amiodarone / Generic mfg. - LARVOL DELTA

Repeated Amiodarone Boluses Did Not Improve Clinical Outcomes Compared to Conventional Amiodarone Dosing in Postoperative Atrial Fibrillation After Cardiac Surgery (ASA 2025) - "Abstract is embargoed at this time."

Clinical • Clinical data • Surgery • Atrial Fibrillation • Cardiovascular

From A Fib to Coma: A Case Report of Amiodarone Induced Phenytoin Toxicity (ASA 2025) - "Phenytoin was stopped and started on lactulose and L carnitine. Afib treatment with amiodarone is theorized to be the cause. It can increase phenytoin levels, and both phenytoin and amiodarone can increase ammonia levels."

Case report • Clinical • CNS Disorders • Epilepsy

Uncovering the Unexpected: A Rare Cause of Ventricular Tachycardia in the Postoperative ICU (ASA 2025) - "After electrolyte optimization, magnesium supplementation, amiodarone and lidocaine boluses, and removal of a pulmonary artery catheter, her episodes improved, though ectopy persisted...Successful retrieval by interventional radiology resolved her arrhythmias. This case highlights the importance of broadening the differential diagnosis for postoperative ventricular tachycardia to include structural causes when standard management fails."

Cardiovascular • Hypotension • Ventricular Tachycardia

Development of a Fast-track, ERAS-based Cardiac Anesthesia Protocol in Surviving Swine Model (ASA 2025) - "We developed Enhanced Recovery after Surgery (ERAS)-based protocol, combining human principles with species-specific adaptations integrating preoperative amiodarone prophylaxis, inflammation targeted methylprednisolone during CPB, tailored anticoagulation, and sugammadex mediated fast-spontaneous extubation. In 18 neonatal pigs, this resource-efficient protocol achieved successful prone-position intubation, reduced intraoperative arrhythmias, spontaneous 2hr extubation and full nutritional recovery within 24hrs-without blood banks or intensive care units. This protocol achieved accelerated rehabilitation paving the way for advancement in translational cardiac research."

Clinical • Anesthesia • Cardiovascular

Amiodarone Toxicity in the Cardiac ICU Following a STEMI (ASA 2025) - "9 days later, he presented again to the ED with acutely worsened shortness of breath, with imaging and bronchoscopy consistent with amiodarone pulmonary toxicity. He ultimately developed end-stage pulmonary, cardiac, and renal failure and was transitioned to comfort care."

Cardiovascular • Renal Disease

Successful Recovery from Amiodarone Pulmonary Toxicity with VV-ECMO Preserving Candidacy for Heart-Kidney Transplant (ASA 2025) - "In the next 24 days the patient's lungs made a drastic recovery with minimal support before transplant. This case highlights the utility of VV-ECMO for unique acute lung injury recovery which preserved candidacy as bridge to dual transplant."

Acute Kidney Injury • Acute Lung Injury • Cardiovascular • Congestive Heart Failure • Heart Failure • Immunology • Renal Disease • Respiratory Diseases • Sarcoidosis • Solid Organ Transplantation • Transplantation • Ventricular Tachycardia

Bypassed, But Not Safe: Catastrophic Stroke Following CABG (ASA 2025) - "Intraoperatively, developed afib with RVR, treated successfully with amiodarone...Neurosurgical intervention was considered, but the family elected for terminal extubation. This case underscores rare but devastating thromboembolic complications post-CABG, even in the absence of known coagulopathy or intraoperative instability."

Cardiovascular • Hematological Disorders • Thrombosis

Advanced Therapy of Recurrent Symptomatic Ventricular Tachycardia requiring ECMO (ASA 2025) - "69M PMHx NICM/HFrEF (LVEF40%), recurrent symptomatic ventricular tachycardia (VT) despite amiodarone therapy and repeated cardioversions and ablations, s/p ICD placement (2023), presented to the ED with dyspnea, dizziness and fatigue, admitted for advanced management of symptomatic VT...Post-operative course complicated by right ventricular dysfunction, and acute pulmonary insufficiency from drug-induced pneumonitis requiring steroid taper. Patient discharged on theophylline in stable condition"

Metastases • Cardiovascular • Fatigue • Heart Failure • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • Ventricular Tachycardia

Successful Cardiac Resuscitation of Persistent Ventricular Fibrillation with Lidocaine After Cardiopulmonary Bypass in Liver Transplant Recipient (ASA 2025) - "Following an uneventful intraoperative course, he had a brief episode of Vfib and was started on amiodarone...The patient had no further events. This case underscores the importance of reviewing immunosuppressant interactions in transplant patients undergoing cardiac surgery and the consideration of utilizing classic, proven anti-arrhythmics."

