apomorphine (apomorphine Linguet) / Imugene - LARVOL DELTA

Treating Morning OFF Episodes in Parkinson’s Disease - Episode 6: Practical Advice for Managing Morning OFF Episodes in Parkinson Disease (NeurologyLive) - "Peter A. LeWitt, MD: In my clinical practice and experience with all 3 on-demand products, that is inhaled levodopa for pulmonary uptake, apomorphine given by subcutaneous injection in liquid form, or apomorphine given in strips that are absorbed through the mucosa under the tongue, each of these has a role to play for certain patients. I use all 3 of them, and some of my patients have tried more than 1 of them. It's hard to know which will work best for every patient. Some patients may have adverse effects, such as lowering of blood pressure or nausea, with apomorphine no matter how you deliver it. For others, inhaling levodopa will have enough throat irritation or coughing that they choose not to continue with this drug. And apomorphine as a drug is probably more potent than levodopa in the doses that are used as on-demand therapies."

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Prof. Rajesh Pahwa, CONy Virtual 2020 (YouTube) - "Prof. Rajesh Pahwa...Apomorphine infusion should be used before surgical therapies are considered?"

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PD OFF Episodes: Optimizing Use of On-Demand Therapy (NeurologyLive) - "Which one to use? It's hard to know. Most patients haven't switched from one to the other. There haven't been head-to-head comparisons. The mode of delivery is different. One is an injection, the other is inhaled. There are possible adverse effects to each formulation in terms of how they're administered. Patients, fortunately, have the option of trying both of them and could perhaps make the right decision as to which one they stick with or how effective it might be."

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Reviewing a Case of Parkinson Disease OFF Episodes (NeurologyLive) - "Peter A. LeWitt, MD: The case I would like to discuss is of a 68-year-old man who was diagnosed with Parkinson disease 5 years ago with a gradual onset and typical features of tremors and slowness of movement. He is responsive to medication. When he was diagnosed, he was started on a regimen on carbidopa, levodopa, and entacapone. This was a triplet combination taken at 4-hour intervals throughout the day."

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