acetylcysteine solution / Generic mfg. - LARVOL DELTA

N-Acetylcysteine (NAC) for Trichotillomania and Excoriation Disorder: An Overview. (PubMed, J Psychosoc Nurs Ment Health Serv) - "Deficiencies in pharmacological protocols and lack of government controls place individuals at risk; therefore, health care providers are well positioned to provide reliable information and educate individuals to make informed decisions about their health. [Journal of Psychosocial Nursing and Mental Health Services, xx(x), xx-xx.]."

Journal • Alopecia • CNS Disorders • Mental Retardation • Obsessive-Compulsive Disorder • Psychiatry

JS-K induces ferroptosis in renal carcinoma cells by regulating the c-Myc-GSTP1 Axis. (PubMed, Sci Rep) - "The cytotoxic effects of erastin and JS-K were evaluated in various renal cell carcinoma (RCC) cell lines and normal human renal epithelial cells...In addition, JS-K induced ferroptosis in RCC cells by reducing cellular GSH levels, increasing lipid peroxidation, and elevating ferrous ion levels, and the effects of JS-K were neutralized by N-acetylcysteine (NAC)...Finally, JS-K inhibited tumor growth in a mouse model by inducing ferroptosis. JS-K induces ferroptosis in RCC cells by depleting glutathione through the inhibition of the c-Myc-GSTP1 axis."

Journal • Genito-urinary Cancer • Kidney Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor • GSTP1 • MYC

Resveratrol and N-acetylcystein reduce hepatic steatosis but enhance initiation and progression of hepatocellular carcinoma by inhibiting GST-pi-MAPK axis in mice. (PubMed, Front Pharmacol) - "Therefore, we investigated the effects of resveratrol (RES) and N-acetylcysteine (NAC) on hepatocellular carcinoma (HCC) development using two fatty liver mouse models...Blockade of GST-pi abrogated the reduction in p-JNK and p-p38 levels and increased apoptosis of HCC cells. Antioxidants may increase the incidence of HCC in a population with fatty liver, despite reduction in ROS production, by inhibiting GST-pi-MAPK axis."

Journal • Preclinical • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor • GSTP1

Quercetin as a therapeutic agent for acute pancreatitis: a comprehensive review of antioxidant, anti-inflammatory, and immunomodulatory mechanisms. (PubMed, Front Pharmacol) - "Furthermore, it examines quercetin's multi-target mechanisms and its advantages over conventional therapies, such as N-acetylcysteine and corticosteroids...One of the main challenges for quercetin's clinical application is its low bioavailability. Future research should focus on strategies to enhance its bioavailability and on conducting large-scale randomized controlled trials to more comprehensively assess its efficacy and safety in the treatment of AP."

Journal • Review • Immune Modulation • Immunology • Inflammation • Pancreatitis

Dual pathogenic mechanisms in lysinuric protein intolerance: Interplay between hyperammonemia and cellular metabolic dysregulation in astrocyte injury. (PubMed, Mol Genet Metab) - "SLC7A7 dysfunction leads to intracellular metabolite disturbances and an increase in vulnerability to ammonia toxicity through ROS production of astrocyte, suggesting hyperammonemia and amino acid deficiencies as potential therapeutic targets in LPI patient care."

Journal • Genetic Disorders • Metabolic Disorders

Meta-analysis of the efficacy and safety of L-carnitine and N-acetylcysteine monotherapy for male idiopathic infertility. (PubMed, Rev Int Androl) - "Both LC and NAC can improve sperm motility, sperm concentration, and normal morphology, and increase serum testosterone concentration, but have no significant effect on other serum hormones."

Clinical • Journal • Monotherapy • Retrospective data • Review • Infertility • Sexual Disorders

Efficacy of N-acetylcysteine and motivational enhancement therapy for nicotine addiction: A randomized clinical trial. (PubMed, Narra J) - "The reported side effects were mild to moderate discomfort and well-tolerated across both groups. These findings highlight the potential of NAC and MET combination in promoting neuroplasticity and supporting nicotine addiction treatment."

Clinical • Journal • CNS Disorders • Nicotine Addiction • Psychiatry • Solid Tumor • Tobacco Cessation

Oligomeric proanthocyanidin attenuates asthma severity and airway remodeling by modulating epithelial-smooth muscle cell interactions. (PubMed, Phytomedicine) - "Our findings provide the first evidence that OPC may offer a promising approach to clinical asthma management by modulating communication between airway structural cells, highlighting the potential of OPC as a potent option to mitigate airway remodeling in asthma."

