AD313 / Apnimed - LARVOL DELTA

The combination of atomoxetine and dronabinol for the treatment of obstructive sleep apnea: a dose escalating, open-label trial. (PubMed, J Clin Sleep Med) - P1/2 | "Ato-Dro 80-5 mg might be useful to reduce OSA severity and led to subjective improvement in those who could tolerate the combination. However, given the numerous side effects and the exploratory nature of this open-label study, our results warrant further validation in larger trials."

Journal • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

The lifestyle of Tuyuhun royal descendants: Identification and chemical analysis of buried plants in the Chashancun cemetery, northwest China. (PubMed, Front Plant Sci) - "The Tuyuhun Kingdom (AD 313-663) was one of the most famous regimes in northwest China during the early medieval period...The assemblage of plant remains in the Chashancun cemetery suggests that millet cultivation played an important role in the livelihoods of Tuyuhun descendants, and the location of the elite Tuyuhun cemetery and multisources of different buried crops may reflect their memory of ancestors and homelands. This case study provides a unique perspective to understand the interactions among human subsistence strategy, geopolitical patterns, and local natural environments in northwest China during the late 7th century."

Journal

Study for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED) (clinicaltrials.gov) - P1/2 | N=15 | Completed | Sponsor: Apnimed | Active, not recruiting ➔ Completed

Trial completion • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Study for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED) (clinicaltrials.gov) - P1/2 | N=15 | Active, not recruiting | Sponsor: Apnimed | Recruiting ➔ Active, not recruiting

Enrollment closed • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Study for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED) (clinicaltrials.gov) - P1/2 | N=15 | Recruiting | Sponsor: Apnimed | Trial completion date: Dec 2021 ➔ Apr 2022 | Trial primary completion date: Dec 2021 ➔ Apr 2022

Trial completion date • Trial primary completion date • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder