acetylcysteine solution / Generic mfg. - LARVOL DELTA

ROS-Mediated Senescence and Autophagy Inhibition Drive 5-FU/Aumolertinib Synergy in Colorectal Cancer. (PubMed, Eur J Pharmacol) - "Although 5-fluorouracil (5-FU) serves as a first-line CRC therapeutic, its clinical utility is constrained by dose-dependent toxicity...Notably, ROS scavenging with N-acetylcysteine reversed these effects. The synergistic tumor growth inhibition was confirmed in HCT116 xenografts using low-dose combination therapy (5-FU 15 mg/kg + AUM 10 mg/kg). Collectively, these findings establish an ROS-dependent autophagic senescence axis as the molecular basis for 5-FU/AUM synergy, offering a novel strategic approach for CRC treatment."

Journal • Colorectal Cancer • Oncology • Solid Tumor

Statement of Retraction: The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome. (PubMed, Gynecol Endocrinol) - No abstract available

Journal • Polycystic Ovary Syndrome

Analyzing Gaps in Care with N-acetylcysteine 3 Bag Method (ASHP 2025) - No abstract available

Administration Delays in Three-Bag versus Two-Bag Intravenous N-acetylcysteine in Pediatric Acetaminophen Overdose (ASHP 2025) - No abstract available

Clinical • Pediatrics

Incidence of Hyponatremia and the Use of N-acetylcysteine for Acetaminophen Ingestion in Pediatric Patients (ASHP 2025) - No abstract available

Clinical • Cardiovascular • Heart Failure • Pediatrics

Evaluation of N-Acetylcysteine in Acute Liver Dysfunction Beyond Acetaminophen (ASHP 2025) - No abstract available

Hepatology • Liver Failure

Two-Bag Versus Three-Bag N-Acetylcysteine Regimen for Pediatric Acetaminophen Overdose (ASHP 2025) - No abstract available

Clinical • Pediatrics

Assessment of N-Acetylcysteine Use at a Regional Teaching Health System in Georgia (ASHP 2025) - No abstract available

Cerebral blood flow ratio of the default mode network to the central executive network as a predictor of executive function following N-acetylcysteine supplementation in vascular mild cognitive impairment participants from the MOVE-IT trial (CTAD 2025) - No abstract available

Alzheimer's Disease • CNS Disorders • Cognitive Disorders

Cerebral Blood Flow Ratio of the Default Mode Network to the Central Executive Network as a Predictor of Executive Function Following N-acetylcysteine Supplementation in Vascular Mild Cognitive Impairment (CTAD 2025) - "Examining whether cerebral blood flow ratios can predict treatment response to N-acetylcysteine in vascular MCI, highlighting personalized neurovascular biomarkers for intervention response."

Alzheimer's Disease • CNS Disorders • Cognitive Disorders

Rolling the Dice on Cirrhosis: Managing Liver Disease Under the Neon Lights! (ASHP 2025) - "Critique the use of N-acetylcysteine in acute liver failure. Learning Objectives: Select pharmacological treatments for alcohol use disorders given a patient case.Develop pain management treatments in patients with cirrhosis.Critique the use of N-acetylcysteine in acute liver failure."

Addiction (Opioid and Alcohol) • Fibrosis • Hepatology • Immunology • Liver Failure

Unravelling the Mechanism of N-Acetylcysteine in Alleviating Smoke-Induced Hypoxia-Driven Ocular Defects in Drosophila melanogaster. (PubMed, Mol Neurobiol) - "Treatment with NAC restored all these abnormalities to normal levels. This research provides insight into how smoke-induced hypoxia disrupts eye development, while NAC shows potential as an effective therapeutic agent in counteracting its harmful effects."

Journal

N-Acetylcysteine as Therapy for Transplantation- Associated Thrombotic Microangiopathy (clinicaltrials.gov) - P2/3 | N=44 | Active, not recruiting | Sponsor: The First Affiliated Hospital of Soochow University

New P2/3 trial • Hematological Disorders • Transplantation

A fluorescent probe for concurrent detection of cysteine, homocysteine, and superoxide anion. (PubMed, Sci Adv) - "In pentylenetetrazole (PTZ)- and acetaminophen (APAP)-induced models of epilepsy and liver injury, BPC revealed notable alterations in Cys, Hcy, and O2•- levels, providing mechanistic insights into redox dysregulation. Moreover, BPC successfully tracked redox restoration following N-acetylcysteine (NAC) treatment. These findings establish BPC as a versatile tool for redox biology and highlight its promise for diagnostic and therapeutic applications."

