Adagio (insulin) / Aerami Therap, Hikma - LARVOL DELTA

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3) (clinicaltrials.gov) - P3 | N=600 | Not yet recruiting | Sponsor: Bristol-Myers Squibb

New P3 trial • Alzheimer's Disease • CNS Disorders

Type 2 Diabetes Mellitus in Saudi Arabia: Prevalence, Risk Factors, and Management Strategies: A Review. (PubMed, Endocr Metab Immune Disord Drug Targets) - "Obesity is the main risk factor for type 2 diabetes mellitus (T2DM), which involves insulin resistance and β-cell dysfunction. This review examines the impact of T2DM in KSA, its risk factors and complications, and the role of Dapagliflozin in its management. It also provides expert opinions on the current situation of T2DM in KSA."

Journal • Diabetes • Genetic Disorders • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus

ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients (clinicaltrials.gov) - P1 | N=12 | Recruiting | Sponsor: University of Florida | Active, not recruiting ➔ Recruiting

Enrollment open • Brain Cancer • CNS Tumor • Glioma • Oligodendroglioma • Oncology • Solid Tumor

ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients (clinicaltrials.gov) - P1 | N=12 | Active, not recruiting | Sponsor: University of Florida | Recruiting ➔ Active, not recruiting

Enrollment closed • Brain Cancer • CNS Tumor • Glioma • Oligodendroglioma • Oncology • Solid Tumor

Once-weekly insulin icodec as novel treatment for type 2 diabetes mellitus: A systematic review and meta-analysis of randomized clinical trials. (PubMed, Diabetes Res Clin Pract) - "This study suggests similar efficacy and safety between insulin icodec and regular basal insulin. Further clinical trials are still needed to confirm the results of our study."

Clinical • Journal • Retrospective data • Review • Diabetes • Endocrine Disorders • Hypoglycemia • Metabolic Disorders • Type 2 Diabetes Mellitus

ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients (clinicaltrials.gov) - P1 | N=12 | Recruiting | Sponsor: University of Florida | Not yet recruiting ➔ Recruiting

Enrollment open • Brain Cancer • CNS Tumor • Glioma • Oligodendroglioma • Oncology • Solid Tumor

Paternal zinc deficiency alters offspring metabolic status in Drosophila melanogaster. (PubMed, J Trace Elem Med Biol) - "These findings underscore the link between zinc status and various physiological and molecular processes, revealing both immediate and intergenerational impacts on metabolic, antioxidant, and inflammatory pathways and providing valuable insights on the implications of paternal zinc deficiency in Drosophila melanogaster."

Journal • Metabolic Disorders

ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients (clinicaltrials.gov) - P1 | N=12 | Not yet recruiting | Sponsor: University of Florida | Initiation date: Jun 2024 ➔ Oct 2024

Trial initiation date • Brain Cancer • CNS Tumor • Glioma • Oligodendroglioma • Oncology • Solid Tumor

VT Cryoablation System Post-Market Clinical Follow-up (PMCF) Study (clinicaltrials.gov) - P=N/A | N=130 | Not yet recruiting | Sponsor: Adagio Medical

New trial • Cardiovascular • Ventricular Tachycardia

ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients (clinicaltrials.gov) - P1 | N=12 | Not yet recruiting | Sponsor: University of Florida

New P1 trial • Brain Cancer • CNS Tumor • Glioma • Oligodendroglioma • Oncology • Solid Tumor

Subserosal Indocyanine Green Plus Submucosal Carbon Nanoparticle Navigated Laparoscopic Gastrectomy (DANCE-01): a Cohort Study. (PubMed, J Gastrointest Surg) - "We propose a novel, feasible and safe tracing strategy for laparoscopic gastrectomy."

