acetylcysteine solution / Generic mfg. - LARVOL DELTA

Yiqi Zishen Formula ameliorates inflammation in mice with chronic obstructive pulmonary disease by inhibiting the PI3K/Akt/NF-κB signaling pathway (PubMed, Nan Fang Yi Ke Da Xue Xue Bao) - "YZF alleviates COPD symptoms and airway inflammation in mice possibly by inhibiting the PI3K/Akt/NF‑κB pathway through its multiple components that interact with multiple targets."

Journal • Preclinical • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • IL1B • IL6 • TNFA

Discovery of a Widespread Polyamine-Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile. (PubMed, ACS Infect Dis) - "In this study, we conducted feeding studies with isotope-labeled polyamines and discovered a network of low-molecular-weight thiol (LMWT) molecules termed clostridithiols (CSHs) constructed from polyamines conjugated with N-acetylcysteine (NAC) moieties...CSH abundance in GI mucosal biopsies positively correlated with colorectal cancer compared with matched healthy control samples. These studies indicate that human microbial metabolism broadly unites polyamine and LMWT functionalities to generate metabolites that may be associated with disease."

Journal • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Oncology • Solid Tumor

Reducing Contrast-Induced Nephropathy Risk in a Murine Model: Role of Avanafil and Vardenafil in Modulating Oxidant/Antioxidant Balance. (PubMed, Cureus) - "The treatment groups with VAR, AVA, and NAC were noted with higher values of TAC, CAT, and GSH, while lower values of TBARS and PROTC indicated a protective effect against oxidative injury. The findings indicate that VAR and AVA effectively control the oxidant/antioxidant status, preventing oxidative stress and the incidence of CIN. Further research would be required to replicate these findings and identify the therapeutic potential of VAR and AVA in clinical conditions."

Journal • Preclinical • Nephrology • Renal Disease • CAT

Altered Propionate Metabolism Promotes Aldosterone Production in Aldosterone-Producing Adenomas (ENDO 2025) - "The elevation of intracellular calcium concentration was later confirmed in MMA-treated cells, and the stimulatory effect of MMA on CYP11B2 expression was reversible by calcium inhibitor nifedipine and calmodulin kinase II inhibitor KN93...This effect was reversible by the reactive oxygen species scavenger N-acetylcysteine...Collectively, we present a previously uncharacterized dysregulation of propionate metabolism as an important contributor to aldosterone production via MMA-induced Cav1.2 glutathionylation. This pathway represents a potentially valuable target for the development of new therapeutic strategies for primary aldosteronism."

Endocrine Disorders

Altered Propionate Metabolism Promotes Aldosterone Production in Aldosterone-Producing Adenomas (ENDO 2025) - "The elevation of intracellular calcium concentration was later confirmed in MMA-treated cells, and the stimulatory effect of MMA on CYP11B2 expression was reversible by calcium inhibitor nifedipine and calmodulin kinase II inhibitor KN93...This effect was reversible by the reactive oxygen species scavenger N-acetylcysteine...Collectively, we present a previously uncharacterized dysregulation of propionate metabolism as an important contributor to aldosterone production via MMA-induced Cav1.2 glutathionylation. This pathway represents a potentially valuable target for the development of new therapeutic strategies for primary aldosteronism."

Endocrine Disorders

Altered Propionate Metabolism Promotes Aldosterone Production in Aldosterone-Producing Adenomas (ENDO 2025) - "The elevation of intracellular calcium concentration was later confirmed in MMA-treated cells, and the stimulatory effect of MMA on CYP11B2 expression was reversible by calcium inhibitor nifedipine and calmodulin kinase II inhibitor KN93...This effect was reversible by the reactive oxygen species scavenger N-acetylcysteine...Collectively, we present a previously uncharacterized dysregulation of propionate metabolism as an important contributor to aldosterone production via MMA-induced Cav1.2 glutathionylation. This pathway represents a potentially valuable target for the development of new therapeutic strategies for primary aldosteronism."

Endocrine Disorders

Evaluation of the Safety and Efficacy of N-acetylcysteine in the Prevention of Paclitaxel-induced Peripheral Neuropathy: A Randomized, Double-blind, and Placebo-controlled Trial. (PubMed, J Res Pharm Pract) - "Breast cancer patients receiving the Adriamycin/Cyclophosphamide-Taxol regimen were enrolled. Glutathione levels, MDA, and TAC differed significantly between the two groups (P < 0.001, <0.001, and 0.04, respectively), but no significant difference in NO levels (P = 0.5). Oral NAC at a dose of 1200 mg daily for two doses can reduce the incidence and severity of PIPN and improve patients' QOL."

