AST6 / Allist - LARVOL DELTA

Massive Hepatic Necrosis in HELLP Syndrome (ATS 2025) - "Pertinent labs on presentation included: ALT 2,900 U/L AST 6,820 U/L, total bilirubin 1.9 mg/dL, INR 0.97, and Cr 2.79. Hepatic necrosis is a recognized catastrophic complication of HELLP syndrome, its occurrence postpartum is rare, and management requires a multidisciplinary approach and early referral to a liver transplant center. Few cases in the literature describe conservative management of hepatic necrosis, highlighting the need for further research to guide management without resorting to liver transplantation."

Atypical Hemolytic Uremic Syndrome • Complement-mediated Rare Disorders • Gynecology • Hematological Disorders • Hepatology • Immunology • Inflammatory Arthritis • Liver Failure • Lupus • Nephrology • Pain • Systemic Lupus Erythematosus

Obeticholic Acid Improves Cholestasis, Liver Fibrosis, and Liver Function in Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid. (PubMed, J Pers Med) - "OCA treatment led to a statistically significant decrease in aspartate aminotransferase (AST; AST baseline: 38.50 [26.25; 50.00] IU/L vs. AST 6-month follow-up: 23.50 [21.50; 44.25] IU/L, p = 0.0012), alanine aminotransferase (ALT; ALT baseline: 55.50 [28.75; 97.00] IU/L vs. ALT 6-month follow-up: 36.50 [28.00; 57.25] IU/L, p = 0.0035), and gamma-glutamyl transferase (GGT; GGT baseline: 168.00 [100.30; 328.50] IU/L vs. GGT 6-month follow-up: 88.00 [44.50; 259.80] IU/L, p = 0.0063), while the decrease in alkaline phosphatase (AP) was not statistically significant (AP baseline: 197.00 [170.00; 253.30] IU/L vs. AP 6-month follow-up: 196.00 [134.00; 227.00] IU/L, p = 0.0915). In none of our patients did therapy with obeticholic acid have to be stopped due to pruritus or poor tolerability. In patients with PBC without adequate response to UDCA, OCA is a promising alternative, which in our group of 16 patients led to a significant improvement of liver enzymes, the..."

Journal • Autoimmune Hepatitis • Cholestasis • Dermatology • Fibrosis • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Primary Biliary Cholangitis • Pruritus • Transplantation

A case of MPGN with TMA in HCV-negative adolescent (IPNA 2025) - "AST 6.6U/L, ALT 8.8 U/L, Urea 29.5 mmol/L, Crea 602 umol/L, LDG 1112, aPTT- 44.6; D-Dimer - 1.53 mg/l, рН- 7.34; рСО2- 44.1; рО2- 61.6; НСО3- 23.4...Two doses of Rituximab (500mg) were administered, and the patient was discharged home...Conclusions In this report, we describe a child with progressive renal failure and pathology exhibiting a membranoproliferative pattern. We thus conclude that this patient exhibited an unusual presentation of chronic thrombotic microangiopathy mimicking MPGN Type II."

Clinical • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Complement-mediated Rare Disorders • Epilepsy • Glomerulonephritis • Hepatitis C • Hepatology • Hypertension • Infectious Disease • Inflammation • Lupus Nephritis • Nephrology • Renal Disease • Thrombosis

Value of constructing a non-invasive diagnostic model based on serum heme oxygenase-1 and glucose regulatory protein 78 for non-alcoholic fatty liver disease (PubMed, Zhonghua Gan Zang Bing Za Zhi) - "A nomogram clinical predictive model HGATL was established using HO-1 (H), GRP78 (G) combined with AST (A), TG (T), and LDL-C (L), with the formula P=-21.469+3.621×HO-1+0.116 ×GRP78+0.674×AST+6.250×TG+4.122 ×LDL-C... The HGATL model can be used as a novel, non-invasive diagnosis model for NAFLD and has a positive application value in NAFLD diagnosis and therapeutic effect evaluation. Therefore, it should be explored and promoted in clinical applications."

