alatriopril (BP 1.137) / Bioprojet - LARVOL DELTA

Drug repurposing for renin inhibition: identifying panobinostat for hypertension management. (PubMed, Mol Divers) - "The in vitro Elisa-based assay revealed Panobinostat has the potential to inhibit the renin enzyme at the half-maximal concentration (IC50) of 201.27 nM, while standard renin inhibitor Aliskiren portrayed an IC50 of 162.22 nM. The comparable potency to clinical renin inhibitors presents this HDAC inhibitor as a dual-functioning ligand. The findings are significant and well correlated with the plethora of evidence suggesting the role of HDACs in regulating RAAS and cardiovascular functions via the post-translational level modulation of chromatins' structures and functions."

Journal • Cardiovascular • Hypertension • Renal Disease