Clinical • Journal • Breast Cancer • Oncology • Pain • Peripheral Neuropathic Pain • Solid Tumor

Jianpi Qushi Heluo Formula ameliorates podocytes injury related with ROS-mediated NLRP3 inflammasome activation in membranous nephropathy by promoting PINK1-dependent mitophagy. (PubMed, J Ethnopharmacol) - "JQHF can alleviate podocyte damage, that through inhibiting ROS-mediated NLRP3 inflammasome activation by improving PINK1-mediated mitophagy."

Journal • Glomerulonephritis • Metabolic Disorders • Nephrology • Renal Disease • IL1B • IL6 • NLRP3 • NPHS1 • PINK1

Management of Acute Fatty Liver of Pregnancy: A Retrospective Study of 12 Cases Compared With Data in the Literature. (PubMed, Cureus) - "Conclusion Both the existing literature and our service's protocol prioritize immediate fetal delivery as the definitive intervention to halt disease progression. While the literature explores adjunctive therapies such as N-acetylcysteine (NAC) and plasmapheresis, the core focus remains on meticulous supportive care to address the numerous complications arising from liver failure."

Journal • Retrospective data • Cardiovascular • Critical care • Gastrointestinal Disorder • Gynecology • Hematological Disorders • Hepatology • Hypertension • Infectious Disease • Liver Failure • Obstetrics • Pain • Renal Disease • Septic Shock

Cartap Poisoning with Paroxysmal Supraventricular Tachycardia: A Case Report. (PubMed, JNMA J Nepal Med Assoc) - "Treatment included amiodarone for supraventricular tachycardia and intravenous N-acetylcysteine, magnesium sulfate, and midazolam for general tonic clonic seizure. Cartap, toxic through ingestion and skin contact, can cause symptoms such as vomiting, convulsions, and cardiac issues like supraventricular tachycardia. Supportive care is crucial, and awareness of its risks is necessary."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Pain • Pulmonary Disease • Ventricular Tachycardia

Outsmarting H. pylori: why local cultures hold the key to effective treatment (BSG 2025) - "Antibiotic regimens were:Amoxicillin, metronidazole, clarithromycin, omeprazoleBismuth subsalicylate, metronidazole, tetracycline, omeprazoleResults 78 patients with treatment-resistant H. pylori underwent gastric biopsy and culture...pylori was isolated in 63 cultures, with 15 finding no growth.Culture sensitivities were as follows:View this table:View inline View popup Abstract P283 Table 1 Culture sensitivities to antibioticsOf note, 41% of cultures were resistant to only one antibiotic, or fully sensitive: 24 cultures were sensitive to four antibiotics (21 resistant to metronidazole, 3 resistant to levofloxacin), while 2 cultures were sensitive to all five tested.Conclusions Our data highlights significant variability in H. pylori antibiotic resistance within a local population, with particularly high metronidazole resistance...Biofilm formation by H. pylori has been found in vivo, and could confer antibiotic resistance despite culture sensitivity. N-acetylcysteine..."

Extranodal Marginal Zone Lymphoma • Gastric Adenocarcinoma • Gastric Cancer • Hematological Malignancies • Infectious Disease • Lymphoma • Marginal Zone Lymphoma • Oncology • Solid Tumor

Ferrous gluconate-loaded sodium alginate hydrogel facilitates ferroptosis in Streptococcus hemolyticus and cures Streptococcal infections. (PubMed, Int J Biol Macromol) - "Moreover, the addition of inhibitors, including liproxstatin-1 (LIP-1), N-Acetylcysteine (NAC) and glutathione (GSH) hindered the happening of ferroptosis. Additionally, the FeGlu-hydrogel displayed a broad bactericidal spectrum against Streptococcus species, including Streptococcus pneumoniae and Streptococcus mutans. Collectively, these results proved that the FeGlu-hydrogel is a promising biomaterial for the treatment of Streptococcus-related infections."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia • Septic Shock • ANXA2

Pharmacological Preconditioning with Diazoxide Upregulates HCN4 Channels in the Sinoatrial Node of Adult Rat Cardiomyocytes. (PubMed, Int J Mol Sci) - "Patch-clamp experiments revealed an increase in the magnitude of ionic currents through HCN4 channels, which was abolished by the reactive oxygen species (ROS) scavenger N-acetylcysteine (NAC) and the selective mitoKATP channel inhibitor 5-hydroxydecanoate (5-HD)...DZX increased nuclear translocation of c-Fos and decreased protein abundance of RE1 silencing transcription factor (REST)/neuron-restrictive silencer factor (NRSF), suggesting the involvement of these factors. Our results suggest that PPC increases the heart rate by upregulating HCN4 channel expression through a mechanism involving c-Fos, REST, and ROS."