Journal • Addiction (Opioid and Alcohol) • Dyslipidemia • Hepatology • Metabolic Dysfunction-Associated Steatotic Liver Disease • HMOX1 • HSPA5

CARDIOGENIC SHOCK AFTER VENLAFAXINE OVERDOSE (CHEST 2023) - "CASE PRESENTATION: A 21-year-old female with history of depression and no known cardiac disease was brought to the ED after ingestion of 14,100 mg of venlafaxine extended-release in a suicide attempt...Lab work showed elevated transaminases (ALT 3,914, AST 6,132), and elevated troponin (72 ng/L)...Three hours later, she had a tonic-clonic seizure, so lorazepam was administered and she was emergently intubated for airway protection...Dobutamine infusion was started and echocardiogram confirmed left ventricular dysfunction with ejection fraction (EF) of 35-40%... As venlafaxine is commonly prescribed for depression, patients and physicians should be aware of potential serious cardiac complications at higher doses."

Atrial Fibrillation • Cardiomyopathy • Cardiovascular • CNS Disorders • Congestive Heart Failure • Depression • Epilepsy • Heart Failure • Psychiatry

[VIRTUAL] DIFFERENTIATING ACETAMINOPHEN (APAP) OVERDOSE FROM ISCHEMIC HEPATITIS (IH) IN PATIENTS WITH ACUTE LIVER FAILURE (ALF): ROLE OF SERUM APAP ADDUCTS (AASLD 2021) - "Median peak lab values for APAP and IH cases respectively were similar: APAP: AST 6,491 IU/L, ALT 4,553 IU/L, Bili 4.5 mg/dL; Ischemia: AST 4930 IU/L, ALT 3226 IU/L, Bili 3.15 mg/ dL . The interchangeable clinical scenarios (found unresponsive with high ALT) make it difficult to reliably distinguish APAP from IH . Presence/absence of serum APAP adducts resolves many (xx) of these cases. We identified 6% with combination injuries (APAP or ischemia plus DILI, etc.) and an additional 1% with apparent combination APAP/ Ischemia injury."

Clinical • Hematological Disorders • Hepatology • Hypotension • Inflammation • Liver Failure • Respiratory Diseases

Induction of Phlorotannins and Gene Expression in the Brown Macroalga Fucus vesiculosus in Response to the Herbivore Littorina littorea. (PubMed, Mar Drugs) - "Soluble phlorotannin levels remained stable during the kinetics and increased significantly only after 12 h in the presence of grazers, compared to the control, before decreasing to the initial steady state for the rest of the kinetics. Under grazing conditions, the expression of vbpo, cyp450 and ast6 genes was upregulated, respectively, at 6 h, 12 h and 24 h, and cyp450 gene was downregulated after 72 h. Interestingly, the pksIII gene involved in the synthesis of phloroglucinol was overexpressed under grazing conditions after 24 h and 72 h. This study supports the hypothesis that phlorotannins are able to provide an inducible chemical defense under grazing activity, which is regulated at different stages of the stress response."

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Electromuscular Incapacitation Current Induced Neuromuscular Tissue Injury. (PubMed, Bioelectromagnetics) - "Maximal energy cardiac defibrillator pulses resulted in rhabdomyolysis and marked elevation of CPK, LDH, and AST 6 h post-shock. Bioelectromagnetics."

Journal • Anesthesia • Atrial Fibrillation • Cardiovascular • Metabolic Disorders • Mood Disorders

A hidden human proteome encoded by 'non-coding' genes. (PubMed, Nucleic Acids Res) - "As the new protein UBAP1-AST6 is localized in the nucleoli and is preferentially expressed by lung cancer cell lines, we biologically verified that it has a function associated with cell proliferation. In sum, we experimentally evidenced a hidden human functional proteome encoded by purported lncRNAs, suggesting a resource for annotating new human proteins."

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