AQCH / Sun Pharma - LARVOL DELTA

Sinococuline, a bioactive compound of Cocculus hirsutus has potent anti-dengue activity. (PubMed, Sci Rep) - "We have recently shown that Aqueous Extract of the stem of Cocculus hirsutus (AQCH) was effective in vitro and in vivo against DENV and was safe in humans...Also, this dose effectively reduced serum viremia and tissue-viral load and inhibited the elevated expression levels of proinflammatory cytokines (TNF-α and IL-6) in several vital organs. Based on these findings, it could be explored further for pre-clinical and clinical developments for the treatment of dengue."

Journal • Dengue Fever • Infectious Disease • IL6 • TNFA

Clinical safety and pharmacokinetic evaluation of aqueous extract of Cocculus hirsutus, an anti-viral phytopharmacetical drug as a potential for the treatment of dengue and COVID-19. (PubMed, Heliyon) - "Dose accumulation was observed and steady state was achieved within 3 days. The information on human pharmacokinetics of AQCH tablets would assist in further dose optimization with defined pharmacokinetic-pharmacodynamic relationship."

Journal • PK/PD data • Dengue Fever • Infectious Disease • Novel Coronavirus Disease

Efficacy and Safety of a Phytopharmaceutical Drug Derived from Cocculus hirsutus in Adults with Moderate COVID-19: a Phase 2, Open-label, Multicenter, Randomized Controlled Trial. (PubMed, Infect Dis Ther) - "AQCH significantly reduced time to clinical improvement, time to viral clearance, and duration of hospitalization. In a pandemic, this has significant potential to decrease healthcare resource utilization and increase hospital bed availability. Further investigation of the therapeutic potential of AQCH in patients with COVID-19 is warranted."

Journal • P2 data • Infectious Disease • Novel Coronavirus Disease

Cocculus hirsutus-Derived Phytopharmaceutical Drug Has Potent Anti-dengue Activity. (PubMed, Front Microbiol) - "Additionally, the AQCH extract reduced serum viremia and small intestinal pathologies, viz., viral load, pro-inflammatory cytokines, and vascular leakage. Based on these findings, we have undertaken the potential preclinical development of C. hirsutus-based phytopharmaceutical, which could be studied further for its clinical development for treating dengue."

Journal • Dengue Fever • Infectious Disease