acetylcysteine solution / Generic mfg. - LARVOL DELTA

Characterization of the heterogeneity in oxidative stress and transcriptional programs within the in vivo microenvironment of ulcerative colitis. (PubMed, Mol Immunol) - "Overall, our findings unveil the heterogeneity in oxidative stress and transcriptional programs among diverse myeloid and T cell subpopulations in UC."

Heterogeneity • Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • CD4 • CD8

Complex Regional Pain Syndrome: Multimodal Analgesia and Interdisciplinary Management in a Clinical Challenge. (ASA 2025) - "Pain management was challenging, requiring a multimodal approach with opioids, NSAIDs, gabapentinoids, ketamine, local anesthetics, corticosteroids, vitamin C, N-acetylcysteine, and bisphosphonates, along with interdisciplinary management involving intensive physical rehabilitation and psychological support. She showed progressive improvement, with ongoing follow-up in pain clinic and orthopedics"

Clinical • Anesthesia • Infectious Disease • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

Metabolic saboteurs: Tire wear particles hijack energy economy of zooplankton. (PubMed, J Hazard Mater) - "Notably, N-acetylcysteine supplementation significantly mitigated TWP-induced mitochondrial dysfunction and metabolic disturbances. Furthermore, a significant dose-dependent decline in Biomarker Response Index (BRI) values was observed with increasing TWP concentrations. This study elucidates TWP's toxic mechanisms in aquatic organisms and underscores low-concentration exposure risks, providing key evidence for assessing long-term ecological impacts of microplastic pollution."

Journal • Metabolic Disorders

Transtympanic Injection of Antioxidant-Eluting Microparticles for Otoprotection From Cisplatin Toxicity in a Mouse Model. (PubMed, Otolaryngol Head Neck Surg) - "Transtympanic N-acetylcysteine microparticle injections provided functional otoprotection in cisplatin-exposed mice."

Journal • Preclinical • Otorhinolaryngology

Severe Pembrolizumab-Induced Liver Injury: Subacute Hepatic Necrosis (ACG 2025) - "This case highlights the presentation, diagnosis and treatment of severe subacute pembrolizumab-induced hepatitis.Case Description/ A 41-year-old female with a history of triple negative breast cancer treated with neoadjuvant therapy (doxorubicin and pembrolizumab, last infusion 2 months prior) and lumpectomy was referred to the hepatology department for severe asymptomatic hepatocellular transaminitis...N-acetylcysteine was initiated however, discontinued due to hyperemesis...Mycophenolate mofetil (MMF) was initiated after three days of steroid therapy due to inadequate biochemical response...This case demonstrates the potential severity of subacute ICI hepatotoxicity following treatment completion, educating clinicians to consider ICI hepatitis in patients presenting with transaminitis and with a history of immune checkpoint inhibitor use.Figure: Histopathology of liver biopsy. Hematoxylin-eosin staining showing portal inflammation with bridging necrosis and..."

Autoimmune Hepatitis • Breast Cancer • Cytomegalovirus Infection • Hepatitis C • Hepatology • Herpes Simplex • Immunology • Infectious Disease • Liver Failure • Solid Tumor • Triple Negative Breast Cancer

Damnacanthus giganteus extract block diffuse large b-cell lymphoma proliferation and EMT by regulating mitochondrial dysfunction and glycolysis. (PubMed, Hereditas) - "‌Our study demonstrates for the first time that DGE effectively suppresses tumor proliferation and EMT during DLBCL progression. These antitumor effects appear to be mediated through modulation of mitochondrial function and glycolysis. These findings position DGE as a promising novel therapeutic candidate for DLBCL treatment, meriting immediate clinical translation and further evaluation."

Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Lymphoma • Metabolic Disorders • Non-Hodgkin’s Lymphoma • Oncology • Transplantation • ANXA5 • CDH2 • VIM

N-Acetylcysteine Roles in Preserving Renal Function Measured by Urinary KIM-1 (Kidney Injury Molecule-1) and Serum Creatinine on Cancer Patients With Cisplatin Based Chemotherapy: A Randomized Placebo-Controlled Trial (clinicaltrials.gov) - P2/3 | N=72 | Not yet recruiting | Sponsor: Fakultas Kedokteran Universitas Indonesia

New P2/3 trial • Acute Kidney Injury • Nephrology • Oncology • Renal Cell Carcinoma • Renal Disease • Solid Tumor

Checkpoint and Checkmate: Concurrent Immune-Mediated Hepatitis and HBV Reactivation in a Cancer Patient (ACG 2025) - "She was receiving Pembrolizumab and Lenvatinib for her RCC...She was started on treatment for hepatitis B reactivation with Tenofovir and N-Acetylcysteine (NAC)...After a multidisciplinary discussion, she was initiated on Solumedrol 1 g/kg in addition to continuing her Tenofovir. Thereafter, the patient's LFTs and INR rapidly improved, and she was transitioned to oral prednisone taper...Therefore, it is imperative to check hepatitis B serologies before immunosuppression and initiate antiviral prophylaxis when indicated. Unfortunately, our patient did not have her serologies checked before starting treatment.Figure: Figure 1, H&E image showing acute hepatitis pattern of injury with lobular disarray, inflammation, hepatocyte swelling, and many acidophil bodiesFigure: Figure 2, Hepatitis B stain image showing the positive staining for hepatitis B (brown color in the hepatocytes)"

Clinical • Genito-urinary Cancer • Hepatitis B • Hepatitis C • Hepatology • Infectious Disease • Liver Failure • Oncology • Renal Cell Carcinoma • Solid Tumor

JAK2/STAT3 Signaling Pathway Modulates Acute Methylmercury Toxicity in the Mouse Astrocyte C8-D1A Cell Line. (PubMed, Neurochem Res) - "Our data demonstrated that pharmacological inhibition of STAT3 using AG490 or C188-9 exacerbated MeHg-induced cell death and compromised antioxidant responses. Furthermore, to fully characterize the role of STAT3 in oxidative stress, we used two different antioxidants, N-acetylcysteine (NAC) and Trolox. Conversely, reactive oxygen species (ROS)-scavenging antioxidants partially ameliorated STAT3 activation, suggesting that MeHg-induced STAT3 activation is mediated, at least in part, by mechanisms independent of ROS. Our findings suggest that STAT3 contributes to neuroprotection against MeHg exposure in astrocytes and is, at least in part, regulated by the increase in ROS levels within these cells."

Journal • Preclinical • CNS Disorders • Inflammation

A Rare Manifestation of Immune Checkpoint Inhibitor Toxicity (ACG 2025) - "Their use has significantly increased since ipilimumab was approved in 2011 for metastatic melanoma...We present a case of immune-mediated cholangitis (IMC) induced by ICI.Case Description/ An 80-year-old female with metastatic endometrial cancer presented to the emergency department with encephalopathy due to hydrocodone-acetaminophen taken for cancer-related pain. She took a 1-week course of trimethoprim-sulfamethoxazole (TMP-SMX) and completed pembrolizumab cycle 19 3 weeks prior to presentation...N-acetylcysteine and antibiotics were prescribed on admission...There are some data to suggest ursodiol may provide added benefit. Further research is necessary to provide diagnostic and management guidance. Figure: CT with contrast demonstrating bile duct thickeningFigure: ALP trend following initiation of glucocorticoids on Day 2"

Checkpoint inhibition • CNS Disorders • Endometrial Cancer • Gastrointestinal Disorder • Hepatology • Immunology • Melanoma • Oncology • Solid Tumor

Protective effect of N-acetylcysteine in doxorubicin-induced primary ovarian failure in female rats. (PubMed, Turk J Obstet Gynecol) - "NAC preserved ovarian reserve and follicular integrity by suppressing oxidative stress, inflammation, and apoptosis induced by DOX. These findings highlight NAC as a promising protective agent against chemotherapy-induced ovarian toxicity."

