anti-IFN α receptor mAb / Roche - LARVOL DELTA

IFN-alpha receptor deficiency enhances host resistance to oral Salmonella enterica serovar Typhimurium infection during murine pregnancy. (PubMed, Am J Reprod Immunol) - "Oral S.Tm exposure leads to placental infection, inflammation and resorption, whereas IFNAR1 deficiency enhances host resistance both in the non-pregnant and pregnant states."

Journal • Preclinical • Immunology • Infectious Disease • Inflammation • IFNA1 • IFNAR1 • IFNAR2

A Study to Assess the Safety and Tolerability of MPDL3280A in Combination With Other Immune-modulating Therapies in Patients With Locally Advanced or Metastatic Solid Tumors (clinicaltrials.gov) - P1; N=200; Recruiting; Sponsor: Hoffmann-La Roche; Not yet recruiting -> Recruiting

Enrollment open • Biosimilar • Melanoma • Non Small Cell Lung Cancer • Oncology • Renal Cell Carcinoma