ALT 836 / ImmunityBio - LARVOL DELTA

Tissue Factor-Targeted ImmunoPET Imaging and Radioimmunotherapy of Anaplastic Thyroid Cancer. (PubMed, Adv Sci (Weinh)) - "Moreover, I-ALT-836 RIT prolongs the survival of ATC-bearing mice. Taken together, TF is a promising marker for ATC and successive use of Cu-NOTA-ALT-836 and I-ALT-836 can realize precise management of ATC."

IO Biomarker • Journal • Anaplastic Thyroid Cancer • Oncology • Solid Tumor • Thyroid Cancer

ImmunoPET imaging of tissue factor expression in pancreatic cancer with (89)Zr-Df-ALT-836. (PubMed, J Control Release) - "Taken together, these results attest to the excellent affinity and TF-specificity of (89)Zr-Df-ALT-836 in vivo. With elevated, persistent, and specific accumulation in TF-positive BXPC-3 tumors, PET imaging using (89)Zr-Df-ALT-836 promises to open new avenues for improving future diagnosis, stratification, and treatment response assessment in pancreatic cancer patients."

Journal • Biosimilar • Pancreatic Cancer

86/90Y-labeled monoclonal antibody targeting tissue factor for pancreatic cancer theranostics. (PubMed, Mol Pharm) - "The use of the 86/90Y theranostic pair allows PET imaging with excellent tumor-to-background contrast and treatment of TF-expressing pancreatic tumors with promising therapeutic outcomes."

Journal

ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment. (PubMed) - Mol Pharm - "PET imaging of (64)Cu-NOTA-heterodimer-ZW800 in BxPC-3 tumor xenografts revealed enhanced tumor uptake (21.0 ± 3.4 %ID/g; n = 4) compared to the homodimer of TRC-105 (9.6 ± 2.0 %ID/g; n=4; p < 0.01) and ALT-836 (7.6 ± 3.7 %ID/g; n=4; p < 0.01) at 24 h post-injection. Also, fluorescence imaging validated the PET imaging, allowing for clear delineation of the xenograft tumors. Dual-labeled heterodimeric imaging agents, like (64)Cu-NOTA-heterodimer-ZW800, may increase the overall tumor accumulation in comparison to single-targeted homodimers, leading to improved imaging of cancer and other related diseases."

Biomarker • Journal