amiodarone / Generic mfg. - LARVOL DELTA

AMIODARONE INCREASES MORTALITY IN ATRIAL FIBRILLATION PATIENTS (ACC 2026) - "Abstract is embargoed at this time."

Clinical • Atrial Fibrillation • Cardiovascular

In Vitro Effects of Liquid Cardiac Drugs on Human Catalase Enzyme. (PubMed, Turk Kardiyol Dern Ars) - "Noradrenaline, adrenaline, and amiodarone hydrochloride have strong inhibitory effects on catalase activity. Catalase inhibition may be responsible for the side effects of these drugs. Therefore, when these drugs are used in treatment, their dosages and duration of administration should be carefully controlled to prevent adverse effects due to catalase enzyme inhibition."

Journal • Preclinical • CAT

Three different indications for left ventricular unloading in one patient with severe heart failure. (PubMed, Am Heart J Plus) - "Indications included acute myocardial infarction-related CS (AMI-CS), ventricular tachycardia (VT) ablation one year later, and elective thyroidectomy for amiodarone-induced hyperthyroidism another year later...No major adverse events occurred. Repeated mAFP use for AMI-CS, VT ablation, and high-risk surgery was feasible and safe, supporting its versatility in complex clinical care."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Endocrine Disorders • Heart Failure • Myocardial Infarction • Ventricular Tachycardia

Case Report: A case of heart failure recovery after non-ischemic cardiomyopathy following chimeric antigen receptor T-cell therapy. (PubMed, Front Cardiovasc Med) - "After the development of the ventricular tachyarrhythmia, amiodarone was initiated for rhythm control...This case showcases a prolonged cardiac recovery following complications of CAR-T therapy. It also provides insight into the successful clinical management of a patient due to CAR-T-induced cardiomyopathy in the setting of potentially complex ventricular arrhythmias."

Journal • B Cell Lymphoma • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Diabetes • Diffuse Large B Cell Lymphoma • Heart Failure • Hematological Malignancies • Hypertension • Inflammation • Lymphoma • Metabolic Disorders • Non-Hodgkin’s Lymphoma • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Ventricular Tachycardia

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens. (PubMed, Kaohsiung J Med Sci) - "Notably, amiodarone showed equivalent anti-tumor efficacy but with fewer side effects on the treated mice compared to the clinical anti-cancer drug Mitomycin C (MMC). Similarly, low autophagy is associated with a poor overall survival rate. Furthermore, repurposing amiodarone-induced autophagy accompanied by trivial side effects shows potential for the treatment of bladder cancer patients."

Journal • Preclinical • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • ATG5

Medication-associated thyroid eye disease: a review. (PubMed, Graefes Arch Clin Exp Ophthalmol) - "Medication-associated TED is an important differential consideration in the work-up of orbital inflammatory disease. The clinico-radiological manifestations and the principles of management of medication-associated TED were similar to that of de novo TED. Certain medications, such as various ICIs, may demonstrate different clinical phenotypes of orbital inflammation, inciting either TED or a "TED-like" orbitopathy without evidence of underlying thyroid dysfunction."

Journal • Review • Endocrine Disorders • Grave’s Disease • Inflammation • Ocular Inflammation • Oncology • Ophthalmology • Thyroid Eye Disease

Case Report: Low cardiac output syndrome with multisystem complications following total repair of tetralogy of fallot. (PubMed, Front Pediatr) - "JET was managed with amiodarone, ivabradine, magnesium, and targeted temperature control...Neuroprotective therapy included piracetam and mannitol...Early recognition and multidisciplinary intervention are essential. This case highlights the potential reversibility of cortical blindness and the importance of comprehensive postoperative surveillance."

Journal • Cardiovascular • Hematological Disorders • Hypotension • Ophthalmology • Pediatrics • Thrombosis

Heart in the crossfire, from epsilon to beyond: cardiac sarcoidosis-a case report. (PubMed, Eur Heart J Case Rep) - "She presented 3 months later with angina and heart failure (HF) symptoms, complicated with ventricular tachycardia (VT) treated with i.v. amiodarone and anti-failure medication...Clinical diagnosis of cardiac sarcoidosis was made based on a histologic diagnosis of extracardiac sarcoidosis with cardiomyopathy/ventricular arrhythmia combined with PET/CMR findings. Cardiac sarcoidosis can have a myriad of symptoms, which may mimic several other disorders leading to a diagnostic challenge."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hepatology • Immunology • Inflammation • Metabolic Disorders • Sarcoidosis • Ventricular Tachycardia

Adherence to guideline recommendations for postoperative atrial fibrillation: a nationwide survey reveals major prevention gaps. (PubMed, Int J Surg) - "This first national survey in China reveals substantial gaps in POAF knowledge and guideline adherence, particularly concerning preventive care. Our findings highlight the global challenge of translating evidence-based POAF recommendations into practice. They emphasize the need for targeted implementation strategies that account for healthcare system constraints in developing economies with large cardiovascular disease burdens."