Journal • Preclinical • Hematological Disorders • Infertility • Oncology • Sexual Disorders • CASP3 • PCNA • TNFA

TB-MET-NAC: A Trial of 2 Disease-Modifying Drugs (Metformin and N-acetylcysteine ) to Promote TB Lung Function Recovery (clinicaltrials.gov) - P3 | N=1104 | Not yet recruiting | Sponsor: Open Source Pharma Foundation

New P3 trial • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Multimodal single-cell transcriptomics with patient-specific iPSC-derived airway organoids as a drug screening approach for cystic fibrosis with nonsense mutations. (PubMed, Biomed Pharmacother) - "Utilizing multimodal single-cell transcriptomics with the ASGARD framework, we found that nintedanib, N-acetylcysteine, and losartan were associated with attenuation of the TNF-α pathway in CF with nonsense mutations. This CF-3D airway organoid model recapitulates aspects of pathogenesis at the single-cell level and serves as a platform for evaluating therapeutics targeting CFTR nonsense mutations."

Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Pulmonary Disease • Respiratory Diseases • CFTR • EGF • TGFB1 • TNFA

Acute Liver Failure From Acetaminophen Toxicity in the Setting of Concurrent Alcohol and Rifampin Use (ACG 2025) - "The acetaminophen level was 96 mcg/mL ~12 hours post-ingestion, and N-acetylcysteine (NAC) therapy initiated...After discharge, he started ethambutol and moxifloxacin for latent TB treatment. Our case emphasizes the elevated risk of severe hepatotoxicity from acetaminophen in combination with certain classes of medications...Furthermore, concurrent alcohol use can further exacerbate this potential. This case highlights the importance of understanding high-risk medication interactions in at-risk individuals using acetaminophen."

CNS Disorders • Crohn's disease • Gastroenterology • Hepatic Encephalopathy • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Liver Failure • Respiratory Diseases • Tuberculosis • CYP2E1 • CYP3A4

The effectiveness and safety of Oral N-acetylcysteine in combination with Narrow-Band Ultraviolet B (NB-UVB) Phototherapy compared with NB-UVB Phototherapy alone in the treatment of Vitiligo: A Pilot study (EADV 2025) - No abstract available

Clinical • Combination therapy • Dermatology • Immunology • Vitiligo

An analysis of the safety and effectiveness of treating vitiligo with microneedling alone and in combination with N-acetylcysteine (EADV 2025) - No abstract available

Clinical • Combination therapy • Dermatology • Immunology • Vitiligo

N-Acetylcysteine as an Adjuvant Therapy in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome with Chronic Kidney Disease: A Case Report (EADV 2025) - No abstract available

Case report • Clinical • Chronic Kidney Disease • Nephrology • Renal Disease • Steven-Johnson Syndrome

Emerging pharmacological strategies for the treatment of cannabis use disorder. (PubMed, Expert Opin Pharmacother) - "Agents discussed include gabapentin, N-acetylcysteine, synthetic cannabinoids, fatty acid amide hydrolase (FAAH) inhibitors, orexin receptor antagonists, and psychedelics...Novel compounds targeting endocannabinoid tone and motivational circuits show promise, but significant research is still needed. Future progress depends on better integration with behavioral care, trial stratification by clinical phenotype, and increased investment in translational research to move beyond withdrawal symptom management toward sustained recovery."

Journal • Substance Abuse

The Pathophysiological Role of Mitochondrial Oxidative Stress in Rheumatic Diseases. (PubMed, J Inflamm Res) - "It also explains the mechanism of mitochondrial dysfunction and the clinical significance of major rheumatic diseases, as well as the clinical transformation status of key antioxidants, the risks/reasons for promoting mitochondrial ROS research in rheumatic diseases, and antioxidant therapy. We conclude that targeting oxidative stress with antioxidant agents,such as polyphenols, garlic, pomegranate, Coenzyme Q10, probiotic, α-lipoic acid, N-acetylcysteine (NAC), selenium, microalgae, fucoidan, resveratrol, quercetin, and curcumin should be considered as promising new strategies for treating rheumatic diseases lacking effective treatments."

Journal • Review • Ankylosing Spondylitis • Immunology • Lupus • Metabolic Disorders • Osteoarthritis • Pain • Rheumatology • Scleroderma • Seronegative Spondyloarthropathies • Systemic Lupus Erythematosus • Systemic Sclerosis

Impact of Dietary Antioxidant Supplements on Atrophic Lesion Progression in Stargardt Disease: A Retrospective Observational Study. (PubMed, J Ophthalmol) - "Patients were grouped into supplement takers and nontakers based on the daily intake of lutein, zeaxanthin, saffron, and N-acetylcysteine... Supplementation with dietary antioxidants did not result in a slower progression rate of DAF lesions in STGD1. Further investigation with randomized trials is needed for evidence-based use of antioxidant supplements for the disease."

Journal • Observational data • Retrospective data • Inherited Retinal Dystrophy • Ophthalmology • Retinal Disorders

Effectiveness of Medical Nutrition Therapy in the Management of Patients with Obesity and Endometriosis: from the Mediterranean Diet To the Ketogenic Diet, Through Supplementation. The Role of the Nutritionist in Clinical Management. (PubMed, Curr Obes Rep) - "Supplementation with omega-3 fatty acids, N-acetylcysteine, resveratrol, vitamins C and E, and probiotics has demonstrated promising anti-inflammatory and antioxidative effects in both preclinical and clinical studies...While conventional treatment focuses on hormonal therapy and surgery, MNT is emerging as a non-invasive, supportive approach. Nutritional interventions can target key pathophysiological mechanisms of endometriosis, such as systemic inflammation, oxidative stress, and hormonal imbalance, offering potential symptom relief and improved clinical outcomes."

Journal • Review • Endometriosis • Genetic Disorders • Gynecology • Infertility • Inflammation • Musculoskeletal Pain • Obesity • Pain • Sexual Disorders • Women's Health

Moh1 coordinates ROS-dependent apoptosis in genotoxic stress response of Candida albicans. (PubMed, Fungal Biol) - "Mechanistically, moh1Δ cells exhibit reduced intracellular reactive oxygen species (ROS), and pharmacological ROS scavenging with N-acetylcysteine abolishes the stress-resistant phenotype...While dispensable for hyphal morphogenesis and virulence in a Galleria mellonella model, Moh1 negatively regulates biofilm formation. Collectively, these findings establish Moh1 as a critical regulator of ROS-dependent apoptosis during genotoxic stress response in C. albicans, offering insights for targeting fungal apoptotic pathways in antifungal strategies."

Journal

The Role of P62/Nrf2/Keap1 Signaling Pathway in Lead-Induced Neurological Dysfunction. (PubMed, CNS Neurosci Ther) - "The P62/Nrf2/Keap1 pathway mediates Pb-induced neuronal dysfunction and highlights its potential as a therapeutic target for mitigating the neurodegenerative effects associated with Pb exposure."

Journal • Alzheimer's Disease • CNS Disorders • HMOX1

Effects of Antioxidants on Oxidative Stress in Adult Patients with Coronary Artery Disease: A Systematic Review. (PubMed, Clin Nutr ESPEN) - "The reviewed RTCs provide evidence that antioxidants may lower OS in patients with CAD. The utility of this conclusion is limited by the studies' methodologies that examine various antioxidants and measure OS through a variety of biomarkers. This heterogeneity in methodologies between studies indicates that further research is needed with standardized interventions and outcomes."

Journal • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Hepatology • Liver Failure • Myocardial Infarction • Nephrology • Renal Disease

Fangchinoline attenuates hepatic fibrosis by regulating taurine metabolism and oxidative stress. (PubMed, Front Pharmacol) - "Cleaning ROS with N-acetylcysteine enhanced the anti-fibrotic effects of FAN. FAN can alleviate hepatic fibrosis by regulating taurine metabolism and oxidative stress, which has an important theoretical value."

Journal • Fibrosis • Hepatology • Immunology • Liver Cirrhosis • TGFB1