Clinical • Cardiovascular • Transplantation

Bilateral Actively-Secreting Adrenalectomy in a Cardiovascularly Compromised Patient (ASA 2025) - "He developed multiple episodes of ventricular tachycardia requiring esmolol and amiodarone loading, and rapid fluctuations in systolic blood pressure of greater than 100mmHg, requiring clevidipine, epinephrine, norepinephrine, and vasopressin. This case highlights anesthetic strategies to manage acutely fluctuating cardiovascular status in patients with active adrenal tissue with poor cardiorespiratory substrate."

Clinical • Anesthesia • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Cushing’s Disease • Endocrine Disorders • Heart Failure • Hypertension • Hypotension • Ventricular Tachycardia

Hemorrhagic Pericardial Effusion After Cytoreductive Surgery: A Rare Postoperative Challenge (ASA 2025) - "Narrow-complex tachycardia prompted IV amiodarone, but hypotension persisted despite rhythm conversion. Bedside TTE revealed large hemorrhagic pericardial effusion, requiring emergent pericardiocentesis (950 mL drained). This case highlights hemorrhagic pericardial effusion as a rare but critical postoperative complication following major abdominal cytoreduction, emphasizing the need for early recognition and prompt pericardiocentesis to prevent mortality and ensure favorable outcome."

Surgery • Acute Kidney Injury • Cardiovascular • Gastroenterology • Hematological Disorders • Hypotension • Nephrology • Pulmonary Embolism • Renal Disease • Respiratory Diseases

Ablation of Ventricular Tachycardia with Decrease in Impella Support in Setting of Electrical Storm (ASA 2025) - "The patient arrived to the EP lab on infusions of norepinephrine, amiodarone, and dobutamine. Weaning of the Impella was performed in order to induce ventricular tachycardia to facilitate mapping for the ablation. After successful ablation and AAI pacemaker placement, the patient tolerated Impella wean with resolution of VT storm and was discharged."

Cardiovascular • Ventricular Tachycardia

Anesthetic Management of a Patient with Refractory Ventricular Tachycardia Undergoing Emergency Craniotomy for Traumatic Subdural Hematoma: A Case Report (ASA 2025) - "He received general anesthesia with an endotracheal tube, was induced with etomidate and succinylcholine, and maintained with sevoflurane. He received 360mg amiodarone, 160mg esmolol, 2000mg calcium gluconate, and repletion of potassium and magnesium with no effect. This case highlights the challenge of maintaining hemodynamic stability secondary to VT in a patient with SDH."

Case report • Clinical • Anesthesia • Cardiovascular • CNS Disorders • Ventricular Tachycardia

HLX and SLC25A20: Immunologic regulators bridging ankylosing spondylitis and uveitis via multi-omics integration and machine learning. (PubMed, PLoS One) - "HLX and SLC25A20 emerge as immunologic regulators bridging AS and uveitis pathogenesis. These findings provide actionable targets for precision diagnostics and therapeutic development in AS-associated uveitis."

Biomarker • Journal • Ankylosing Spondylitis • Immunology • Inflammation • Inflammatory Arthritis • Ocular Inflammation • Ophthalmology • Rheumatology • Seronegative Spondyloarthropathies • Uveitis

An incidental atrial fibrillation. Is the best the enemy of good? (PubMed, Rev Med Suisse) - "We report an 80-year-old male with newly diagnosed slow AF, referred for an electrical cardioversion after amiodarone loading...Following cardioversion and despite medication cessation, the patient developed a symptomatic bradycardia with junctional rhythm prompting a pacemaker insertion. This case highlights the value of tailored care, unified judgement and the importance of considering a watchful waiting approach in selected patients."

