AGK2 / Harvard Medical School, Shanghai Jiao Tong University, Chongqing Medical University - LARVOL DELTA

Lactylation of METTL16 promotes cuproptosis via mA-modification on FDX1 mRNA in gastric cancer. (PubMed, Nat Commun) - "Combining elesclomol with AGK2, a SIRT2-specific inhibitor, induce cuproptosis in gastric tumors in vitro and in vivo. These results reveal the significance of non-histone protein METTL16 lactylation on cuproptosis in tumors. Given the high copper and lactate concentrations in GC, cuproptosis induction becomes a promising therapeutic strategy for GC."

Journal • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • FDX1 • METTL16

MYO1F regulates antifungal immunity by regulating acetylation of microtubules. (PubMed, Proc Natl Acad Sci U S A) - "AGK2 also promotes proinflammatory gene expression in human peripheral blood mononuclear cells after Dectin stimulation. Taken together, our findings describe a key role for MYO1F in promoting antifungal immunity by regulating the acetylation of α-tubulin and microtubules, and our findings suggest that Sirt2 deacetylase inhibitors may be developed as potential drugs for the treatment of fungal infections."

Journal • Infectious Disease • Inflammation • SYK