Journal • Preclinical • Cardiovascular • FOS

Complex Regional Pain Syndrome: Multimodal Analgesia and Interdisciplinary Management in a Clinical Challenge. (ASA 2025) - "Pain management was challenging, requiring a multimodal approach with opioids, NSAIDs, gabapentinoids, ketamine, local anesthetics, corticosteroids, vitamin C, N-acetylcysteine, and bisphosphonates, along with interdisciplinary management involving intensive physical rehabilitation and psychological support. She showed progressive improvement, with ongoing follow-up in pain clinic and orthopedics"

Clinical • Anesthesia • Infectious Disease • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

N-Acetyl Cysteine as a promising therapeutic approach in ovarian cancer: potential and perspectives. (PubMed, Acad Oncol) - "The membrane-permeable cysteine precursor N-acetylcysteine (NAC) can enhance the intracellular cysteine pool and thus results in decreased oxidative stress...While NAC holds therapeutic promise in alleviating treatment-associated toxicities, its application in ovarian cancer requires careful consideration based on tumour subtype, redox context, and treatment timing. Future research incorporating subtype-specific models and clinical trials will be essential to delineate the precise role of NAC and optimize its integration into ovarian cancer treatment regimens."

Journal • Oncology • Ovarian Cancer • Solid Tumor • DYRK1B

CPF Induces GC2spd Cell Injury via ROS/AKT/Efcab6 Pathway. (PubMed, Cells) - "In addition, further validation through qRT-PCR, Western blot, and experiments involving the inhibition of intracellular ROS generation with N-acetylcysteine collectively confirmed that CPF induces male reproductive damage through the ROS/AKT/Efcab6 pathway. These studies elucidate potential targets and molecular mechanisms underlying CPF-induced male infertility, providing a theoretical basis for the prevention of male reproductive damage caused by pesticide residues."

Journal • Infertility • Sexual Disorders • NOX3

Inhalable N-Acetylcysteine-loaded Lactose-coated PLGA Nanoparticles for Tuberculosis Treatment. (PubMed, Pharm Res) - "These preliminary findings suggest that lactose-coated NAC-PLGA NPs can open the door to new therapeutic options against one of the most drug-refractory and drug-resistant infectious diseases, TB."

Journal • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Prevention and treatment of anthracycline-induced cardiotoxicity: a systematic review and network meta-analysis of randomized controlled trials. (PubMed, Cardiooncology) - "Apart from Dexrazoxane, Carvedilol, a β-blocker, also appears to show significant potential in preventing AIC. Furthermore, our results indicate that there is insufficient evidence to support the beneficial effects of statins, Sildenafil, Ivabradine, Levocarnitine, N-acetylcysteine, Glutathione, Coenzyme Q10, Vitamin E, and Vitamin C in preventing LVEF decline and exerting a positive effect on the prevention of AIC."

Journal • Retrospective data • Review • Cardiovascular • Oncology

ROS-Dependent Endoplasmic Reticulum Stress Is Involved in Silica-Induced Pulmonary Fibrosis through the GRP78/CHOP/TXNIP/NLRP3 Signaling Pathway in Rats. (PubMed, Chem Res Toxicol) - "In this study, male rats were intratracheally instilled with a single dose of crystalline silica (SiO2) suspension (100 mg/mL, 1 mL) to establish silicosis and then were injected intravenously with 1 mL of N-Acetylcysteine (NAC) (at the dose of 20, 40, or 80 mg/kg, respectively) daily to inhibit ROS-dependent ERS...Moreover, the higher the dose of NAC intervention, the more pronounced the effects. The results demonstrated that ROS-dependent ERS is deeply involved in silica-induced pulmonary fibrosis through the GRP78/CHOP/TXNIP/NLRP3 signaling pathway in rats."