Journal • Atrial Fibrillation • Cardiovascular

HIGH-DENSE OPACITIES IN THE LUNG: A CASE OF AMIODARONE PULMONARY TOXICITY (CHEST 2025) - No abstract available

Clinical

NATIONAL TRENDS IN AMIODARONE USE AND EXPENDITURES IN THE UNITED STATES: ANALYSIS OF THE MEDICAL EXPENDITURE PANEL SURVEY 2001-2020 (CHEST 2025) - No abstract available

Cardiovascular

PULMONARY CRYPTOCOCCOSIS OR AMIODARONE TOXICITY? A DIAGNOSTIC CHALLENGE OF PULMONARY INFILTRATES (CHEST 2025) - No abstract available

A DOSE OF TROUBLE: A CASE OF FUROSEMIDE TRIGGERING AMIODARONE-INDUCED HYPOTHYROIDISM (CHEST 2025) - No abstract available

Clinical • Endocrine Disorders

DRUG-INDUCED EOSINOPHILIC PNEUMONIA IN THE SETTING OF CONCURRENT DAPTOMYCIN AND AMIODARONE USE (CHEST 2025) - No abstract available

Infectious Disease • Pneumonia • Respiratory Diseases

AMIODARONE-INDUCED ACUTE RESPIRATORY DISTRESS SYNDROME: A SERIOUS PULMONARY COMPLICATION (CHEST 2025) - No abstract available

Acute Respiratory Distress Syndrome • Respiratory Diseases

An exploratory study of landiolol plus amiodarone versus amiodarone monotherapy in paediatric junctional ectopic tachycardia after surgery. (PubMed, Cardiol Young) - "In this retrospective analysis, combined landiolol and amiodarone therapy demonstrated a shorter time to heart rate control compared to amiodarone alone, especially when landiolol was initiated first. These findings require confirmation in prospective studies."

Journal • Monotherapy • Cardiovascular • Hypotension • Pediatrics

Atypical Presentation of Systemic Amyloid Light Chain (AL) Amyloidosis. (PubMed, Cureus) - "Atrial fibrillation was noted on ECG and was treated with both rate- and rhythm-controlled amiodarone...However, this is neither supported nor refuted as the gold standard by the available literature. The patient was transferred to a higher level of care at a center specifically focused on the treatment of amyloidosis to receive the current gold standard of treatment, which was unavailable at our facility due to a lack of these specialized medications, as well as a provider comfortable with the use of these treatments."

Journal • Amyloidosis • Atrial Fibrillation • Cardiac Amyloidosis • Cardiovascular • Congestive Heart Failure • Fatigue • Heart Failure • Respiratory Diseases

Complex Endocrine Interplay: Amiodarone-Induced Thyrotoxicosis in Autoimmune Polyglandular Syndrome Type 2 (ATA 2025) - "He also has a history of recurrent myopericarditis, managed with chronic prednisone, and atrial flutter previously treated with amiodarone...He remains clinically stable on physiologic glucocorticoid replacement and fludrocortisone, without current need for levothyroxine.DiscussionAPS2 frequently includes Hashimoto's thyroiditis, which predisposes patients to hypothyroidism...Patients with APS2 may be more susceptible to developing amiodarone-induced thyrotoxicosis (AIT) due to underlying thyroid autoimmunity. While amiodarone's high iodine content typically exacerbates hypothyroidism, true reversal of Hashimoto's thyroiditis with restoration of endogenous thyroid function is uncommon."

Cardiovascular • Celiac Disease • Endocrine Disorders • Immunology • Nephrology • Renal Disease

Thyroidectomy for Recalcitrant Amiodarone Induced Thyrotoxicosis: A Case Series (ATA 2025) - "All patients received a combination of methimazole and prednisone for an average of six weeks, without improvement in thyroid function, and with ongoing cardiac decompensation. Delay in surgical intervention is often attributed to concerns over operative risk, contributing to poorer outcomes. (3) These cases highlight the importance of early recognition of refractory AIT and the timely involvement of a multidisciplinary team—including endocrinology, cardiology, endocrine surgery, and cardiac anesthesia—to optimize patient outcomes and reduce procedural risks."

Clinical • Anesthesia • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Endocrine Disorders • Ventricular Tachycardia