Journal • CNS Disorders • Epilepsy • Hepatology • Liver Failure

MSC affect the sensitivity of CML cells to TKIs through mitochondrial transfered via tunneling nanotubes (ASH 2025) - "Compared to normal cells, CML cells have higher ROS levels, and treatment with the ROS inhibitor N-acetylcysteine (NAC) increased CML cell resistance...Therefore, we propose that during CML treatment, MSCs modulate CML cell metabolism and restore TKI sensitivity by transferring mitochondria via TNTs. Our study reveals the critical role of BMM cells in supporting CML cells through TNTs, suggesting that targeting this interaction could improve therapeutic outcomes for CML."

Chronic Myeloid Leukemia • Hematological Malignancies • Leukemia

Adaptive rebalancing of ROS composition averts LSD1 inhibitor–induced oxidative stress in AML (ASH 2025) - "Importantly, ATRA's efficacy enhances significantly when combined with arsenictrioxide (ATO), which elevates reactive oxygen species (ROS), a group of reactive oxygen-containingmolecules including superoxide anions that collectively contribute to oxidative stress.To examine the role of ROS during LSD1 inhibition, we treated primary patient-derived AML samples andcell lines with LSD1i (GSK-LSD1) and monitored ROS dynamics using selective intracellular biosensors andROS type-specific fluorescent probes...Notably, scavenging ROSwith N-acetylcysteine (NAC) significantly impairs differentiation, indicating that ROS plays a critical role inmediating the pro-differentiation effects of LSD1i. To validate that LSD1 regulates ROS, we developed amurine leukemogenic model by transducing hematopoietic stem and progenitor cells (HSPCs) fromLsd1fl/fl conditional knockout mice with the MLL-AF9 oncogene and tamoxifen-inducible Crerecombinase...Rather than decreasing overall ROS..."

Oxidative stress • Acute Myelogenous Leukemia • Acute Promyelocytic Leukemia • Hematological Malignancies • Leukemia • CYBB • KDM1A • MPO

KMT2A::AF6 fusion protein localizes to PML nuclear bodies and undergoes ATO-induced degradation: A potential novel therapeutic approach for KMT2A::AF6-rearranged Acute Myeloid Leukemia (ASH 2025) - "Given that PML and its client proteins undergo proteasomal degradation upon arsenic trioxide(ATO) treatment via SUMO-dependent ubiquitination, we tested whether KMT2A::AF6 protein follows asimilar fate...Blocking the proteasomewith MG132 prevented this degradation, confirming that KMT2A::AF6, as well as PML, is degraded via theSUMO–ubiquitin–proteasome axis...This effect was partially reversed by N-acetylcysteine (NAC), suggesting a ROS-dependent mechanism, described to be the very first step by which ATO drives PML proteasomal-mediated degradation. Moreover, ATO treatment induced myeloid differentiation both in vitro and in exvivo patient-derived cells (PDXs), supporting a transcriptional change at support of a targeted KMT2A:.AF6fusion protein degradation mechanism.In vivo, ATO monotherapy (8 mg/kg) moderately delayed disease progression in KMT2A::AF6 PDX models,while its combination with low-dose cytarabine (20 mg/kg) significantly reduced leukemic burden andprolonged..."

Acute Myelogenous Leukemia • Acute Promyelocytic Leukemia • Hematological Malignancies • Leukemia • Targeted Protein Degradation • HOXA10 • HOXA11 • HOXA9 • KMT2A • RARA

N-acetylcysteine Restores Impaired Dentate Gyrus Neurogenesis in a Neonatal Maternal Separation Rat Model. (PubMed, Exp Neurobiol) - "Notably, NAC rescued diminished neurogenesis in EAAC1 knockout mice, demonstrating its efficacy under both stress-induced and transporter-deficient redox imbalance. These findings identify NAC as a potent modulator of hippocampal neuroplasticity, acting through the restoration of redox and inflammatory homeostasis, and support its potential as an early therapeutic strategy to mitigate long-lasting neurodevelopmental consequences of ELS."

Journal • Preclinical • Inflammation

Differential Effects on Acetaminophen-induced Nephrotoxicity and Liver Injury Following Modulation of Glutathione Resynthesis. (PubMed, Food Chem Toxicol) - "N-acetylcysteine (NAC) prevents APAP-induced liver damage, but not AKI, highlighting the need to address differential inter-organ responses to APAP toxicity...In contrast, NAC protected against APAP hepatotoxicity but not AKI. Thus, these findings demonstrate critical organ-specific responses to APAP toxicity and underscore the need for targeted therapeutic strategies specifically addressing APAP-induced kidney injury."

