amiodarone / Generic mfg. - LARVOL DELTA

The Concomitant Therapy of Direct Oral Anticoagulants with Amiodarone in Atrial Fibrillation: A Meta-analysis. (PubMed, J Cardiovasc Pharmacol Ther) - "No significant differences in stroke or systemic embolism were found between the two groups (OR 0.86; 95% CI 0.74, 1.00; P = .05; I2 = 34%).Conclusion and RelevanceThe concomitant therapy of amiodarone and DOACs did not significantly increase the bleeding risks or decrease the risk of stroke or systemic embolism compared to the DOAC monotherapy. The drug-drug interactions between amiodarone and DOACs may not be clinically significant."

Journal • Retrospective data • Atrial Fibrillation • Cardiovascular • Gastroenterology

Implantable cardioverter-defibrillator therapy compared to amiodarone in Chagas cardiomyopathy: a systematic review and meta-analysis (ESC-WCC 2025) - No abstract available

Retrospective data • Review • Cardiomyopathy • Cardiovascular

Survival impact of amiodarone therapy in heart failure: insights from the Icelandic Heart Failure registry (ESC-WCC 2025) - No abstract available

Cardiovascular • Congestive Heart Failure • Heart Failure

Very low dose amiodarone is safe and effective in control of atrial fibrillation [WITHDRAWN] (ESC-WCC 2025) - No abstract available

Atrial Fibrillation • Cardiovascular

Prognostic comparison between implantable cardioverter-defibrillator and amiodarone in cancer patients (ESC-WCC 2025) - No abstract available

Clinical • Cardiovascular

Amiodarone-induced vasculitis ended by limb loss in a patient with rheumatic heart disease (ESC-WCC 2025) - "Implementation of the ESC Guidelines"

Clinical • Cardiovascular • Heart Failure

THYROTOXICOSIS WITH PROLONGED CARDIAC EFFECT DUE TO EXCESS LIOTHYRONINE CONSUMPTION 'OVER THE COUNTER': A CASE REPORT AND RECOMMENDATIONS FOR POLICY MAKERS (PubMed, Harefuah) - "Liothyronine consumption has been associated with substantial thyrotoxicosis and cardiac damage. The Liothyronine tablets were provided to the patient by an unauthorized party, as a weight losing nutritional supplement. However, this was done without a medical examination or indication. The increase in demand for "weight-losing" products 'over the counter', the lack of effective enforcement in the chain, the way these products are presented and the possibility of those who are not authorized to market and supply them, emphasize the need to settle the regulation of this issue as soon as possible."

Journal • Cardiovascular • Critical care • Endocrine Disorders • Obesity • Pain

ATRIAL FIBRILLATION PREVALENCE AND ITS MANAGEMENT IN THE AGING TRANSFUSION-DEPENDENT BETA-THALASSEMIA (EHA 2025) - "Amiodarone was the most widely used drug... This is the first study evaluating AF prevalence and its management in β-TDT. AF is a clinically relevant issue in thalassemia pts with a prevalence higher than the general population. Also, stroke prevalence in this cohort is higher than in the thalassemia population in general, and the CHA2DS2-VASc score presents some limitations."

Anemia • Atrial Fibrillation • Beta-Thalassemia • Cardiovascular • Congestive Heart Failure • Diabetes • Genetic Disorders • Heart Failure • Hematological Disorders • Metabolic Disorders

Antiarrhythmic efficacy and safety of oral mexiletine in dogs with ventricular arrhythmias: a multicentre, retrospective analysis. (PubMed, J Am Vet Med Assoc) - "Mexiletine was highly effective in suppressing VA, but reversible gastrointestinal TRSE occurred relatively frequently. Useful information on the effects of mexiletine in dogs with VAs is provided."