Journal • Asthma • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • CCL11 • TGFB1 • TNFA

Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage. (PubMed, Biomech Model Mechanobiol) - "N-acetylcysteine (NAC) has emerged as an antioxidant capable of inhibiting oxidative stress, cell death, and cartilage degeneration post-impact...These results enhance understanding of the temporal effects of impact-related cell damage and treatment that are critical for the development of effective treatments for PTOA. In the future, our modeling framework could increase understanding of time-dependent mechanisms of oxidative stress and downstream effects in injured cartilage and aid in developing better treatments to mitigate PTOA progression."

Journal • Immunology • Mood Disorders • Osteoarthritis • Pain • Rheumatology

Nebulized Heparin and N-Acetylcysteine do Not Improve Outcomes of Intubated Burn Patients With Grade II or III Inhalation Injuries. (PubMed, Am Surg) - "An inhalational protocol did not improve outcomes in burn patients suffering abbreviated injury score (AIS) grade II-III inhalation injuries at our institution. Moving forward, large, multicenter, randomized control trials are needed to determine the true efficacy of nebulized heparin and N-acetylcysteine for AIS grade II-III injuries."

Journal

Differential mitochondrial function drives sex differences in T cell exhaustion (IMMUNOLOGY 2025) - "Treatment with antioxidant (N-acetylcysteine) or mitophagy inducer (nicotinamide riboside) mitigated the sex differences in exhausted phenotype in T cells, suggesting that differences in mitochondria function may be a driver of sex differences in T cell exhaustion. Furthermore, combining anti-PD1 and 4-1BB agonist antibodies, which enhance mitochondrial function in T cells, improved survival of both male and female pre-clinical GBM models. These findings suggest that differential mitochondrial dysfunction drives sex differences in T cell exhaustion, offering a target for sex-specific therapies.Keywords: Cells T Cells; Processes Cell Activation Costimulation Cytotoxicity Inflammation"

IO biomarker • Brain Cancer • CNS Tumor • Glioblastoma • Metabolic Disorders • Oncology • Solid Tumor

Reversing Alcohol-Dependent Effects on HIV Replication: Are There Roles for Pioglitazone and N-Acetylcysteine? (PubMed, Am J Respir Cell Mol Biol) - No abstract available

Journal • Addiction (Opioid and Alcohol) • Human Immunodeficiency Virus • Infectious Disease

Efficacy, Safety, and Cost-Effectiveness of N-Acetylcysteine in Preventing Amphotericin B Nephrotoxicity in Egyptian Patients with Hematological Malignancies: A Randomized Controlled Trial. (PubMed, Hosp Pharm) - P=N/A | "This study evaluated the efficacy, safety, and cost-effectiveness of oral N-acetylcysteine (NAC) in preventing AmB-d nephrotoxicity and promoting renal recovery in Egyptian hematological malignancy patients. The favorable NNT for renal recovery suggests clinical relevance, warranting further investigation in larger studies. Trial registration: ClinicalTrials.gov identifier, NCT06122311."

HEOR • Journal • Acute Kidney Injury • Hematological Disorders • Hematological Malignancies • Infectious Disease • Nephrology • Oncology • Renal Disease

Synergistic impact of antioxidant combinations on collagen and elastin synthesis in human dermal fibroblasts. (PubMed, Biomed Mater Eng) - "Objective: The objective of this study was to evaluate the individual and combined effects of N-acetylcysteine (NAC), Coenzyme Q10 (CoQ10), Niacinamide (NIAC), Gamma Cyclodextrin (GAMMA), Retinol (RET), Epigallocatechin Gallate (EGCG), and Ellagic Acid (ELA) on collagen type I and elastin synthesis in human dermal fibroblasts (HDFs)... The combination of EGCG with CoQ10, Retinol, or NAC presents a promising strategy for enhancing skin elasticity and firmness by promoting both elastin and collagen synthesis. These findings suggest that antioxidant combinations can be developed for effective anti-aging skincare formulations."

Journal

METTL3-dependent m6A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation. (PubMed, Autophagy) - "Finally, we concluded that restoring SNAP29 by inhibiting METTL3 and YTHDF2 reversed the "autophagy-mitochondrial crisis", defined for the first time as disrupted autophagic flux, mitochondrial damage, mitochondrial protein leakage, and the occurrence of parthanatos. The reversal of this crisis ultimately promoted the survival of ischemic flaps.Abbreviations: AAV = adeno-associated virus; ACTA2/α-SMA = actin alpha 2, smooth muscle, aorta; AIFM/AIF = apoptosis-inducing factor, mitochondrion-associated; ALKBH5 = alkB homolog, RNA demythelase; Baf A1 = bafilomycin A1; CQ = chloroquine; DHE = dihydroethidium; ECs = endothelial cells; F-CHP = 5-FAM-conjugated collagen-hybridizing peptide; GO = gene ontology; HUVECs = human umbilical vein endothelial cells; KEGG = Kyoto Encyclopedia of Genes and Genomes; LC-MS/MS = liquid chromatography-tandem mass spectrometry; LDBF = laser doppler blood flow; m6A = N6-methyladenosine; MAP1LC3/LC3 = microtubule-associated protein 1..."

Journal • Pain • Transplantation • ACTA2 • ALKBH5 • CD31 • MAP1LC3B • METTL3 • PARP1 • PECAM1 • SQSTM1 • VAMP8 • WT1 • WTAP • YTHDF2

LOW- AND HIGH-DOSE RIFAXIMIN VERSUS LOW-DOSE RIFAXIMIN COMBINED WITH N-ACETYLCYSTEINE FOR TREATING DIARRHEA-PREDOMINANT IRRITABLE BOWEL SYNDROME: A DOUBLE-BLIND, RANDOMIZED PROOF-OF-CONCEPT TRIAL (DDW 2025) - No abstract available

Clinical • Gastrointestinal Disorder

EFFICACY OF N-ACETYLCYSTEINE PLUS SIMETHICONE IN IMPROVING MUCOSAL VISIBILITY DURING UPPER GASTROINTESTINAL ENDOSCOPY: A SYSTEMATIC REVIEW AND META-ANALYSIS (DDW 2025) - "Conclusion : This meta-analysis indicates that NAC plus simethicone, particularly the dose of 600mg, is effective in improving the mucosal visibility and reducing procedure time during endoscopy. These findings have important implications, as enhanced mucosal visibility during endoscopy can significantly increase procedural efficacy, leading to better patient outcomes and increased endoscopist's satisfaction."

Retrospective data • Review • Gastrointestinal Disorder

AGE-SPECIFIC AND RACE/ETHNICITY-SPECIFIC DISPARITIES IN 28-DAY AND 90-DAY OUTCOMES FOLLOWING HOSPITALIZATION FOR ALCOHOL-ASSOCIATED HEPATITIS AMONG VETERANS IN THE UNITED STATES (DDW 2025) - "Adjusted multivariable Cox proportional hazards models (adjusted for age, sex, race/ethnicity, presence of ascites, hepatic encephalopathy, number of organ failures [renal, cardiovascular, respiratory], MELD score, and treatment with steroids or N-acetylcysteine) were used to evaluate predictors of death or LT within 28 days and within 90 days of AH hospitalization...Conclusion : Among a national cohort of veterans hospitalized for AH, nearly 1 in 5 died or received LT within 90 days of AH hospitalization. Significant disparities were observed, with older age being associated with worse outcomes, and Black/African American race/ethnicity associated with better outcomes."

Clinical • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Hepatic Encephalopathy • Hepatology • Inflammation • Renal Disease

IN-HOSPITAL OUTCOMES AMONG A NATIONAL COHORT OF VETERANS HOSPITALIZED FOR ALCOHOL-ASSOCIATED HEPATITIS (DDW 2025) - "Adjusted Cox proportional hazards models (adjusted for age, sex, race/ethnicity, presence of ascites, hepatic encephalopathy, number of organ failures [renal, cardiovascular, respiratory], MELD score, and treatment with steroids or N-acetylcysteine) evaluated predictors of in-hospital death or LT...Older age, higher MELD score, and increasing number of end-organ failures at time of admission were associated with increased risks of death or LT. Greater awareness of the dangers of unhealthy alcohol use and improved efforts to implement routine screening of alcohol use disorder with prompt linkage to alcohol addiction treatment resources in Veterans is urgently needed to curb this rising epidemic of ALD in this vulnerable population."