Journal • Acute Kidney Injury • Hepatology • Liver Failure • Nephrology • Renal Disease • KIM1

The management and clinical outcome of paracetamol poisoning in South African adults: A single-centre retrospective review. (PubMed, S Afr Med J) - "A high case fatality rate was observed in the studied population. Early identification of at-risk individuals and prompt initiation of NAC can reduce poor outcomes. Larger multicentre studies are needed to identify independent predictors of paracetamol-induced hepatoxicity and mortality in Africa."

Clinical data • Journal • Retrospective data • Acute Kidney Injury • Addiction (Opioid and Alcohol) • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Liver Failure • Nephrology • Renal Disease

The Mitigating Effect and Mechanism of Polydeoxyribonucleotide Against Zoledronic Acid-Induced Growth Suppression of Human Gingival Fibroblasts. (PubMed, Int J Mol Sci) - "Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, is widely used to treat osteoporosis and bone metastases. The antioxidant N-acetylcysteine (NAC) similarly reduced ZA-induced ROS and p-TBK1 levels and improved cell growth, although it had limited effects on p-PKB at 8 h. Importantly, delayed PDRN treatment following ZA exposure reversed ZA-induced cell growth inhibition and TBK1 activation in a dose- and time-dependent manner. In summary, these findings demonstrate that ZA suppresses HGF-1 cell growth through ROS production, TBK1 activation, and inhibition of PKB and STAT-3, whereas PDRN counteracts these effects primarily by suppressing TBK1 activation and oxidative stress."

Journal • Oncology • Osteoporosis • Rheumatology • Solid Tumor • STAT3

Neuroprotective and Antioxidant Properties of Different Novel Steroid-Derived Nitrones and Oximes on Cerebral Ischemia In Vitro. (PubMed, Int J Mol Sci) - "To advance neuroprotective strategies that could improve the safety and efficacy of existing treatments while preserving brain tissue, we synthesized and evaluated seven new nitrones (MC3, MC5, MC7) and oximes (MC1, MC2, MC4, MC6) derived from different neuroactive steroids-ethisterone (MC1-3), mifepristone (MC4-5) and stanolone (MC6-7)-in an in vitro model of cerebral ischemia. Overall, these derivatives exhibited neuroprotective and antioxidant effects superior to those of the reference compounds cholesteronitrone ChN2, α-tert-butyl nitrone (PBN) and N-acetylcysteine (NAC)...Among them, the stanolone-derived nitrone MC7, which lacks conjugated double bonds, displayed the most balanced and robust profile, consistently enhancing cell viability, reducing necrotic cell death, and suppressing superoxide anion production. Consequently, MC7 has been selected as a promising lead compound for further in vivo studies of cerebral ischemia."

Journal • Preclinical • Cardiovascular • Ischemic stroke

Management of acute liver failure-an updated literature review. (PubMed, World J Crit Care Med) - "Early identification of etiology allows targeted treatments, such as N-acetylcysteine for acetaminophen toxicity or antivirals for hepatitis...Emerging therapies, including stem cell treatments and immunomodulatory agents, show potential to revolutionize care. This review emphasizes the need for a multidisciplinary approach and continued research to improve outcomes and refine therapeutic strategies."

Journal • Review • CNS Disorders • Critical care • Hematological Disorders • Hepatic Encephalopathy • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Transplantation

Amino alkyl-alkyl/aryl sulphides (DRDE-07 and analogues) as promising cytoprotectants for sulphur and nitrogen mustards - A review. (PubMed, Toxicol Rep) - "These compounds showed better protection compared to other experimented molecules, such as amifostine, N-acetylcysteine, melatonin, sodium thiosulphate, and flavonoids...Among them, DRDE-30 showed the best protection for SM and nitrogen mustards, as well as against radiation, and also as a cytoprotectant for anticancer agents. In this review, all the published papers on the DRDE series of compounds are compiled and discussed, with the aim that if any one of these molecules is recommended as an oral prophylactic drug, further development would occur for a more effective, broad-spectrum cytoprotectant."

Journal • Review • Oncology

Reactive oxygen species elevations in human immune cell subsets during sepsis are mitigated by norepinephrine and N-acetylcysteine. (PubMed, World J Crit Care Med) - "ROS levels are elevated in specific PBMC subsets in sepsis, particularly CD3+ T cells and CD14+ monocytes. NE and NAC reduced ROS accumulation in vitro, supporting their potential role as redox modulators. These findings warrant further mechanistic investigation into immune redox regulation in sepsis."

Journal • Infectious Disease • Inflammation • Septic Shock • CD14