aceclofenac / Generic mfg. - LARVOL DELTA

Anti-inflammatory drugs as potential antimicrobial agents: a review. (PubMed, Front Pharmacol) - "NSAIDs, namely aceclofenac, diclofenac, and ibuprofen, were tested in clinical trials with patients diagnosed with uncomplicated urinary tract infections (UTIs) and cellulitis...Similarly, aspirin caused a high survival rate in M. tuberculosis-infected mice and strong to moderate in vitro activity against E. coli, B. cereus, P. aeruginosa, Enterobacter aerogenes, Klebsiella pneumoniae and Salmonella choleraesuis (MIC 1.2-5 mg/L). Moreover, topical application of celecoxib resulted in a high reduction in MRSA burden in mice...These data suggest that certain non-steroidal anti-inflammatory drugs (NSAIDs) are promising drug candidates for the development of dual-action drugs for the potential treatment of combined infectious and inflammatory diseases such as tuberculosis, musculoskeletal infections and UTIs. Nevertheless, future clinical trials must be conducted to ascertain the antibacterial effect of these NSAIDs before their practical use."

Journal • Review • Cholera • Dermatology • Immunology • Infectious Disease • Inflammation • Musculoskeletal Diseases • Nephrology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Rheumatology • Tuberculosis • GDF15

ULTRASOUND-GUIDED COMMON PERONEAL NERVE BLOCK AND SCAR INFILTRATION FOR CHRONIC POSTOPERATIVE NEUROPATHIC PAIN: A CASE REPORT (ASRA-SPRING 2025) - "Minimal residual pain at the nailing site wasmanaged conservatively with oral analgesics (T.Amitriptyline 5 mg at bedtime for 5 days, followed by 10mg at bedtime, and Tablet with combination of 100 mg ofaceclofenac, 325 mg of paracetamol, and 15mg ofserratiopeptidase for 3 days) and physiotherapy.Follow-up at three months confirmed sustained pain reliefand functional improvement.ResultsThis case underscores the efficacy of ultrasound-guided nerve blocksand scar infiltration in addressing chronic postoperative neuropathicpain. Ultrasound-guided peripheralnerve blocks and scar infiltration have been explored as effectiveinterventional strategies to alleviate chronic postoperative pain. Thiscase report discusses a patient with chronic neuropathic painfollowing tibia and fibula fracture surgery, emphasizing the role oftargeted pain management techniques."

Case report • Clinical • Fibrosis • Immunology • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Neuralgia • Orthopedics • Pain

Overall compilation of adverse effects of non-steroidal anti-inflammatory drugs: a hypothesis-free systematic investigation using a nationwide cohort study. (PubMed, Front Pharmacol) - "Further, we assessed the association between five NSAID subtypes (aceclofenac, meloxicam, loxoprofen, celecoxib, and naproxen) and AEs, and compared their adjusted hazard ratios (aHRs) with each other. Our findings enhance the understanding of NSAID safety profiles by identifying dose-response and duration-time AEs. They also contribute to better diagnosis and management of AEs while providing valuable guidelines for both patients and clinicians."

Adverse events • Journal • Hematological Disorders • Immunology • Nephrology • Osteoarthritis • Pain • Rheumatology

Formulation and Evaluation of Microsponges-loaded Transdermal Gel for the Management of Osteoarthritis. (PubMed, Recent Adv Inflamm Allergy Drug Discov) - "The findings indicate that Formulation F1 exhibits superior entrapment and enhanced drug release. The kinetics study suggests that the optimized formulation aligns well with the Higuchi model and adheres to the Fickian transport drug release mechanism. Animal study findings suggest that optimized formulation Ace(B) may possess ideal -anti-osteoarthritic activity for osteoarthritic disease. Further clinical trials on humans may be conducted in order to make the research fruitful for society."

Journal • Gastrointestinal Disorder • Immunology • Osteoarthritis • Pain • Rheumatology

Effects of App-assisted Home Exercise Program in Patients With Frozen Shoulder (clinicaltrials.gov) - P=N/A | N=21 | Completed | Sponsor: Chang Gung Memorial Hospital | Recruiting ➔ Completed | N=76 ➔ 21

Enrollment change • Trial completion

Dynamic Behavior of the Glassy and Supercooled Liquid States of Aceclofenac Assessed by Dielectric and Calorimetric Techniques. (PubMed, Molecules) - "This is supported by significant differences observed between the FTIR spectra of the amorphous and crystalline samples, which are likely related to aggregation differences resulting from variations in the hydrogen bonds between the two phases. Additionally, the pronounced decoupling between translational and relaxational motions, as deduced from the low value of the fractional exponent x = 0.72, derived from the fractional Debye-Stokes-Einstein (FDSE) relationship, further supports this interpretation."

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EXPRESSION OF CONCERN: HSP70 Inhibition Reverses Cell Adhesion Mediated and Acquired Drug Resistance in Multiple Myeloma. (PubMed, Br J Haematol) - "Nimmanapalli, E. Gerbino, W. S. Dalton, V. Gandhi, and M. Alsina, "HSP70 Inhibition Reverses Cell Adhesion Mediated and Acquired Drug Resistance in Multiple Myeloma," British Journal of Haematology 142, no...However, without an explanation of the anomaly in the figure and in the absence of the original raw data, the journal team could not verify the authenticity of this figure and could not exclude that these concerns might have affected some of the conclusions of the article. Therefore, the journal has decided to issue an Expression of Concern to inform and alert the readers."

Biomarker • Clinical • Journal • Retrospective data • Review • Hematological Disorders • Hematological Malignancies • Multiple Myeloma • Oncology

Low-Level Laser Therapy with Pharmacotherapy in the Management of Myofascial Pain Dysfunction Syndrome with or without Other Temporomandibular Disorders. (PubMed, Indian J Dent Res) - "Both LLLT and a combination of LLLT and drug therapy are effective in the management of myofascial pain. LLLT + pharmacotherapy combination is more efficient at improving pain and mouth opening."

Journal • Fibromyalgia • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Open observational study with a retrospective analysis of the efficacy and tolerability of aceclofenac in patients with acute non-specific low back pain (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "The use of NSAIDs for low back pain is effective and safe. Aceclofenac and nimesulide are superior to dexketoprofen and lornoxicam in terms of functional activity associated with low back pain and health-related quality of life. Aceclofenac demonstrated the most favorable safety profile and a lower risk of chronicity (compared to nimesulide and lornoxicam) and recurrence (compared to dexketoprofen) of low back pain."

Journal • Observational data • Retrospective data • Back Pain • Cardiovascular • Gastrointestinal Disorder • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Control of neuropathic pain in lumbosacral dorsalgia (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "It has been shown that the intensity of neuropathic pain decreases with the administration of pregabalin. In acute nonspecific back pain, the use of aceclofenac is effective. The severity of musculotonic pain syndrome is significantly reduced when using tolperizone (Midocalm-long). The results of the analyzed studies confirm the effectiveness and safety of the combination."

Journal • Review • Back Pain • Musculoskeletal Pain • Neuralgia • Pain

Synthesis and pharmacological evaluation of heteroarylamide derivatives as potential analgesic, anti-inflammatory, antidiarrheal and cytotoxic agents. (PubMed, Heliyon) - "Evaluation of anti-inflammatory activity unveiled that compound 4 exhibited 36.9 %, 64.17 %, 82.9 % and 93.9 % inhibition of paw edema as compared to aceclofenac's inhibition of 35.5 %, 78.6 %, 79.3 % and 91.2 % at the 1st, 2nd, 3rd and 4th hours, respectively. Compounds 5 and 6 exerted considerable antidiarrheal effects with 85.00 % and 71.67 % inhibition of defecation at 25 mg/kg dose, respectively, whereas, the standard loperamide showed 85.00 % inhibition...Molecular docking analysis suggested that certain macromolecular targets such as cyclooxygenase-2, muscarinic M3 receptor and matrix metalloproteinase 9 (MMP9) might be involved for the observed activities. As predicted by in silico ADME/T analysis, the compounds also possessed good pharmacokinetic properties."

Journal • Pain • MMP9

Bidirectional Long Short-Term Memory-Based Detection of Adverse Drug Reaction Posts Using Korean Social Networking Services Data: Deep Learning Approaches. (PubMed, JMIR Med Inform) - "In addition, the entire process was further verified using the nonsteroidal anti-inflammatory drug aceclofenac...Based on these data, we developed a model that classifies ADR posts. This confirmed that a model that can leverage social data to monitor ADRs automatically is feasible."

Adverse drug reaction • Journal

Tarlock K, Gerbing RB, Ries RE, et al. Prognostic impact of cooccurring mutations in FLT3-ITD pediatric acute myeloid leukemia. Blood Adv. 2024;8(9):2094-2103. (PubMed, Blood Adv) - No abstract available

Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • Pediatrics • FLT3

Strategic development of aceclofenac loaded organosomes for topical application: An explorative ex-vivo and in-vivo investigation for arthritis. (PubMed, Int J Pharm) - "Pseudoplastic behaviour of the developed product was indicated by the rheological results, and it also demonstrated biocompatibility through skin compliance studies. Based on the current findings, it appears that OS may be a better choice for managing arthritis and related inflammations."

Journal • Preclinical • Immunology • Inflammation • Rheumatology • IL1B • IL6 • TNFA

Solubility and thermodynamic analysis of aceclofenac in different {Carbitol + water} mixtures at various temperatures. (PubMed, BMC Chem) - "ACF-Carbitol had the strongest molecular interactions in contrast to ACF-water. Based on the results of this study, Carbitol holds significant potential for enhancing the solubility of ACF in water."