Clinical • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Hepatic Encephalopathy • Hepatology • Inflammation • Psychiatry • Renal Disease

CORTICOSTEROID THERAPY IN HOSPITALIZED VETERANS WITH SEVERE ACUTE ALCOHOL-ASSOCIATED HEPATITIS IS NOT ASSOCIATED WITH IMPROVED 28-DAY OR 90-DAY OUTCOMES (DDW 2025) - "Adjusted multivariable Cox proportional hazards models (adjusted for age, sex, race/ethnicity, presence of ascites, hepatic encephalopathy, number of organ failures [renal, cardiovascular, respiratory], MELD score, and treatment with steroids or N-acetylcysteine) evaluated predictors of death or LT within 28 days and within 90 days of SAH hospitalization...Conclusions : Among a national longitudinal cohort of veterans hospitalized with SAH, treatment with corticosteroids was not associated with significant differences in risk of death or LT within 28 days or within 90 days. These data among a large generalizable cohort continues to raise doubt about the clinical benefit of corticosteroids in all patients with SAH and emphasizes the urgent need for novel therapies to treat this highly fatal condition."

Clinical • Cardiovascular • CNS Disorders • Hepatic Encephalopathy • Hepatology • Inflammation • Renal Disease

LONG TERM SURVIVAL IN ACETAMINOPHEN-INDUCED ACUTE LIVER FAILURE WITH CONTINUOUS RENAL REPLACEMENT THERAPY (DDW 2025) - "Groups were matched by age, laboratory values, and use of N-acetylcysteine...This study underscores the critical impact of CRRT on outcomes in ALF, likely due to the severity of the underlying condition. Future research could focus on identifying modifiable factors or interventions to improve survival in patients with ALF requiring CRRT."

Cardiovascular • CNS Disorders • Hepatic Encephalopathy • Hepatology • Hypertension • Liver Failure • Nephrology • Renal Disease

THE ROLE OF TGF-β SIGNALING ON DENDRITIC CELLS IN MODULATING OXIDATIVE STRESS AND SHAPING INTESTINAL MICROBIOTA (DDW 2025) - " CD11c-Cre; Tgfbr2fl/fl mice (DCR2KO) received drinking water with or without 3.0% N-acetylcysteine (NAC) for 7 days... TGF-β signaling in DCs inhibits Notch signaling and ROS generation in the intestinal epithelium, thereby preventing dysbiosis. The link between Notch signaling and oxidative stress is crucial for understanding the pathogenesis of IBD."

Oxidative stress • Gastroenterology • Gastrointestinal Disorder • Immunology • HES1 • ITGAX • MUC2 • TFF3 • TGFB1 • TGFBR2

Neuroimaging Study of N-acetylcysteine in Excoriation (Skin-Picking) Disorder (clinicaltrials.gov) - P4 | N=90 | Active, not recruiting | Sponsor: Guangdong Provincial People's Hospital

New P4 trial • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry

Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review. (PubMed, Ann Med Surg (Lond)) - "This review discusses trials evaluating the effects of supplementation with various antioxidants, including Ginkgo biloba, melatonin, omega-3 fatty acids, vitamins A, N-acetylcysteine, lipoic acid, xanthophylls, and crocin, on cognitive performance...These mechanisms range from mitigating OS, inflammation, and glutamate-induced neurotoxicity in the CNS to addressing secondary symptoms such as depression and fatigue, which are often linked to cognitive decline. By reviewing the current evidence, this review not only underscores the therapeutic potential and limitations of antioxidant supplementation but also provides guidance for future research to optimize study design and advance our understanding of cognitive preservation strategies in MS."

Journal • Review • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Depression • Fatigue • Inflammation • Multiple Sclerosis • Psychiatry

N-acetylcysteine treatment for skin-picking in children and young adults with PWS: A randomized placebo-controlled cross-over trial. (ESPE-ESE 2025) - "NAC appears to have beneficial effects on skin-picking in a subgroup of patients with PWS, particularly in boys, without safety concerns. While NAC may be considered in children and young adults with PWS, its effects should be assessed on an individual basis. Treatment should be discontinued if no significant benefits are observed."

Clinical • Infectious Disease • Prader–Willi syndrome