Journal

[VIRTUAL] ADAGIO: A phase IIb, open-label, single-arm, multicenter study assessing the efficacy and safety of adavosertib (AZD1775) as treatment for recurrent or persistent uterine serous carcinoma (SGO 2021) - No abstract available

Clinical • P2b data • Endometrial Serous Adenocarcinoma • Oncology • Uterine Cancer

Cryoablation for Monomorphic Ventricular Tachycardia (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Adagio Medical | Trial completion date: Oct 2022 ➔ Oct 2023 | Trial primary completion date: Jun 2022 ➔ Dec 2022

Trial completion date • Trial primary completion date • Cardiovascular • Ventricular Tachycardia

'Asking for help': a qualitative interview study exploring the experiences of interpersonal counselling (IPC) compared to low-intensity cognitive behavioural therapy (CBT) for women with depression during pregnancy. (PubMed, BMC Pregnancy Childbirth) - "Identifying and treating depression in pregnancy is important for the future health of both mother and child. Low-intensity perinatal-specific talking therapies delivered by psychological wellbeing practitioners in routine NHS primary care services in England are acceptable to pregnant women with mild-moderate depression. The strategies used in IPC to manage depression, including identifying triggers for low mood, and communicating the need for help, may be particularly appropriate for the perinatal period."

Clinical • Interview • Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Fasted Bioequivalence Study of 2 Olanzapine Film-coated Tablets, 5 mg, in Healthy, Adult Male and Female Subjects. (clinicaltrials.gov) - P1; N=32; Completed; Sponsor: Joint Stock Company "Farmak"

Clinical • New P1 trial

ADAGIO: a phase IIb international study of the Wee1 inhibitor adavosertib in women with recurrent or persistent uterine serous carcinoma. (PubMed, Int J Gynecol Cancer) - P2b | "Study completion and presentation of results are projected to be at the end of 2022. ClinicalTrials.gov: NCT04590248."

Clinical • Journal • P2b data • Endometrial Cancer • Endometrial Serous Adenocarcinoma • Oncology • Sarcoma • Solid Tumor • Uterine Cancer

No margin for non-adherence: Probabilistic kaplan-meier modeling of imatinib non-adherence and treatment response in CML (ADAGIO study). (PubMed, Leuk Res) - "There is virtually no margin for nonadherence, if the objective is to optimize the likelihood of treatment response, and a minimal margin to avoid impaired treatment response."

Journal • Chronic Myeloid Leukemia • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology

Impact of the introduction of EUCAST's concept of "area of technical uncertainty". (PubMed, Eur J Clin Microbiol Infect Dis) - "Susceptibility to amoxicillin-clavulanic acid and piperacillin-tazobactam in Enterobacterales (Escherichia spp., Klebsiella spp., Proteus spp.), piperacillin-tazobactam in Pseudomonas aeruginosa, and amoxicillin-clavulanic acid and cefuroxime in Haemophilus influenzae was studied...For piperacillin-tazobactam, a category change from S to R was found in 33/92 (35.9%) of Pseudomonas aeruginosa. We conclude that ATU testing has a substantial impact on the correct interpretation of antimicrobial resistance, at the expense of turn-around time and with the cost of additional workload."

Journal • Infectious Disease • Respiratory Diseases

Allometric scaling laws for temporal proximity in perceptual organization. (PubMed, Psychol Rev) - "Using a behavioral method for measuring path vividness, it is demonstrated that proximity constraints for the percept of illusory motion paths also satisfy an allometry. These two examples of proximity constraint scaling suggest that allometry may be a generic feature of temporal integration."

Journal • Immunology

Renal Function and Patient-Reported Outcomes in Stable Kidney Transplant Patients Following Conversion From Twice-Daily Immediate-Release Tacrolimus to Once-Daily Prolonged-Release Tacrolimus: A 12-Month Observational Study in Routine Clinical Practice in Germany (ADAGIO). (PubMed, Transplant Proc) - "Conversion of stable kidney transplant recipients from IR-T to PR-T provided stable kidney and graft function over 12 months (Verband Forschender Arzneimittelhersteller--registered study: NIS ADV-02)."

Clinical • Journal • Observational data • Gastrointestinal Disorder • Nephrology • Transplantation