymphoma and Impact of Bruton Tyrosine Kinase Inhibitor (CIS 2025) - "A 55-year-old male with a history of systemic lupus erythematosus (SLE) on hydroxychloroquine, antiphospholipid antibody syndrome on warfarin, anal cancer s/p resection, long-standing splenomegaly, and lymphadenopathy with unremarkable core needle biopsy in 2018 was diagnosed with marginal zone lymphoma via excisional lymph node biopsy in 2023...After starting rituximab for lymphoma, he developed severe neutropenia (0.47 cells/μL), Candida esophagitis (requiring transient PEG tube placement), and a left ethmoid and sphenoid sinus abscess and orbital cellulitis due to Aspergillus fumigatus...For Pneumocystis jiroveci (PCP), antiviral and antifungal prophylaxis, he receives dapsone, acyclovir, and voriconazole, respectively...Ibrutinib, a first-generation BTK inhibitor, improves T cell exhaustion with treatment of B cell lymphomas; similar findings were not observed for zanubrutinib, although studies are limited. Furthermore, recommendations on opportunistic infection..."

Anal Carcinoma • B Cell Lymphoma • Dermatology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Lymphoma • Marginal Zone Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Ocular Infections • Ocular Inflammation • Oncology • Septic Shock • Solid Tumor • Systemic Lupus Erythematosus • CD4 • CD8

Disseminated Varicella-Zoster Virus-Associated Acute Retinal Necrosis in a Post-Bone Marrow Transplant Patient. (PubMed, Ocul Immunol Inflamm) - "A 45-year-old male with aplastic anaemia who underwent a bone marrow transplantation developed GVHD and was treated with ruxolitinib and tacrolimus...The patient's right eye symptoms were resolved with topical acyclovir and supportive care, achieving a best-corrected visual acuity of 6/6...Our case highlights the disseminated and asymmetric nature of herpes zoster infection in the context of severe immunosuppression. This emphasizes the need to balance effective GVHD treatment and reinforces the importance of ongoing vigilance and timely management of these high-risk individuals."

Journal • Aplastic Anemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Herpes Zoster • Immunology • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Retinal Disorders • Transplantation • Varicella Zoster

Effect of combined antimicrobial photodynamic therapy and photobiomodulation therapy in the management of recurrent herpes labialis: a randomized controlled trial. (PubMed, Sci Rep) - "Group 1 (control): 5% Acyclovir was applied as a topical cream, and a non-activating laser was applied...aPDT + PBMT outperforms control (p = 0.001) and PBMT (p = 0.090) groups in healing. The findings indicate that aPDT and PBMT offer a promising approach to treating RHL."

Journal • Pain

HERPES SIMPLEX ENCEPHALITIS IN A PATIENT TREATED WITH INFLIXIMAB FOR ULCERATIVE COLITIS: A CASE REPORT AND LITERATURE REVIEW (SSAT 2025) - "The patient was treated with intravenous acyclovir, leading to clinical improvement.Discussion This case highlights the potential for reactivation of latent HSV in patients undergoing TNF-? inhibitors, even in the absence of typical clinical or radiological findings.ConclusionHerpes simplex virus encephalitis, while rare, should be considered in patients presenting with neurological symptoms following infliximab therapy. Early recognition and prompt initiation of antiviral therapy are crucial, especially in cases where diagnostic workup is inconclusive but clinical suspicion remains high."

Case report • Clinical • Review • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Hepatitis B • Hepatology • Herpes Simplex • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pain • Respiratory Diseases • Tuberculosis • Ulcerative Colitis

HERPES SIMPLEX ENCEPHALITIS IN A PATIENT TREATED WITH INFLIXIMAB FOR ULCERATIVE COLITIS: A CASE REPORT AND LITERATURE REVIEW (DDW 2025) - "The patient was treated with intravenous acyclovir, leading to clinical improvement. Conclusion Herpes simplex virus encephalitis, while rare, should be considered in patients presenting with neurological symptoms following infliximab therapy. Early recognition and prompt initiation of antiviral therapy are crucial, especially in cases where diagnostic workup is inconclusive but clinical suspicion remains high."

Case report • Clinical • Review • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Hepatitis B • Hepatology • Herpes Simplex • Immunology • Inflammatory Bowel Disease • Pain • Respiratory Diseases • Tuberculosis • Ulcerative Colitis

Use of nucleic acid testing for herpes simplex virus and detection of acyclovir-resistant strains (JSNE 2025) - No abstract available

Herpes Simplex

Acyclovir treatment for patients with suspected meningitis who tested positive for VZV in cerebrospinal fluid with a multiplex PCR panel (JSNE 2025) - No abstract available

Clinical • CNS Disorders • Infectious Disease

Herpes Zoster Without Vesicles: An Atypical Linear Erythematous Plaque on the Inner Thigh. (PubMed, Cureus) - "Initial topical treatments were ineffective, but prompt antiviral therapy with acyclovir led to complete resolution within six weeks. The case highlights the diagnostic challenges posed by atypical presentations of HZ and the importance of early diagnosis and treatment to prevent complications, such as postherpetic neuralgia. It also emphasizes the need to consider HZ in differential diagnoses even in the absence of typical vesicular eruptions to facilitate timely intervention and improved patient outcomes."

