AC-710 / Daiichi Sankyo - LARVOL DELTA

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PDGF Receptor Alpha Signaling Is Key for Müller Cell Homeostasis Functions. (PubMed, Int J Mol Sci) - "This effect could be blocked by the PDGFR family inhibitor AC710...Of note, the effect size was comparable to pharmacological blockade of PDGF signaling alone or in combination with anti-vascular endothelial growth factor (VEGF) therapy-a treatment regimen currently being tested in clinical trials. These data imply that targeting PDGF to treat retinal neovascular diseases may have short-term beneficial effects, but may elicit unwarranted side effects given the putative negative effects on Müller cell homeostatic functions potentially interfering with a long-term positive outcome."

Journal • PDGFRA