acetaminophen + opioids (SCP-1) / St. Charles Pharma - LARVOL DELTA

TRRRE: Evaluation of Coagulopathy in Critically Ill COVID-19 Patients. (clinicaltrials.gov) - P=N/A; N=70; Completed; Sponsor: Assiut University; Recruiting ➔ Completed; N=50 ➔ 70

Clinical • Enrollment change • Trial completion • Hematological Disorders • Hemophilia • Infectious Disease • Novel Coronavirus Disease

Evaluation of Coagulopathy in Critically Ill COVID-19 Patients. (clinicaltrials.gov) - P; N=50; Recruiting; Sponsor: Assiut University

Clinical • New trial • Hematological Disorders • Hemophilia • Infectious Disease • Novel Coronavirus Disease

Decoding Cytoskeleton-Anchored and Non-Anchored Receptors from Single-Cell Adhesion Force Data. (PubMed) - "Experiments with latrunculin-A-treated PC3 cells corroborated these observations. The plots thus reveal details of the anchoring of bonds to the cell and provide a better understanding of receptor-ligand interactions."

Journal • Biosimilar • Oncology • Prostate Cancer

DIVERSION-HF: A Study to Investigate the Safety and Efficacy of a Novel Furosemide Regimen (clinicaltrials.gov) - P1/2; N=10; Not yet recruiting; Sponsor: Todd M. Koelling, M.D.

New P1/2 trial • Biosimilar • Cardiovascular • Heart Failure

Genome-Wide Identification and Characterization of Carboxypeptidase Genes in Silkworm (Bombyx mori). (PubMed) - Int J Mol Sci - "...Here, we analyzed the silkworm genome database and characterized 48 carboxypeptidases, including 34 metal carboxypeptidases (BmMCP1-BmMCP34) and 14 serine carboxypeptidases (BmSCP1-BmSCP14), to better understand their diverse functions...Microarray analysis showed that the carboxypeptidases had distinct expression patterns, whereas quantitative real-time PCR demonstrated that the expression level of 13 carboxypeptidases significantly decreased after starvation and restored after re-feeding. Overall, our study provides new insights into the functional and evolutionary features of silkworm carboxypeptidases."

Journal • Biosimilar

LTRs of Endogenous Retroviruses as a Source of Tbx6 Binding Sites. (PubMed, Front Chem) - "Moreover, by comparing gene expression between control mice (Tbx6 +/-) and Tbx6-deficient mice (Tbx6 -/-), we demonstrate that at least four genes, Twist2, Pitx2, Oscp1, and Nfxl1, are down-regulated with Tbx6 deficiency. These results suggest that ORR1A, ORR1B, ORR1C and ORR1D may contribute to the evolution of mammalian embryogenesis."

Journal • Biosimilar

"Convincing evidence for the first effective #schizophrenia treatment: https://t.co/FLjKfELXti #ASCP17" (@MedscapeNeuro)

Biosimilar • CNS Disorders • Schizophrenia

Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells. (PubMed) - Biol Direct - "Our results suggest that employing As- or LbCpf1 nuclease to induce homology directed repair in N2a cells, although is less effective at present than employing SpCas9, it is an equally or more effective tool than the most frequently used orthogonal Cas9 counterparts of SpCas9. These findings support the position of Cpf1 nucleases on the side of SpCas9 on the palette of effective genome engineering tools."

Journal • Biosimilar • Oncology

Engineered Cpf1 variants with altered PAM specificities. (PubMed) - "...BV3L6 Cpf1 (AsCpf1) and Lachnospiraceae bacterium ND2006 Cpf1 (LbCpf1) is limited by their requirement of a TTTV protospacer adjacent motif (PAM) in the DNA substrate...Introducing the identified PAM-interacting mutations at their corresponding positions in LbCpf1 similarly altered its PAM specificity. Together, these variants increase the targeting range of Cpf1 by approximately threefold in human coding sequences to one cleavage site per ∼11 bp."

Journal • Biosimilar

Activity and Specificity of Engineered CRISPR-Cpf1 Nucleases in Human Cells (ASGCT 2017) - "...BV3L6 and Lachnospiraceae bacterium ND2006 (AsCpf1 and LbCpf1, respectively) to examine their usefulness as genome editing reagents...We will also describe how mutations analogous to those present in our previously described high-fidelity SpCas9 (SpCas9-HF) variants(3) can be implemented to retain high genome-wide specificity as needed for Cpf1 nucleases. Overall, our results suggest that both natural and engineered forms of Cpf1 nucleases are robust and useful enzymes, findings that should encourage broader implementation of these genome editing reagents."

Biomarker • Preclinical • Biosimilar • Gene Therapies • Oncology

A Genomic Survey of SCPP Family Genes in Fishes Provides Novel Insights into the Evolution of Fish Scales. (PubMed, Int J Mol Sci) - "...By comparing the gene structures of recently reported candidate genes, SCPP1 and SCPP5, for determining scale phenotypes, we found that the hypothesis is suitable for Astyanax mexicanus, but denied by S. anshuiensis, even though they are both sparsely scaled for cave adaptation. Thus, we conclude that, although different fish species display similar scale phenotypes, the underlying genetic changes however might be diverse. In summary, this paper accelerates the recognition of the SCPP family in teleosts for potential scale evolution."

Journal • Biosimilar