Journal • Dermatology • Endocrine Disorders • Herpes Zoster • Immunology • Neuralgia • Pain • Urticaria • Varicella Zoster

Bidirectional transfer of pritelivir across term human placenta and its effect on placental functions. (PubMed, J Pharmacol Exp Ther) - "Genital herpes in pregnancy is treated with nucleoside analog drugs such as acyclovir to reduce the risk of mother-to-neonate transfer of the virus. Although fetal exposure to the drug is plausible, pritelivir did not impact the viability and functionality of the placenta. Higher transplacental transfer of pritelivir in the fetal-to-maternal direction rather than maternal-to-fetal direction suggested the involvement of placental membrane transporters."

Journal • Breast Cancer • Herpes Simplex • Infectious Disease • Oncology • Solid Tumor

Herpes Zoster Myelitis Mimicking Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Disease: A Case Report. (PubMed, Cureus) - "Intravenous methylprednisolone (IVMP) was initiated; however, the patient's symptoms did not improve...We subsequently initiated treatment with acyclovir, and paralysis and bladder-rectum disorders improved...First, it is difficult to distinguish herpes zoster myelopathy from MOGAD because herpes zoster myelopathy presents as an H-shaped lesion in the conical area. Second, when treating myelopathy, virological confirmation via cerebrospinal fluid examination should be repeated until other diseases are diagnosed."

Journal • CNS Disorders • Herpes Zoster • Infectious Disease • Inflammation • Neuromyelitis Optica Spectrum Disorder • Rare Diseases • Solid Tumor • Varicella Zoster

Development of Varicella Zoster Encephalitis Following Live Vaccination in a Patient with Ataxia Telangiectasia (CIS 2025) - "While inpatient, she was treated with intravenous acyclovir, and intravenous immunoglobulin (IVIG) replacement was started under the direction of neurology, infectious diseases, and immunology services...The recommendation following vaccination is to monitor clinically for the development of infectious sequelae. For this particular patient, the lesions diagnosed as coxsackie viral infection were more likely acute disseminated VZV infection."

Clinical • Ataxia • Cardiovascular • CNS Disorders • Epstein-Barr Virus Infections • Hematological Disorders • Hematological Malignancies • Herpes Zoster • Immunology • Infectious Disease • Lymphoma • Measles • Movement Disorders • Mumps • Oncology • Pediatrics • Primary Immunodeficiency • Pruritus • Rubella • Varicella Zoster

Successful Use of Anifrolumab and Baricitinib Combination Therapy in an Infant with Spondyloenchondrodysplasia with Immune Dysregulation (SPENCD-I) (CIS 2025) - "He was given IVIG and started on dexamethasone...He is on acyclovir and pentamidine for infectious prophylaxis, along with regular PCR monitoring for EBV, CMV, and BK virus. There is a paucity of published experience with baricitinib and anifrolumab in this age-range. This case demonstrates the safe and effective use of these medications in this young child with SPENCD-I, a severe type 1 interferonopathy."

Combination therapy • Autoimmune Hepatitis • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Hepatology • Immune Thrombocytopenic Purpura • Immunology • Infectious Disease • Inflammation • Interferonopathies • Rare Diseases • Renal Disease • Thrombocytopenia • Thrombocytopenic Purpura • Vasculitis • TRAP

Homozygous STAT-1 Loss of Function Presenting with Recurrent Respiratory Infections and Pneumocystis jirovecii Pneumonia (CIS 2025) - "She was started on prophylactic IVIG and acyclovir and regularly screened for EBV, CMV, and HHV-6...Ultimately, Pneumocystis jirovecii pneumonia was diagnosed by PCR from bronchoalveolar lavage; she improved with trimethoprimsulfamethoxazole...Given high risk for myco-bacterial infection, empiric treatment with azithromycin, amikacin, and linezolid was initiated...Planned conditioning regimen was rituximab, targeted dosing rATG, targeted busulfan, targeted fludarabine, and thiotepa...Graft-versus-host prophylaxis was tocilizumab and abatacept... Complete STAT1 deficiency is a severe immunodeficiency that is historically fatal in early life without curative HSCT. Our case supports the need for early transplant before the acquisition of and complications due to severe infections."