Journal • Retrospective data • Cardiovascular • Ventricular Tachycardia

Antiarrhythmic drug use in atrial fibrillation among different European countries - as determined by a physician survey. (PubMed, Int J Cardiol Heart Vasc) - "However, while amiodarone was frequently (88-93 %) used in heart failure with reduced left ventricular ejection fraction, it was also a typical treatment choice for minimal/no-structural heart disease (SHD) (28 %), particularly in UK...Sotalol (16-41 %) and dronedarone use (10-54 %) in CAD varied among countries...Despite recognizing the importance of guidelines, deviations in AAD use were common with the potential to compromise patient safety. These findings indicate the need for more educational support for optimal AAD selection in AF management."

Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Renal Disease

Gender Disparities in cardiovascular outcomes among patients with Sarcoid Myocarditis: A retrospective cohort study (EULAR 2025) - "We employed propensity score matching for age at the time of the index event, race/ethnicity, comorbidities (diabetes mellitus, hyperlipidemia, hypertension, chronic kidney disease (CKD), tobacco use, chronic rheumatic heart disease, acute rheumatic fever, sarcoidosis of lung, overweight and obesity), medications (aspirin, statins, methotrexate, azathioprine, mycophenolate mofetil, and rituximab) resulting in 3,338 patients in each cohort... Before propensity matching, the female cohort was noted to have higher rates of diabetes (24.6% versus (vs) 22.4%), obesity (30.3% vs 22.4%), and methotrexate use (13.7% vs 9.8%), while males had more CKD (17.1 vs 14.2%) and amiodarone use (12.7% vs 7.3%)... Our study suggests that females with sarcoid myocarditis have a lower risk of mortality, major cardiovascular events, heart failure, and arrhythmias. Additional research is needed to explore the underlying mechanisms that could contribute to the gender disparities in sarcoid..."

Retrospective data • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Dyslipidemia • Genetic Disorders • Heart Failure • Hypertension • Inflammation • Metabolic Disorders • Nephrology • Obesity • Oncology • Renal Disease • Sarcoidosis

FLECA-ED: Flecainide Versus Amiodarone in the Cardioversion of Paroxysmal Atrial Fibrillation at the Emergency Department, in Patients With Coronary Artery Disease Without Residual Ischemia (clinicaltrials.gov) - P3 | N=80 | Recruiting | Sponsor: Hippocration General Hospital | N=200 ➔ 80 | Trial completion date: Nov 2024 ➔ Jan 2026 | Trial primary completion date: Oct 2024 ➔ Dec 2025

Enrollment change • Trial completion date • Trial primary completion date • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease

Therapeutic plasmapheresis in the management of thyrotoxicosis: a-retrospective study with emphasis on critically ill patients. (PubMed, Endocrine) - "Our study is among the largest series in the literature. Consistent with existing literature, it has been demonstrated that TPE was reliable and effective in establishing rapid and effective euthyroid state not only in cases of antithyroid drug side effects, ineffectiveness, and thyroid storm but also before non-thyroidal emergency surgeries."

Journal • Retrospective data • Endocrine Disorders • Grave’s Disease

Refractory supraventricular tachycardia from a coronary sinus diverticulum leading to cardiogenic shock: a challenging ablation case. (PubMed, Monaldi Arch Chest Dis) - "Despite boluses of adenosine and amiodarone perfusion, the patient experienced recurrent supraventricular tachycardia (SVT), leading to cardiogenic shock...Successful radiofrequency ablation was performed, resulting in clinical and left ventricular ejection fraction improvement. This case highlights the challenges in managing incessant SVT with cardiogenic shock and complex ablation procedures."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Ventricular Tachycardia

A single center experience of concomitant administration of sofosbuvir/velpatasvir and amiodarone after heart and lung transplantation. (PubMed, JHLT Open) - "Episodes of bradycardia were transient, resolved with intervention, and did not require the discontinuation of SOF/VEL. In patients requiring the combination of SOF/VEL and amiodarone, consideration of therapeutic options is warranted prior to the addition of other bradycardia-inducing medications."