Journal

Revitalizing common drugs for antibacterial, quorum quenching, and antivirulence potential against Pseudomonas aeruginosa: in vitro and in silico insights. (PubMed, 3 Biotech) - "In this context, the present study was undertaken to scrutinize the anti-quorum sensing (QS) and antivirulence potential of commonly consumed drugs such as fexofenadine (FeX), ivermectin (IvM), nitrofurantoin (NiT), levocetrizine (LvC), atorvastatin (AtS), and aceclofenac (AcF), against P. aeruginosa...Moreover, the findings were validated by computational studies that predicted strong molecular interactions between the test drugs and QS receptors of P. aeruginosa. Hence, this study is the first to suggest the prospect of repurposing FeX, IvM, NiT, LvC, AtS, and AcF against P. aeruginosa."

Journal • Preclinical

A Case Report With Dual Diagnosis of Candidiasis in a Patient With Uncontrolled Diabetes Mellitus. (PubMed, Cureus) - "The oral lesions were treated using the local application of clotrimazole gel and the discomfort subsided with Aceclofenac. The underlying condition was treated by a general physician who prescribed the tablet metformin 500mg. The patient was educated about the predisposing condition, and motivated to make some lifestyle changes and to maintain a proper diet."

Journal • Candidiasis • Diabetes • Infectious Disease • Metabolic Disorders

Establishment of nanoparticle screening technique: A pivotal role of sodium carboxymethylcellulose in enhancing oral bioavailability of poorly water-soluble aceclofenac. (PubMed, Int J Biol Macromol) - "Based on our screening technique, the SNEDDS was selected as the optimal nanoparticle with the highest bioavailability of aceclofenac. Thus, our nanoparticle screening technique should be an excellent guideline for solubilization research to improve the solubility and bioavailability of many poorly water-soluble bioactive materials."

Journal

Therapeutic Potential of Nanocarriers in the Management of Rheumatoid Arthritis. (PubMed, Curr Rheumatol Rev) - "These nanocarriers loaded with curcumin, Aceclofenac, Boswellic acid, methotrexate, resveratrol, etc. can improve drug stability, prolong circulation time, and enhance targetability to inflamed tissues. By overcoming the limitations of traditional therapies, these technologies have the potential to improve patient outcomes and quality of life. Future research should focus on optimizing nanocarrier design, evaluating long-term safety, and conducting clinical trials to validate their efficacy in RA management."

Journal • Immunology • Inflammation • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Molecular Docking Analysis of Four Drugs (Phenytoin, Amoxicillin, Aceclofenac and Ciprofloxacin) and Their Association With Four Human Leukocyte Antigen (HLA) Alleles. (PubMed, Cureus) - "The drug phenytoin exhibited the lowest binding energy (LBE) with all four HLA alleles (HLA-B x 5101, HLA-B x 1501, HLA-A x 02:06, and HLA-B x 57:01). Conclusions The present findings provide new knowledge about the four drugs (phenytoin (PHT), amoxicillin (AMX), aceclofenac (ACE) and ciprofloxacin (CIP)) and their binding affinities with HLA alleles, which may cause cutaneous adverse drug reactions."

Journal • Hepatology • HLA-B

Nape seven needles combined with pressing moxibustion for cervical vertigo: a randomized controlled trial (PubMed, Zhongguo Zhen Jiu) - "Nape seven needles combined with pressing moxibustion can effectively alleviate the clinical symptoms, and improve the hemorheology and hemodynamics in CV patients."

Clinical • Journal • Musculoskeletal Pain • Otorhinolaryngology • Pain • Vertigo • EDN1

Analgesic eluting bone cement: A novel approach for targeted pain management in total knee arthroplasty - An in-vitro study. (PubMed, Knee) - "Polymethylmethacrylate bone cement can elute analgesics in vitro. Among the five drugs studied, naproxen had the best release kinematics from polymethylmethacrylate bone cement. Analgesic eluting bone cement is a novel approach for targeted postoperative pain management in TKA."

Journal • Preclinical • Musculoskeletal Pain • Orthopedics • Pain

Paracetamol Combination Therapy for Back Pain and Osteoarthritis: A Systematic Review and Meta-Analyses. (PubMed, Drugs) - "Low-to-moderate quality evidence supports the oral use of some paracetamol plus NSAID combinations for short-term pain relief with no increased risk of harm for low back pain and osteoarthritis compared to its non-paracetamol monotherapy comparator."

Combination therapy • Journal • Review • Back Pain • Immunology • Lumbar Back Pain • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatology

Assessing the Knowledge, Attitude, and Practice of Orthopedicians for Pain Management by Multimodal Approach: A Prospective, Cross-Sectional, and Observational Survey. (PubMed, Cureus) - " The combination of tramadol and paracetamol was identified as the most preferred choice of analgesics for prolonged orthopedic pain management."

Journal • Gastrointestinal Disorder • Musculoskeletal Pain • Orthopedics • Pain

The effect of aceclofenac and etoricoxib on platelet aggregation activity in bone trauma (ISTH 2024) - "Before surgery, aggregation activity in ACF group was significantly reduced relative to the control (table 1), however, on the 1st day after surgery it increased to the control level, which probably can be the result of a higher platelet consumption (table 2). By 7th day, aggregation activity in ACF group decreased again relative to the control. In ETC group, aggregation did not differ from the control during entire study period, and no postoperative reactive thrombocytosis was detected."

Hematological Disorders • Thrombocytosis