Journal • Atrial Fibrillation • Cardiovascular • Preventive care

Marked QTc Interval Prolongation Associated With Dronedarone in Paroxysmal Atrial Fibrillation and No Structural Disease. (PubMed, Cureus) - "Dronedarone, a multichannel antiarrhythmic drug, was developed as a safer alternative to amiodarone for atrial fibrillation. We describe the case of a 44-year-old male with paroxysmal atrial fibrillation and no structural heart disease who developed marked QTc prolongation while receiving dronedarone, despite being asymptomatic. This case highlights the potential for clinically silent but significant QTc prolongation during dronedarone therapy, underscoring the importance of careful ECG monitoring, even in low-risk patients."

Journal • Atrial Fibrillation • Cardiovascular • Heart Failure

An episode-based approach for assessing the impact of dyskalaemia on critical care outcomes - results from a territory-wide cohort study. (PubMed, Anaesth Intensive Care) - "Having dyskalaemic episodes during the ICU stay was significantly associated with increased odds of ICU mortality and arrhythmias."

Journal • Cardiovascular • Critical care

Impact of extracorporeal membrane oxygenation modes on voriconazole exposure in critically ill patients. (PubMed, J Antimicrob Chemother) - "ECMO support did not significantly reduce voriconazole Cmin compared with the non-ECMO group. However, VAV-ECMO is associated with reduced voriconazole exposure, suggesting a configuration-specific rather than uniform ECMO effect. Routine therapeutic drug monitoring remains essential."

Journal • Observational data • Retrospective data • Infectious Disease

Rare Chromosome 18q Rearrangements and Hypoplastic Right Heart Syndrome: A Case Report and Genetic Insights (ACMG 2026) - "Outcome and Follow-Up At reporting, she was discharged with nasogastric tube feeding and continuation of Enalapril and Amiodarone for tachycardia and Lovenox for thrombus. Diagnostic Workup Postnatal echocardiogram revealed membranous pulmonary atresia with intact ventricular septum, a mildly hypoplastic right ventricle, severely hypoplastic tricuspid valve with thickened leaflets and short chordae, and a tortuous patent ductus arteriosus (PDA). Single-nucleotide polymorphism (SNP) microarray identified a 4.2 Mb terminal deletion and a 48.0 Mb proximal duplication on chromosome 18q, consistent with a karyotype as 46,XX,der(18)(pter→q23::q23→q11.2:), indicating an inverted duplication and terminal deletion of 18q."

Case report • Clinical • Cardiovascular • Gynecology • Hematological Disorders • Hypertension • Thrombosis • DSG2 • ZKSCAN1 • ZNF23

Postoperative Atrial Fibrillation after Lung Resection: Reevaluating the Role of Amiodarone Prophylaxis. (PubMed, Ann Thorac Surg) - No abstract available

Journal • Atrial Fibrillation • Cardiovascular

Transcriptomic and ultrastructural responses to Amiodarone-Itraconazole in naturally benznidazole-resistant and -susceptible Trypanosoma cruzi strains. (PubMed, PLoS Negl Trop Dis) - "Our study underscores the potential of Amiozole as a combinatorial therapy against T. cruzi strains with distinct resistance profiles. Nevertheless, further research using infective forms, variable dosages, and diverse intra-DTU lineages is essential to validate its clinical applicability for Chagas disease."

Journal • Metabolic Disorders

Safety of extensive pulsed field ablation for atrial fibrillation in a patient with left ventricular assist device: a case report. (PubMed, Eur Heart J Case Rep) - "Despite amiodarone and beta-blockers, the patient experienced symptomatic recurrent AF and atrial flutter with multiple episodes per day of low flow alarm by the LVAD...This case highlights the feasibility and the safety of PFA-assisted PVI, PWI, and CTI ablation in LVAD patients. No complications related to the transseptal approach or interference of pulsed field energy with the LVAD have been detected."