Journal • Cardiovascular • Hepatitis C • Infectious Disease • Inflammation • Transplantation

Plasmapheresis as a Life-Saving Intervention in Amiodarone-Induced Thyroid Storm (ERA 2025) - "Amiodarone was discontinued, thiamazole and prednisolone were started...Postoperatively, the patient recovered without complications and was transitioned to lifelong levothyroxine therapy... This case highlights the efficacy of plasmapheresis in managing refractory AIT, particularly in patients with critically thyrotoxicosis and severe clinical instability. Plasmapheresis offers rapid hormonal control by removing protein-bound thyroid hormones, bridging the gap between medical therapy and surgical intervention. Early recognition and initiation of plasmapheresis in high-risk patients, especially when standard therapies fail to control symptoms, could improve outcomes and reduce morbidity associated with AITS."

Cardiovascular

Amiodarone and Ravuconazole Combination Potentiates Chemotherapy against Drug-Resistant Trypanosoma cruzi Strains. (PubMed, ACS Omega) - "These findings demonstrate a positive in vivo interaction between ravuconazole and amiodarone against T. cruzi infection. Furthermore, they highlight the relevance of the host genetic background and parasite strain on treatment outcomes."

Journal • Infectious Disease • IL10

Exploring Public Interest in Atrial Fibrillation and Its Treatment Measures: A Google Trends Analysis. (PubMed, Cureus) - " This study demonstrates a rising public interest in AF. Searches related to medications such as amiodarone, metoprolol, diltiazem, and flecainide, as well as procedures including cardioversion, artificial cardiac pacemaker, and left atrial appendage occlusion, have all shown increasing trends."

Journal • Atrial Fibrillation • Cardiovascular • Respiratory Syncytial Virus Infections

Non-operation room anesthesia during polypectomy in colonoscopy for a patient with pattern of Wolff-Parkinson White (Euroanaesthesia 2025) - "He was treated in that period with atenolol 50mg x 2 and denied ablation...We used dexmedetomidine 3 mcg/kg + ketamine 2 mg/kg i/v for NORA. Adenosine, procainamide, and amiodarone were kept on standby...Our case aims to highlight that proper medical knowledge combined with appropriate precautions can avoid sympathetic stimulation. They are the key to a successful outcome in patients with WPW syndrome undergoing sedation during colonoscopy."

Clinical • Aesthetic Medicine • Anesthesia • Cardiovascular • CNS Disorders • Movement Disorders

Ventricular tachycardia refractory to cardioversion in a pediatric patient without congenital cardiac anomaly: case report (Euroanaesthesia 2025) - "There was no response and a diagnosis of a ventricular tachycardia was made and initially intravenous amiodarone was tried and synchronized cardioversion was planned...It can occur in children with cardiomyopathy, following some heart surgeries, and with inherited diseases that affect the heart's electrical system (e.g. Long QT syndrome, Brugada's syndrome), also metabolic or electrolyte abnormalities and medication toxicity. In the case of our patient on futher investigation Human coronavirus OC43 infection was detected with molecular PCR testing and the patient was discharged with oral beta blocker for rhythm control."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Genetic Disorders • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Pediatrics • Ventricular Tachycardia

Stellate ganglion block: the future treatment for electrical cardiac storms – case report (Euroanaesthesia 2025) - "Current pharmacological treatment (amiodarone, beta-blockers) have limitations regarding their effectiveness[1,2]...We presente a case of a patient with electrical storm treated with stellate ganglion block.Case Report: A 69-year-old male patient with a past medical history of atrial fibrillation (on dabigatran anticoagulation), heart insufficiency (EF 49%), alcohol and tobacco consumption, type II diabetes mellitus and benign prostatic hyperplasia (BPH), was admitted for revascularization angioplasty after an inferolateral STEMI...Three VT episodes were recorded within 24 hours after the SGB, hemodynamic stability was achieved and no further dysrhythmic episodes were observed subsequently. SGB is an effective, minimally invasive and with low risk of complications technique for recurrent VT/VF. Currently, it's not included in the guidelines, with the potential to be part of the treatment for refractory VT/VF[1,2]."