Journal • Preclinical • Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases • HSPA5 • NLRC5 • NLRP3 • TXNIP

SENP1-Sirt3 axis regulates type II alveolar epithelial cell activity to confer resistance against oxidative damage in lung tissue. (PubMed, Redox Biol) - "In bleomycin-induced pulmonary fibrosis models, activating the SENP1-Sirt3 axis via Sirt3 SUMOylation site mutation (Sirt3 K223R) reduced Superoxide Dismutase 2 (SOD2) acetylation, thereby lowering mitochondrial reactive oxygen species (mtROS) accumulation and apoptosis. Antioxidant N-acetylcysteine (NAC) supplementation mirrored these benefits, reinforcing ROS clearance as a therapeutic mechanism. These findings highlight SENP1-Sirt3 as a pivotal regulator of AT2 resilience, offering a potential strategy to mitigate fibrosis by targeting mitochondrial oxidative stress and cellular plasticity."

Journal • Fibrosis • Immunology • Inflammation • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • KRT8 • SIRT3 • SOD2

Neobractatin and Trametinib Synergistically Induce Apoptosis and Gasdermin E-Dependent Pyroptosis in Pancreatic Cancer Cells. (PubMed, MedComm (2020)) - "Further research demonstrated that the combination increased intracellular reactive oxygen species (ROS), while N-acetylcysteine (NAC, a ROS scavenger) reversed the cell growth inhibition and AKT suppression. In vivo, the combination significantly inhibited tumor growth by inducing pyroptosis and apoptosis, outperforming gemcitabine. Our findings provide novel insights into the potential of combining NBT and trametinib to induce pyroptosis and apoptosis through the ROS/AKT/GSDME axis, offering a theoretical basis for future PDAC treatment."

Journal • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • GSDME • MIR149

Effect of N-Acetylcysteine, Ascorbic Acid, and a Vitamin E Analog on Oxidative and Storage Lesions in Canine Packed Red Blood Cells. (PubMed, J Vet Emerg Crit Care (San Antonio)) - "The addition of AA and a VE to canine pRBCs reduced ROS accumulation but did not prevent glutathione depletion during routine storage. Further studies using antioxidants as additives in canine pRBCs are warranted."

Journal

Reciprocal c-Abl-GPx1 regulation controls CA1 neuronal viability to oxidative stress via ERK1/2-DRP1-mediated mitochondrial dynamics. (PubMed, Neuropharmacology) - "Imatinib and N-acetylcysteine (NAC, an antioxidant) attenuated these post-SE events and CA1 neuronal death. However, GPx1 knockdown deteriorated SE-induced CA1 neuronal degeneration accompanied by augmenting c-Abl Y245 phosphorylation and mitochondrial elongation in CA1 neurons. These findings indicate that the impaired reciprocal regulation between c-Abl and GPx1 may cause CA1 neuronal degeneration in response to oxidative stress by abrogating ERK1/2-DRP1-mediated mitochondrial fission."

Journal • CNS Disorders • Epilepsy • Hematological Malignancies • Leukemia • Oncology • ABL1 • GPX1

NCOA5 suppresses tumor progression and cisplatin resistance in non-small cell lung cancer by interfering with PRDX6 transcription. (PubMed, Biochem Pharmacol) - "The chemosensitive effect of NCOA5 on CDDP-resistant NSCLC cells was impaired by N-acetylcysteine, an inhibitor of reactive oxygen species (ROS). Our data reveal a crucial role for NCOA5 in NSCLC progression and CDDP resistance. Thus, targeting the NCOA5/PRDX6 axis may be a promising strategy to overcome CDDP resistance in NSCLC."

Journal • Lung Cancer • Metabolic Disorders • Non Small Cell Lung Cancer • Oncology • Solid Tumor • PRDX6

Breaking the cycle of oxidative stress for better behavioral health in autism spectrum disorder: A scoping review. (PubMed, Asian J Psychiatr) - "Interventions such as N-acetylcysteine (NAC), vitamin and mineral supplementation, and dietary antioxidants have shown promise in mitigating oxidative damage and improving social responsiveness...Well-designed randomized placebo-controlled trials (RCTs) integrating clinical and psychodiagnostic measures with precision medicine frameworks, are crucial for developing targeted therapies that, restoring redox homeostasis, may optimize neurodevelopmental outcomes. By summarizing current evidence and addressing these gaps, this review underscores the therapeutic potential of oxidative stress correction in improving the quality of life of individuals with ASD."

Journal • Review • Autism Spectrum Disorder • Genetic Disorders • Inflammation