Journal • Anesthesia • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure

Cardiac Sympathetic Denervation for Termination of Ventricular Tachycardia Storm: A Multidisciplinary Case. (PubMed, JACC Case Rep) - "Autonomic neuromodulation, including CSD, is an adjunctive therapeutic approach for VT storm, offering sustained sympathetic suppression and VT control. Patients who demonstrate good VT suppression with LSGB, suggesting a predominant sympathetic contribution, may be favorable candidates for CSD."

Journal • Anesthesia • Cardiomyopathy • Cardiovascular • Heart Failure • Transplantation • Ventricular Tachycardia

Delayed-Onset Amiodarone Induced Thyrotoxicosis After Glucagon-Like Peptide-1 Agonist-Related Weight Loss. (PubMed, JCEM Case Rep) - "He was treated with prednisone and methimazole with eventual resolution of hyperthyroidism. Delayed AIT should be considered in the differential diagnosis of new-onset thyrotoxicosis in patients previously treated with amiodarone who experience significant weight loss."

Journal • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Ventricular Tachycardia

RAGING HEART, CALM THYROID: REFRACTORY AF CONTROLLED WITH IV AMIODARONE WITHOUT WORSENING HYPERTHYROIDISM (ACC 2026) - "Abstract is embargoed at this time."

Endocrine Disorders

A RARE THOUGH FATAL EVENT: A CASE OF AMIODARONE INDUCED ACUTE LIVER FAILURE AUTHORS (ACC 2026) - "Abstract is embargoed at this time."

Clinical • Hepatology • Liver Failure

SAFETY AND EFFICACY OF CLASS IC VS AMIODARONE ANTIARRHYTHMIC AGENTS IN PATIENTS WITH CONGENITAL HEART DISEASE: A RETROSPECTIVE MULTI-CENTER STUDY (ACC 2026) - "Abstract is embargoed at this time."

Retrospective data • Cardiovascular • Heart Failure

FROM BLOCK TO BEAT: THEOPHYLLINE RESCUE OF AMIODARONE-RELATED SINUS NODE DYSFUNCTION (ACC 2026) - "Abstract is embargoed at this time."

Cardiovascular

Effect of bone marrow stem cell conditioned medium on amiodarone-induced submandibular salivary gland and kidney damage in male albino rats. (PubMed, BMC Oral Health) - No abstract available

Journal • Preclinical

Impact of Advanced Cardiac Life Support Medications on Discharge Neurological Function for Survivors of Cardiac Arrest When Using ECPR. (PubMed, Circ Heart Fail) - "Antiarrhythmics were associated with better neurological outcomes (amiodarone: CPC ≤ 1 [odds ratio [OR], 1.28 [95% CI, 1.00-1.65]; P=0.048] and CPC ≤ 2 [OR, 1.38 [95% CI, 1.06-1.78]; P=0.015]; lidocaine: CPC ≤ 1 [OR, 1.69 [95% CI, 1.32-2.17]; P<0.001], CPC ≤ 2 [OR, 1.82 [95% CI, 1.39-2.38]; P<0.001], CPC ≤ 3 [OR, 1.76 [95% CI, 1.30-2.40]; P<0.001]). The unweighted cumulative effects model demonstrated a dose-dependent increasing relationship between epinephrine doses and harm for all CPC levels (OR, 0.89-0.94; P<0.001 for all). Our data support that increasing doses of epinephrine and nonantiarrhythmic advanced cardiovascular life support medications both worsen the probability of neurologically intact survival for patients who undergo extracorporeal cardiopulmonary resuscitation."

Journal • Cardiovascular • CNS Disorders

Avoiding Intubation in Severe Acute Respiratory Distress Syndrome Due to Mixed Amiodarone Toxicity and Haemophilus Influenzae: A Case of Permissive Hypoxemia. (PubMed, Cureus) - "The steroid regimen was escalated to prednisone 160 mg/day. The patient was discharged without requiring intubation. This case highlights the importance of reviewing historical imaging to identify drug-induced toxicity and suggests that, in selected patients with preserved respiratory drive, a noninvasive approach tolerating severe hypoxemia may be a viable alternative to intubation."

Intubation • Journal • Acute Respiratory Distress Syndrome • Infectious Disease • Influenza • Pneumonia • Pulmonary Disease • Respiratory Diseases