Bone Marrow Transplantation • Graft versus Host Disease • Immunology • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Primary Immunodeficiency • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections • IFNG • STAT1

FOXN1 Deficiency Associated to Severe Viral Infections and Anti–IFN-α/-ω Neutralizing Antibodies (CIS 2025) - "At 10, he was hospitalized for severe varicella and pneumonia, treated with acyclovir, ceftriaxone, and vancomycin...He improved with voriconazole, caspofungin, and posaconazole...Neutralizing capacity was confirmed in vitro via STAT-1 phosphorylation assays. The patient's STAT-1 response to IFN-alpha 2 and IFN-omega was significantly reduced, indicating neutralization, even at high IFN concentrations, while IFN-beta remained unaffected."

Alopecia • Anemia • CNS Disorders • Dental Disorders • Dermatology • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immune Thrombocytopenic Purpura • Immunology • Infectious Disease • Pneumonia • Respiratory Diseases • Thrombocytopenic Purpura • Varicella Zoster • CD4 • CD8 • IFNA1 • STAT1

CRYONEUROLYSIS: A POTENTIAL TREATMENT FOR POSTHERPETIC NEURALGIA (ASRA-SPRING 2025) - "She had a previous unsuccessful trial of Acyclovir, Gabapentin, and Medrol dose pack for five days. Six months later, she was evaluated at the office and was initiated on Lyrica and Nortriptyline...Discussion Cryoneurolysis describes the application of extreme cold to targeted nerve tissue. The primary goal to disrupt the conduction of pain signals from the periphery to the central nervous system and eliminate or diminish the experience of pain.1 Our patient had very reassuring results treating her postherpetic neuralgia with cryoneurolysis, which could potentially be help millions of people in the future."

Herpes Zoster • Infectious Disease • Neuralgia • Pain • Varicella Zoster

Herpes Simplex Encephalitis in a Patient Treated with Infliximab for Ulcerative Colitis: A Case Report and Literature Review (ASCRS 2025) - "The patient was treated with intravenous acyclovir, leading to clinical improvement.Results/Outcomes: This case highlights the potential for reactivation of latent HSV in patients undergoing TNF-α inhibitor therapy, an association that has been rarely reported. Along with our case this underscores the importance of clinicians maintaining a high index of suspicion for HSV encephalitis in patients receiving TNF-α inhibitors, even in the absence of typical clinical or radiological findings.Conclusion/ Herpes simplex virus encephalitis, while rare, should be considered in patients presenting with neurological symptoms following infliximab therapy. Early recognition and prompt initiation of antiviral therapy are crucial, especially in cases where diagnostic workup is inconclusive but clinical suspicion remains high."

Case report • Clinical • Review • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Hepatitis B • Hepatology • Herpes Simplex • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pain • Respiratory Diseases • Tuberculosis • Ulcerative Colitis

Unilateral Oral Herpes Zoster in an Elderly Female: A Case Report and Review of the Literature. (PubMed, Clin Cosmet Investig Dermatol) - "The diagnosis was based on clinical presentation, and treatment included systemic oral acyclovir and pain management with paracetamol...The report also underscores the potential role of risk factors such as advanced age and chronic conditions in herpes zoster susceptibility. This case contributes to the literature on oral manifestations of herpes zoster and stresses the need for clinical vigilance in diagnosing and managing such cases."

Journal • Herpes Zoster • Pain • Varicella Zoster

Synthesis, X-ray diffraction, and computational studies of acyclovir and HBG analogs derived from Triazolyl-1,4-benzothiazine and their oxidized forms for breast cancer and SARS-CoV-2. (PubMed, Comput Biol Chem) - "Molecular docking studies revealed significant interactions, highlighting compound 11b's favorable binding with the target protein AKT1, achieving a binding energy of -6.43 kcal/mol, which is close to the Capivasertib standard. Similarly, compound 12b showed interactions akin to hydroxychloroquine, with a binding energy of -6.29 kcal/mol for the SARS-CoV-2 target protein...Finally, the two most promising compounds, 11b and 12b, selected from the docking results, were analyzed using Density Functional Theory (DFT). These analyses revealed significant variations in their electronic properties, providing valuable insights into their reactivity, stability, and polarity."

Journal • Breast Cancer • Infectious Disease • Novel Coronavirus Disease • Oncology • Respiratory Diseases • Solid Tumor

Vitamin Vortex: A Rare Case of Scurvy and Concurrent Deficiency (ATS 2025) - "Given concerns for a central nervous system infection, the patient was initiated on broad-spectrum antibiotics and acyclovir... Scurvy can present in complex and atypical ways, particularly in older adults. Clinicians must remain vigilant for signs of nutritional deficiencies, as timely diagnosis and intervention are crucial for improving patient outcomes. This case underscores the importance of recognizing the multifaceted nature of nutritional deficiencies in clinical practice."

Clinical • Acute Kidney Injury • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Dermatology • Dyslipidemia • Fatigue • Hematological Disorders • Hypertension • Infectious Disease • Inflammation • Nephrology • Renal Disease • Rheumatology • Thrombocytopenia • Vasculitis