Case report • Clinical • Anesthesia • Atrial Fibrillation • Benign Prostatic Hyperplasia • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Ophthalmology • Type 2 Diabetes Mellitus • Ventricular Tachycardia

Acute right heart failure in a patient with undiagnosed pulmonary hypertension following spinal surgery: a case report (Euroanaesthesia 2025) - "This significantly raises morbidity, mortality and challenging perioperative management in major surgeries.Case Report: A 72-year-old woman with hypertension, chronic bronchitis, chronic kidney disease, and previous spinal surgeries was scheduled for spinal arthrodesis (T3-Sacro) due to failed prior instrumentation.Anesthesia was initiated with intrathecal morphine, followed by general anesthesia...During surgery, the patient experienced hypotension, 900 mL blood loss, and ventricular tachycardia, which were managed with fluid resuscitation, blood transfusion, vasopressors, and amiodarone.Postoperatively, she was transferred to the ICU...Treatment with vasopressors and milrinone stabilized her within 72 hours...Echocardiography and AngioCT were key in excluding pulmonary embolism and identifying right ventricular dysfunction.Learning Points: PH enhances the risk of perioperative complications, particularly right heart failure. Early detection, hemodynamic stability, and..."

Case report • Clinical • Surgery • Anesthesia • Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Heart Failure • Hypertension • Hypotension • Nephrology • Pulmonary Arterial Hypertension • Pulmonary Disease • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Ventricular Tachycardia

The dilemma of choosing safe anaesthetic medicines for a patient with Brugada syndrome needing vitrectomy! If the same patient needs a laparotomy, what pharmacological agents should you choose? (Euroanaesthesia 2025) - "Lignocaine, Amiodarone, Tramadol, Metoclopramide and Ketamine are on the orange list (preferably avoid)2. Caution with Vagotonic manoeuvres (e.g pneumoperitoneum, neck surgery) bradycardia precipitates VT/VF. Avoid hyperthermia3.If GA is necessary (e.g. laparotomy), safer drugs are Thiopentone, Fentanyl, Sevoflurane, NDMR, Paracetamol, NSAIDs, Dexamethasone, Ondansetron and Sugammadex."

Clinical • Aesthetic Medicine • Anesthesia • Cardiovascular • Dyslipidemia • Genetic Disorders • Hypertension • Metabolic Disorders

The phenomena of arrhythmia-induced cardiomyopathies (AICM): what comes first, the chicken or the egg? (Euroanaesthesia 2025) - "Consequently, a therapy with amiodarone and beta blocker was gradually designed to control the arrhythmic pattern. After the decrease of heart rate, we continued to treat the heart failure with beta blocker carvedilol, digoxin, ACE inhibitor and diuretics...Even if the causative arrhythmia is apparent, the clarification of a cause-effect relationship sometimes provokes a diagnostic "headache" for the treating physician, since diagnosis may be confirmed only retrospectively. Raising awareness of the difficulties of diagnosis and all available treatment options is essential for a better management of dysrhythmia in children."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fatigue • Heart Failure • Infectious Disease • Pain • Pediatrics

Predicting drug-drug interactions and optimal dosing of betrixaban with physiologically based pharmacokinetic modeling in patients with renal impairment who were coadministered with P-glycoprotein inhibitors. (PubMed, J Int Med Res) - "ObjectiveTo optimize dosing adjustments in patients with renal impairment who were coadministered with P-glycoprotein inhibitors-verapamil or amiodarone-using a physiologically based pharmacokinetic model.MethodsThe developed physiologically based pharmacokinetic model was corroborated using previously reported pharmacokinetic parameters across multiple doses, ratio values in drug-drug interactions, and pharmacokinetic ratio values in patients with renal impairment.ResultsThe physiologically based pharmacokinetic model exhibited fold errors between 0.7 and 1.3 and effectively illustrated changes in pharmacokinetic ratios in patients with renal impairment. For patients with severe renal impairment, it may be reasonable to avoid concurrent use of betrixaban with P-glycoprotein inhibitors.ConclusionsThe coadministration of P-glycoprotein inhibitors elevates the exposure of betrixaban and may heighten the risk of major bleeding. Reduced dosing regimens are recommended for..."

Journal • PK/PD data • Renal Disease